An EEG Study of The Neurodevelopmental H PDF
An EEG Study of The Neurodevelopmental H PDF
An EEG Study of The Neurodevelopmental H PDF
severe (12% of the cases). The rCBF was assessed by means The results are interpreted within the framework of a model of
of SPECr using 99rc-HMPAO as a tracer in six brain regions: the brain's functions underlying allocation ofattention as suggestive
dorsolateral prefrontal, orbito-frontal, anterior temporal, temporo- dissociated neuronal activation in schizophrenia.
parietal, occipital, and basal ganglia.
Results: 1) The mild schizophrenic defect were better detected
by the BVRT than by the SPECT (p < 0.01). 2) The rCBF was
normal in four cases (16%), and the remaining 21 (84%) showed Wed-P34
SCHOOL FOR PSYCHOPHYSICAL SELF_REGULATION OF
hypoperfusion in the frontal (dorsolateral prefrontal and orbito-
DIABETES MELLITUS PATIENTS
frontal) and/or basal ganglia regions. 3) No significant relationship
was found between the relatively lower rCBF and the degree of L Maslova1• / Moscow Research Institute of Psychiatry. Moscow.
the defect. 4) The presence of BOTH (EITHER) treatment non- Russia
compliance AND (OR) substance (alcohol) abuse was related to the
degree of the defect (p < 0.05). 5) The schizophrenic defect was The diabetes mellitus often proceeds against a background of
significantly associated (p < 0.05) with a history of schizophrenia available or secondary psychic disorders. Our eight-year experi-
among the first-degree relatives (parents or siblings). ence indicates that such patients need treatment in the "School
Conclusion: The results of this study are in favour of a multi- for psychophysical self-regulation". The treatment was applied
factorial ethiopathogenic hypothesis of schizophrenia. to the insulin-dependent and non-dependent patients in conjunc-
tion with manic-depressive psychosis, latent schizophrenia and
marginal forms of neuro-psychic disorders. Patients were examined
Wed-P32 by clinical-psychopathological and psychological methods. The
AN EEG STUDY OF THE NEURODEVELOPMENTAL HY-
training provides maximum information on the nature of disease,
POTHESIS OF SCHIZOPHRENIA. MEASURES OF EEG AC-
methods of self-control, prophylaxis of complications, peculiarities
TIVITY AND EEG REACTIVITY
of individual treatment - everything for continuous stable cure
M. Koukkou', A. Federspiel, E. Braker, C. Hug, H. Kleinlogel, procedure. The patient's chronic stress, the shattering of the shaped
M.C.G. Merlo. University Hospital of Psychiatry. EEG Broin- stereotype, disturbances in the relationship and his fear for his
Mapping Labor. CH-3000 Bern 60. Switzerland future have to be taken into account. Thus, the main purpose of
the psychiatric, psychotherapeutic and psychological help to the
The hypothesis that irregular regressive phenomea in the organi- given contingent is in the first place a relief of mental state and a
sational level of the neuronal network (representational network) reduction of symptoms.
underlie the manifestation of productive schizophrenic symptoms The psychological aspect ofour program includes such purposes
is tested with EEG data in three groups of normal adolescents, as to devise optimal styles for overcoming the nosogenic stress,
in first-episode, neuroleptics-naive schizophrenics and in matched to develop an adequate subjective conception of the disease, to
controls (total: 70 subjects). correct one's self-appraisal, to form some self-regulation habits.
EEG (19 channel) theta, alpha and beta band centroid frequency The communicative connections within the group established, the
was used as indicators of the level of complexity and momentary patients became able to join actively in the psychosocial relations
excitability of the neuronal network. after the treatment. The combination of the training program with
Schizophrenics showd lower theta and higher alpha and beta the psycho-corrective measures allows to improve a quality of the
centroids in EEG activity and partial similarities in theta and alpha therapy, to prevent a development ofneuro-psychical disorders, and
centroid behavior with the two younger groups of juveniles. it ensures psychosocial adaptation in the society.
The results are interpreted within the framework of a model
of the brain's functions underlying allocation of attention as sug-
gesting dissociated (partially regressed and partial1y over-activated)
neuronal activation, i.e., dissociated contents of working memory
Wed-P35
ELECTROCONVULSIVE THERAPY IN SCHlZOAFFECTIVE
in schizophrenia.
DISORDER
A. Garrido. C/fnica Nra. Sro. de la Paz, Madrid, Spain
Wed-P33
ESTIMATION OF DIMENSIONAL COMPLEXITY OF MULTI-
IntrOduction: As it is known, ECT relieves such symptoms as
CHANNEL EEG IN FIRST EPISODE SCHIZOPHRENICS. AN
delusions, hal1ucinations and agitation, but not the underlying
EXTENSION AND REPLICATION OF A FINDING
schizophrenic apathy, social withdrawal and emotional unrespon-
A. Federspiel·, M. Koukkou, M.C.G. Merlo. University Hospital siveness, It is most useful when severe symptoms have developed
of Psychiatry. EEG Brain-Mapping Labor. CH-3000 Bern 60. suddenly in a patient who was previously in good mental health, es-
Switzerland pecially if there are also striking changes in mood (schizoaffective
disorders).
In nine first episode, neuroleptic-naive acute schizophrenics and in Material and Method: The sample was consisted 73 inpa-
18 matched in age, sex and basic education controls, the dimen- tients with diagnosis of schizoaffective disorders. Two groups were
sional complexity of 19 EEG recordings (computed in 12 local stablished: twenty four with EeT treatment and forty nine with
gradients) was assessed by computing the correlation dimension neuroleptic drugs.
during 10 seconds in five recording conditions: resting and after Results: There were statistical differences between them in
the presentation of four short sentences. relation of gender and age. The therapeutic efficacy of ECT was
The correlation dimension of schizophrenics was significant assessed by using Hamilton Rating Scale for Depression and
higher in 26 of the 12 locations (resting 8 times; sentence I, 5 Clinical Global Impression Scale showed marked improvement in
times; sentence 2, 5 times; sentence 3, 4 times and sentence 4, 70"10 of patients in both groups. But group with ECT (average
4 times). The results confirm our previous findings with 12 first 8.5/patient) showed less days of hospitalisation: 20.8 versus 37.5
episode schizophrenics where only two recordings were available. days.