Chemspeed offers Automated

Workstations and Partial or

Entire Product Development
Solutions

Downscaling, Standardizing, Accelerating

Analytical Sample Preparation
Flexible, Easy, and Rugged
11.04.2018
Chemspeed Technologies Steffen Eller
Head Workflow/Chemistry/Support

Chemspeed Technologies Proprietary

Agenda

• Challenges
• Enabling technologies and proprietary innovations
• Selection of Case Studies
• Summary
• Company

Chemspeed Technologies Proprietary

You certainly face challenges like …

➢ Time constrains, increasing amount of samples in

routine analysis with no staff increase

➢ Budget constraints, larger design with less material

➢ Slow, labour-intensive manual bench-top work

➢ Safety issues in manipulating aggressive chemicals

(acids, bases…) and API’s

➢ Lack of consistency between samples, leading to not

comparable and/or not meaningful analysis results

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Agenda

• Challenges
• Enabling technologies and proprietary innovations
• Selection of Case Studies
• Summary
• Company

Chemspeed Technologies Proprietary

Our Product Lines are designed to boost R&D Throughput

Established Product Line New Product Line

SWING FLEX Systmes
R&D Platform R&D Platforms

Revolutionary future Product Concept

SMOLE
Strategic Consumables

New Product Line

FLEXSHUTTLE
‘Product Development Factory’

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4 Dimensions of Scalable Flexibility and Modularity

All product lines designed on one platform

• Sample Preparation
• Synthesis
• Process Dev.
• Formulation
• Application
• Testing

• Workflow Management Software

For Product Development in Different Markets

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4 Dimensions of Scalable Flexibility and Modularity

Complete intuitive,
flexible, software solution:
design, execute, analyze,
report (variety of 3rd party
software, e.g.: JMP,
Spotfire)

Variety of 3rd party

instruments e.g.: More than 60 robotic
rheometer, centrifuge, tool-features available
microwave, GC, HPLC, (patented)
GPC, NIR, PSD,
cryostats, vacuum
pumps, …

Broad selection of
racks, vials, plates,
precision reactors and
formulation vessels /
blenders

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Chemspeed’s Rack, Reactor, Formulation Vessel Technology

The Reactors & Formulation Vessels / Blenders

Sample Preparation Synthesis

Disposable formats for sample High-throughput and high-output array
preparation and synthesis screening
Disposable & reusable
synthesis reactors
(glass)

Process Research Formulation

High-output process High performance
research reactors formulation vessels /
Exchangeable design, blenders
proven concept Exchangeable stirrer
Exchangeable scraper

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AutoSuite Software
The Software (modular):
• Design with e.g. VLab, JMP, MODDE
• Execute with AutoSuite User Interface & Executor
• Integrate with AutoSuite API
• Analyze & Report with e.g. VLab, Spotfire, LIMS, ELN

Configuration

Application

Monitoring

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AutoSuite Workflow Management Software

• Designed for today’s laboratories which increasingly rely on technology

and automation
• Aids scientists who need to execute related tasks/workflows across
many different systems
• Orchestrates laboratory tasks/workflows across these systems, putting
an unparalleled amount of flexibility and utility in the hands of the
scientist

If / Else
Drag & drop

Drag & Drop

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Internet of Lab Tools / IoLT

THE FEDERATED LABORATORY

Individual modules or operators performing their tasks independently,

but linked by central data management

FLEXSHUTTLE SWING / SWING XL line

Laboratory
SQL Server
Data Vault
Web Server

FLEX line 3rd Party

Equipment

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Example Integrations of 3rd Party Instruments

User defined / customized

racks e.g. for NMR

Holder for MALDI-TOF plate

Integrated SPE or filtration

cartridges
Holder for AFM wafer

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Example Integrations of 3rd Party Instruments

HPLC, GC,
GPC

Standardized Examples:
SWING VISCO / RHEO robotic platform
SWING QuECheRS robotic platform
SWAVE robotic platform

