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    Pancreasul - Embriologie

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    The pancreas forms from two buds, a dorsal and ventral bud, originating from the lining of the duodenum. The dorsal bud is located in the dorsal mesentery while the ventral bud is near the bile duct. As the duodenum rotates, the ventral bud moves behind the dorsal bud. Later, the tissue and ducts of the two buds fuse. The ventral bud forms the uncinate process and lower head, while the dorsal bud forms the rest of the pancreas. The main pancreatic duct forms from the fusion of the dorsal and ventral pancreatic ducts. Molecular signals from surrounding tissues regulate pancreas development and formation of endocrine cell types.

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    Pancreasul - Embriologie

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    The pancreas forms from two buds, a dorsal and ventral bud, originating from the lining of the duodenum. The dorsal bud is located in the dorsal mesentery while the ventral bud is near the bile duct. As the duodenum rotates, the ventral bud moves behind the dorsal bud. Later, the tissue and ducts of the two buds fuse. The ventral bud forms the uncinate process and lower head, while the dorsal bud forms the rest of the pancreas. The main pancreatic duct forms from the fusion of the dorsal and ventral pancreatic ducts. Molecular signals from surrounding tissues regulate pancreas development and formation of endocrine cell types.

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    Traducere si adaptare conform Larsen.

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    Pancreasul - embriologie

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    The pancreas forms from two buds, a dorsal and ventral bud, originating from the lining of the duodenum. The dorsal bud is located in the dorsal mesentery while the ventral bud is near the bile duct. As the duodenum rotates, the ventral bud moves behind the dorsal bud. Later, the tissue and ducts of the two buds fuse. The ventral bud forms the uncinate process and lower head, while the dorsal bud forms the rest of the pancreas. The main pancreatic duct forms from the fusion of the dorsal and ventral pancreatic ducts. Molecular signals from surrounding tissues regulate pancreas development and formation of endocrine cell types.

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    Download as docx, pdf, or txt
    27 views2 pages

    Pancreasul - Embriologie

    Uploaded by

    mitimedia
    The pancreas forms from two buds, a dorsal and ventral bud, originating from the lining of the duodenum. The dorsal bud is located in the dorsal mesentery while the ventral bud is near the bile duct. As the duodenum rotates, the ventral bud moves behind the dorsal bud. Later, the tissue and ducts of the two buds fuse. The ventral bud forms the uncinate process and lower head, while the dorsal bud forms the rest of the pancreas. The main pancreatic duct forms from the fusion of the dorsal and ventral pancreatic ducts. Molecular signals from surrounding tissues regulate pancreas development and formation of endocrine cell types.

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    Langman 13E 2015

    The pancreas is formed by two buds, dorsal and ventral, originating from the endodermal lining
    of the duodenum (Fig. 15.19). Whereas the dorsal pancreatic bud is in the dorsal mesentery,
    the ventral pancreatic bud is close to the bile duct (Fig. 15.19). When the duodenum rotates to
    the right and becomes C-shaped, the ventral pancreatic bud moves dorsally in a manner similar
    to the shifting of the entrance of the bile duct (Fig. 15.19). Finally, the ventral bud comes to lie
    immediately below and behind the dorsal bud (Fig. 15.20). Later, the parenchyma and the duct
    systems of the dorsal and ventral pancreatic buds fuse (Fig. 15.20B). The ventral bud forms the
    uncinate process and inferior part of the head of the pancreas. The remaining part of the gland is
    derived from the dorsal bud. The main
    pancreatic duct (of Wirsung) is formed by the distal part of the dorsal pancreatic duct and the
    entire ventral pancreatic duct (Fig. 15.205). The proximal part of the dorsal pancreatic duct either
    is obliterated or persists as a small channel, the accessory pancreatic duct (of Santorini). The
    main pancreatic duct, together with the bile duct, enters the duodenum at the site of the major
    papilla; the entrance of the accessory duct (when present) is at the site of the minor papilla. In
    about 10% of cases, the duct system fails to fuse, and the original double system persists.
    In the third month of fetal life, pancreatic islets (of Langerhans) develop from the
    parenchymatous pancreatic tissue and scatter throughout the pancreas. Insulin secretion begins
    at approximately the fifth month. Glucagon- and somatostatin-secreting cells also develop from
    parenchymal cells. Visceral mesoderm surrounding the pancreatic buds forms the pancreatic
    connective tissue.
    Molecular Regulation of Pancreas Development
    FGF2 and ACTIVIN (a TGF-(3 family member) produced by the notochord and endothelium of
    the dorsal aorta repress SHH expression in gut endoderm destined to form the dorsal pancreatic
    bud. The ventral bud is induced by visceral mesoderm. As a result, expression of the
    PANCREATIC AND DUODENAL HOMEO- BOX1 (PDX) gene is upregulated. Although all of
    the downstream effectors of pancreas development have not been determined, it appears that
    expression of the paired homeobox genes PAX4 and PAX6 specifies the endocrine cell lineage,
    such that cells expressing both genes become
    3 (insulin), 8 (somatostatin), and 7 (pancreatic polypeptide) cells; whereas those expressing
    only PAX6 become a (glucagon) cells.
    Translate:
    Pancreasul este format din doi muguri, dorsal si ventral, ce origineaza din “marginea”
    endodermica a duodenului (Fig. 15.19). In timp ce mugurele pancreatic dorsal se afla in
    mezenterul dorsal, mugurele pancreatic ventral se situeaza in ductul biliar (Fig. 15.19). Din punct
    de vedere evolutiv, duodenul se roteste spre dreapta si capata forma literei “C”, in acelasi timp in
    care mugurele pancreatic ventral se deplaseaza posterior intr-o maniera similara deplasarii caii de
    intrare a ductului biliar (Fig. 15.19). Prin urmare, mugurele ventral se va situa in raport imediat
    postero-inferior fata de mugurele dorsal. Mai tarziu, parenchimul, impreuna cu ductele biliare ale
    mugurilor pancreatice dorsal si ventral, vor fuziona (Fig. 15.20B). Mugurele ventral formeaza
    procesul uncinat si segmentul inferior al capului de pancreas. Restul glandei deriva din mugurele
    dorsal. Ductul pancreatic principal (al lui Wirsung) este format de segmentul distal al ductului
    pancreatic dorsal si intregul duct pancreatic ventral (Fig. 15.20B). Segmentul proximal al
    ductului pancreatic dorsal poate fi obliterat, alteori persista sub forma de canalicul, denumit duct
    pancreatic accesor (al lui Santorini). Ductul pancreatic principal, impreuna cu ductul biliar,

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