The document provides a checklist for determining eligibility for thrombolytics in stroke treatment. It lists absolute exclusion criteria, cautions/warnings, and expanded treatment criteria. Reasons for non-treatment are also given.
The document provides a checklist for determining eligibility for thrombolytics in stroke treatment. It lists absolute exclusion criteria, cautions/warnings, and expanded treatment criteria. Reasons for non-treatment are also given.
The document provides a checklist for determining eligibility for thrombolytics in stroke treatment. It lists absolute exclusion criteria, cautions/warnings, and expanded treatment criteria. Reasons for non-treatment are also given.
The document provides a checklist for determining eligibility for thrombolytics in stroke treatment. It lists absolute exclusion criteria, cautions/warnings, and expanded treatment criteria. Reasons for non-treatment are also given.
Yes No ABSOLUTE EXCLUSION CRITERIA Hemorrhagic stroke, mass effect or edema on baseline CT, or history of intracranial hemorrhage Suspicion of subarachnoid hemorrhage Intracranial neoplasm, arteriovenous malformation or aneurysm Previous cerebral infarction or head trauma within past three months Sustained or uncontrolled hypertension (Systolic greater than 185 or Diastolic greater than 110 after attempt to treat HTN) Onset of symptoms is more than three hours prior to the beginning of treatment (unless utilizing 3-4.5 hr. extended window) Major surgery within 14 days prior Platelet count below 100,000 INR greater than 1.7 Blood glucose below 50 mg/dL Patient received warfarin (Coumadin®), heparin, or lovenox within 48 hours preceding onset of symptoms and PTT not in normal range Direct thrombin inhibitors or direct factor Xa inhibitors within the last 48 hrs Severe neurological deficits at discretion of neurologist Arterial puncture at non-compressible site within previous 7 days Severe complicated condition, such as AIDS or cancer, that would confound treatment Age < 18 years of age Yes No Cautions/Warnings Known bleeding disorder or associated condition with high risk of bleeding, GI or GU bleeding within the past 21 days. Recent acute myocardial infarction within one month Major surgery within 14 days prior Seizure at onset of stroke symptoms or pretreatment Rapidly Improving neurologic deficit Sensory loss, ataxia, dysarthria alone or minimal weakness Preexisting neurologic, psychiatric or other illness that would confound treatment If female, patient has positive blood or urine pregnancy test on record Lumbar Puncture within 7 days Yes No Expanded Treatment (3-4.5 hrs) Criteria Serious trauma in the previous 14 days All of the above EXCEPT ABSOLUTE CONTRAINDICATIONS: Pericarditis or subacute bacterial endocarditis Age > 80 years Significant liver or kidney dysfunction Taking oral anticoagulants regardless of INR Diabetic hemorrhagic retinopathy NIHSS >25 Combination of previous stroke and diabetes mellitus
REASONS FOR NON-TREATMENT WITH THROMBOLYTICS
Time Patient/Family Refused Uncontrolled Hypertension No IV access CT finding Platelet count (less than 100,000) Stroke severity Abnormal aPTT, PT/INR Blood Glucose less than 50 Active internal bleeding (previous 21 days) Recent IC surgery (3 mo.) Head trauma/Stroke
Additional considerations may apply, and these are guidelines to be used at the discretion of the attending physician.