Centrifuge

Dual Asymmetric Biotage InitiatorTM EXP

Centrifuge Rheometer Microwave synthesizer

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Chemspeed’s Knowledge & Uniqueness - Exchangeable Robotic Tools

The Tools:
• Exchangeable Robotic Tools
(patented)
• More than 60 Robotic Features
available

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Chemspeed’s Knowledge & Uniqueness - Gravimetric Substance Handling

Overhead gravimetric dispensing of solids, liquids, viscous

liquids, pastes, waxes from sub mg to 100’s of grams
(patented)

Classical workflow - solid dispensing

Move Move
Weigh Solid Weigh
reactor to reactor
Reactor Dispensing Reactor
Balance back

Classical workflow - liquid dispensing

Aspirate Dispense Weigh Calculate Aspirate Dispense
Calculate
Reference Reference Reference Sample Sample Sample
Density
Volume Volume Volume Volume Volume Volume

Chemspeed’s way: condensing multiple time-consuming, error-prone

operations in one task
Overhead gravimetric dispensing directly into
conditioned, measured, stirred reactors Gravimetrically Dispensing of Solids,
Liquids, Pastes, …
Robotic Tool Integrated Balance, resolution 0.1 mg Directly into the Targets
Additional Desktop Balance, resolution 0.01 mg

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Gravimetric Dispensing Unit for Powders – Fine Dosing (GDU-P(fd))

Target weight [mg] 1 10 20 100

Aerosil
Average [mg] 1.0 10.3 20.6 100.2
Standard deviation [mg] 0.1 0.1 0.1 0.2
Average dispense time [s] 41 42 69 310
Mg Stearate
Average [mg] 1.0 10.0 20.1 100.5
Standard deviation [mg] 0.1 0.3 0.2 0.5
Average dispense time [s] 54 22 31 76
MCC
Average [mg] 1.0 10.1 20.1 100.3
Standard deviation [mg] 0.1 0.1 0.2 0.3
Average dispense time [s] 27 71 69 103
Lactose DC
Average [mg] 1.1 10.1 20.3 100.3
Standard deviation [mg] 0.2 0.3 0.3 0.4
Average dispense time [s] 14 16 20 45
CaHPO4
Average [mg] 1.0 10.3 20.3 99.9
Standard deviation [mg] 0.1 0.2 0.2 0.1
Average dispense time [s] 19 27 32 63

Figure 1: Gaussian curve for the 10 mg aerosil dispenses Table 1: Results of 10 dispenses for each compound

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SWILE & SWIP - Pick & Decision Dispensing

Discover the Revolution in Reformatting of Materials

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SWILE - Pick & Decision Dispensing

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SWILE - Pick & Decision Dispensing

Target Mean
Value Value Precision
Compound (mg) (mg) (%)
Fumed 0.50 0.54 11
silica 1.00 0.99 7
2.00 1.95 3
5.00 4.96 2
Palladium(II) 0.50 0.56 12
acetyl- 1.00 1.01 9
acetonate 2.00 2.00 4
5.00 5.05 2
Starch 0.50 0.52 9
1.00 1.00 7
2.00 1.99 4
5.00 5.03 2
Nickel(II) 0.50 0.49 11
acetate 1.00 1.07 6
dihydrate 2.00 2.03 5
5.00 5.04 2
Vanillin 0.50 0.49 11
1.00 0.99 9
2.00 2.05 3
5.00 4.96 1
Table 1: Results of 10 dispenses for each compound with
desired target weight und preselected precision: 0.50 mg (+/-
15%); 1.00 mg (+/- 10%); 2.00 mg (+/- 5%) und 5.00 mg (+/- 2%)

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SWIP - Pick & Decision Dispensing

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SWIP - Pick & Decision Dispensing

Table 1: Results of 4 consecutive pick & dispenses of 96-400 Phthalo Green ( = 1150 g/mL) with 2.00 mg
desired target weight und preselected precision: +/- 10%; alteration of depth of immersion by 0.5 mm until target
amount reached.

