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    PC Kus

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    danielguerin
    The document discusses pseudocatalase cream (PC-KUS) developed by Professor Schallreuter for treating vitiligo by removing high levels of hydrogen peroxide from the skin, summarizes basic research findings on vitiligo, and warns that copied versions of pseudocatalase cream from other groups have been shown to be ineffective unlike the original PC-KUS formulation.

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    PC Kus

    Uploaded by

    danielguerin
    3K views13 pages
    The document discusses pseudocatalase cream (PC-KUS) developed by Professor Schallreuter for treating vitiligo by removing high levels of hydrogen peroxide from the skin, summarizes basic research findings on vitiligo, and warns that copied versions of pseudocatalase cream from other groups have been shown to be ineffective unlike the original PC-KUS formulation.

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    The document discusses pseudocatalase cream (PC-KUS) developed by Professor Schallreuter for treating vitiligo by removing high levels of hydrogen peroxide from the skin, summarizes basic research findings on vitiligo, and warns that copied versions of pseudocatalase cream from other groups have been shown to be ineffective unlike the original PC-KUS formulation.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    3K views13 pages

    PC Kus

    Uploaded by

    danielguerin
    The document discusses pseudocatalase cream (PC-KUS) developed by Professor Schallreuter for treating vitiligo by removing high levels of hydrogen peroxide from the skin, summarizes basic research findings on vitiligo, and warns that copied versions of pseudocatalase cream from other groups have been shown to be ineffective unlike the original PC-KUS formulation.

    Copyright:

    Attribution Non-Commercial (BY-NC)
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    of 13

    Professor Karin U Schallreuter MD

    Institute for Pigmentary Disorders, Greifswald, Germany


    Fax: +49-3834-515573, email: [email protected]

    Clinical and Experimental Dermatology,


    University of Bradford, Bradford, United Kingdom
    Fax: +44-1274-236489, email: [email protected]

    Pseudocatalase (PC-KUS) Update

    May 2002

    What is Vitiligo ?
    Vitiligo is an idiopathic acquired disease, which is characterized by a sudden
    loss of the skin colour. This is not only a harmless anomaly. Patients suffer
    from severe psychological stress. Consequently other illnesses can occur.
    The etiology of vitiligo is still unclear. The incidence ranges between 0.5 –
    1% of the world population affecting all skin colours and gender equally.
    Vitiligo can appear at any age but the peak onset is around the age of 20
    years. Approximately 40% of the patients have another affected member in
    the family. An isomorphic response (Koebner- phenomenon) is observed in
    45% of affected individuals. This can trigger the onset of the disease after
    an injury/trauma and it can worsen an ongoing vitiligo. Vitiligo can itch!
    Basic Research Leads to New Knowledge
    · Melanocytes are still present in longstanding ( > 25 years)
    depigmented skin of patients with vitiligo.
    (Tobin et al, J.Pathol (2000) 191: 407- 416.)

    · All patients with vitiligo generate and accumulate hydrogen


    peroxide (H2O2) in their epidermis.
    (Schallreuter et al, J.Invest Dermatol (2001) 116: 167-174. Schallreuter et al,
    J.Invest Dermatol (1999) 4: 91-96.)

    · To date there are six sources of H2O2 generation documented in


    vitiligo.
    (Schallreuter et al, Science (1994) 263: 1444-1446, Rokos et al, (2002);
    Biochem Biophys Res Commun. 292:805-811)

    · The patients with vitiligo cannot efficiently remove these high


    levels of H2O2 due to low catalase, glutathione peroxidase and
    thioredoxin reductase levels.
    (Schallreuter et al, J.Invest Dermatol (1991) 97:1081-1085, Beazley et al, British
    Journal Dermatol, (1999) 141: 301-303. Schallreuter et al, J.Invest Dermatol (1986)
    87: 728-732. Schallreuter, Wood, J. Photochem Photobiol (2001) 64:179-184.)

    · This patient group has difficulties to maintain the calcium


    balance in the skin.
    ( Schallreuter et al, Arch Dermatol. Res (1996) 288: 11-13, Schallreuter
    and Pittelkow, Arch Dermatol Res. (1988) 280: 137-139.)

