Peri-Operative Anticoagulation Bridging Guidelines

Anticoagulation Bridging Based on Thrombotic Risk and Indication

Risk of TE Mechanical Valves Mechanical Valve AF AF VTE VTE
Bridge Therapy Bridge Therapy Bridge Therapy
High Any mitral prosthesis Stop warfarin 5 days CHADS2* score >4 Stop warfarin 5 days prior Recent (<3 months) VTE Stop warfarin 5 days prior
Older mechanical aortic prior to procedure History of CVA or TIA to procedure to procedure
valve (caged ball/tilting Begin LMWH 3 days (or Rheumatic valvular heart Begin LMWH 3 days (or 36 Begin LMWH 3 days (or 36
disk) 36 hrs) pre-op (when INR disease hrs) pre-op (when INR < Cancer and thrombosis hrs) pre-op (when INR <
Recent (< 6 months) CVA < 2.0) 2.0) Thrombosis and 2.0)
or TIA o CrCl >30 mL/min: o CrCl >30 mL/min: Severe antiphospholipid o CrCl >30 mL/min:
Enoxaparin 1 mg/kg Enoxaparin 1 mg/kg SC antibody syndrome Enoxaparin 1 mg/kg SC
Bileaflet mechanical aortic SC every 12 hrs every 12 hrs PNH every 12 hrs
valve and one of the o CrCl <30 mL/min: o CrCl <30 mL/min: Myeloproliferive o CrCl <30 mL/min:
following: Enoxaparin 1 mg/kg Enoxaparin 1 mg/kg SC syndrome Enoxaparin 1 mg/kg SC
a) Atrial fibrillation SC every 24 hrs every 24 hrs every 24 hrs
b) CHF o Last dose 24 hr prior o Last dose 24 hr prior to o Last dose 24 hr prior to
c) HTN to surgery surgery surgery
d) Age >75 Check INR on morning of Check INR on morning of Check INR on morning of
e) Diabetes procedure procedure procedure
f) Prior CVA/TIA Restart warfarin Restart warfarin Restart warfarin
immediately post-op immediately post-op immediately post-op
Remember DVT Px Remember DVT Px Remember DVT Px
Hold therapeutic heparin Hold therapeutic heparin Hold therapeutic heparin
for 48 hrs post-op for 48 hrs post-op for 48 hrs post-op
Moderate CHADS2 score of 0-3 Hold warfarin for 5 days VTE in last 3-12 months Stop warfarin 5 days prior
and no prior CVA/TIA Obtain INR on morning of Recurrent VTE to procedure
procedure Restart warfarin
Restart warfarin post-op immediately post-op
No Bridging therapy Remember DVT Px
Low Bileaflet mechanical aortic Hold warfarin for 5 days necessary Single VTE occurred >12 Stop warfarin 5 days prior
valve without atrial Obtain INR on morning of months ago and no other risk to procedure
fibrillation and no other procedure factors Restart warfarin
risk factors for stroke Restart warfarin post-op immediately post-op
No Bridging therapy Remember DVT Px
necessary
Note: TE – Thromboembolism, VTE – venous thromboembolism, AF – Atrial Fibrillation, CVA – cardiovascular accident, TIA – transient ischemic attack
*CHADS2 score estimates the risk of stroke.
1 point for the following risk factors: CHF, HTN, Age >74, Diabetes
2 points for secondary prevention in patients with a prior ischemic stroke or TIA
If possible, delay elective surgery for 3 months following VTE

OHSU Anticoagulation Bridging Guidelines

Reviewed by: OHSU Anticoagulation Sub-Committee of P&T Committee
Approved by: P&T Committee
Date: 1/30/12
Consider the bleeding risk from the procedure. For low bleeding risk procedures (i.e. dental extractions, skin biopsy, cataracts and colonoscopy without
biopsy), warfarin can continue without interruption. See Table: Procedures that can be Performed on Warfarin
Procedures that can be Performed on Warfarin
Ophthalmic Dental Dermatologic Gastrointestinal
Cataract surgery Trabeculectomy Restorations Mohs’ surgery Diagnostic esophagogastroduodenoscopy
Uncomplicated extractions Simple excisions Colonoscopy without biopsy
Endodontics Diagnostic endoscopic retrograde
Prosthetics cholangiopancreatography
Periodontal therapy Biliary stent without sphincterotomy
Dental hygiene Endoscopic ultrasonography without biopsy
Push enteroscopy

