Ijipsrmnr 880
Ijipsrmnr 880
Ijipsrmnr 880
Abstract
An ideal drug delivery system reduces the undue exposure of the drug to other tissues and thus is
responsible for accurately delivering the drug at a desired rate and thus minimize its side-effects.
Modified-release dosage form is a product that alters the timing and rate of release of drug substance
and it refers to both delayed and extended release systems for oral administration. The basic rational
for modified release drug delivery is to alter the Pharmacokinetics and pharmacodynamics of
pharmacologically active moieties by using release modifying polymers and novel techniques like
fluidization, pelletization and thus effectively optimize the bioavailability and resulting blood
concentration-time profiles of drugs .3Oral modified release dosage form can be broadly classified
into two categories: Single-unit and Multiple-unit dosage forms.
Keywords: Dextromethorphan Hydrobromide, fluidization, pelletization, Drug-Resin complex.
Corresponding Author:
Abhijeet Kunwarpuriya
Research Scholar (Ph.D.), Faculty of Pharmacy,
Pacific Academy of Higher Education and Research University,
Udaipur, INDIA
Email: abhijust111@gmail.com
Phone: +91- 9860579111 / 8983026666
Formulation Details
Ratio A (1:3) Ratio B (1:1) Ratio (2:1)
[Drug: Resin]
Ingredients mg/unit % w/w mg/unit % w/w mg/unit % w/w
Drug 30 25.00 30 50 60 66.66
Sodium polysterene
90 75.00 30 50 30 33.33
Sulfonate
Purified water q.s. q.s. q.s. q.s. q.s. q.s.
Theoretical weight of
drug-resin complex 120 100 60 100 90 100
(mg)
Table 11: Dissolution of drug resin complexes with different ratios of drug: resin
Time (hrs) Ratio A(1:0.5) Ratio B (1:1) Ratio C (1:3)
% of Drug released
0.5 88.0 48.9 43.1
1 99.3 57.9 48.2
3 105.5 61.3 50.1
Fig.2: Dissolution of drug resin complexes with different ratios of drug: resin
The drug: resin ratio was optimized as ratio ‘1:3’ for further development of Drug-Resin
complex based on dissolution profile.
Table 12: Optimization of contact time between drug and resin.
Time of sample withdrawal Concentration of Drug in filtrate
After 20 minute stirring 0.31
After 40 minute stirring 0.44
After 60 minute stirring 0.36
After 80 minute stirring 0.44
After 100 minute stirring 0.16
After 120 minute stirring 0.08
After 140 minute stirring 0.08
Fig.7: Dissolution profiles of trials taken for optimizing percentage of PEG 4000 coat