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Agenda

• Challenges
• Enabling technologies and proprietary innovations
• Selection of Case Studies
• Summary
• Company

Chemspeed Technologies Proprietary

Selection of Case Studies

1. Viscosity and Rheology Screening

2. Water Analysis by Karl Fischer Titration

3. Content Uniformity - Sample Preparation for QC of Hard Lozenges

4. Solubility Screening

5. Dissolution Testing

6. Automated Solid Reformatting into Capsules for Isotope Ratio Testing

7. Sample Preparation and IC Analysis

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1. Viscosity and Rheology Screening – SWING VISCO and/or RHEO
Automated viscosity and / or rheology measurement for QC
Gravimetric Dispensing and / or
Screw Capping Tool

Integrated
Rheometer
(e.g. TA, Anton Paar)

Product
Storage

Robotic Viscosity
Measurement Tool with Washing
Station
Disposable, barcoded glass vials in shakable,
(Brookfield)
heatable / coolable racks

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1. Viscosity and Rheology Screening – Example Worklfow

Dispense Measure Measure Measure

sample pH viscosity rheology

External software

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2. Water Analysis by Karl Fischer Titration

Sample Preparation for Water Analysis by Karl Fischer

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2. Water Analysis by Karl Fischer Titration

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3. Content Uniformity - Sample Preparation for QC of Hard Lozenges

Place
Add Add Homogenize HPLC
lozenge
water ethanol solution injection
into vial

Objectives
• Implement fully automated system where the only manual step
would be the addition of the lozenge into the vial
• Increase reproducibility compared to manual procedure
• Prove robustness based on 8-hour shifts or longer
• Run under GMP conditions

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3. Content Uniformity - Sample Preparation for QC of Hard Lozenges

Place
Add Add Homogenize HPLC
lozenge
water ethanol solution injection
into vial
No cross-
contamination !

Volumetric liquid High-shear HPLC injection

dispensing (4NH) homogenizer valve

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3. Content Uniformity - Sample Preparation for QC of Hard Lozenges

• Platform successfully running in the QC lab

• Working under GMP conditions, following

the European Pharmacopoeia 2.9.40

• System suitability tests performed on a

daily basis

• Strict IQ / OQ / PQ procedures SWING SP robotic platform

implemented

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4. Solubility Screening

Saturated solution

Add active Add solvent Agitation at T, HPLC

Cool down Filtration
ingredient (mixture) dissolve injection

Dissolution by solvent addition

Measure
Add active Agitation Add solvent
concentration
ingredient (and heating) slowly
over time

HPLC injection
valve

High efficiency shakeable

Overhead gravimetric Overhead gravimetric
racks with disposable vials of
solid, powder liquid aspiration and
different volumes, incl. set-up
dispensing tool dispensing tool (GDU-V)
for heating & cooling,
(SWILE)
filtration

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5. Dissolution Testing

Add Close Place vials

Add
dosage sample Stir for x min into Centrifuge
solvent
unit in vial vial centrifuge

Dissolution

Volumetric Centrifuge
liquid
dispensing
(4NH) Magnetic Stir
Rack
Screw /
Unscrew Tool

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5. Dissolution Testing - Work-Up & Analysis

Sample Preparation (Work-up) Analysis

Transfer
Dilute Add solvent
Aspirate Inject into sample Transfer to UV
sample (50x dilution) Mix
100uL sample HPLC volume to UV cuvettes measurement
if needed accuracy <1%
dilution vial

Volumetric
liquid
dispensing
(4NH)
Overhead
Volumetric liquid gravimetric Spectrophotometer
dispensing (4NH) liquid aspiration Shakeable rack
and HPLC injection and dispensing
(GDU-V)

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6. Automated Solid Reformatting into Capsules for Isotope Ratio Testing

FLEX SWILE
Automated Workstation
(example picture)

Overhead gravimetric pick & decision dispensing

directly from source into capsules

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6. Automated Solid Reformatting into Capsules for Isotope Ratio Testing

