COURSE SYLLABUS

BIOE339 Biostatistics (2020 Summer)

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1. Course Credit
3 hrs
2. Prerequisites
MATH210, CS 109
3. Schedule
Mon-Thur 1p-3:20p, (5/18-6/11)
4. Course Professors
Lead Professor
Name: Dr. Zhinan Wang
Title: Clinical Assistant Professor
Virtual Meet: https://uichicago.webex.com/meet/znw
Email: [email protected]
Teaching Assistant
Name: Ryan Morley
Email: [email protected]

5. Course Description
The course is designed for bioengineering undergraduate students. It provides the students
with selected important topics in biostatistical concepts and reasoning. Topics include
descriptive statistics, statistical hypothesis testing (t-tests, chi-squared tests, etc.) and its
application to group comparison, estimation, confidence intervals, analysis of variance, linear
regression and correlation, popular statistic computing software. This course will explore the
use of statistical methodology in designing, interpreting, and presenting research experiments
and observations.

6. Course Objectives
1. Learning Outcomes
Upon successful completion of this course, the student will be able to:  
a. Identify, formulate, and solve complex engineering problems by applying principles of
engineering, science, and mathematics.
b. Develop and conduct appropriate experimentation, analyze and interpret data, and use
engineering judgment to draw conclusions.
c. Apply the principles of engineering, biology, human physiology, chemistry, calculus-
based physics, mathematics (through differential equations) and statistics.
d. Analyze, model, design, and realize bio/biomedical engineering devices, systems,
components, or processes.
e. Make measurements on, and interpret data from, living systems.
2. Performance Criteria
Upon successful completion of this course, the student will be able to:  
a. Solve complex bioengineering problems by applying principles of sampling and
probability distribution.
b. Design and develop appropriate experimentation, analyze and interpret data using
proper hypothesis testing.
c. Utilize statistics and probability methods in the study of bioengineering systems.
d. Understand the roles biostatistics serves in biological research.

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 e. Develop working skills using a high-level programming language (MATLAB) in
statistical calculations.
f. Gain ability of handling bio-data generated from real world applications.

7. Materials
Required: Biostatistics – A foundation for analysis in the health, W.Q. Daniel and Cross, 10th
or 9th edition, Wiley, 2013, ISBN 0-471-45654-3.

Lecture slides and reading materials other than the textbook will be posted before each lecture.

Reference:
(1) Probability & statistics for engineers & scientists, Walpole et al. 9th edition, Pearson, 2011.
ISBN-10: 0321629116, ISBN-13: 978-0321629111.
(2) Handbook of Biological Statistics (3rd edition), McDonald, J.H. 2014. Sparky House
Publishing, Baltimore, Maryland. Download at http://www.biostathandbook.com/

8. Course Outline and Expectations

We meet online via Blackboard Collaborate for each meeting. All meeting will be
recorded for later use. Multiple homework will be assigned.

Multiple homework and projects will be assigned and collected through Blackboard. Late
submission is subjected to penalties unless you provide convincing explanation such as
conference registration, competition, emergency, or illness (with physician's note), etc.
Homework classified as overdue will have 10% penalty enforced for each day until the 4 th
day after due. That is the time the solution is posted. Any submission after that will be
scored 0.

Copying solutions, in whole or in part, from other students, old homework solutions, or
any other source without acknowledgment constitutes plagiarism and is a violation of
academic integrity at UIC and will automatically result in a fail in this class.

Participation/Attendance is not required during the scheduled online sessions. It is high

encouraged, though.

Course Communication Policy

All questions need to be asked publicly (you can be anonymous) on Piazza.
www.piazza.com/uic/summer2020/bioe339 . Please enroll yourselves asap. This will help
us to organize all questions and generate inspirations.

The instructor will NOT use email to answer course material related questions. Only email
me or TA for private concerns and other matters. Email me to schedule a web meeting
using Webex if you need to talk face to face.

General Course Communication Guidelines

 Be sensitive to different cultural and linguistic backgrounds, as well as different
political and religious beliefs.

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  Use good taste when composing your responses. Swearing and profanity should be
avoided. Also consider that slang terms can be misunderstood or misinterpreted.
 Be respectful of others’ views and opinions. Avoid “flaming” (publicly attacking or
insulting) others.
 Be careful when using acronyms. If you use an acronym it is best to spell out its
meaning first, then put the acronym in parentheses afterward, for example: Frequently
Asked Questions (FAQs). After that you can use the acronym freely throughout your
message.
 Use good grammar and spelling and avoid using text messaging shortcuts.
 In emails, always identify yourself and what class and section you are in. It is a good
practice to put your course and section in the subject line. This helps your instructor
identify course related emails.

9. Technology Requirements
Computer/Technology Requirements
MATLAB is required at all time during the semester. Make sure you have a running
copy on your laptop.
Minitab is required for the last two weeks. See Lecture 0 for more details.

