E BM Definitions

Evidence-Based Medicine Definitions
Following are some basic definitions of important Evidence-Based Medicine (EBM) concepts that will help you
develop your understanding of the language and methodology of EBM.
What is Evidence-Based Medicine?
Evidence-Based Medicine
Evidence based medicine is the conscientious, explicit, and judicious use of current best evidence in making decisions
about the care of individual patients. The practice of evidence based medicine means integrating individual clinical
expertise with the best available external clinical evidence from systematic research. (From BMJ 1996;312:71-72)
Evidence-based medicine asks questions, finds and appraises the relevant data, and harnesses that information for
everyday clinical practice. Evidence-based medicine follows four steps:
formulate a clear clinical question from a patient's problem

search the literature for relevant clinical articles
evaluate (critically appraise) the evidence for its validity and usefulness
implement useful findings in clinical practice
The term "evidence based medicine" (no hyphen) was coined at McMaster Medical School in Canada in the 1980's to
label this clinical learning strategy, which people at the school had been developing for over a decade. (From BMJ
1995;310:1122)
Other Important EBM Concepts
Absolute Risk Reduction

The absolute arithmetic difference (risk difference) in rates of harmful outcomes between experimental (EER) and control
groups (CER), calculated as the rate of harmful outcome in the control group minus the rate of harmful outcome in the
experimental group (CEREER). Use restricted to a beneficial exposure or intervention. (From Users Guide to the
Medical Literature Glossary; accessed online through JAMA on 3/18/05)
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors
hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined
populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics. (From
Medical Subject Headings; accessed through PubMed on 3/18/05)
Confidence Interval (CI)

Range between two values within which it is probable that the true value lies for the whole population of patients from
which the study patients were selected. (From Users Guide to the Medical Literature Glossary; accessed online through
JAMA on 3/18/05)
Double Blinded Method

A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually
getting which specific treatment. (From Medical Subject Headings; accessed through PubMed on 3/18/05)
Gold Standard
A method having established or widely accepted accuracy for determining a diagnosis that provides a standard to which a
new screening or diagnostic test can be compared. The method need not be a single or simple procedure but could
include follow-up of patients to observe the evolution of their conditions or the consensus of an expert panel of clinicians.
(From Users Guide to the Medical Literature Glossary; accessed online through JAMA on 3/18/05)
Likelihood Ratio
The likelihood of a given test result in a patient with the target disorder compared to the likelihood of the same result in a
patient without that disorder. (From Glossary of Terms in Evidence Based Medicine, http://www.cebm.net/glossary.asp)
Ehrman Medical Library | 550 First Avenue, New York, NY 10016 | Phone: (212) 263-8483 | library.med.nyu.edu | R. Faraino- Jan-06
Longitudinal Studies
Studies in which variables relating to an individual or group of individuals are assessed over a period of time. (From
Medical Subject Headings; accessed through PubMed on 3/18/05)
Meta analysis
A quantitative method of combining the results of independent studies (usually drawn from the published literature) and
synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc.,
with application chiefly in the areas of research and medicine. (From Medical Subject Headings; accessed through
PubMed on 3/18/05)
Number Needed to Treat

The number of patients who need to be treated over a specific period of time to achieve one additional good outcome.
When discussing NNT, it is important to specify the intervention, its duration, and the good outcome. It is the inverse of
the absolute risk reduction (1/ARR). (From Users Guide to the Medical Literature Glossary; accessed online through
JAMA on 3/18/05)
P-Value
The probability that results as or more extreme than those observed would occur if the null hypothesis were true and the
experiment were repeated over and over. A P value < 0.05 means that there is a less than 1 in 20 probability of the result
occurring by chance alone if the null hypothesis were true. (From Users Guide to the Medical Literature Glossary;
accessed online through JAMA on 3/18/05)
Prognostic Study
A study that enrolls patients at a point in time and follows them forward to determine the frequency and timing of
subsequent events. (From Users Guide to the Medical Literature Glossary; accessed online through JAMA on 3/18/05)
Randomized Controlled Trial

Experiment in which individuals are randomly allocated to receive or not receive an experimental preventive, therapeutic,
or diagnostic procedure and then followed to determine the effect of the intervention. (From Users Guide to the Medical
Literature Glossary; accessed online through JAMA on 3/18/05)
Relative Risk
Ratio of the risk of an event among an exposed population to the risk among the unexposed. (From Users Guide to the
Medical Literature Glossary; accessed online through JAMA on 3/18/05)
Sensitivity and Specificity

Measures for assessing the results of diagnostic and screening tests. Sensitivity represents the proportion of truly
diseased persons in a screened population who are identified as being diseased by the test. It is a measure of the
probability of correctly diagnosing a condition. Specificity is the proportion of truly non-diseased persons who are so
identified by the screening test. It is a measure of the probability of correctly identifying a non-diseased person. (From
Last, Dictionary of Epidemiology, 2d ed)
Standard Error
The standard deviation of an estimate of a population parameter. The standard error of the mean is the standard deviation
of the estimate of the population mean value. (From Users Guide to the Medical Literature Glossary; accessed online
through JAMA on 3/18/05)
Systematic Review
A literature review focused on a single question which tries to identify, appraise, select and synthesize all high-quality
research evidence relevant to that question. (From Glossary of Terms in Evidence Based Medicine,
http://www.cebm.net/glossary.asp)
Notes
Ehrman Medical Library | 550 First Avenue, New York, NY 10016 | Phone: (212) 263-8483 | library.med.nyu.edu | R. Faraino- Jan-06

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Evidence-Based Medicine Definitions

What is Evidence-Based Medicine?

formulate a clear clinical question from a patient's problem

Other Important EBM Concepts

Absolute Risk Reduction

Confidence Interval (CI)

Double Blinded Method

Number Needed to Treat

Randomized Controlled Trial

Sensitivity and Specificity

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