Safety Data Sheet

According to Thermo Fisher Scientific

https://www.fishersci.com/store/msds?partNumber=AC326921000&productDescription=NHEXANE&vendorId=VN00032119&countryCode=US&language=en
Effective Date: 10.26.2009 Page 1 of 9
Hexane, 1L

SECTION 1: Identification of the substance/mixture and of the supplier

Product Name: Hexane
Manufacturer/Supplier Trade Name: Thermo Fisher Scientific
Manufacturer/Supplier Article number: 110-54-3
Recommended uses of the product and uses restrictions on use: Laboratory Chemicals
Manufacturer Details: Suppliers Details:
Fisher Scientific Acros Organic
One Reagent Lane One Reagent Lane
Fair Lawn, NJ 07410 Fair Lawn, NJ 07410

Emergency telephone number: 001-201-796-7100

SECTION 2: Hazards identification

Classification of the substance or mixture

This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Flammable
Flammable liquids, category 2

Toxic
Specific target organ toxicity, category 3

Irritant
Skin Corrosion, category 2

Skin Corrosion/irritation Category 2

Serious Eye Damage/Eye Irritation Category 2
Reproductive Toxicity Category 2
Specific target organ toxicity (single exposure) Category 3
Target Organs - Respiratory system, Central nervous system (CNS).
Specific target organ toxicity - (repeated exposure) Category 1
Target Organs - Liver, Heart, Blood.
Aspiration Toxicity Category 1

Signal Word
Danger

Hazard Statements
Highly flammable liquid and vapor
May be fatal if swallowed and enters airways
Causes skin irritation
 Safety Data Sheet
According to Thermo Fisher Scientific
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Effective Date: 10.26.2009 Page 2 of 9
Hexane, 1L
Precautionary Statements
Prevention
Obtain special instructions before use
Do not handle until all safety precautions have been read and understood
Use personal protective equipment as required
Wash face, hands and any exposed skin thoroughly after handling
Wear eye/face protection
Do not breathe dust/fume/gas/mist/vapors/spray
Do not eat, drink or smoke when using this product
Use only outdoors or in a well-ventilated area
Keep away from heat/sparks/open flames/hot surfaces. - No smoking
Keep container tightly closed
Ground/bond container and receiving equipment
Use explosion-proof electrical/ventilating/lighting/equipment
Use only non-sparking tools
Take precautionary measures against static discharge
Keep cool
Response
IF exposed or concerned: Get medical attention/advice
Inhalation
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
Skin
If skin irritation occurs: Get medical advice/attention
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower
Wash contaminated clothing before reuse
Eyes
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue
rinsing
If eye irritation persists: Get medical advice/attention
Ingestion
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
Do NOT induce vomiting
Fire
In case of fire: Use CO2, dry chemical, or foam for extinction
Storage
Store locked up
Store in a well-ventilated place. Keep container tightly closed
Disposal
Dispose of contents/container to an approved waste disposal plant
Hazards not otherwise classified (HNOC)
Toxic to aquatic life with long lasting effects

Other non-GSH classification:

 Safety Data Sheet
According to Thermo Fisher Scientific
https://www.fishersci.com/store/msds?partNumber=AC326921000&productDescription=NHEXANE&vendorId=VN00032119&countryCode=US&language=en
Effective Date: 10.26.2009 Page 3 of 9
Hexane, 1L

SECTION 3: Composition/information on ingredients

Component CAS-No Weight %

Hexane 110-54-3 >95

SECTION 4: First aid measures

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at
least 15 minutes. Get medical attention.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Obtain
medical attention.

Inhalation Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-
to-mouth method if victim ingested or inhaled the substance; give
artificial respiration with the aid of a pocket mask equipped with a one-
way valve or other proper respiratory medical device. Obtain medical
attention. Aspiration into lungs can produce severe lung damage.

Ingestion Do not induce vomiting. Call a physician or Poison Control Center

immediately. If vomiting occurs, lean victim forward to reduce the risk of
aspiration.

Most important symptoms and effects

Breathing difficulties. Inhalation of high vapor concentrations may cause symptoms like
headache, dizziness, tiredness, nausea and vomiting

Notes to Physician Treat symptomatically

SECTION 5 : Firefighting measures

Suitable Extinguishing Media CO 2, dry chemical, dry sand, alcohol-resistant foam. Cool closed
containers exposed to fire with water spray.

Unsuitable Extinguishing Media Water may be ineffective. This material is lighter than water and
insoluble in water. The fire could easily be spread by the use of water in
an area where the water cannot be contained

Flash Point -22 °C / -7.6 °F

Method - No information available
Autoignition Temperature 223 °C / 433.4 °F
Explosion Limits
Upper 7.5 vol %
Lower 1.1 vol %
Sensitivity to Mechanical Impact No information available
Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical

Flammable. Risk of ignition. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and
flash back.
Containers may explode when heated.
 Safety Data Sheet
According to Thermo Fisher Scientific
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Effective Date: 10.26.2009 Page 4 of 9
Hexane, 1L
Hazardous Combustion Products
Carbon monoxide (CO) Carbon dioxide (CO2)
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent)
and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.