    · For the first time patients with vitiligo can be diagnosed based
    on their ability to metabolize the essential amino acid L-
    phenylalanine. 40% of all patients have difficulties to deal with
    L-phenylalanine. A specific test allows to tailor the treatment for
    each individual patient.
    ( Schallreuter et al, Biochem Biophys Res Commun. (1988) 395-399 and unpublished
    data)

    · Clinical evaluation of a large patient group does not support the


    autoimmune hypothesis in vitiligo as the primary event.
    (Schallreuter et al, Dermatology (1994) 188: 269-275.)

    A New Treatment as a Result of Basic Research


    Pseudocatalase cream plus calcium has been originally developed by
    Schallreuter et al and was used as a substitution for low catalase levels in the
    treatment of vitiligo (K U Schallreuter, J M Wood and K R Lemke et al.
    Treatment of vitiligo with a topical application of pseudocatalase and
    calcium in combination with short term UVB exposure, Dermatology, 190:
    223-229, 1995).The word pseudocatalase has been introduced by these
    authors to differentiate between the natural enzyme catalase and a chemical
    complex which does the same job, i.e. degrading hydrogen peroxide.
    In this context, it is noteworthy that catalase cannot penetrate the top
    layer of the skin. Therefore, it is important to note that any products
    containing natural catalase in a cream are basically ineffective, and any
    product advertised as catalase in the treatment of vitiligo should be used
    with caution.

    · Repigmentation with pseudocatalase cream PC-KUS can be achieved in


    all skin colours and is independent of the percentage of depigmented skin
    and the duration of the disease! First signs of repigmentation can be
    observed after 3-4 months.

    · This treatment modality can also successfully repigment lips, ears


    and genitals. However, the response on fingers and feet is disappointing.
    (Schallreuter et al, Dermatology (1995) 190: 223-229.)

    · The removal of high levels of epidermal H2O2 with narrowband


    UVB activated pseudocatalase – PC-KUS coincides with –
    stabilization of the depigmentation process followed by
    repigmentation.
    (Schallreuter et al, 1995,190:223-229, J.Invest Dermatol, 2001, 116:167-174 Int.
    Journal of Dermatol 2002 in press.)

    · The treatment has no side effects providing the liver function of


    the affected individual is normal.
    (Schallreuter et al, Dermatology (1995) 190: 223-229.)

    · A significant faster initiation of repigmentation can be induced


    with the combination of climatotherapy at the Dead Sea together
    with pseudocatalase PC-KUS over a period of 21 days. First
    repigmentation occurs between the day 14-20. This fast
    repigmentation lasts for an additional 4 months when continued
    with daily treatment using narrowband UVB activated
    pseudocatalase PC-KUS.
    (Schallreuter et al, Int. Journal of Dermatol (2002) in press.)
    For further information see: http://www.brad.ac.uk/admin/pr/February2002/skin.htm

    · The shelf life of pseudocatalase PC-KUS stored at 4°C is 12


    months.

    Pseudocatalase Copies

    Recently a copied pseudocatalase cream plus calcium P-CAT has been


    advertised by Northwestern University in Chigaco, Illinois, USA. Much
    confusion has taken place since the same name has been used from the
    original publication by Schallreuter et al 1995. The publications from
    Schallreuter et al on the subject of pseudocatalase have been used to support
    the efficacy of this treatment. More recently Community Drug, 517
    Greenfield Avenue, Suite B, Pittsburgh is offering the same formulation
    for sale via the internet.

    The creams from both Northwestern and Community Drug are neither tested
    and do not hold their promise in reduction of hydrogen peroxide, which is
    important for recovery from the oxidative stress in the skin of all patients.
    Both creams have been examined and analysed in our laboratory in vivo and
    in vitro on patients skin. The data clearly shows that both copied
    pseudocatalase complexes are identical but have very little effect.

    FT-Raman spectroscopy of hydrogen peroxide (H2O2) in vitro (a) and in vivo in the
    skin of a patient with vitiligo (b) before and after application of pseudocatalase

    Pseudocatalase copies
    PC-KUS
    Time = 0 minutes
    Raman Intensity (Arbitrary Units)

    +1 minute

    +2 minutes

    +3 minutes

    +4 minutes

    +5 minutes

    +6 minutes

    950 900 850 800 Initial H2O2 on the skin of Narrow band UVB after H2O2 after 5 minutes
    -1 the patient application of cream
    Wavenumber (cm )

    1. Both Pseudocatalase plus calcium (P-CAT) from Northwestern


    University and pseudocatalase plus calcium from Community Drug do
    not show any effect after 5 minutes compared to the PC-KUS
    formulation which removes the H2O2 completely.