Peri-Operative Antiplatelet Management for Major Surgery

Major surgery and How to proceed Exception How to proceed with exception
Aspirin for primary prevention* Stop aspirin 5 days before surgery*
Aspirin in high-risk patients* Continue aspirin* Surgery in closed space, expected Stop aspirin 5 days before surgery*
(diabetes, history of CV events, documented major bleeding complications Consider restarting within 24 hours*
CV disease, increased global risk)
Aspirin plus clopidogrel in high risk patients 1. Elective surgery: delay until no Surgery in closed space, expected If delaying surgery not possible/semi-urgent surgery necessary:
dual inhibition necessary. major bleeding complications Stop clopidogrel 5 days before surgery, consider bridging (short
2. Semi-urgent surgery: continue acting GPIIb/IIIa antagonist).
aspirin ± clopidogrel on a case Consider stopping also aspirin in particular patients.
by case basis. Consider resuming dual antiplatelet therapy as soon as possible.
3. Urgent surgery (within 24
hours): continue aspirin and
clopidopgrel
*Extends also to patients on clopidogrel monotherapy.
Minor Surgery: do not stop antiplatelet therapy.
Implement multidisciplinary consult in patients with (potential) bleeding complications.
Low molecular weight heparin: NOT a substitute for platelet inhibiting drugs.
Avoid plasmatic anticoagulation (LMWH, OAC) during surgery.

OHSU Anticoagulation Bridging Guidelines

Reviewed by: OHSU Anticoagulation Sub-Committee of P&T Committee
Approved by: P&T Committee
Date: 1/30/12
Peri-Operative Antiplatelet Management for Coronary & Carotid Stent Patients

Emergency Urgent Elective

Assess risk of bleeding DES > 1 yr DES < 1 yr

BMS > 4 wks BMS < 4 wks

Low Intermediate High STOP.

Delay
Surgery

Length of DAPT Stop DAPT

Contact Int Card
DES < 1 yr DES > 1 yr
Continue DAPT BMS < 4 wks BMS > 4 wks

Assess risk of thrombosis

Stop thienopyridine, Cont low dose ASA
Contact Int Card
Low High

Proceed with surgery Hospital admit

ASA=aspirin; BMS=bare metal stent; DES=drug eluting stent; DAPT=dual

OHSU Anticoagulation Bridging Guidelines
antiplatelet therapy (ASA & thienopyridine); Int Card=interventional
Reviewed by: OHSU Anticoagulation Sub-Committee of P&T Committee
Approved by: P&T Committee cardiologist; Thienopyridines=clopidogrel, prasugrel, ticagrelor
Date: 1/30/12 Carotid stents are BMS
PRADAXA® (dabigatran)
Low Bleeding Risk Med- High Bleeding Risk
Continue dabigatran Discontinue dabigatran 1-2 days if CrCl ≥ 50ml/min
Discontinue dabigatran 3-5 days if CrCl < 50 ml/min
Consider longer times for patients undergoing major surgery, spinal puncture, or placement of a spinal or epidural catheter or port, in whom complete hemostasis may be
required. Resume Pradaxa® (dabigatran) when safe to do so.

XARELTO® (rivaroxaban)
Low Bleeding Risk Med- High Bleeding Risk
Continue rivaroxaban Discontinue rivaroxaban 24 hours if CrCl ≥ 50ml/min
Discontinue rivaroxaban 36 hours if CrCl < 50 ml/min

Use of Rivaroxaban for Bridging

Patient eligible for consideration:
Patients on warfarin who require bridging for surgical procedures in whom LMWH is contraindicated or cannot be obtained
Contraindications
Creatinine clearance < 30 mL/min
Pregnancy
Protocol
1. Stop warfarin 5 days before surgery
2. Day 3 before surgery start rivaroxaban 10 mg BID
3. Give last dose of rivaroxaban on the morning of the day before surgery
4. Use pneumatic compression stockings during OR until ambulating
5. Start prophylaxis 24 hours after surgery if there is surgical hemostasis with rivaroxaban
6. Restart maintenance dose of warfarin night of surgery
7. Restart therapeutic dose of rivaroxaban 48-72 hours after surgery and stop when INR is > 2

OHSU Anticoagulation Bridging Guidelines

Reviewed by: OHSU Anticoagulation Sub-Committee of P&T Committee
Approved by: P&T Committee
Date: 1/30/12
References for anticoagulation and antiplatelet therapy management guidelines:

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OHSU Anticoagulation Bridging Guidelines

Reviewed by: OHSU Anticoagulation Sub-Committee of P&T Committee
Approved by: P&T Committee
Date: 1/30/12
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OHSU Anticoagulation Bridging Guidelines

Reviewed by: OHSU Anticoagulation Sub-Committee of P&T Committee
Approved by: P&T Committee
Date: 1/30/12