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    BP301TP PDF

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    Vidit Oberoi
    This document outlines the scope, objectives, topics, and experiments covered in the Pharmaceutical Organic Chemistry II course at Gujarat Technological University. The course deals with the preparation, reactions, and reactivity of organic compounds, with a focus on reaction mechanisms and orientation. Topics include benzene and its derivatives, phenols, aromatic amines, aromatic acids, fats and oils, and poly nuclear hydrocarbons. The practical component involves techniques like recrystallization and steam distillation, and determination of oil values. Students will also prepare various organic compounds in the laboratory. Recommended textbooks are provided.

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    BP301TP PDF

    Uploaded by

    Vidit Oberoi
    207 views2 pages
    This document outlines the scope, objectives, topics, and experiments covered in the Pharmaceutical Organic Chemistry II course at Gujarat Technological University. The course deals with the preparation, reactions, and reactivity of organic compounds, with a focus on reaction mechanisms and orientation. Topics include benzene and its derivatives, phenols, aromatic amines, aromatic acids, fats and oils, and poly nuclear hydrocarbons. The practical component involves techniques like recrystallization and steam distillation, and determination of oil values. Students will also prepare various organic compounds in the laboratory. Recommended textbooks are provided.

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    This document outlines the scope, objectives, topics, and experiments covered in the Pharmaceutical Organic Chemistry II course at Gujarat Technological University. The course deals with the preparation, reactions, and reactivity of organic compounds, with a focus on reaction mechanisms and orientation. Topics include benzene and its derivatives, phenols, aromatic amines, aromatic acids, fats and oils, and poly nuclear hydrocarbons. The practical component involves techniques like recrystallization and steam distillation, and determination of oil values. Students will also prepare various organic compounds in the laboratory. Recommended textbooks are provided.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    207 views2 pages

    BP301TP PDF

    Uploaded by

    Vidit Oberoi
    This document outlines the scope, objectives, topics, and experiments covered in the Pharmaceutical Organic Chemistry II course at Gujarat Technological University. The course deals with the preparation, reactions, and reactivity of organic compounds, with a focus on reaction mechanisms and orientation. Topics include benzene and its derivatives, phenols, aromatic amines, aromatic acids, fats and oils, and poly nuclear hydrocarbons. The practical component involves techniques like recrystallization and steam distillation, and determination of oil values. Students will also prepare various organic compounds in the laboratory. Recommended textbooks are provided.

    Copyright:

    © All Rights Reserved
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    of 2

    GUJARAT TECHNOLOGICAL UNIVERSITY

    B.Pharm
    SEMESTER: III
    Subject Name: Pharmaceutical Organic Chemistry II
    Subject Code: BP301TP

    Scope: This subject deals with general methods of preparation and reactions of some organic
    compounds. Reactivity of organic compounds are also studied here. The syllabus emphasizes on
    mechanisms and orientation of reactions. Chemistry of fats and oils are also included in the syllabus.

    Objectives: Upon completion of the course the student shall be able to


    1. Write the structure, name and the type of isomerism of the organic compound
    2. Write the reaction, name the reaction and orientation of reactions
    3. Account for reactivity/stability of compounds,
    4. Prepare organic compounds

    Sr No Topics %
    weightage
    1. Benzene and its derivatives: 10
     Analytical, synthetic and other evidences in the derivation of structure of
    benzene, Orbital picture, resonance in benzene, aromatic characters,
    Huckel’s rule
     Reactions of benzene - nitration, sulphonation, halogenation-
    reactivity, Friedelcrafts alkylation- reactivity, limitations, Friedelcrafts
    acylation.
     Substituents, effect of substituents on reactivity and orientation of mono
    substituted benzene compounds towards electrophilic substitution reaction
     Structure and uses of DDT, Saccharin, BHC and Chloramine
    2. Phenols*: 10
    Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure
    and uses of phenol, cresols, resorcinol, naphthols
    Aromatic Amines*:
    Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl
    diazonium salts
    Aromatic Acids*:
    Acidity, effect of substituents on acidity and important reactions of benzoic
    acid.
    3. Fats and Oils: 10
     Fatty acids – reactions.
     Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying
    oils.
     Analytical constants – Acid value, Saponification value, Ester value, Iodine
    value, Acetyl value, Reichert Meissl (RM) value – significance and principle
    involved in their determination.
    Polynuclear hydrocarbons:
    4.  Synthesis, reactions 8
     Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene,
    Diphenylmethane, Triphenylmethane and their derivatives
    5. Cyclo alkanes*: 7
     Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory,
    Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of
    strainless rings), reactions of cyclopropane and cyclobutane only

    Practical

    Experiments involving laboratory techniques


     Recrystallization
     Steam distillation

    Determination of following oil values (including standardization of reagents)


     Acid value
     Saponification value
     Iodine value

    Preparation of compounds

     Benzanilide/Phenyl benzoate/Acetanilide from Aniline/ Phenol /Aniline by acylation reaction.


     2,4,6-Tribromo aniline/Para bromo acetanilide from Aniline/
     Acetanilide by halogenation (Bromination) reaction.
     5-Nitro salicylic acid/Meta di nitro benzene from Salicylic acid / Nitro benzene by nitration reaction
     Benzoic acid from Benzyl chloride by oxidation reaction.
     Benzoic acid/ Salicylic acid from alkyl benzoate/ alkyl salicylate by hydrolysis reaction.
     1-Phenyl azo-2-napthol from Aniline by diazotization and coupling reactions.
     Benzil from Benzoin by oxidation reaction.
     Dibenzal acetone from Benzaldehyde by Claison Schmidt reaction
     Cinnammic acid from Benzaldehyde by Perkin reaction
     P-Iodo benzoic acid from P-amino benzoic acid

    Recommended Books (Latest Editions)

    1. Organic Chemistry by Morrison and Boyd


    2. Organic Chemistry by I.L. Finar , Volume-I
    3. Textbook of Organic Chemistry by B.S. Bahl & Arun Bahl.
    4. Organic Chemistry by P.L.Soni
    5. Practical Organic Chemistry by Mann and Saunders.
    6. Vogel’s text book of Practical Organic Chemistry
    7. Advanced Practical organic chemistry by N.K.Vishnoi.
    8. Introduction to Organic Laboratory techniques by Pavia, Lampman and Kriz.

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