Thyroid Science 3(6):CR1-9, 2008 www.ThyroidScience.

com Case Report

Regeneration of Human Scar Tissue with Topical Iodine:

A Preliminary Report—Part 1 (Three Years)
David M. Derry, MD, PhD*

*332-425 Simcoe Street, Victoria B.C. Canada, V8V 4T3

Contact: [email protected]
R eceived: M ay 12, 2008
Accepted: M ay 20, 2008

Abstract. Since Spallanzini first described salamander limb regeneration in 1769, there has been slow prog-
ress in understanding this process. Potential treatment benefits from regeneration are worth the effort. A
hypothesis that topical iodine would regenerate human scar tissue is tested by applying Lugol’s solution to
four scars of various sizes, degree of damage, and location for variable lengths of time. Regeneration starts
a few days after applying iodine and stops and forms adult scar if applications are discontinued. One face scar
has completely regenerated. The wrist scar’s terminal stages are being studied. The remaining two scars on
the abdomen are behaving as if they are one and could take considerably longer to complete. Waiting for
completion delays availability of this information for scientists, physicians, and patients.
For the past three years, Nikon Cool Pix cameras recorded regeneration changes. Regenate material found
under plastic wraps on the scars comes in two forms, snow-like and globular. Their function is unknown. Two
black dots both 5 mm apart seen on the wrist and abdominal scar store iodine and appear to coordinate regen-
eration. Hair is the regeneration workhorse and does an amazing number of things. Amongst the hair activities
are free movement to any cell within its range in any direction and self-amputation possibly to strengthen re-
generating tissue. Hair delivers regenate material and may be sending cell signals by touch, regenate material,
and electrical impulses. The hypothesis that topical iodine in the form of Lugol’s solution regenerates human
scar tissue back to normal is supported by these preliminary findings.

Keywords: Hair • Hair movement • Iodine • Regeneration • Scars • Self-amputation • Skin • Wound healing

Introduction gland function and pathology. Iodine is found in ev-

ery body cell and fluid.[5][6][7] In relation to regenera-
Regeneration and Wound Healing tion, thyroidectomy makes it abnormal and excess
Spallanzini in 1769 and Martin 230 years later thyroid hormone inhibits it.[1][8, p.149]
expressed the same hope that a way is found to re- In 1997 while treating patients with Lugol’s io-
generate human tissue damage back to normal.[1][2] dine for fibrocystic disease, [9][10] out of curiosity, the
Unfortunately, we are not yet close to unraveling author applied Lugol’s solution to a 50-year-old face
either regeneration or wound healing. We do not scar that resulted from removal of a birth mole.
understand regeneration and progress is limited.[1] Topical applications for three consecutive days did
Wound healing is also complex.[15] Cotran says, “The nothing. On the fourth day, the thin 2 cm white scar
magic behind the seemingly precise orchestration of became red and hyperemic. Could this be regenera-
these events (wound healing) under normal condi- tion? A hypothesis was formed: topical iodine in Lu-
tions remains beyond our grasp. . . .” [3, p.109] On the gol’s form could regenerate human scar tissue back
other hand, Tsoni says, “The field of limb regenera- to normal. Eight years later, the author began iodine
tion will prove to be one of the most important in the applications to test this hypothesis.
biomedical field.” [23, p.203]
Materials and Methods
Iodine
Elemental iodine discovered in 1812 by Courtois Lugol’s Solution
has been a universal antiseptic for 150 years, [4] and Lugol’s solution is made of 5% free iodine and
its only established human body function is making 10% potassium iodide in water. Free iodine (elemen-
thyroid hormones in thyroid glands from dietary io- tal iodine) is only slightly soluble in water, but 200
dine. Long term iodine intake levels dictate thyroid years ago Henri Lugol, a Paris physician, discovered
2 Derry, D.M.: Regeneration of human scar tissue with topical iodine . . . Thyroid Science 3(6):CR1-9, 2008

