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    Potential Anticancer Effect of Red Spinach (Amaranthus Gangeticus) Extract

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    Vea Camille
    The study aimed to determine the anti-cancer effects of red spinach (Amaranthus gangeticus) extract. In vitro tests showed that the aqueous extract inhibited the proliferation of liver and breast cancer cell lines, with IC50 values of 93.8 μg/ml and 98.8 μg/ml respectively. In vivo tests on rats exposed to chemical carcinogens found that supplementation with 10% red spinach extract inhibited activity of tumor marker enzymes, indicating potential anticancer activity. The study concluded that red spinach extract showed anticancer potential in both in vitro and in vivo experiments.

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    Potential Anticancer Effect of Red Spinach (Amaranthus Gangeticus) Extract

    Uploaded by

    Vea Camille
    64 views3 pages
    The study aimed to determine the anti-cancer effects of red spinach (Amaranthus gangeticus) extract. In vitro tests showed that the aqueous extract inhibited the proliferation of liver and breast cancer cell lines, with IC50 values of 93.8 μg/ml and 98.8 μg/ml respectively. In vivo tests on rats exposed to chemical carcinogens found that supplementation with 10% red spinach extract inhibited activity of tumor marker enzymes, indicating potential anticancer activity. The study concluded that red spinach extract showed anticancer potential in both in vitro and in vivo experiments.

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    Calabash

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    Calabsh ebr

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    The study aimed to determine the anti-cancer effects of red spinach (Amaranthus gangeticus) extract. In vitro tests showed that the aqueous extract inhibited the proliferation of liver and breast cancer cell lines, with IC50 values of 93.8 μg/ml and 98.8 μg/ml respectively. In vivo tests on rats exposed to chemical carcinogens found that supplementation with 10% red spinach extract inhibited activity of tumor marker enzymes, indicating potential anticancer activity. The study concluded that red spinach extract showed anticancer potential in both in vitro and in vivo experiments.

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    © All Rights Reserved
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    Download as docx, pdf, or txt
    64 views3 pages

    Potential Anticancer Effect of Red Spinach (Amaranthus Gangeticus) Extract

    Uploaded by

    Vea Camille
    The study aimed to determine the anti-cancer effects of red spinach (Amaranthus gangeticus) extract. In vitro tests showed that the aqueous extract inhibited the proliferation of liver and breast cancer cell lines, with IC50 values of 93.8 μg/ml and 98.8 μg/ml respectively. In vivo tests on rats exposed to chemical carcinogens found that supplementation with 10% red spinach extract inhibited activity of tumor marker enzymes, indicating potential anticancer activity. The study concluded that red spinach extract showed anticancer potential in both in vitro and in vivo experiments.

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    Potential anticancer effect of

    red spinach (Amaranthus gangeticus)


    extract.
    The objective of this study was to determine the anti cancer effects of
    red spinach Amaranthus gangeticus Linn) in vitro and in viva. For in vitro study,
    microtitration cytotoxic assay was done using 3-(4,5-dimethylthiazol-2-il)-2,5-diphenil
    tetrazoliurn bromide (MTT) kit assay. Results showed that aqueous extract of A
    gangeticus inhibited the proliferation of liver cancer cell line (HepG2) and breast
    cancer cell line (MCF-7). The IC50 values were 93.8 μg/ml and 98.8 μg/ml for HepG2
    and MCF-7, respectively. The inhibitory effect was also observed in colon cancer cell
    line (Caco-2), but a lower percentage compared to HepG2 and MCF-7. For normal cell
    line (Chang Liver), there was no inhibitory effect. In the in vivo study,
    hepatocarcinogenesis was monitored in rats according to Solt and Farber (1976)
    without partial hepatectomy. Assay of tumour marker enzymes such as glutathione S-
    transferase (GST), gamma-glutamyl transpeptidase (GGT), uridyl diphosphoglucuronyl
    transferase (UDPGT) and alkaline phosphatase (ALP) were carried out to determine
    the severity of hepatocarcinogenesis. The result found that supplementation of 5%,
    7.5% and 10% of A. gangeticus aqueous extract to normal rats did not show any
    significant difference towards normal control (P <0.05). The exposure of the rats to
    chemical carcinogens diethylnitrosamine (DEN) and 2- acetylaminofluorene (AAF)
    showed a significant increase in specific enzyme activity of GGT, GST, UDPGT and
    ALP compared to normal control (P <0.05). However, it was found that the
    supplementation of A. gangeticus aqueous extract in 5%, 7.5% and 10% to cancer-
    induced rats could inhibit the activity of alt tumour marker enzymes especially at
    10% (P <0.05). Supplementation of anti cancer drug glycyrrhizin at suggested dose
    (0.005%) did not show any suppressive effect towards cancer control (P <0.05). In
    conclusion, A. gangeticus showed anticancer potential in in vitro and in vivo studies.
    [ABSTRACT FROM AUTHOR]

    Asia Pacific Journal of Clinical Nutrition. Dec2004, Vol. 13 Issue 4, p396-400. 5p.
    Calabash tree, scientifically known as Crescentia cujete has been used by local
    communities as remedy for several illnesses. Because of its many uses in
    folkloric healing, Calabash tree is considered as miracle tree of General Santos
    City.

    Inspired with the indigenous knowledge on Calabash tree, biology students of


    Notre Dame of Dadiangas University in General Santos City undertook a study
    to determine the active ingredients of Calabash tree potential for medical uses.

    Analysis showed that Calabash fruit and leaf extracts contain flavonoids such as
    quercetin and anthraquinone, the important phytochemicals for antiangiogenic
    activities, a process that inhibits the growth and development of new blood
    vessels in the body.

    Antiangiogenesis controls the spread of tumour cells in the body by disabling


    the transport of nutrients toward the cancerous cells. Normally, tumour starts
    from a single cell and divides to make more cancer cells. The growth of
    malignant cells will depend on the availability of specific nutrients being
    transported by blood vessels.

    In laboratory experiments, the researchers have analyzed the effects of


    calabash extracts (fruit and leaf extracts) to duck eggs. The extracts have
    successfully halted the formation of new blood vessels as shown by the lower
    number of branching points in ducks embryo compared to the control samples.
    With these findings, researchers claimed that calabash extracts has the ability
    to prevent blood vessel growth and development and could be used to help
    prevent the spread of cancer cells in the human body. Researchers also believe
    that calabash tree could be a natural resource that can be used in the
    development of cheaper and locally available anti-cancer treatments.

    This study won 3rd prize during the Gruppo Medica Award for outstanding
    undergraduate thesis in herbal medicine during the 7th Philippine National Health
    Research System (PNHRS) Week held in Plaza del Norte Hotel and Convention
    Center, Laoag City, Ilocos Norte.

    http://www.pchrd.dost.gov.ph/index.php/14-r-d-updates/3132-calabash-contains-active-ingredients-
    potential-for-cancer-treatment

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