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Comparative efficacy of non-sedating antihistamine updosing in patients

with chronic urticaria

Article  in  World Allergy Organization Journal · November 2014

DOI: 10.1186/1939-4551-7-33 · Source: PubMed

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Sánchez-Borges et al. World Allergy Organization Journal 2014, 7:33
http://www.waojournal.org/content/7/1/33
journal
ORIGINAL RESEARCH Open Access

Comparative efficacy of non-sedating

antihistamine updosing in patients with
chronic urticaria
Mario Sánchez-Borges1*, Ignacio Ansotegui2, Jorge Montero Jimenez3, Maria Isabel Rojo4, Carlos Serrano5
and Anahí Yañez6

Keywords: Angioedema, Antihistamines, Chronic urticaria

Introduction 36.6% at 12 months, 51.2% at 24 months, and 66.1% at

Urticaria and angioedema lasting more than 6 weeks have 60 months, while the remission rates were 11.5%, 13.9%,
been designated as chronic urticaria (CU). It encompasses and 27.7%, respectively [5].
two major subtypes: chronic spontaneous urticaria (CSU) In patients that do not respond to standard doses, the
(previously known as chronic idiopathic urticaria) (CIU) next step in guideline-based therapy is to increase AH
and chronic inducible urticaria. CSU has been defined doses up to 4 times [3]. Investigations assessing the
as wheals and/or angioedema that are endogenous and response to various NSAHs have demonstrated that
independent of any external physical stimulus. It affects up-dosing is significantly more effective in reducing
0.5 to 1% of the population [1]. In 40 to 45% of patients symptoms of CU than standard-dose treatment [6].
with CSU autoantibodies to the high affinity IgE receptor According to Kaplan, high-dose antihistamines are effect-
(FcεRI) or to IgE itself are thought to play a psathogenic ive in 45-60% of patients with CSU [7], while about one
role, whereas 55 to 60% of cases are considered idiopathic third are antihistamine resistant regardless of which dose
[2]. Inducible urticarias include all forms of physical is used [8,9].
urticarias (cold-induced, heat-induced, solar, and pressure The present article is a review of the literature on the
urticaria). treatment of CU with increased doses of NSAHs in order
According to the International Guidelines for the man- to investigate if there are differences in efficacy between
agement of urticaria and angioedema non-sedating, second the various second generation AHs that have been studied
generation antihistamines (NSAHs) are recommended in controlled protocols. It must be noticed, however,
for the treatment of CU [3]. Nevertheless, a considerable that it is difficult to find clinical investigations that
proportion of patients do not respond sufficiently to strictly follow the criteria recommended by the guidelines
NSAHs. According to Humphreys and Hunter up to on the management of urticaria, and therefore studies
40% of patients with CU may not achieve good control included in this review were those in which higher doses
with antihistaminic therapy [4]. They reported that out of NSAHs were used regardless of the clinical response to
of 390 CU patients who were treated with antihistamines conventional doses.
44% responded well, 29% became asymptomatic, and AHs included in this review are desloratadine, levoce-
15% showed partial improvement. In a recent paper tirizine, fexofenadine, and the recently introduced NSAHs
from Japan it was observed that the improvement rates rupatadine and bilastine. Bilastine belongs to the piperidine
(defined as a urticaria symptom score UAS ≤ 3) in 117 class of antihistamines as do loratadine, desloratadine, and
CU patients who received standard doses of AHs were fexofenadine. Like other antihistamines bilastine is an H1
receptor inverse agonist. In vitro studies have shown that
* Correspondence: [email protected]
1
bilastine has a high specific affinity for the H1-receptor but
Allergy and Clinical Immunology Department, Centro Médico-Docente la,
Trinidad and Clínica El Avila, 6a transversal Urb. Altamira, piso 8, consultorio
it has no or very low affinity for 30 other tested receptors.
803, Caracas 1060, Venezuela The affinity for the H1 receptor is 3 and 6 times higher
Full list of author information is available at the end of the article