Destination:
Silver or tin capsules
e.g. ø3,3 x 5,0mm or ø5,0 x 9,0mm
on MTP

Source:
glass vial

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7. Sample Preparation and IC Analysis

Sample Preparation for IC and

Potentiometric Titration Analysis

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7. Sample Preparation and IC Analysis

Barcode Multi Multi

GDU-Pfd 4 NH 4 NH Rack Rack Rack 4 NH 4 NH
reader Gripper Gripper
Read
Dispense Dispense Dispense Mix and Inject
Barcode Cover Wait Cool Open
Solid water HCl heat Filtration in IC
Solid Flask 15 min to RT Flask
in Flask in Flask in Flask 105°C Port
Containers

SPE Filtration Rack

Heat / Cool / Stir Rack

Barcode reader 4 NH Tool

4-NH = 4-Needle Head (Liquid Handling Tool)

GDU-Pfd = Gravimetric solid dispensing

MultiGripper

GDU-Pfd

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Agenda

• Challenges
• Enabling technologies and proprietary innovations
• Selection of Case Studies
• Summary
• Company

Chemspeed Technologies Proprietary

Summary

✓ Persistent throughput, reproducibility and accuracy!

✓ Enabling technology allows commercially viable automation for

most workflows in R&D and QC

✓ Chemspeed is in the position to adapt to complex workflows and

develop the corresponding tools needed for it

✓ Chemspeed‘s flexible and modular concept allows unattended

workflows

✓ Chemspeed – your innovative partner for pharma, synthesis,

formulation and quality control!

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Agenda

• Challenges
• Enabling technologies and proprietary innovations
• Selection of Case Studies
• Summary
• Company

Chemspeed Technologies Proprietary

About Chemspeed Technologies

• Swiss company, located nearby Basel

• Privately owned

• Globally operating, global installation base (Asia, Europe, America)

• More than 70% of Chemspeed staff have an academic degree in chemistry or

engineering

Headquarters
Manufacturing & UK Office US Office US Office
R&D (York) (New Jersey) (Columbus)
(Switzerland)

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About Chemspeed Technologies

• Chemspeed offers automated workstations and partial or

entire product development solutions

• 20 years of expertise in speeding up research and

innovation in chemical industry and academia

• Pharmaceuticals, Agrochemicals, Fine & Specialty

Chemicals, Renewables, Catalysts, Polymers,
Nanomaterials, Biomaterials, Lubricants, Paints &
Coatings, Personal & Home Care, Nutrition

• Proprietary technology base (reactors, robotic tool

exchange, gravimetric dispensing, SMOLE, SMOLEFIN)
with unlimited, license-free access for our customers

• Research achievements with Chemspeed tools belong

solely to our customers

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Chemspeed is expanding - New Headquarters in Füllinsdorf, Switzerland

o 5’000 m2 floor-
space with a
potential of up
to 13’000 m2
o Consolidation of
the 4 sites
o Improved
communication
and efficiency

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Where to find us

DISTRIBUTORS

Europe:
Labtim – Slovenia, Bosnia,
Croatia

Asia and Australia:

AMR Inc – Japan

Bargal – Israel

CM Corp - Korea

Thermo Fisher Scientific - Korea

Inkarp – India

ITS – Indonesia

ITS - Malaysia

ITS - Singapore

ITS – Thailand

Nikyang – China

Nikyang – Hong Kong

Thermo Fischer – Australia

Chemspeed Technologies – Headquarters Please visit us at Utek - Taiwan

Chemspeed Technologies – Subsidiaries VN ITS – Vietnam

Chemspeed Technologies – Distributors

our booth: South America:

B1.329 SINC – Brazil

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Thank you

Please visit us
at our booth:
B1.329
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This PowerPoint presentation is the proprietary intellectual property of Chemspeed
Technologies AG.

Chemspeed Technologies AG • Wölferstrasse 8 • 4414 Füllinsdorf • Switzerland •

Phone +41 (0) 61 816 95 00 • Fax +41 (0) 61 816 95 09
www.chemspeed.com / • [email protected]

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