that potassium iodide increased free iodine’s solu- iodine evaporation worked best.
bility in water. Three chemical iodine species exist in
Lugol’s solutions: free elemental iodine, triiodide, Documentation w ith Cameras
and iodide. [11][12][13] Free iodine reacts with water to Scar regeneration monitoring with normal micro-
make Lugol’s solution brown, triiodide’s weaker yel- scopic procedures is impossible. Several small Nikon
low color is not visible, and iodide is colorless.[4] Cool Pix cameras with 5-to-8 mega pixels recorded
changes. A zoom lens and one camera with an enlar-
Four Scars ging attachment enabled magnifications of 3-to-20
During the 8 years between Lugol’s solution scar times.
applications, the author gained three new scars: two Photographing in order to learn what changes
abdominal and one on the left wrist. (Figures 1 and were occurring is unusual because there is no way of
2.) An 18cm vertical abdominal scar was opened telling what you will find. New findings, stumbled
three times and accompanied by a horizontal colos- upon, were automatically recorded. These findings
tomy scar. If we include the old one, there are four were followed-up with a time-lapse photographic ap-
scars to study. proach. Watching the regenerating area with a mag-
nifying glass was like watching clouds—slow, and
not helpful.

Figure 2. Wrist coordinating centers. They are dark be-

cause of the uptake of iodine for storage. They are 5mm
apart. A partial trace of the residual scar in white is seen
above the upper center. These two centers stayed in place
during regeneration. This picture is taken 1.5 years after
starting applications. The iodine stain is easily seen.
Figure 1. Photo of 18 cm abdominal scar which was
opened three times. Note the abundance of hair growth, in-
duced by iodine, around the scar. The two black dots are
the coordinating centers (5mm apart) and are level with the Results
colostomy scar seen on the right of the picture (left of the
abdomen). The umbilicus disappeared for two months and
reappeared in this form. Note that applications of iodine Definitions of Regeneration Terms,
have been stopped, and the scars have reverted to the Free Iodine, and Skin Behavior
adult form. The coordinating centers have stayed in place.
Coordination Centers
As long as iodine is applied daily with a plastic
Best Method of Iodine Application cover, regeneration continues. Over three years of
After medical discharge, Lugol’s solution ap- study, no two pictures of any scar are the same even
plied topically to scars began regeneration within when the second is taken only a few minutes later
several days. Daily scar application of iodine and than the first. Two dots 5mm apart appeared on both
covering with plastic to retain moisture and prevent wrist and abdominal scars. The dots seem to coor-
 Derry, D.M.: Regeneration of human scar tissue with topical iodine . . . Thyroid Science 3(6):CR1-9, 2008 3

dinate tissue activities and are named coordinating two hours, 80% within two days, and by the third
centers. (Figures 1 and 2.) day 88% has evaporated. No further evaporation
takes place. Therefore 12% of any one application
Regenate Material: Two Types gets into skin tissues as iodide. Covering with plastic
minimizes evaporation and helps the regeneration
W hite Regenate Material. While under plas- rate. Iodide is also soluble in skin and would add to
tic wrap, a snow-like substance named white regen- tissue levels.[12][21]
ate material fell like snow onto scars, producing flat
white layers. As topical iodine application levels in- Skin Response to Excess
creased progressively, the white regenate material Iodine Application
became yellow, green, light brown, and then brown.
Without plastic wrapping, regeneration was con- If iodine applications were excessive especially
siderably slower and much less interesting photo- on skin and not the scar, slight stinging resulted for
graphically, and exhibited few signs of either kind of a few minutes. This caused no ill effects, but may be
regenate material. a tissue signaling that iodine is not needed at that
site, time, and dosage. Scars and scabs were much
more iodine tolerant. Skin removes excess iodine
triggering a few surface cell deaths (apoptosis). [10]
These dying cells in turn release more proteins for
iodine to react with. This more heavily-stained dead
tissue sloughs off, but when under wrap it recycles
into regenerating scar.

Figure 3. Abdominal scar below the umbilicus. A number

of globular regenerating masses are shown clearly soon af-
ter removing the plastic wrap. There is no special shape or
size. The dark color likely is stored iodine. Abundant hair
is intimately involved with every aspect of regeneration.
Some sense of the finger-like swellings that continuously
bind the two sides together can be seen on both sides. The
large round non-descript area at the bottom of the photo-
graph is the partially formed umbilical hernia.
Figure 4. Wrist globular mass (regenerating material) as
seen through plastic wrap. There is yellow regenerating
Globular (Masses) Regenate Material. Un- material (white with iodine in it). It was difficult to tell if glob-
der plastic wrap— once regeneration was well under ular mass shape changes or small movements were arti-
facts of body movement. Abdominal globular masses were
way—globular non-descript masses appeared on scar mostly 5-10mm in size, and wrist masses 1-2mm. This
areas on both abdominal and wrist scars. These mass is about 3mm long. It changed direction many times
globular masses had no standard shape or size and but did not move. It lasted about 2 days and then disap-
changed shape frequently. Most globular masses had peared.
hair associated with them. (Figures 3 and 4.)