© 2014 Sánchez-Borges et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the
Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public
Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this
article, unless otherwise stated.
Sánchez-Borges et al. World Allergy Organization Journal 2014, 7:33 Page 2 of 5
http://www.waojournal.org/content/7/1/33

Table 1 Studies included in this comparative analysis

Author Year Drug Study Treatment Urticaria n Parameter Reference
design duration (days) subtype of efficacy numbers
Finn 1999 Fexofenadine DB,PC 28 CSU/CIU 439 MPS 17
Nelson 2000 Fexofenadine R,DB,PC 28 CSU/CIU 418 MPS 18
Giménez-Arnau 2007 Rupatadine R,DB,PC 28 CSU/CIU 329 MPS 19
Dubertret 2007 Rupatadine R,DB,PC 28 CSU/CIU 277 MPS 20
Siebenhaar 2009 Desloratadine R,DB,PC 7 ACU 30 % SF 21
Staevska 2010 Desloratadine DB,PC 28 CSU/CIU 40 % SF 22
Staevska 2010 Levocetirizine DB,PC 28 CSU/CIU 40 % SF 22
Krause 2013 Bilastine R,DB,PC 7 ACU 20 % SF 23
DB double-blind, PC placebo-controlled, R randomized.
CSU chronic spontaneous urticaria, CIU chronic idiopathic urticaria, ACU acquired cold urticaria.
MPS mean pruritus score, % SF percentage of symptom-free patients.

than for cetirizine and fexofenadine, respectively [10,11]. most studies NSAHs were administered for 28 days,
Rupatadine fumarate is a new potent, long acting, orally although in the papers by Siebenhaar (with desloratadine)
active dual antagonist of both histamine H1 and Platelet- and Krause (with bilastine) the drugs were given for 7 days.
Activating Factor (PAF) receptors. In in vivo and in vitro Six articles included patients with CSU/CIU and other 2
studies rupatadine was as potent or even more potent studied patients with acquired cold urticaria. Four investi-
than other second generation antihistamines (loratadine, gations chose mean pruritus scores as the main outcome,
terfenadine and cetirizine) or selective PAF antagonists [12]. and the other 4 utilized the percentage of symptom-free
patients as the main parameter of efficacy.
Methods Table 2 presents the results of the 8 studies in regard
A literature search of PubMed/MEDLINE looking spe- to efficacy of the treatment. It can be observed that the
cifically at the studies that investigated the effects of in- proportion of symptom improvement was highly variable,
creased doses of NSAHs in patients with all subtypes of ranging from 3.4% to 71.6%, depending on the drug and
CU was conducted. For analysis of the efficacy, only dose. The best responses were obtained with fexofenadine,
double-blind, placebo-controlled studies were selected, rupatadine, and bilastine.
whereas uncontrolled studies were excluded. The statistical comparison of the data is shown in
Data on study drug, doses, study design, treatment Figure 1. There were not significant differences in effi-
duration, subtype of urticaria being treated, number of cacy between fexofenadine and bilastine, rupatadine and
patients, and main parameter of efficacy, were collected.
When available, efficacy data were pooled from different Table 2 Efficacy of increased doses of non-sedating
studies that utilized the same drug dose. The proportions antihistamines in patients with chronic urticaria
of patients responding to the therapy were compared using Efficacy
the Fisher’s exact test with a significance level of p < 0.05.
Authorref Drug Dose (mg) Responders/n %
Finn [17] Fexofenadine 120 BD 46/89 51.6
Results
Twelve studies that investigated the effects of higher Finn [17] Fexofenadine 240 BD 54/83 64.9
doses of NSAHs were identified in this search. Among Nelson [18] Fexofenadine 120 BD 33/77 42.8
those, 3 papers dealing with the treatment of patients Nelson [18] Fexofenadine 240 BD 46/82 56.0
with CSU were excluded from analysis because of their Giménez-Arnau [19] Rupatadine 20 QD 69/109 63.3
open design, 2 employing cetirizine and one that utilized Dubertret [20] Rupatadine 20 QD 48/67 71.6
ebastine [13-15]. Another study by Metz et alwas also
Siebenhaar [21] Desloratadine 20 QD 15/30 50.0
excluded because it assessed exclusively the effects of a
20 mg dose of rupatadine in patients with acquired cold Staevska [22] Desloratadine 10 QD 7/36 19.4
urticaria whereas no comparisons with other doses of Staevska [22] Desloratadine 20 QD 1/29 3.4
the drug were done [16]. Staevska [22] Levocetirizine 10 QD 8/31 25.8
Table 1 summarizes the details from 8 double-blind, Staevska [22] Levocetirizine 20 QD 5/23 21.7
placebo-controlled studies included in this report. Two in- Krause [23] Bilastine 40 QD 11/20 55.0
vestigations used fexofenadine, rupatadine, or desloratadine,
Krause [23] Bilastine 80 QD 12/20 60.0
and one study was done with levocetirizine or bilastine. In
Sánchez-Borges et al. World Allergy Organization Journal 2014, 7:33 Page 3 of 5
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A) 70
¶
60