NFPA
Health Flammability Instability Physical Hazard
2 3 0 N/A

SECTION 6 : Accidental release measures

Personal Precautions
Use personal protective equipment. Ensure adequate ventilation. Evacuate personnel to safe areas.
Remove all sources of ignition. Take precautionary measures against static discharges.

Environmental Precautions
Do not flush into surface water or sanitary sewer system.
Avoid release to the environment. Collect spillage.

Methods for Containment and Clean Up

Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.
Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Take
precautionary measures against static discharges.

SECTION 7 : Handling and storage

Handling
Wear personal protective equipment. Do not get in eyes, on skin, or on clothing. Do not breathe vapors or
spray mist. Keep away from open flames, hot surfaces and sources of ignition. Use only non-sparking tools. Use
explosion-proof equipment. Take precautionary measures against static discharges. To avoid ignition of vapors by
static electricity discharge, all metal parts of the equipment must be grounded.

Storage
Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat and sources of ignition.
Flammable area.

SECTION 8 : Exposure controls/personal protection

Components ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA)
Hexane TWA: 50ppm (Vacated) TWA: 50ppm IDLH: 1100 ppm TWA: 50 ppm
Skin (Vacated) TWA: 180mg/m3 TWA: 50ppm TWA: 176 mg/m3
TWA:500ppm TWA: 180 mg/m3
TWA:1800mg/m3

Legend
ACGIH - American Conference of Governmental Industrial Hygienists
OSHA - Occupational Safety and Health Administration
 Safety Data Sheet
According to Thermo Fisher Scientific
https://www.fishersci.com/store/msds?partNumber=AC326921000&productDescription=NHEXANE&vendorId=VN00032119&countryCode=US&language=en
Effective Date: 10.26.2009 Page 5 of 9
Hexane, 1L
NIOSH IDLH: The National Institute for Occupational Safety and Health Immediately Dangerous to Life or Health
Engineering Measures
Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are
close to the workstation location. Use explosion-proof electrical/ventilating/lighting/equipment.

Personal Protective Equipment

Eye/face Protection
Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection
regulations in 29 CFR 1910.133 or European Standard EN166.

Skin and body protection

Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or
other symptoms are experienced.

Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice.

SECTION 9 : Physical and chemical properties

Flash Point -22 °C / -7.6 °F
Evaporation Rate No information available
Flammability (solid,gas) Not applicable

Flammability or explosive limits

Upper 7.5 vol %
Lower 1.1 vol %
Vapor Pressure 160 mbar @ 20 °C
Vapor Density 2.97
Specific Gravity 0.659
Solubility immiscible
Partition coefficient; n-octanol/water No data available
Autoignition Temperature 223 °C / 433.4 °F
Decomposition Temperature No information available
Viscosity 0.31 mPa s at 20 °C
Molecular Formula C6 H14
Molecular Weight 86.18

SECTION 10 : Stability and reactivity

Reactive Hazard None known, based on information available
Stability Stable under normal conditions.
Conditions to Avoid Incompatible products. Heat, flames and sparks. Exposure to light.
Keep away from open flames, hot surfaces and sources of ignition.
Incompatible Materials Strong oxidizing agents, Halogens
Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2)
Hazardous Polymerization Hazardous polymerization does not occur.
Hazardous Reactions None under normal processing.

SECTION 11 : Toxicological information

Acute Toxicity
Product Information
Component Information:
Component LD50 Oral LD50 Dermal LC50 Inhalation
Hexane LD50 = 25 g/kg ( Rat ) LD50 = 3000 mg/kg ( Rabbit ) LC50 = 48000 ppm ( Rat ) 4 h
 Safety Data Sheet
According to Thermo Fisher Scientific
https://www.fishersci.com/store/msds?partNumber=AC326921000&productDescription=NHEXANE&vendorId=VN00032119&countryCode=US&language=en
Effective Date: 10.26.2009 Page 6 of 9
Hexane, 1L

Toxicologically Synergistic No information available

Products
Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Irritating to eyes and skin

Sensitization No information available
Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS-No IARC NTP ACGIH OSHA Mexico

Hexane 110-54-3 Not listed Not listed Not listed Not listed Not listed

Mutagenic Effects Mutagenic effects have occurred in experimental animals.

Reproductive Effects Experiments have shown reproductive toxicity effects on laboratory animals.
Developmental Effects Developmental effects have occurred in experimental animals.
Teratogenicity Teratogenic effects have occurred in experimental animals.
STOT - single exposure Respiratory system Central nervous system (CNS)
STOT - repeated exposure Liver Heart Blood
Aspiration hazard No information available

Symptoms / effects, both acute and delayed

Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea and
vomiting
Endocrine Disruptor Information No information available

Other Adverse Effects

Tumorigenic effects have been reported in experimental animals. See actual entry in RTECS for complete
information.

