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    Adelax: Only For The Use of Medical Professionals

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    Adelax is a combination drug containing flupentixol and melitracen used to treat anxiety, depression, and apathy. It is administered orally and reaches maximum serum concentration after around 4 hours. Common side effects are rare but can include restlessness, insomnia, and extrapyramidal symptoms. It should not be taken with MAO inhibitors or by those with certain medical conditions.

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    Adelax: Only For The Use of Medical Professionals

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    parthibanemails5779
    55 views2 pages
    Adelax is a combination drug containing flupentixol and melitracen used to treat anxiety, depression, and apathy. It is administered orally and reaches maximum serum concentration after around 4 hours. Common side effects are rare but can include restlessness, insomnia, and extrapyramidal symptoms. It should not be taken with MAO inhibitors or by those with certain medical conditions.

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    Medical

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    Flupentixol+Melitracen

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    Adelax is a combination drug containing flupentixol and melitracen used to treat anxiety, depression, and apathy. It is administered orally and reaches maximum serum concentration after around 4 hours. Common side effects are rare but can include restlessness, insomnia, and extrapyramidal symptoms. It should not be taken with MAO inhibitors or by those with certain medical conditions.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    55 views2 pages

    Adelax: Only For The Use of Medical Professionals

    Uploaded by

    parthibanemails5779
    Adelax is a combination drug containing flupentixol and melitracen used to treat anxiety, depression, and apathy. It is administered orally and reaches maximum serum concentration after around 4 hours. Common side effects are rare but can include restlessness, insomnia, and extrapyramidal symptoms. It should not be taken with MAO inhibitors or by those with certain medical conditions.

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    Only for the use of Medical Professionals

    Adelax®
    Flupentixol + Melitracen

    Presentation: Adelax¨ Tablets: Pink, round, biconvex, film-coated tablet. Each tablet
    contains Flupentixol 0.5 mg as Dihydrochloride BP and Melitracen 10 mg as Hydrochloride
    INN.

    Description: Adelax¨ is a combination preparation of two well known and time tested
    molecules: flupentixol - a neuroleptic with anxiolytic and antidepressant properties of its
    own when given in small doses, and melitracen - a bipolar thymoleptic with activating
    properties in low doses. In combination, the compounds exert antidepressant, anxiolytic and
    activating properties.
    Maximum serum concentration is reached in about 4 hours after oral administration of both
    flupentixol and melitracen. The biological half-life of flupentixol is about 35 hours and that
    of melitracen is about 19 hours. The combination of flupentixol and melitracen does not
    seem to influence the pharmacokinetic properties of the individual compounds.

    Indications: Adelax¨ is indicated for the treatment of different types of anxiety, depression
    and apathy. These include:
    Psychogenic depression
    Depressive neuroses
    Masked depression
    Psychosomatic affections accompanied by anxiety and apathy
    Menopausal depressions
    Dysphoria and depression in alcoholics and drug addicts

    Adelax¨ is also indicated for maintenance in psychogenic depressions and other psychoses.

    Dosage & administration: Adults: Usually 2 tablets daily: morning and noon. In severe
    cases the morning dose may be increased to 2 tablets. Elderly patients: 1 tablet in the
    morning. Maintenance dose: Usually 1 tablet in the morning. In case of insomnia and severe
    restlessness additional treatment with sedative in the acute phase is recommended.

    Side-effects: In the recommended doses side-effects are rare. Restlessness, insomnia,


    hypomania reported, rarely dizziness, tremor, visual disturbances, headache,
    hyperprolactinaemia, extrapyramidal symptoms may be observed.
    Contra-indications: The immediate recovery phase after myocardial infarction. Defects in
    bundle-branch conduction. Untreated narrow angle glaucoma. Acute alcohol, barbiturate
    and opiate intoxications. Flupentixol-melitracen combination should not be given to patients
    who have received a MAO-inhibitor within two weeks. Not recommended for excitable or
    overactive patients since its activating effect may lead to exaggeration of these
    characteristics.

    Precautions: If previously the patient has been treated with tranquilizers with sedative
    effect these should be withdrawn gradually.
    Use in pregnancy and lactation: Flupentixol-melitracen combination should preferably not be
    given during pregnancy and lactation. Drug interactions: Flupentixol-melitracen combination
    may enhance the response to alcohol, barbiturates and other CNS depressants.
    Simultaneous administration of MAO-inhibitors may cause hypertensive crises. Neuroleptics
    and thymoleptics reduce the antihypertensive effect of guanethidine and similar acting
    compounds and thymoleptics enhance the effects of adrenaline and noradrenaline.

    Overdosage: Symptoms: Incase of overdosage the symptoms of intoxications by


    melitracen, especially of anticholinergic nature, dominate. More rarely extrapyramidal
    symptoms due to flupentixol occur. Treatment: Symptomatic and supportive. Gastric lavage
    should be carried out as soon as possible and activated charcoal may be administered.
    Measures aimed at supporting the respiratory and cardiovascular systems should be
    instituted. Epinephrine (adrenaline) must not be used for such patients. Convulsions may be
    treated with diazepam and extrapyramidal symptoms with biperiden.

    Pharmaceutical precautions
    Store in a cool dry place. Protect from light

    Package quantities
    Adelax¨ Tablets: Cartons of 80 tablets in Alu-Alu blister

    ® Registered Trade Mark

    ACI Limited
    Narayangan
    j,
    Bangladesh

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