Scribd Logo
Upload

Welcome to Scribd!

  • 46 views

    Uncrossed Blood: Teguh Triyono

    Uploaded by

    Herlina Ina
    1) Group O red blood cells can be used safely in emergency transfusions when pre-transfusion compatibility testing is not possible due to the urgent nature of the transfusion. 2) The overall risk of hemolysis from receiving uncrossmatched blood in an emergency is low at 0.1%, though it is still preferable to use crossmatched blood when time allows. 3) For women of childbearing age or those where determination is difficult, Rh-negative red blood cells should be used preferentially in emergency transfusions to avoid risk of anti-D formation. Others can receive Rh-positive blood which carries small risk of anti-D formation.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Uncrossed Blood: Teguh Triyono

    Uploaded by

    Herlina Ina
    46 views15 pages
    1) Group O red blood cells can be used safely in emergency transfusions when pre-transfusion compatibility testing is not possible due to the urgent nature of the transfusion. 2) The overall risk of hemolysis from receiving uncrossmatched blood in an emergency is low at 0.1%, though it is still preferable to use crossmatched blood when time allows. 3) For women of childbearing age or those where determination is difficult, Rh-negative red blood cells should be used preferentially in emergency transfusions to avoid risk of anti-D formation. Others can receive Rh-positive blood which carries small risk of anti-D formation.

    Original Description:

    Donor

    Original Title

    -56953669

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    1) Group O red blood cells can be used safely in emergency transfusions when pre-transfusion compatibility testing is not possible due to the urgent nature of the transfusion. 2) The overall risk of hemolysis from receiving uncrossmatched blood in an emergency is low at 0.1%, though it is still preferable to use crossmatched blood when time allows. 3) For women of childbearing age or those where determination is difficult, Rh-negative red blood cells should be used preferentially in emergency transfusions to avoid risk of anti-D formation. Others can receive Rh-positive blood which carries small risk of anti-D formation.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    46 views15 pages

    Uncrossed Blood: Teguh Triyono

    Uploaded by

    Herlina Ina
    1) Group O red blood cells can be used safely in emergency transfusions when pre-transfusion compatibility testing is not possible due to the urgent nature of the transfusion. 2) The overall risk of hemolysis from receiving uncrossmatched blood in an emergency is low at 0.1%, though it is still preferable to use crossmatched blood when time allows. 3) For women of childbearing age or those where determination is difficult, Rh-negative red blood cells should be used preferentially in emergency transfusions to avoid risk of anti-D formation. Others can receive Rh-positive blood which carries small risk of anti-D formation.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 15

    UNCROSSED BLOOD

    TEGUH TRIYONO
    Dept. of Clinical Pathology
    Faculty of Medicine, Gadjah Mada University
    RSUP dr. Sardjito
    Yogyakarta, Indonesia
    Blood Group Antibody
    Blood group Anti-A Anti-B
    A - IgG>
    IgM>>>
    B IgG>
    IgM>>> -

    O IgG>>> IgG>>>
    Transfusion With O Donors
    PATIENT MAJOR MINOR
    Blood group
    A COMPATIBLE INCOMPATIBLE
    B COMPATIBLE INCOMPATIBLE

    O COMPATIBLE COMPATIBLE
    AB COMPATIBLE INCOMPATIBLE
    O Transfusion

    AHTR
    DHTR
    The responsible hospital service or location for the emergency transfusions
    and distribution of 45-day all-cause mortality. ETU = emergency trauma
    unit;OB = obstetrics. ( ) Day 45 mortality; ( ) episodes.
    Trends in the serum biochemical markers of haemolysis following cWB transfusion in non-group
    O and group O recipients. Shown are the median and the interquartile range for (a) haptoglobin,
    (b) total bilirubin, (c) lactate dehydrogenase (LDH), (d) creatinine and (e) serum potassium. e
    grey shaded areas represent the reference ranges for each analyte. e only signi cant di erence (*)
    between the non-group O and group O cWB recipients in any of these analytes was the median
    serum total bilirubin on day 0.

    HAPTOGLOBIN
    TOT BILIRUBIN
    LDH
    CREATININE
    NA

    Seheult. Transfusion Medicine, 2017, 27, 30–35


    Summary of Data for Recipients of
    Incompatible ER RBCs

    Goodell. Am J Clin Pathol 2010;134:202-206


    • transfusion of ER RBCs before completion of
    routine blood bank testing carries a low but real
    risk of receipt of antigen-incompatible RBCs
    (1.5% of ER units or 2.6% of ER episodes) and
    non-ABO alloantibody-mediated HTRs (0.1% of
    ER units or 0.4% ER episodes).
    • This overall risk is low, posing an acceptable risk
    in the urgent transfusion setting.
    Goodell. Am J Clin Pathol 2010;134:202-206
    Yazer. Anesthesiology 2018; 128:650-6
     Uncrossmatched erythrocytes should not be denied to an acutely
    hemorrhaging or severely anemic unstable patient if the results of
    pretransfusion testing are not available when the patient requires an
    urgent transfusion.
     Overall risk of hemolysis following the transfusion of uncrossmatched
    erythrocytes to patients needing an emergency transfusion of 0.1%,
    however, uncrossmatched erythrocytes should not be used in otherwise
    stable patients who can wait until crossmatched units become available.
     RhD − erythrocytes (crossmatched or uncrossmatched) should be
    preferentially administered to women of childbearing potential whose
    RhD type is unknown, or to patients where making this determination is
    difficult; all others, including males, should receive RhD+ erythrocytes.
    Yazer. Anesthesiology 2018; 128:650-6
    • The risk of a RhD− patient forming anti-D after receipt of RhD+
    erythrocytes is relatively small, preserve the inventory of RhD−
    erythrocytes for females of childbearing potential (typically de ned as ≤
    50 yr old).
    • The risk of forming unexpected antibodies after receipt of
    uncrossmatched erythrocytes should be identical to that after receipt
    of crossmatched erythrocytes.
    • Emerging evidence suggests that it is safe to transfuse group A plasma
    and group O WB to traumatically injured recipients of unknown ABO
    group.
    • Group O RBCs can continue to be used safely
    in cases of emergency transfusion, which pre-
    cludes pretransfusion compatibility testing in
    all patient populations.

    Mulay et al. Transfusion. Volume 53, July 2013


    Biochemical markers of hemolysis in a subset of non–group O ( , 3 or 4 units, n 5 23) and group O
    (, 3 or 4 units,n 5 14) recipients of between 3 and 4 units of cold-stored LTOWB.
    There were no significant differences between the non–group O and
    group O cold-stored LTOWB recipients for any of the analytes measured at any time point.

    HAPTOGLOBIN
    TOT BILIRUBIN
    LDH
    CREATININ
    POTASSIUM

    Seheult.Transfusion. Volume 58, October 2018


    • Administration of ≤2 units of cWB in civilian
    trauma resuscitation was not associated with
    clinically significant changes in laboratory
    haemolysis markers.

    You might also like