Immunological Activities Associated With Milk.: Author Information

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Immunological activities associated with

milk.
Kelleher SL1, Lönnerdal B.

Author information

1
Department of Nutrition, University of California, Davis, California, USA.

Abstract

Milk contains a multitude of components that can, or may, provide immune protection to the
suckling offspring and that also may promote development of neonatal immune competence. In
addition, these specialized factors are essential for the protection of the mammary gland, the
offspring's food source, from pathogen colonization and lactation failure. Breast milk also
facilitates the establishment of a gut flora that inhibits colonization by many pathogens and
stimulates the growth of beneficial microorganisms. Maternal immunity can be transferred to the
infant via antibodies, primarily of the sIgA type in humans, as well as by leukocytes including
effector and memory T lymphocytes. In this way, protection is provided passively against the
pathogens to which the mother has been exposed. Currently, there is much interest in
determining the protective efficacy of oral supplementation with immunoglobulins from the milk
of lactating animals hyperimmunized against specific pathogens. An array of immunostimulatory
components in milk, notably cytokines, may be protected against intestinal proteolysis, thereby
providing the offspring with a prepackaged immune response system. These components may
help to boost the infant's immature immune system. At the same time, anti-inflammatory factors
in breast milk help to modulate cytokine responses to infection, thereby facilitating defense while
minimizing tissue damage such as that which occurs in infants with necrotizing enterocolitis.
Undoubtedly, the many components constituting the repertoire of immune and
immunomodulating agents in milk interact synergistically to protect both the mammary gland
and the offspring from invading pathogenic microorganisms.

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