Free Iodine’s Behavior on Skin Wrist Scar Details

Lugol’s free iodine stains skin brown and evapo- The wrist scar was a source of detail because it
rates rapidly. A stain loses 50% free iodine within was easy to photograph. Two weeks post injury the
4 Derry, D.M.: Regeneration of human scar tissue with topical iodine . . . Thyroid Science 3(6):CR1-9, 2008

wound became infected. Antiseptic iodine applica- Abdominal Scars (Laparotomy

tions cleared the infection. When the scab fell off, in X3 and Colostomy)
the middle of the 2cm scar were two dark dots 5mm During the initial healing process, the scar below
apart straddling the radial artery. In retrospect, these the umbilicus had an obvious tissue deficit and thus
two dots indicate that regeneration starts during anti- was healing with secondary intention. Whereas,
septic iodine applications. The dots remain in place above the umbilicus scar edges were apposed and
during regeneration (3 years). Time-lapse photog- healing was by primary intention.
raphy suggests that they coordinate regeneration. The two scar areas above and below regenerated
During regeneration, it appears as if everything differently. At any time, either the upper or the lower
moved except coordinating centers and hair follicles. half of the scar was active while the other half was
Wrist coordinating centers were composed of one quiet. The halves switched roles at about 6-month
cell storing iodine. The centers continuously changed intervals. The top half scar formed crevasses with ab-
appearance within two minutes—for three years. undant regenate material and hair. (Figures 5 and 6.)
There was also a palpable subcutaneous ridge be-
tween the wrist centers (this did not happen with the
abdominal scar).
Because nearby wrist hair interfered with photo-
graphing the coordinating centers, only once—early
in the process—were hairs shaved away. Better co-
ordinating center pictures resulted, but the shaving
slowed regeneration. As we learn below, hair is a re-
generation workhorse.

Figure 6. This picture is also of the upper part of the scar

closer to the umbilicus. The umbilicus is the round white
mass on the right hand side. The umbilicus was on its way
to disappearing at this point. There is abundant regenate
material and hair around the central crevasse. Picture is
taken through a plastic wrap. In the middle, some regenate
material can be seen sticking to the plastic wrap. More of
a brown color regenate material is sticking to the wrap on
the lower left side of the scar. The white glistening is an
artifact from the wrap.

Figure 5. This is a picture of the top of the abdominal scar

about a month after starting applications of iodine. Note the
Below the umbilicus regeneration was interes-
large number of new hairs adjacent to and in the crevasse.
At the end of the crevasse there is a tiny black dot. This ting. The two scar sides had a significant deficit gap.
was the first sign of the coordinating centers for the ab- The walls approached each other acting somewhat
dominal scars. like two hands with fingers extended pointing at each
other as they came together. (Figure 3.) One or more
“fingers” on one side would slide over the gap and
Face Scar Regeneration attach to the other side. Then the opposite side would
The face scar was the easiest to regenerate. No do the same thing. These swellings (like fingers of
coordinating centers appeared at any time. As sur- the hand) just welled up from tissues, and might not
gery was done by a plastic surgeon, there was mini- take longer than a couple of hours to cross over and
mal tissue damage and it was gone in 6 months. complete. The (finger-like) swellings were thick until
 Derry, D.M.: Regeneration of human scar tissue with topical iodine . . . Thyroid Science 3(6):CR1-9, 2008 5

later stages of regeneration, when they thinned. This Wrist centers remained in place from beginning
went on for years. to end. Each center in both pairs was independent
and acted differently. The wrist centers had a pal-
Three Hernias: Umbilical, Left Side pable subcutaneous ridge between them while the
Abdominal, and Colostomy Muscle abdominal centers had no such connection. Both
The umbilicus exhibited various appearances pairs of centers took up iodine avidly after staining,
during the first year. At one point the umbilicus dis- and stored it.
appeared. A couple of months later umbilical tissue
reappeared (Figure 1), and a year later it formed an
umbilical hernia to aid regeneration.
Tw o Other Hernias. Two other hernias, one a
small abdominal hernia opposite the umbilicus and
another, a colostomy muscle hernia, moved medially
(each towards the middle) towards and began mer-
ging with the umbilical hernia. In Figure 1 where the
scar has been regenerating for over a year, there is
still no sign of either the abdominal hernia or the co-
lostomy hernia (which become prominent a year or
so later).