SECTION 12 : Ecological information

Eco toxicity
Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. The product
contains following substances which are hazardous for the environment.

Component Freshwater Algae Freshwater Fish Microtox Water Flea

Hexane Not listed LC50: 2.1-2.98 mg/L, 96h Not Listed EC50: 3.87 mg/L/48h
flow-through (Pimephales
Promelas)
Persistence and Degradability Persistence is unlikely based on information available.
Bioaccumulation/ Accumulation No information available.
Mobility Will likely be mobile in the environment due to its volatility.

Component Log Pow

Hexane 4.11

SECTION 13 : Disposal considerations

Waste Disposal Methods

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous
waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to
ensure complete and accurate classification.
 Safety Data Sheet
According to Thermo Fisher Scientific
https://www.fishersci.com/store/msds?partNumber=AC326921000&productDescription=NHEXANE&vendorId=VN00032119&countryCode=US&language=en
Effective Date: 10.26.2009 Page 7 of 9
Hexane, 1L

SECTION 14 : Transport information

DOT
UN-No UN1208
Proper Shipping Name Hexanes
Hazard Class 3
Packing Group II

TDG
UN-No UN1208
Proper Shipping Name HEXANES
Hazard Class 3
Packing Group II

IATA
UN-No UN1208
Proper Shipping Name Hexanes
Hazard Class 3
Packing Group II
IMDG/IMO
UN-No UN1208
Proper Shipping Name Hexanes
Hazard Class 3

SECTION 15 : Regulatory information

All of the components in the product are on the following Inventory lists: Australia Complete Regulatory
Information contained in following SDS's X = listed China Canada The product is classified and labeled according to
EC directives or corresponding national laws The product is classified and labeled in accordance with Directive
1999/45/EC Europe TSCA Korea Philippines Japan U.S.A. (TSCA) Canada (DSL/NDSL) Europe
(EINECS/ELINCS/NLP) Australia (AICS) Korea (ECL) China (IECSC) Japan (ENCS) Philippines (PICCS).

International Inventories
Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECL
Hexane X X - 203- 438-390 X X X X X
777-6 -3

Legend:
X - Listed
E - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.
F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.
N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is
considered to cover the designated polymer made with any free-radical initiator regardless of the amount
used.
P - Indicates a commenced PMN substance
R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.
S - Indicates a substance that is identified in a proposed or final Significant New Use Rule
T - Indicates a substance that is the subject of a Section 4 test rule under TSCA.
XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of
the TSCA Inventory Data Base Production and Site Reports (40 CFR 710(B).
Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.
Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified
list of low concern reactants that comprises one of the eligibility criteria for the exemption rule.

U.S. Federal Regulations

 Safety Data Sheet
According to Thermo Fisher Scientific
https://www.fishersci.com/store/msds?partNumber=AC326921000&productDescription=NHEXANE&vendorId=VN00032119&countryCode=US&language=en
Effective Date: 10.26.2009 Page 8 of 9
Hexane, 1L
TSCA 12(b) Not applicable

SARA 313
Components CAS-No Weigth % SARA 313- Threshold Values %
Hexane 110-54-3 >95 1.0
CWA (Clean Water Act) Not applicable

Clean Air Act

Component HAPS Data Class 1 Ozone Depletors Class 2 Ozone Depletors

Hexane X -

OSHA Occupational Safety and Health Administration

Not applicable

CERCLA This material, as supplied, contains one or more substances regulated as a

hazardous substance under the Comprehensive Environmental Response
Compensation and Liability Act (CERCLA) (40 CFR 302).

Components Hazardous Substances RQs CERCLA EHS RQs

Hexane 5000lb -
California Proposition 65 This product does not contain any Proposition 65 chemicals

U.S. State Right-to-Know

Regulations
Components Massachusetts New Jersey Pennsylvania Illinois Rhode Island
Hexane X X X X X

U.S. Department of Transportation

Reportable Quantity (RQ): Y

DOT Marine Pollutant N
DOT Severe Marine Pollutant N

U.S. Department of Homeland Security

This product does not contain any DHS chemicals.

Other International Regulations

Mexico – Grade Serious risk, Grade 3

SECTION 16 : Other information

Prepared by: Regulatory Affairs

Thermo Fisher Scientific
Email: [email protected]

Creation Date: 26-Oct-2009

Revision Date: 19-Jan-2018
Print Date: 19-Jan-2018
 Safety Data Sheet
According to Thermo Fisher Scientific
https://www.fishersci.com/store/msds?partNumber=AC326921000&productDescription=NHEXANE&vendorId=VN00032119&countryCode=US&language=en
Effective Date: 10.26.2009 Page 9 of 9
Hexane, 1L
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and
belief at the date of its publication. The information given is designed only as a guidance for safe handling,
use, processing, storage, transportation, disposal and release and is not to be considered a warranty or
quality specification. The information relates only to the specific material designated and may not be valid
for such material used in combination with any other materials or in any process, unless specified in the text