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    Obesidad

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    Cristian Chavez
    The document analyzes the genetic and environmental influences on body mass index (BMI) and waist circumference in children aged 8-11 years old growing up during increases in pediatric obesity. It finds substantial heritability for BMI and waist circumference at 77% each. While the genetic influence on waist circumference is largely shared with BMI, there is also a significant independent genetic effect accounting for 40% of the influence.

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    Obesidad

    Uploaded by

    Cristian Chavez
    8 views2 pages
    The document analyzes the genetic and environmental influences on body mass index (BMI) and waist circumference in children aged 8-11 years old growing up during increases in pediatric obesity. It finds substantial heritability for BMI and waist circumference at 77% each. While the genetic influence on waist circumference is largely shared with BMI, there is also a significant independent genetic effect accounting for 40% of the influence.

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    Obesity

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    The document analyzes the genetic and environmental influences on body mass index (BMI) and waist circumference in children aged 8-11 years old growing up during increases in pediatric obesity. It finds substantial heritability for BMI and waist circumference at 77% each. While the genetic influence on waist circumference is largely shared with BMI, there is also a significant independent genetic effect accounting for 40% of the influence.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    8 views2 pages

    Obesidad

    Uploaded by

    Cristian Chavez
    The document analyzes the genetic and environmental influences on body mass index (BMI) and waist circumference in children aged 8-11 years old growing up during increases in pediatric obesity. It finds substantial heritability for BMI and waist circumference at 77% each. While the genetic influence on waist circumference is largely shared with BMI, there is also a significant independent genetic effect accounting for 40% of the influence.

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    © All Rights Reserved
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    of 2

    American Journal of Clinical Nutrition, Vol. 87, No.

    2, 398-404, February 2008


    © 2008 American Society for Nutrition

    Evidence for a strong genetic influence on childhood


    adiposity despite the force of the obesogenic
    environment1,2,3
    Jane Wardle, Susan Carnell, Claire MA Haworth and Robert Plomin
    1
    From the Department of Epidemiology and Public Health, Health Behaviour Research Centre,
    University College London, London, United Kingdom (JW and SC), and the Social, Genetic and
    Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, United
    Kingdom (CMAH and RP)

    Background: Body mass index (BMI) has been shown to be highly heritable, but most
    studies were carried out in cohorts born before the onset of the "obesity epidemic."

    Objective: We aimed to quantify genetic and environmental influences on BMI and


    central adiposity in children growing up during a time of dramatic rises in pediatric
    obesity.

    Design: We carried out twin analyses of BMI and waist circumference (WC) in a UK
    sample of 5092 twin pairs aged 8–11 y. Quantitative genetic model-fitting was used for
    the univariate analyses, and bivariate quantitative genetic model-fitting was used for the
    analysis of covariance between BMI and WC.

    Results: Quantitative genetic model-fitting confirmed substantial heritability for BMI


    and WC (77% for both). Bivariate genetic analyses showed that, although the genetic
    influence on WC was largely common to BMI (60%), there was also a significant
    independent genetic effect (40%). For both BMI and WC, there was a very modest
    shared-environment effect, and the remaining environmental variance was unshared.

    Conclusions: Genetic influences on BMI and abdominal adiposity are high in children
    born since the onset of the pediatric obesity epidemic. Most of the genetic effect on
    abdominal adiposity is common to BMI, but 40% is attributable to independent genetic
    influences. Environmental effects are small and are divided approximately equally
    between shared and nonshared effects. Targeting the family may be vital for obesity
    prevention in the earliest years, but longer-term weight control will require a
    combination of individual engagement and society-wide efforts to modify the
    environment, especially for children at high genetic risk.

    Key Words: Heritability • waist circumference • BMI • childhood obesity • twins

    Related articles in AJCN:


    Obesity—still highly heritable after all these years
    Solomon K Musani, Stephen Erickson, and David B Allison
    AJCN 2008 87: 275-276. [Full Text]

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