Dihybrid Cross Practice
Dihybrid Cross Practice
Dihybrid Cross Practice
Two unlinked loci effect mouse hair color. AA or Aa mice are agouti. Mice with
genotype aa are albino because all pigment production is blocked, regardless of the
phenotype at the second locus. At the second locus, the Ballele (agouti coat) is
dominant to the b allele (black coat). What would be the result of a cross between two
agouti mice of genotype AaBb?
Tutorial
A Punnet Square for the AaBb x AaBb cross is shown below. Rather than the 9:3:3:1
seqregation of phenotypes normally seen with an AaBb x AaBb dihybrid cross, the
phenotypic ratio is 9:3:4. There are only three different phenotypes for hair color, agouti,
black and albino. The individual with genotype recessive for both traits, i.e. aabb, has the
same albino phenotype as the aaBB and aaBb individuals due to epistasis. The albino
phenotype masks any phenotype that might be caused by the recessive homozygous,
recessive bb genotype.