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    Biomonitoring of 5 Flourouracil - Any

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    Agus Tiany
    This scientific paper discusses biological monitoring and early detection of workers exposed to 5-fluorouracil (5-FU). 5-FU is commonly used to treat cancers but occupational exposure can occur for healthcare workers who prepare and administer it. Existing biomarkers for 5-FU exposure have short half-lives, making them ineffective for monitoring. The aim of the paper is to review research on biological monitoring of 5-FU exposed workers and identify effective methods for detecting exposure and potential health effects. It will search literature databases and analyze studies that have evaluated biomarkers for 5-FU among nurses and pharmacists handling the drug.

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    Biomonitoring of 5 Flourouracil - Any

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    Agus Tiany
    37 views5 pages
    This scientific paper discusses biological monitoring and early detection of workers exposed to 5-fluorouracil (5-FU). 5-FU is commonly used to treat cancers but occupational exposure can occur for healthcare workers who prepare and administer it. Existing biomarkers for 5-FU exposure have short half-lives, making them ineffective for monitoring. The aim of the paper is to review research on biological monitoring of 5-FU exposed workers and identify effective methods for detecting exposure and potential health effects. It will search literature databases and analyze studies that have evaluated biomarkers for 5-FU among nurses and pharmacists handling the drug.

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    pemeriksaan biomonitoring pada pekerja terpajan

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    Biomonitoring of 5 Flourouracil_any

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    This scientific paper discusses biological monitoring and early detection of workers exposed to 5-fluorouracil (5-FU). 5-FU is commonly used to treat cancers but occupational exposure can occur for healthcare workers who prepare and administer it. Existing biomarkers for 5-FU exposure have short half-lives, making them ineffective for monitoring. The aim of the paper is to review research on biological monitoring of 5-FU exposed workers and identify effective methods for detecting exposure and potential health effects. It will search literature databases and analyze studies that have evaluated biomarkers for 5-FU among nurses and pharmacists handling the drug.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    37 views5 pages

    Biomonitoring of 5 Flourouracil - Any

    Uploaded by

    Agus Tiany
    This scientific paper discusses biological monitoring and early detection of workers exposed to 5-fluorouracil (5-FU). 5-FU is commonly used to treat cancers but occupational exposure can occur for healthcare workers who prepare and administer it. Existing biomarkers for 5-FU exposure have short half-lives, making them ineffective for monitoring. The aim of the paper is to review research on biological monitoring of 5-FU exposed workers and identify effective methods for detecting exposure and potential health effects. It will search literature databases and analyze studies that have evaluated biomarkers for 5-FU among nurses and pharmacists handling the drug.

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    of 5

    Scientific Paper 2.

    BIOLOGICAL MONITORING AND EARLY DETECTION


    TO WORKERS EXPOSED TO 5-FLUOROURACIL

    Agustiany
    1806363760

    Lecturers:
    DR. Dr. Astrid Sulistomo, MPH, Sp.Ok
    Dr. Suryo Wibowo, MKK, Sp.Ok

    OCCUPATIONAL MEDICINE SPECIALIST EDUCATION PROGRAM


    FACULTY OF MEDICINE UNIVERSITAS INDONESIA
    JAKARTA
    MAY 2019
    CHAPTER 1
    INTRODUCTION

    1.1. Background
    Cancer incidence has been increasing for years leading to an increased use of chemotherapy
    by antineoplastic drugs, usually highly toxic compounds. In France, more than 49 400
    healthcare professionals (HCP) are occupationally exposed to these drugs and could be
    contaminated through systemic absorption of the drugs handled. Most professional
    exposures occur through dermal and oral exposure due to poor hygienic precautions.
    Respiratory contamination may also occur.1

    Occupational exposure to antineoplastic drugs can occur in hospital pharmacies and in


    hospitals where ANDs are prepared or administered to patients, mainly through inhalation
    and skin contact. The health risks related to handling antineoplastic drugs have therefore
    become a major concern for occupational medicine in hospitals. Several guidelines for the
    safe handling of antineoplastic have been developed by professional associations and health
    agencies.2

    However, to evaluate the occupational health risks associated with handling these drugs,
    reliable quantitative data on exposure levels are needed. Biological monitoring can be used
    advantageously to assess personal exposure as it takes into account all the exposure routes.
    Since it is unrealistic to measure all antineoplastic drugs, the most frequently used
    compounds, including cyclophosphamide, ifosfamide, methotrexate and 5-fluorouracil (5-
    FU), have generally been used as occupational exposure markers.2

    One of the antineoplastic drugs most frequently handled by HCP is 5-fluorouracil (5-FU). It is
    prescribed in the treatment of breast, digestive and ovarian cancers. An analytical method
    has been developed for 5-FU urine11 assay but due to the very short half-life of 5-FU
    (approximately 8 to 20 minutes),12 this biomarker is not efficient enough for biological
    monitoring of 5-FU exposures.1