50

Response rate (%) 40

30

20

10

0
Fexofenadine 120 mg BD Fexofenadine 240 mg BD Rupatadine 20 mg QD

B) 70
¶
60

50
Response rate (%)

40

30

20

10

0
Desloratadine Desloratadine Levocetirizine Levocetirizine Bilastine 40 mg Bilastine 80 mg
10 mg QD 20 mg QD 10 mg QD 20 mg QD QD QD

Figure 1 Efficacy of increased doses of nonsedating antihistamines in patients with chronic urticaria. A) According to mean pruritus
score (MPS). *Fexofenadine 120 mg vs Fexofenadine 240 mg p = 0.01, ¶ Fexofenadine 120 mg vs Rupatadine 20 mg p = 0.0001, ♦ Fexofenadine
240 mg vs Rupatadine 20 mg p = 0.03. B) According to percentage of symptom-free patients. * Desloratadine 10 mg vs Desloratadine 120 mg,
Desloratadine 10 mg vs Levocetirizine 10 mg, Desloratadine 10 mg vs Levocetirizine 20 mg, Desloratadine 20 mg vs Levocetirizine 10 mg, Desloratadine
20 mg vs Levocetirizine 20 mg, Levocetirizine 10 mg vs Levocetirizine 20 mg, Bilastine 40 mg vs Bilastine 80 mg p n.s. ¶ Desloratadine 10 mg vs Bilastine
40 mg p = 0.006. ♦ Desloratadine 10 mg vs Bilastine 80 mg p = 0.002. ♠ Desloratadine 20 mg vs Bilastine 40 mg, Desloratadine 20 mg vs Bilastine 80 mg,
Levocetirizine 10 mg vs Bilastine 40 mg p = 0.02. ♣ Levocetirizine 10 mg vs Bilastine 80 mg p = 0.01.

bilastine, and desloratadine and levocetirizine. However, have generally been accomplished without compromising
fexofenadine, rupatadine, and bilastine showed signifi- patient’s safety, since no increased rates of side effects,
cantly higher efficacy than desloratadine or levocetirizine, including somnolence, have been observed.
and rupatadine had higher efficacy than fexofenadine. The mechanisms explaining patient’s benefits from
up-dosing are not completely understood, but increased
Discussion in vivo receptor occupancy [24,25], and effects of anti-
According to current recommendations, patients with histamines on additional receptors have been proposed
CU who do not respond to licensed doses of NSAHs [26]. Observed differences in response to different NSAHs
should be switched to higher doses in order to obtain a cannot be explained by terminal elimination half-life,
better disease control. A number of publications that duration of action, higher tissue/plasma concentration
evaluated different NSAHs in increasing doses have ratios or the presence of active metabolites in the skin
clearly demonstrated that a higher proportion of patients [27]. An alternative hypothesis would be a differential
previously uncontrolled exhibit significant improvements H1-receptor occupancy by free (unbound) H1 antihista-
of their symptoms after going through this approach [6]. mine [25,28]. The results discussed in present paper are
It is important to mention that these enhanced results in agreement with a previous report by Church and
Sánchez-Borges et al. World Allergy Organization Journal 2014, 7:33 Page 4 of 5
http://www.waojournal.org/content/7/1/33

