Cirrhosis of Liver
Cirrhosis of Liver
Cirrhosis of Liver
ABSTRACT
OBJECTIVE: To determine the etiological factors, complication(s) and prognosis of patients suf-
fering from liver cirrhosis in our setup.
DESIGN: Cross-sectional study.
SETTING: Medical and surgical departments of Liaquat University Hospital Hyderabad/
Jamshoro, Sindh – Pakistan, from April 2005 to April 2007.
METHODS: Patients having an evidence of cirrhosis of liver on ultrasound examination of abdo-
men were enrolled. All those patients who were not confirmed to be cirrhotic, excluded from
this study. All cases were studied to determine the etiological factors, complications and prog-
nosis of disease. All data were recorded on a proforma. Patients with acute variceal hemorrhage
were referred to surgical department for endoscopic sclerotherapy or variceal band ligation.
RESULTS: Total 100 patients were studied, 67(67%) males and 33(33%) females. Their mean age
was 53.09 with SD= 8.85814 years. Majority of patients, 52(52%) had HCV infection, 16(16%) had
HBV infection, 16(16%) had HBV and HCV co-infection, 08(08%) had alcohol abuse, 01(01%) had
primary biliary cirrhosis, 02(02%) had Wilson’s disease and no etiological factors were recorded
in 05(05%) patients. Ascites was present in 59(59%) cases, portal hypertension in 42(42%), eso-
phageal varices in 29(29%), spontaneous bacterial peritonitis in 29(29%), acute variceal hemor-
rhage in 27(27%), hepatic encephalopathy in different grades in 24((24%), hepatorenal syndrome
in 09(09%) and hepatocellular carcinoma in 07(07%) patients. All patients with acute variceal
episode(s) were adequately and timely treated in surgical department. When cirrhotic patients
were grouped into child-Pugh’s classification, 37(37%) were in class ‘A’ category, 37(37%) in
class ‘B’ category, and 26(26%) in class ‘C’ category.
CONCLUSION: HCV infection is the major risk factor for cirrhosis in our setup. Ascites was the
commonest complication. Patients with child-Pugh’s class ‘A’ cirrhosis had significantly longer
survival than patients with child-Pugh’s class ‘B’ and ‘C’. A multidisciplinary approach for pre-
vention and control of ever increasing HCV infection must be adopted and to make the public
awareness through the mass media about its drastic complications, and possible modes of its
transmission.
KEY WORDS: Liver. Cirrhosis. Viral hepatitis. HCV infection. Ascites.
sessed by using modified Child-Pugh’s classification prognosis of the disease was assessed by using
for grading prognosis in cirrhotic patients. It was de- modified Child-Pugh’s classification for grading prog-
vised in 1964 by Child and Turcotte and modified in nosis in cirrhotic patients. Child-Pugh’s classification
1973 by Pugh, et al.14 We undertook this study to de- has scores for five parameters i.e. serum bilirubin,
termine the etiological factors, complications and serum albumin, prothrombin time, ascites and hepatic
prognosis of patients suffering from liver cirrhosis. encephalopathy. It grades cirrhosis in three grades;
Child-Pugh’s 'A' grade (score less than 7), Child-
PATIENTS AND METHODS
Pugh’s 'B' grade (score 7-9) and Child-Pugh’s 'C'
This study was conducted in the medical and surgical grade (score more than 9).14 Patients were followed
departments of Liaquat University Hospital Hydera- during their stay in the hospital and subsequent follow
bad/ Jamshoro from April 2005 to April 2007. Patients up visit(s) at hospital and whether they survived or
having an evidence of cirrhosis of liver on ultrasound expired. Statistical analysis was performed by using
examination of abdomen were included in study. All SPSS 13.0.