    2. The shelf life of both pseudocatalase copies is very short, whereas the
    shelf life of PC-KUS is 12 months.

    3. The patient information from both Northwestern University and


    Community Drug do state that there are no systemic side effects. This
    is not true because the cream contains manganese. This compound
    can be toxic under certain conditions. Any accumulation could clearly
    lead to complications. In good medical practice the patient should be
    tested before starting the treatment and the patient should be
    controlled by a qualified physician every 10-12 months.

    Pseudocatalase PC-KUS has been successfully used in over 1000


    patients. This treatment modality is a very disciplined approach.
    In our hands we can repigment 95% of all affected individuals.
    The results are excellent regardless of skin color, extent and
    duration of the disease, as well as the age of the patient.

    Figures 2a/b

    Repigmentation of the face.

    Mrs Maxine Whitton has suffered from vitiligo for 47 years. Figure 2a shows her
    face before treatment with PC-KUS and Figure 2b shows her face 12 months later.
    Note the even skin colour – there is no hyperpigmentation despite her dark skin
    colour.
    Figure 3a/b
    Repigmentation of lips and ears.
    Figure 4
    Vitiligo for 21 years since adolescence, showing the face before and after 4 months
    treatment with narrowband activated pseudocatalase PC-KUS.
    Figure 5
    Extensive acute vitiligo of the back before and after 8 months treatment with
    narrowband activated pseudocatalase PC-KUS.

    Figure 6

    One example of fast repigmentation with Combined Climatotherapy at the Dead Sea
    and pseudocatalase PC-KUS.
    Figure 7

    Repigmentation of hands with narrowband activated pseudocatalase PC-KUS after


    8 months
    Patients comments:
    “I just wanted to say hello and say thank you once again for all your hard work and commitment
    to your research. Without it I would not be experiencing marvelous repigmentation right now, so
    thank you once again. Further please know that your hard work is appreciated by all your
    patients because you make it possible for us to live normal lives again!!!! “

    “I had to write as I wanted to thank you all again for the work you're doing. My kids went back to
    school today and so I saw friends I hadn't seen all summer. They were just amazed by the
    change in me. I'm on cloud 9, so happy!”

    “ I have tried many things the past 4 years or so to try and improve my vitiligo – dietary changes,
    homeopathy etc – and the pseudocatalase/UVB treatment is the ONLY one which has produced
    any improvement at all. So of course I am very pleased and very impressed with the method you
    and your colleagues have pioneered.”

    “I have discovered something wonderful today…..2 black eyelashes amongst the white ones!!!!
    Do you recall, half of one eyelid was white, that repigmented, but the lashes stayed white, well I
    discovered 2 black eyelashes coming through in the middle of the row of white lashes!!!”
    Are you interested in this treatment?

    We are offering individually tailored treatment for vitiligo in the


    Institute for Pigmentary Disorders in Association with the University of
    Greifswald in Germany.
    For further information please contact: -

    Mrs Angela Panske

    Institute for Pigmentary Disorders e.V. in Association


    with the Ernst-Moritz-Arndt University Greifswald
    Biotechnikum
    Walter-Rathenau-Str. 49a
    17489 Greifswald
    Germany
    Fax: +49 (0)3834 515573
    email: [email protected]

    Mrs Susan Shergill

    Clinical and Experimental Dermatology


    Department of Biomedical Sciences
    University of Bradford
    Bradford
    West Yorkshire
    BD7 1DP, UK
    Fax: +44 (0)1274 235290
    E-mail: [email protected]

    There is a book, which could be important to you.

    Do you want to know how patients with vitiligo see themselves with their disease?
    Do you want to know how much these individuals suffer?

    Then you must read "Damned White Spots" by Professor Karin Uta Schallreuter.
    The book is unique and gives a real insight into the feelings of other people, who
    have vitiligo.

    To order the book please contact Mrs Susan Shergill by Fax: +44 1274 235290 or
    E-mail: [email protected]
    The proceeds from this book will go towards vitiligo research.
    ATTENTION

    “PATIENTS BEWARE OF ADVERTISED PSEUDOCATALASE WHERE


    THERE ARE NO PEER REVIEWED PUBLICATIONS IN THE
    INTERNATIONAL DERMATOLOGY JOURNALS THAT SUPPORT OR
    SUBSTANTIATE THE EFFICACY OF THE PRODUCTS ON THE
    MARKET CLAIMING PSEUDOCATALASE ACTIVITY WITHOUT
    CLINICAL PROOF”.

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