Figure 8. This is not hair #1, but the image shows the
same type of kink that hair #1 did just prior to self-amputa-
ting at the kink site. A pair of hairs in the foreground ema-
nate from the same follicle.

Hair (Workhorse of
Regeneration): Hair Types
Hair activities were central to regenerating scars.
Time-lapse photography helped tease out details of
hair’s multiple activities. There are many types of
hairs such as long, short, small, fine, thick, flat, and
Figure 7. The two abdominal coordinating centers in one occasionally hollow. Hairs occur sometimes in
of their many types of appearances. Viewing on the back groups of two or three. This is a summary of some of
camera screen, it was easier to see that they were made
of numerous cells. It was not possible at the time to cap- the findings on hair activities.
ture this impression. The multicolor is real; no artificial
stains except for iodine have been applied. In most cases, Some of Hair’s Activities:
each color represented a different cell. Remember that ev-
erything in the picture is alive, even hair—when viewed as C Hairs on their own move accurately to any cell
a functional follicular unit. location within reach in all directions. Some-
times wrist movement aided the hair movement.
C Hair movements were by short rapid jerks.
Abdominal Coordination Centers C Self-amputation is a repeating continuous prop-
For about a year there were two much larger co- erty of hair in regenerating tissue.
ordinating centers centrally placed on the big scar C Hair stubs with follicle, after complete self- am-
5mm apart and consisting of more than 50 cells. putation, may disappear completely for weeks
(Figures 1, 5, and 7.) and then reappear and grow back.
6 Derry, D.M.: Regeneration of human scar tissue with topical iodine . . . Thyroid Science 3(6):CR1-9, 2008

C Hair carried regenate material to cells, coordin- spots numerous times. All these movements may be
ating centers, and to tissues in general. controlled by iodine, but arrector pili muscles near
C Hair follicles appeared to be the source of white hair follicles also cause moving.[14, p.355]
regenerating material. Source of Snow -Like Regenate Material.
In the first year it took many photographs to arrive at
Hair cell and tissue signaling: the conclusion that white regenate material forms in
C Hair may have multiple methods of cell signal- follicles and then transports up the hair. The mech-
ing such as touch, electrical, regenate material, anism of regenate material movement on hair is un-
and inter-hair communications. known. Most times white material is flat on the hair.
The white material on hairs is discontinuous, raising
Hair Study Methods and Hair Movement. the possibility of coding by another signaling system.
Wrist field hairs were numbered. Hair #1 is flat,
making direction changes easier. (Figures 8-12.) All
hairs are capable of moving on their own in short
rapid jerks. Wrist movement aids hair movement
sometimes. Destination changes occur as many as 6
times per day and more at night. Only once did the
author see hair #1 move. Staring at the hairs for an
hour was useless and mind-numbing.

Figure 10. Photograph of hair #1 and the two wrist coor-

dinating centers. Hair #1 is delivering regenate material to
the coordination center on the ulnar side of the wrist. Hair
#1 is shortened even further in this picture. Regenate ma-
terial can be seen on hair #1 and around the other coor-
dinating center. Discontinuous regenate material shows on
the hair curving over the top coordinating center in an al-
most code-like manner. The thinness of hair #1 near the
follicle is related to this hair’s flatness. Depending upon
how the hair is photographed along its length, it can go
back and forth between thick and thin.

