Blanda Thomas Randolph Atherosclerosis Pamphlet

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Figure 3: Timeline of Atherosclerosis

For More Information:

Further reading:

About atherosclerosis, heart disease, diet, and

possible treatments.

American Heart Association (AHA)

Mayo Clinic

National Heart, Lung, and Blood Institute

General Information:
Atherosclerosis:
The figures were appended from the following
A Segway to Heart Disease
sources.
Complications of Figure 1: thinglink.com
Atherosclerosis An Overview of the Disease,
Figure 2: Dr. Keefe Manning, PSU

Stenosis: Narrowing of blood vessel Figure 3: wikipedia.org


Complications, and Treatment
resulting in decreased blood flow. Options for Those Diagnosed
Figure 4: mayfieldclinic.com
Plaque rupture: Portion of plaque Figure 5: medgurus.org or At Risk
breaks off and begins circulating in the
blood stream.

Plaque rupture can lead to heart attack


or stroke either by circulation of the
portion in blood stream to smaller
vessels, or clot formation in an already
narrowed blood vessel.

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What is Atherosclerosis? Stenosis Treatment Options
The narrowing of blood vessels will lead to decreased blood
Atherosclerosis, a form of arteriosclerosis, is supply and decreased oxygen delivered to tissues. Atherosclerosis can begin in the pre-
a disease that results in the hardening of the adolescent stage of development, and can go
Your blood vessels can initially combat the effects of
artery walls from the formation of plaque. undetected for many years because there
stenosis by dilating, but the smooth muscle cells can only
are no symptoms that are associated with
relax to a certain point.
How Does the Plaque Form? initial plaque formation.
Figure 4: Blood Vessel With Stenosis
1. An injury to the blood vessel wall can result in Common preventative techniques are to
circulating cholesterol, like high-density lipoprotein exercise regularly, and consume the
(HDL) and low-density lipoprotein (LDL), to leave the good cholesterol (HDL).
blood stream and enter the tissue, as well as attract Stenosed valve
circulating immune cells. Angioplasty is a common procedure
employed to open up narrowed blood
2. LDL, considered the bad cholesterol, affects change
vessels with a stent or balloon.
in the tissue by making the cells of the blood vessel
wall attract white blood cells (immune cells).
More modern approaches employ the use of
3. This leads to an early sign of atherosclerosis in which medications that facilitate the removal of
immune cells digest the LDL and become foam cells excess LDL from the body which can slow, or
which are precursors to fatty streaks (plaque). Common signs of stenosis:
halt plaque formation (Regeneron-Praluent).
4. Foam cells will continue to form, and smooth muscle Shortness of breath Angioplasty
cells will migrate into the fatty streak, resulting in the
continued growth of the plaque. Chest pain
Stent or balloon insertion into stenosed blood vessel can
Rapid fatigue during mild exertion push plaque back and re-open vessel.
Figure 2: Plaque Formation
*Not all patients exhibit noticeable symptoms* Figure 5: Angioplasty Procedure

2.
Plaque Rupture
1. Intense physical exertion can result in a portion of the
4. plaque that has formed breaking off because of increased
blood pressure during heavy exercise.

This can stimulate platelet activity and the clotting cascade


which can cause further stenosis leading to blockage of that
blood vessel, or plaque can travel through circulation to
3. smaller capillaries inducing blockage in other vessels.
Balloon catheter Metal stent

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