Maurer [29] who proposed that although the Ki may be heterogeneity between studies included in regard to various
an indicator of anti-H1 antihistamine potency in vitro, aspects of the investigation such as the subtype of chronic
the large differences in volume of distribution and tissue urticaria under study, duration of the treatment, study
accumulation in humans preclude this from being a good design, drug doses, and primary outcomes.
predictor of clinical efficacy in CSU. We can conclude that increased doses of NSAHs show
In a previous review article we had proposed that an improved efficacy in patients with CU who do not
favorable responses to high doses of NSAHs in patients respond to approved doses. According to the studies
with CU were not uniformly observed, and it was likely presented in this paper, this conclusion would be ap-
that there would be dissimilar results when outcomes plicable to CSU/CIU and acquired cold urticaria, but
from different studies were compared [6]. Present art- more research would be necessary to be able to elucidate
icle shows that in fact some higher doses of NSAHs, if this approach is valid for other types of urticaria. There
notably fexofenadine, rupatadine, and bilastine, induced are differences in efficacy of these drugs that should be
better objective improvements than desloratadine and taken into account in the clinical setting. The use of
levocetirizine (Table 2, Figure 1). The reasons for these double approved doses of fexofenadine, rupatadine, or
differences are not clear at this time, but may depend bilastine shows an objective improvement in most (>50%)
on differential properties of the drugs, such as their of patients that respond to antihistamines. Desloratadine
chemical structure, in vivo anti-inflammatory actions, requires four times the approved dose to reach similar
metabolism, blockade of various receptors, and interac- results.
tions with transporter systems (e.g., P-glycoprotein) [30]. There is still the need for additional studies designed
In the case of fexofenadine, however, two studies demon- to investigate the response to high doses of NSAHs in
strated that higher doses were not more efficacious than patients who do not respond to recommended doses,
the standard 60 mg twice a day dose [17,18]. adapted to current guideline recommendations.
Since more than 30% of CU patients are refractory to
antihistamine therapy, additional pharmacological strat- Competing interests
egies are available. Alternative drugs inducing better MSB, IA, JMJ, MIR, CS and AY have been advisors for FAES Farma, Sanofi,
Menarini and Pfizer.
responses in AH-resistant CU, as based on scientific
evidences, include the addition of leukotriene receptor
antagonists, corticosteroids, cyclosporine, or omalizumab Authors’ contributions
All authors contributed equally in drafting the manuscript. All authors read
[7,31,32]. The choice of alternative, off-label agents, and approved the final manuscript.
should be based on availability, relative safety, and socio-
economic considerations. Author details
1
Allergy and Clinical Immunology Department, Centro Médico-Docente la,
When administering high doses of antihistamines Trinidad and Clínica El Avila, 6a transversal Urb. Altamira, piso 8, consultorio
questions on their safety are usually put forward. Studies 803, Caracas 1060, Venezuela. 2Department of Allergy and Immunology,
conducted up to now have not demonstrated important Hospital Quirón Bizkaia, Erandio, Spain. 3Unidad de Alergia, Hospital Mexico,
CCSS, San Jose, Costa Rica. 4Allergy, Juarez Hospital, Mexico City, Mexico.
concerns on predictable or newer adverse effects of up 5
Allergy Unit, Hospital Fundación Valle del Lili, Cali, Colombia.
to 4 times recommended doses of NSAHs. Headache 6
Investigaciones en Alergia y Enfermedades Respiratorias, InAER, Buenos
was the most frequent adverse effect reported for fexofe- Aires, Argentina.
nadine [17] and rupatadine [19], but its incidence was Received: 20 June 2014 Accepted: 30 September 2014
not higher than in placebo-treated patients. Somnolence, Published: 26 November 2014
drowsiness, or sedation was uncommon, although for
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