Figure 9. A photograph of hair #1 down the center with Hair Self-Amputation Multiple Methods.
some regenate material on it. This is about b its actual
size. The two coordinating centers are easily seen and While watching hair #1, a kink formed about ¼ of
present in a multitude of different forms all the way through the way up the hair from the follicle to the point the
regeneration. They are 5mm apart and there is a firm kink touched skin. (Figure 8.) Within a few hours
palpable subcutaneous ridge between the two centers not
visible in this picture.
hair #1 self-amputated at that point. The cut-off hair
end sank into regenerating tissues. The proximal
short hair end continued as if nothing had happened,
Hairs also went to new destinations by rising up sending regenate material to nearby tissues. About a
above skin vertically and then coming down at their week later hair #1 self-amputated again near the fol-
destinations an hour or two later. These destinations licle leaving only a short stub. (Figure 12.)
appear to be exact, as the hairs return to the same Then, approximately a month later, hair #1 re-
 Derry, D.M.: Regeneration of human scar tissue with topical iodine . . . Thyroid Science 3(6):CR1-9, 2008 7

grew again to normal size. On two occasions stub physicians, scientists, and patients (with their physi-
and follicle disappeared completely only to return cians) can examine regeneration themselves. Regen-
again several weeks later. Self-amputation is a gener- eration is both unbelievably marvelous and at the
al hair phenomenon during regeneration. (Figure 12.) same time mysterious because so many questions
arise as it progresses.

Total Time of Regeneration

Because abdominal and colostomy scars act as
if they are one big scar, when considered together,
regeneration may take longer. Waiting for comple-
tion seems unnecessary. Regeneration attended to
properly without stopping should be considerably
faster. But as this was an exploratory experiment and
there was no hurry, stopping and starting regenera-
tion was repeated many times, sometimes for as long
as 4 months.

Figure 11. Hair #1 making contorted moves, when it is

longer, to deliver regenate material and/or signals to the
lower center area. It’s length is considerably longer than in
the previous photograph. There are two small areas of re-
genate material on hair #1. Other hairs also show white re-
genate material.

Oral Iodine and Regeneration

Oral iodine had no detectable influence on re- Figure 12. Picture of wrist regenerating area (radial artery
generation. Even high doses did not stop adult scar runs under this area and between the two coordinating
formation when topical iodine was discontinued. centers). The hand is to the right of the picture. The arrow
points to what is left of the stub of hair #1. Including hair
#1, there are 15 hair stubs in this picture. This illustrates
What About Controls? the magnitude of hair self-amputation.
Normal controls were not possible. Multiple
scars of different types, sizes, and severities—along
with stopping and starting regeneration numerous Tw o Types of Regenate Materials
times for variable periods—provided the only pos- (Snow -Like and Globular Mass Type)
sible controls. A by-product of regeneration is regenate ma-
terial. There are likely more unidentified regenate
Discussion materials. Because of their reactions with iodine
(changing color), regenate materials may turn out to
The Hypothesis be a host of new proteins with therapeutic potential.
The results of this case report support a hypo- Tsoni[1] states that a salamander’s blastema formation
thesis: Topical iodine in the form of Lugol’s solution is characterized by synthesis of more than 130
regenerates human scar tissue back to normal. unique proteins; during dedifferentiation 26 new pro-
Checks of result validity were put into methods and teins are made. These are two hallmarks of salaman-
results. The procedure, as described, is harmless. So, der regeneration. Globular masses could be another
8 Derry, D.M.: Regeneration of human scar tissue with topical iodine . . . Thyroid Science 3(6):CR1-9, 2008

form of regenate proteins. More recent DNA studies structure would encourage access to ocean iodine at
show several hundred genes are involved with blas- all times.[19, p.420, p.428][20, p.499]
tema formation when compared to normal limbs.
Treatment Potential
Plastic W rap Effects and Verification
on Regeneration Rate If verified, regeneration induced by topical io-
Covering scar tissue with plastic definitely ac- dine could be a treatment approach with significant
celerates regeneration. It also makes photography potential. But even before that potential is realized,
more interesting. Two other benefits may come from scientists, patients, and physicians should examine
covering regenerating areas: retaining moisture (sim- regeneration. As results reported here have taken
ilar to a fetal skin regeneration environment) [22] and three years and are still incomplete, further results
preventing free iodine evaporation.[21] may take some time to examine.

Hair Self-Amputation Acknow ledgment. I would like to acknowledge

The finding of purposeful hair movement is the support and advice of Dr. Nasser Shojania, der-
startling. The only movement we are aware of is hair matology pathologist.
erection when a person is emotionally upset.
Self-amputation of hair was another unexpected References
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