    1.2. Problem Statement


    Epidemiological studies showed increased risk of fetal malformations, spontaneous
    abortions, reduced fertility and even cancers such as leukemia in healthcare professionals.
    Antineoplastic drugs have thus been listed as hazardous drugs for handling in healthcare
    settings due to their potential risk of carcinogenic and/or mutagenic effect and/or
    reproductive toxicity.1

    Nurses and pharmacy employees are exposed at the workplace to a wide spectrum of these
    agents in sub-therapeutic concentrations, with unknown biological consequence.3 Recently,
    the National Institute for Occupational Safety and Health (NIOSH) published an ‘Alert’
    document addressed to workers handling hazardous drugs (including cancer
    chemotherapeutics).4

    A study conducted by Delia Cavallo et al. proved that exposure to 5-FU in oncology nurses and
    pharmacists had a chromosomal aberrations frequency that was significantly higher than in
    controls (p < 0.01 for each group). They found an increase of about 2.5-fold for total structural
    aberrations (4–6- fold without gaps) and, in particular, an increase of up to 5.0-fold for breaks
    in exposed groups as compared with control subjects.5

    Due to the risks associated with 5-FU, it is important to evaluate and monitor occupational
    exposures through biomonitoring. Workers that exposed to 5-FU are pharmacists and nurses
    who prepare this medicine for cancer patients.

    1.3. Objective
    The aim of this scientific paper is:
    1) To increase knowledge about 5-FU for all occupational health doctor.
    2) To find out about health effects caused by 5-FU exposure.
    3) To determine the biological monitoring and early detection of workers exposed to
    5-FU, based on research studies.

    1.4. Methods
    Search Strategy
    Literature searching were conducted to determine the biological monitoring of workers
    exposed to 5-FU through an electronic database review: Pubmed, Scopus and Cochrane. The
    keywords used were “5 Flurouracil AND biological monitoring AND workers”. The inclusion
    criteria of this searching were clinical trial, review, systematic review, and full text. The
    exclusion criteria was inaccessible article. The searching was done in April, 21th 2019 at 19.50
    PM. The result of this searching is shown as bellow table (Table 1)
    Table 1. Searching strategy using database from PubMed, Google Scholar and Cochrane
    Database Search strategy Hit Selection

    PubMed ("fluorouracil"[MeSH Terms] OR 23


    "fluorouracil"[All Fields] OR "5 fluorouracil"[All
    Fields]) AND ("environmental monitoring"[MeSH
    Terms] OR ("environmental"[All Fields] AND
    "monitoring"[All Fields]) OR "environmental
    monitoring"[All Fields] OR ("biological"[All Fields]
    AND "monitoring"[All Fields]) OR "biological
    monitoring"[All Fields]) AND ("occupational
    groups"[MeSH Terms] OR ("occupational"[All
    Fields] AND "groups"[All Fields]) OR
    "occupational groups"[All Fields] OR
    "workers"[All Fields])
    Scopus TITLE-ABS-KEY ( 5-fluorouracil AND "biological 20
    monitoring" )

    Figure 1. Flow chart search strategy


    CHAPTER 2
    LITERATURE REVIEW

    2.1.

    REFERENCE
    1. Alice D, Benoit A, Beatrice M, Karine T, Marine R, Mohamed SC, Catherine VE, Mathieu M,
    Antoine V and Mireille CR. Biomonitoring of occupational exposure to 5-fluorouracil by
    assaying α-fluoro-β-alanine in urine with a highly sensitive UHPLC-MS/MS method.
    Analyst, 2018, DOI: 10.1039/C8AN00479J.
    2. S Ndaw, F Denis, P Marsan, A d’Almeida, A Robert. Biological monitoring of occupational
    exposure to 5-fluorouracil: Urinary fluoro-alanine assay by high performance liquid
    chromatography tandem mass spectrometry in health care personnel. Journal of
    Chromatography B, 878 (2010) 2630–2634.
    3. IARC, Some Antiviral and Antineoplastic Drugs, and Other Pharmaceutical Agents, vol. 76,
    1999.
    4. NIOSH, Alert Document Preventing Occupational Exposure to Antineoplastic and other
    Hazardous Drugs in Health Care Settings, US Department of Health and Human Service,
    Public Occupational Safety and Health DHHS, 2004, NIOSH Publication No. 2004-165.
    5. Delia C, Cinzia LU, Barbara P, Arianna DF, Margherita G, Federico MR, Alessandro M, Sergio
    L. Evaluation of genotoxic effects induced by exposure to antineoplastic drugs in
    lymphocytes and exfoliated buccal cells of oncology nurses and pharmacy employees.
    Mutation Research 587 (2005) 45–51.
    6.

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