those patients who were not confirmed to be cirrhotic,
RESULTS
excluded from this study. These patients were care-
fully examined to determine the etiology of the dis- During the study period, 100 patients with a diagnosis
ease, complication(s) at the time of presentation and of cirrhosis of liver were studied. Majority 67(67%)
prognosis of the disease. Data were recorded on a were males and 33(33%) were females. Their mean
proforma specially designed for this purpose. For each age was 53.09 with SD=8.85814 years. Various etio-
patient full blood count, liver function tests, serology logical factors of cirrhosis of the liver are given in Ta-
for hepatitis, renal function tests, blood sugar, serum ble I. Table II shows distribution of complications
electrolytes, serum albumin and coagulation profile among patients. Using modified Child-Pugh’s classifi-
were carried out. Blood was also collected for antimi- cation for grading prognosis in cirrhotic patients is
tochondrial antibodies, serum copper and serum shown in Table III. In the analysis of laboratory find-
caeruloplasmin. An abdominal ultrasound for liver ings, high bilirubin was found in 58%, hyponatremia,
and splenic size, parenchymal echogenicity, portal and low hemoglobin were found in 68% and 59% pa-
vein diameter, and ascites was also carried out. In tients respectively. In 42% patients, there was high
case of ascites, an ascitic tap was done to look for blood urea while creatinine was above normal limits in
spontaneous bacterial peritonitis. Any evidence of the 18% patients. Hypoalbuminemia (serum albumin
presence of other co-existent complications of cirrho- <3.3g/dl) was found in 40% patients. Leukocytosis
sis of liver was also recorded. CT scan of the abdo- (total leukocyte count >11000/ml) was a feature in the
men was also carried out in suspected eight cases of laboratory data of 47% patients. The rest of patients
liver cell mass. Patients with acute variceal hemor- had either normal or low TLC. Coagulation profile was
rhage were referred to surgical department for endo- abnormal in a fraction of patients with 54% patients
scopic sclerotherapy or variceal band ligation. The having prothrombin time > 5 seconds. However,
TABLE I:
ETIOLOGICAL FACTORS
thrombocytopenia (platelate count <150,000/ml) was a complications. In advanced stages of cirrhosis the
consistent finding in 72% patients. Antimitochondrial only option is a liver transplant.15 Nadeem, et al has
antibodies were found positive in one patient, whereas reported that cirrhosis of liver is a frequent cause of
serum copper and serum caeruloplasmin were posi- admission in hospitals and HCV was the most com-
tive in two patients. An abdominal ultrasound con- mon cause. At least 50% of infected patients, develop
firmed features of liver cirrhosis in 100% and ascites
TABLE II:
DISTRIBUTION OF COMPLICATIONS
Male Female
Complication Total
No. % No. %
None 28 68.2 13 31.7 41
Ascites Slight 27 65.8 14 34.2 41
Mod- Severe 12 66.6 6 33.4 18
Portal hypertension 31 73.8 11 26.2 42
Esophageal varices 22 75.8 7 24.2 29
SBP 20 68.9 9 31.1 29
None 53 69.7 23 30.3 76
Encephalopathy Slight- moderate 12 63.2 7 36.8 19
Mod- severe 2 40 3 60 5
Hepatorenal syndrome 6 66.7 3 33.3 9
Heptocellular carcinoma 4 57.2 3 42.8 7
Hematamesis 21 77.8 6 22.2 27
ascites and liver related problems among 08% of pa- rhosis with the hepatorenal syndrome as reported in
tients with previous alcohol abuse. In this study, one other studies that hepatorenal syndrome is a progres-
cirrhotic patient had primary biliary cirrhosis, which is sive disorder associated with advanced cirrhosis and
not an uncommon finding as reported in other stud- portal hypertension.37,38 In this study, we evaluated the
ies,20-23 whereas 02% of patients had Wilson’s dis- prognostic staging of patients with cirrhosis on the
ease, as reported in other studies.21-23 Surprisingly, in basis of Child-Pugh’s classification and observed 37%
our study the etiological factor was not recognized in had Child-Pugh’s 'A' grade of prognosis, 26% had
05% of patients and known as cryptogenic cirrhosis as Child-Pugh’s 'B' grade of prognosis and 26% had
reported by Nadeem, et al.5 Early studies conducted Child-Pugh’s 'C' grade of prognosis. Yan, et al has
in which patients recruited at different stages of cirrho- reported that 22% of the patients had cirrhosis of
sis usually identified portal hypertension and its main Child-Pugh grade A, 41% of grade B and 36% of
clinical consequences (that is, ascites and oesophag- grade C.14 Liver function tests showed a steady de-
eal bleeding) as the most frequent causes of transition crease from Child-Pugh’s grade A to grade B and to
from compensated to decompensated cirrhosis and of grade C. During our study period, 26% of total patients
liver related probelms. Furthermore such events were with class ‘C’ of Child-Pugh’s classification, expired as
reported to have profound effects on survival rates.24- reported in other studies that differences between the
26
In this study, ascites was recorded as commonest three Child-Pugh’s grades were significant.14,39
complication of cirrhosis and was present in 59% of
CONCLUSION
patients and to mark decompensation of liver disease
as reported in other studies.24,27 The incidence of SBP We conclude that chronic HCV infection is the major
in patients with cirrhosis and ascites varies from 7- risk factor for cirrhosis in our patients. Ascites is the
23% in the West.28,29 It is around 33% in Pakistan30,31 commonest complication. Patients with Child-Pugh’s
and we observed that spontaneous bacterial peritoni- class ‘A’ cirrhosis had significantly longer survival than
tis developed in up to 29% of patients with cirrhosis patients with Child-Pugh’s class ‘B’ and ‘C’. A multidis-
and ascites. In this study, 27% of patients presented ciplinary approach for prevention and control of ever
with acute variceal hemorrhage, who were referred to increasing HCV infection must be adopted to make
surgical department for endoscopic sclerotherapy or the public awareness through the mass media about
variceal band ligation, were adequately treated. The its drastic complications, and possible modes of its
most frequent complication of cirrhosis and portal hy- transmission.
pertension with a mortality of 17–42% per bleeding
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AUTHOR AFFILIATION:
Dr. Suhail Ahmed Almani (Corresponding Author)
Associate Professor, Department of Medicine
Liaquat University of Medical & Health Sciences
(LUMHS) Jamshoro, Sindh - Pakistan
Email: saalmani 123@ yahoo.com