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    Exel Perhitungan Stabilitas Obat

    Uploaded by

    Wilda Lutfiyah
    The document contains data from experiments measuring the concentration of a drug over time. It provides concentration measurements at various time points. It then performs linear regression analysis on the data in both linear and logarithmic scales to determine the degradation rate constant (k), half-life, and time for 90% degradation. The results are used to calculate the activation energy and frequency factor for the degradation reaction based on Arrhenius equations. Finally, it predicts an expiration time for a drug batch prepared at 7:00 using the calculated k value.

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    © All Rights Reserved
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    Exel Perhitungan Stabilitas Obat

    Uploaded by

    Wilda Lutfiyah
    48 views5 pages
    The document contains data from experiments measuring the concentration of a drug over time. It provides concentration measurements at various time points. It then performs linear regression analysis on the data in both linear and logarithmic scales to determine the degradation rate constant (k), half-life, and time for 90% degradation. The results are used to calculate the activation energy and frequency factor for the degradation reaction based on Arrhenius equations. Finally, it predicts an expiration time for a drug batch prepared at 7:00 using the calculated k value.

    Original Description:

    perhitungan stabilitas obat

    Original Title

    EXEL PERHITUNGAN STABILITAS OBAT

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    The document contains data from experiments measuring the concentration of a drug over time. It provides concentration measurements at various time points. It then performs linear regression analysis on the data in both linear and logarithmic scales to determine the degradation rate constant (k), half-life, and time for 90% degradation. The results are used to calculate the activation energy and frequency factor for the degradation reaction based on Arrhenius equations. Finally, it predicts an expiration time for a drug batch prepared at 7:00 using the calculated k value.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Download as xlsx, pdf, or txt
    48 views5 pages

    Exel Perhitungan Stabilitas Obat

    Uploaded by

    Wilda Lutfiyah
    The document contains data from experiments measuring the concentration of a drug over time. It provides concentration measurements at various time points. It then performs linear regression analysis on the data in both linear and logarithmic scales to determine the degradation rate constant (k), half-life, and time for 90% degradation. The results are used to calculate the activation energy and frequency factor for the degradation reaction based on Arrhenius equations. Finally, it predicts an expiration time for a drug batch prepared at 7:00 using the calculated k value.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Download as xlsx, pdf, or txt
    of 5

    Waktu Waktu Waktu

    Kons obat
    (menit) = (menit) = Co-C = k.t (menit) = ln Co/C
    (%)
    x x x
    0 1 0 0.0000000 0 0.0000000
    10 2.734 10 -1.7340000 10 -1.0057657
    20 1.742 20 -0.7420000 20 -0.5550339
    30 0.968 30 0.0320000 30 0.0325232
    40 1.734 40 -0.7340000 40 -0.5504308784
    50 2.945 50 -1.9450000 50 -1.0801088171
    slope = b = k 0.0170029 0.0098485
    r = linearitas 0.1443038 0.1505742
    a = intersep -0.4287619048 -0.2802563223
    t1/2 = 0,693/k 70.3660455907
    t90% = 0,105/k 10.6615220592
    Waktu Waktu Waktu
    Kons obat
    (menit) = (menit) = Co-C = k.t (menit) = ln Co/C
    (%)
    x x x
    0 1 0 0.0000000 0 0.0000000
    10 1.234 10 -0.2340000 10 -0.2102609
    20 2.406 20 -1.4060000 20 -0.8779656
    30 3.656 30 -2.6560000 30 -1.2963697
    40 2.945 40 -1.9450000 40 -1.0801088
    50 2.992 50 -1.9920000 50 -1.0959421
    slope = b = k 0.0466943 0.0243076
    r = linearitas 0.6887446 0.7402935
    a = intersep -0.2048095238 -0.1524179877
    t1/2 = 0,693/k 28.5096019352
    t90% = 0,105/k 4.3196366568
    Waktu Waktu Waktu
    Kons obat
    (menit) = (menit) = Co-C = k.t (menit) = ln Co/C
    (%)
    x x x
    0 1 0 0.0000000 0 0.0000000
    10 2.289 10 -1.2890000 10 -0.8281150
    20 2.304 20 -1.3040000 20 -0.8346467
    30 2.734 30 -1.7340000 30 -1.0057657
    40 4.273 40 -3.2730000 40 -1.4523162
    50 6.125 50 -5.1250000 50 -1.8123788
    slope = b = k 0.0914486 0.0317303
    r = linearitas 0.8945996 0.9173224
    a = intersep 0.1653809524 -0.19561211
    t1/2 = 0,693/k 21.84032297
    t90% = 0,105/k 3.309139844
    t T 1/T --> sbg x k
    40 313 0.00319 0.0170029
    55 328 0.00305 0.0466943
    70 343 0.00292 0.0914486
    b=slope=-Ea/R -5041.3414732497 -5041.34147325 6034.904318353
    intercept = ln A 12.3058103386
    A=anti ln 16,184 220,976
    Ea = -b*R=-b*8,314 41,914

    ln k27=(- -4.49866
    Ea/8,341)*(1/300)+lnA
    antiln k27 0.0111238788 "=K27"

    T90% = 0,105/k 9.4391535526 menit


    Waktu daluarsa = waktu pembuat 07.00 + 9,4 menit = 07.09 ###
    grafik 1 grafik 2 grafik 3 grafik 4
    LN K --> sbg y
    -4.07437
    -3.06413
    -2.39198

    R = 8,314 J/mol K

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