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    Phospholipids: Phosphatidylserine & Phosphatidylcholine

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    miadelfior
    Phosphatidylserine and phosphatidylcholine are phospholipids that are commonly found in dietary supplements for older adults experiencing memory issues. As aging is associated with changes in brain lipid composition, supplementation with these phospholipids, which are integral parts of neuronal membranes, has been proposed to help prevent cognitive decline. Some studies found that phosphatidylserine supplementation was associated with better cognitive performance compared to placebo, while others found no effect on memory or cognitive function. However, current evidence is limited due to small trial sizes, short durations, and varying dosing and outcomes across studies. Larger and more rigorous trials are still needed before recommending phospholipid supplements.

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    Phospholipids: Phosphatidylserine & Phosphatidylcholine

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    miadelfior
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    Phosphatidylserine and phosphatidylcholine are phospholipids that are commonly found in dietary supplements for older adults experiencing memory issues. As aging is associated with changes in brain lipid composition, supplementation with these phospholipids, which are integral parts of neuronal membranes, has been proposed to help prevent cognitive decline. Some studies found that phosphatidylserine supplementation was associated with better cognitive performance compared to placebo, while others found no effect on memory or cognitive function. However, current evidence is limited due to small trial sizes, short durations, and varying dosing and outcomes across studies. Larger and more rigorous trials are still needed before recommending phospholipid supplements.

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    Phospholipids

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    Phosphatidylserine and phosphatidylcholine are phospholipids that are commonly found in dietary supplements for older adults experiencing memory issues. As aging is associated with changes in brain lipid composition, supplementation with these phospholipids, which are integral parts of neuronal membranes, has been proposed to help prevent cognitive decline. Some studies found that phosphatidylserine supplementation was associated with better cognitive performance compared to placebo, while others found no effect on memory or cognitive function. However, current evidence is limited due to small trial sizes, short durations, and varying dosing and outcomes across studies. Larger and more rigorous trials are still needed before recommending phospholipid supplements.

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    Download as docx, pdf, or txt
    47 views2 pages

    Phospholipids: Phosphatidylserine & Phosphatidylcholine

    Uploaded by

    miadelfior
    Phosphatidylserine and phosphatidylcholine are phospholipids that are commonly found in dietary supplements for older adults experiencing memory issues. As aging is associated with changes in brain lipid composition, supplementation with these phospholipids, which are integral parts of neuronal membranes, has been proposed to help prevent cognitive decline. Some studies found that phosphatidylserine supplementation was associated with better cognitive performance compared to placebo, while others found no effect on memory or cognitive function. However, current evidence is limited due to small trial sizes, short durations, and varying dosing and outcomes across studies. Larger and more rigorous trials are still needed before recommending phospholipid supplements.

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    © All Rights Reserved
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    Phospholipids: Phosphatidylserine & Phosphatidylcholine

    The phospholipids phosphatidylserine (PS) and phosphatidylcholine


    are the second most frequently endorsed substances for older
    adults with memory complaints by proprietors of dietary
    supplements.[70] Because aging is associated with changes in lipid
    composition in the brain, supplementation with phospholipids, which
    are fundamental components of neuronal membranes, has been
    suggested to be effective therapy for preventing cognitive
    decline.[71] PS is a phospholipid in the inner leaflet of mammalian
    plasma membranes and it plays a key role in the function of
    neuronal membranes, such as in signal transduction, cell-to-cell
    communication and cell growth regulation.[71] Because cytidine 5'-
    diphosphocholine is a precursor essential for the synthesis of
    phosphatidylcholine, which is one of the cell membranes degraded
    during cerebral ischemia to highly toxic free FAs and free radicals,
    administration of cytidine 5'-diphosphocholine may protect cell
    membranes by accelerating phospholipid resynthesis.[72] A review
    by the Cochrane Collaboration on cytidine 5'-diphosphocholine, at
    600–1000 mg daily for the treatment of cognitive, emotional and
    behavioral impairment in older patients with cognitive impairment or
    dementia, suggests a positive effect on memory and behavior in the
    short and medium term especially in patients with cognitive deficits
    associated with cerebrovascular disorders.[72] In a recent
    randomized trial with 157 participants, PS supplementation, which
    contained PS and an ω-3 long-chain PUFA attached to its
    backbone (300 mg PS and 79 mg of DHA plus eicosapentaenoic
    acid [PS-DHA]), was associated with better cognitive performance
    in 15 weeks' follow-up compared with placebo in nondemented
    older adults with memory complaints.[71] In another randomized trial
    with 120 participants with age-associated memory impairment,
    soybean-derived PS at a dose of 300 and 600 mg daily for up to 12
    weeks did not affect memory or other cognitive functions.[73] No
    serious adverse events were reported with short-term PS and
    phosphatidylcholine supplementation. Current evidence for the use
    of phospholipids for cognitive enhancement is limited; trials are
    relatively small, short-term, and with heterogeneous dosing,
    modalities of administration and outcome measures.[72] Larger trials
    are needed to confirm these findings before recommending the use
    of phospholipid supplementation.
    https://www.medscape.com/viewarticle/759453_8

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