Scribd Logo
Upload

Welcome to Scribd!

  • 15 views

    HIV-1 Antiretroviral Drug Therapy: Reference

    Uploaded by

    jollybe
    The document discusses HIV-1 antiretroviral drug therapy. It notes that treatment of patients with antiviral drugs can suppress HIV-1 replication to undetectable levels, representing a significant medical advancement. Researchers' understanding of the HIV-1 virus and its replication cycle has enabled the development of 24 FDA-approved drugs across six classes that inhibit the virus through different mechanisms. The document aims to review the principles of antiretroviral drug therapy, how the drugs work, and causes of treatment failure like drug resistance.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    HIV-1 Antiretroviral Drug Therapy: Reference

    Uploaded by

    jollybe
    15 views1 page
    The document discusses HIV-1 antiretroviral drug therapy. It notes that treatment of patients with antiviral drugs can suppress HIV-1 replication to undetectable levels, representing a significant medical advancement. Researchers' understanding of the HIV-1 virus and its replication cycle has enabled the development of 24 FDA-approved drugs across six classes that inhibit the virus through different mechanisms. The document aims to review the principles of antiretroviral drug therapy, how the drugs work, and causes of treatment failure like drug resistance.

    Original Description:

    siv?SDMG

    Original Title

    Hiv

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document discusses HIV-1 antiretroviral drug therapy. It notes that treatment of patients with antiviral drugs can suppress HIV-1 replication to undetectable levels, representing a significant medical advancement. Researchers' understanding of the HIV-1 virus and its replication cycle has enabled the development of 24 FDA-approved drugs across six classes that inhibit the virus through different mechanisms. The document aims to review the principles of antiretroviral drug therapy, how the drugs work, and causes of treatment failure like drug resistance.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    15 views1 page

    HIV-1 Antiretroviral Drug Therapy: Reference

    Uploaded by

    jollybe
    The document discusses HIV-1 antiretroviral drug therapy. It notes that treatment of patients with antiviral drugs can suppress HIV-1 replication to undetectable levels, representing a significant medical advancement. Researchers' understanding of the HIV-1 virus and its replication cycle has enabled the development of 24 FDA-approved drugs across six classes that inhibit the virus through different mechanisms. The document aims to review the principles of antiretroviral drug therapy, how the drugs work, and causes of treatment failure like drug resistance.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 1

    HIV-1 antiretroviral drug therapy

    Abstract
    The most significant advance in the medical management of HIV-1 infection has been
    the treatment of patients with antiviral drugs, which can suppress HIV-1 replication to
    undetectable levels. The discovery of HIV-1 as the causative agent of AIDS together
    with an ever-increasing understanding of the virus replication cycle have been
    instrumental in this effort by providing researchers with the knowledge and tools
    required to prosecute drug discovery efforts focused on targeted inhibition with specific
    pharmacological agents. To date, an arsenal of 24 Food and Drug Administration
    (FDA)-approved drugs are available for treatment of HIV-1 infections. These drugs are
    distributed into six distinct classes based on their molecular mechanism and resistance
    profiles: (1) nucleoside-analog reverse transcriptase inhibitors (NNRTIs), (2) non-
    nucleoside reverse transcriptase inhibitors (NNRTIs), (3) integrase inhibitors, (4)
    protease inhibitors (PIs), (5) fusion inhibitors, and (6) coreceptor antagonists. In this
    article, we will review the basic principles of antiretroviral drug therapy, the mode of
    drug action, and the factors leading to treatment failure (i.e., drug resistance).

    Reference
    https://www.ncbi.nlm.nih.gov/m/pubmed/22474613/

    You might also like