New Drugs 2018

Dr. Ranjan Kumar Patel

New Drug Mechanism of Action Use
Lutathera Radiolabeled somatostatin Somatostatin receptor
analog positive
gastroenteropancreatic
neuroendocrine tumors

Bictegravir Integrase inhibitor HIV

Apalutamide Androgen receptor antagonist Prostate cancer

Tezacaftor + Tezacaftor is a corrector and Cystic fibrosis in patients aged

Ivacaftor ivacaftor is a potentiator of 12 years and older who are
cystic fibrosis transmembrane homozygous for the F508del
regulator mutation or who have at least
one mutation in the cystic
fibrosis transmembrane
conductance regulator (CFTR)
gene that is responsive to
tezacaftor/ivacaftor based on
in vitro data and/or clinical
evidence

Ibalizumab Anti CD-4 receptor monoclonal Multidrug resistant HIV

antibody

Tildrakizumab Anti IL-23 monoclonal Ab Plaque psoriasis

Burosumab Anti Fibroblast growth factor 23 X linked hypophosphatemia

(KRN23) blocking antibody

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Dr. Ranjan Kumar Patel
Fostamatinib Spleen tyrosine kinase inhibitor Immune thrombocytopenic
purpura

Tolvaptan V2 receptor inhibition Autosomal dominant

decreases cyclic AMP which polycystic kidney disease
results in decreased water
secretion and proliferation of
cells, resulting in decreased
growth of cysts

Erenumab Anti CGRP-receptor monoclonal Prophylaxis of migraine by

antibody subcutaneous route 70/140
mg once monthly

Avatrombopag oral thrombopoietin receptor Thrombocytopenia in patients

Lusutrombopag agonist with chronic liver disease,
prior to any procedure

Lokelma (sodium Highly-selective, oral Hyperkalemia

zirconium potassium-removing agent
cyclosilicate preferentially captures
potassium in exchange for
hydrogen and sodium and
increases fecal potassium
excretion

Pegvaliase Phenylalanine-metabolizing Phenylketonuria who have

enzyme uncontrolled blood
phenylalanine concentrations
greater than 600 micromol/L
on existing management

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Dr. Ranjan Kumar Patel

Lofexidine Central alpha-2 agonist To decrease withdrawal

symptoms in opioid
dependence

Andexanet alfa Recombinant protein that is a To reverse anticoagulant

modified form of factor Xa effect of factor Xa inhibitors

Baricitinib Janus Kinase 1 and 2 inhibitor Rheumatoid arthritis not

responding to TNF alpha
inhibitors

Moxidectin Stimulates glutamate sensitive O. volvulus

chloride channels, which leads
to flaccid paralysis in helminths

Cannabidiol Unknown LGS or Dravet syndrome in

children more than 2 years of
age

Plazomicin Aminoglycoside Complicated UTI including

pyelonephritis caused by gram
negative organisms

Binimetinib MEK 1/2 inhibitor Unresectable or metastatic

melanoma which is positive
for BRAF V600E or V600K
mutation

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 New Drugs 2018
Dr. Ranjan Kumar Patel
Encorafenib BRAF inhibitor Used along with binimetinib
for condition mentioned
above

Tecovirimat Inhibits orthopoxvirus VP37 Smallpox

envelope wrapping protein

Ivosidenib Inhibitor of mutant Isocitrate Relapsed or refractory AML

Dehydrogenase 1 (IDH1) positive for Isocitrate
Dehydrogenase 1 (IDH1)
mutation

Tafenoquine Hypnozoite cidal drug Radical cure of malaria caused

by P. vivax

Elagolix GnRH receptor antagonist Endometriosis associated pain

Mogamulizumab Anti CCR4 receptor antibody Relapsed or refractory mycosis

fungoides or Sezary syndrome

Patisiran It is double stranded SiRNA Hereditary transthyretin

which degrades mutant and mediated amyloidosis
wild type transthyretin (TTR) associated polyneuropathy
mRNA and decreases
deposition of transthyretin in
tissues

Migalastat Pharmacological chaperone Fabry disease

that binds to active site of alpha
galactosidase A and facilitates

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 New Drugs 2018
Dr. Ranjan Kumar Patel
its transfer from endoplasmic
reticulum to lysosomes

Stiripentol Acts via inhibitory As an add on to clobazam for

neurotransmitter GABA treatment of LGS or Dravet
syndrome

Cenegermin Recombinant human nerve Neurotrophic keratitis

(bkbj) growth factor

Lanadelumab Anti kallikrein monoclonal Prophylaxis of hereditary

antibody angioedema

Eravacycline Tetracycline Complicated abdominal

infections

Doravirine Non Nucleoside Reverse HIV

Transcriptase Inhibitor (NNRTI)
Moxetumomab- Immunotoxin made up of anti Relapsed or refractory hairy
Pasudotox CD-22 monoclonal antibody and cell leukemia with prior 2
pseudomonas exotoxin, PE38 systemic therapy failure
including purine analogs
Fremanuzumab Anti CGRP ligand monoclonal Prophylaxis of migraine
Galcenezumab antibodies

Duvelisib Dual inhibitor of Relapsed or refractory CLL and

phosphatidylinositol-3 kinases SLL
(PI3K) delta and gamma
Cemiplimab Anti PD-1 antibody Metastatic or advanced
cutaneous squamous cell

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 New Drugs 2018
Dr. Ranjan Kumar Patel
carcinoma, that can not be
treated by surgery or radiation
Sarecycline Tetracycline antibiotic Inflammatory non nodular
acne in age group > 9 years
Omadacycline Tetracycline antibiotic Community acquired
pneumonia and acute
bacterial skin infection
Dacomitinib EGFR tyrosine kinase inhibitor Non small cell cancer of lungs

Elapegademase Recombinant adenosine Adenosine deaminase severe

deaminase enzyme combined immune deficiency
(ADA-SCID)
Baloxavir Inhibits viral replication by Acute uncomplicated
marboxil inhibiting endonuclease activity influenza
of polymerase acidic protein
(present in viral RNA
polymerase complex) required
for viral gene transcription
Rifamycin RNA polymerase inhibitor Traveler’s diarrhoea caused by
E. coli
Inotersen Antisense oligonueotide that Polyneuropathy of hereditary
degrades wild and mutant type transthyretin mediated
TTR mRNA and decreases TTR amyloidosis
protein deposits in tissues
Emapalumab Anti-interferon gamma Primary hemophagocytic
monoclonal antibody lymphohistiocytosis (HLH)
Revefenacin Long acting anticholinergic (M3 COPD
antagonist)

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 New Drugs 2018
Dr. Ranjan Kumar Patel
Sufentanil Opioid agonist Acute pain not responding to
other drugs
Talazoparib Poly ADP ribose polymerase BRCA mutated HER2 negative
(PARP) inhibitor breast cancer
Lorlatinib ALK/ROS1 tyrosine kinase Non small cell lung cancer
inhibitor resistant to other drugs in this
class like alectinib or Ceritinib
Glasdegib Hedgehog pathway inhibitor AML along with cytarabine in
patients > 75 years or in
patients with comorbidities
that are contraindication for
intensive induction
chemotherapy

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