Blackboard Learning Management System

For all technical questions about Blackboard, email ACCC-Learning Technology
Solutions at [email protected]

10. Grading and Evaluation

Final Grade Calculation
Assessments Percentages
HW 1 15%
HW 2 15%
HW 3 15%
HW 4 15%
HW 5 15%
Final Project 25%
Total Percentage For Course 100%

Grading
In determining the final course grade, the following scale is used:
[89.5, 100] = A
[79.5, 89.5) = B
[69.5, 79.5) = C
[59.5, 69.5) = D
[0, 59.5) = F

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11. Course Topics

Topic 1 Biomedical data collection and presentation

Topic 2 Probability and random variables
Topic 3 Special probability distributions
Topic 4 PDF and CDF
Topic 5 Sampling distribution
Topic 6 Estimation and confidence interval
Topic 7 P-value and error
Topic 8 Hypothesis testing
Topic 9 1-way and 2-way ANOVA
Topic 10 Experiment design
Topic 11 Correlation and linear regression
Topic 12 Academic conclusion and statistics software

12. UIC Resources (in 2020 Summer, many offices may have special opening time arrangement)

If you find yourself having difficulty with the course material or any other difficulties in
your student life, do not hesitate to ask for help! Come to me, or if it is about an issue
beyond this class, please contact your college advisors, or get help from any number of
other support services on campus. You can get a referral to the right place, or help on the
spot, from a concerned advisor in the Undergraduate Success Center (USC) at
[email protected]

See also:

The Writing Center, located in Grant Hall 105, offers one-on-one consultation with
student writers who need help developing ideas, or need advice, guidance or additional
instruction on any aspects of writing in any class. Tutors are prepared to spend fifty
minutes per appointment, and there is no limit to the number of tutoring sessions you can
have each semester. Make an appointment and be on time! Bring the paper on which
you're working, as well as any related drafts or notes, and information about the
assignment. For an appointment, call the Writing Center at (312) 413-2206, or stop by
room 105 of Grant Hall. Visit the Writing Center website https://writingcenter.uic.edu for
more information

The Math and Science Learning Center, located in the Science and Engineering South
Building (SES) at 845 W. Taylor St. 3 rd Floor, Room 247, is a meeting place for students
in Math, Biological Sciences, Chemistry, Earth and Environmental Sciences, and Physics.
At the MSLC, students can meet with graduate teaching assistants for tutoring in 100-level
courses, arrange informal group study sessions with other students, or meet up with
friends to attend one of the workshops, seminars, or other activities sponsored by the SLC

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during the semester. Visit the website at https://mslc.uic.edu/, call 312-355-4900 or email
at [email protected]

The UIC Library

The library is located both on east and west campus, provides access to resources, study
rooms, and research support both online via chat and in person. At Daley Library on the
east side of campus, stop by the reference desk in the IDEA Commons, or make an
appointment for research help on either side of campus. Learn more about library policies
at http://library.uic.edu/. To find research materials in specific subject areas view the
Research Guides at http://researchguides.uic.edu/.

The Academic Center for Excellence can help if you feel you need more individualized
instruction in reading and/or writing, study skills, time management, etc. Phone: (312)
413-0031.

Counseling Services are available for all UIC students. You may seek free and
confidential services from the Counseling Center www.counseling.uic.edu. The
Counseling Center is located in the Student Services Building; you may contact them at
(312) 996-3490. In addition to offering counseling services, the Counseling Center also
operates the InTouch Crisis Hotline from 6:00 p.m.-10:30 p.m. They offer support and
referrals to callers, as well as telephone crisis interventions; please call (312) 996-5535.

Campus Advocacy Network

Under the Title IX law you have the right to an education that is free from any form of
gender-based violence and discrimination. Crimes of sexual assault, domestic violence,
sexual harassment, and stalking are against the law and can be prevented. For more
information or for confidential victim-services and advocacy contact UIC’s Campus
Advocacy Network at 312-413-1025 or visit http://can.uic.edu/. To make a report to UIC’s
Title IX office, email [email protected] or (312) 996-5657.

CAMPUS SECURITY
You may wish to include the following section on security issues at UIC:

As a UIC student, you've chosen to live in one of the nation's largest cities. But, as at any
university, crime is a reality. At UIC, we are strongly committed to our public safety
programs, and we encourage students to be proactive in learning what programs and
services are available in case of an emergency. You are DISCOURAGED from staying in
university buildings alone, including lab rooms, after hours and are ENCOURAGED to
use the POLICE/STUDENT patrol escort if you are uncomfortable traveling anywhere on
campus. You may request an escort to accompany you to your campus destination on foot
by calling 312-996-2830, and between 11:00 pm and 7:00 am you can dial the Red Car
service (312-996-6800) if you are alone and need to leave the building. Through Red Car,
the university has established a safe evening transportation service for university
employees, students, visitors, and other authorized individuals. The car travels between
university facilities within the following general boundaries: Clinton Street on the east;

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Western Avenue on the west; Jackson Boulevard on the north; and, 16th on the south. This
service is available only to individuals possessing a valid UIC i-card. The i-card is
required to ensure the safety of the driver and other passengers. Consult the following for
more information: http://www.uic.edu/uic/studentlife/campus/safety.shtml

Also you can subscribe your cell phone to receive text message alerts. An immediate SMS
text alert will be sent in case of a serious crime in progress, a weather emergency, or other
urgent situation. (https://accountportal.uic.edu/auth/manage?dispatch=set_sms_panel).

Finally, by dialing 5-5555 from a campus phone, you can summon Police or Fire for any
on-campus emergency. You may also set up the complete number, 1-312-355-5555, on
speed-dial on your cell phone. For more information contact:
http://www.uic.edu/uic/studentlife/campus/emergency-information.shtml

Emergency Response Recommendations

You may wish to include the following section on emergency response systems at UIC:
The emergency response guide can be found at the following website:
https://ready.uic.edu/. Please review and acquaint yourself with the guide and
recommendations for various emergency situations.