STG - Obg PDF
STG - Obg PDF
STG - Obg PDF
GUIDELINES
OBSTETRICS &
GYNAECOLOGY
1
Development Team
Dr Ashley J D'cruz
Narayana Hrudyalya Hospital. Bangalore
2
Reviewed By
Dr Abha Singh
Dir. Prof &HOD
Obst& Gynae ,
LHMC& SSKHospital, New Delhi
3
LEIOMYOMA UTERUS/FIBROMYOMA/FIBROID UTERUS
Leiomyoma of uterus also called as fibromyoma or fibroid uterus is a benign tumor of uterus,
essentially composed of smooth muscle tissue and a variable amount of fibrous connective
tissue. It is the most common tumor of uterus , and is found in 20% of women in reproductive
age group. 1
Leiomyomas are the reason behind one-third of all hospital admissions to gynecology services
and one of the commonest indications for hysterectomy. 2
Fibroid Uterus is more common among older nulliparous and obese women, particularly the
ones with family history of this disease. Based on the location of tumor in the uterus, various
types of myoma are-subserous, intramural and submucous fibroids.
Nearly 20-30% women in reproductive age group have fibroid uterus. At any given time, nearly
15-25 million Indian women have fibroid uterus.
III.DIFFERENTIAL DIAGNOSIS
Adenomyosis
Bicornuate uterus
Ovarian tumor
Retroperitoneal connective tissue tumor
Calcified tuberous pyosalpinx
Complications:
4
Pregnancy complications like spontaneous abortion, preterm delivery, abruption-
placentae
Labor complications: Inertia, Dystocia, PPH
History
-Lower abdominal and pelvic pain: Not a common symptom but may occur in cases of
fibroid polyp/ torsion of pedicle of subserous pedunculated fibroid/ degeneration of fibroid/
sarcomatous change in fibroid
Infertility
5
Pregnancy complications-Increase in size with red degeneration, abortions, preterm
labor, malpresentations
Examination
P/S exam- Submucosal fibroid polyp may be seen coming out of the cervix into the
vagina .with ulceration of surface of mass,seen as white discharge or bleeding.
P/V-Bimanual pelvic examination reveals an enlarged irregular firm uterus, but it may be
symmetrically enlarged in cases of intramural and submucous fibroid. Subserous fibroid
may be felt attached to the uterus or it may be felt as irregularity on one side or as an
adnexal mass in case it is pedunculated or broad ligament fibroid. Submucosal fibroid
polyp may be seen/ felt coming out of the cervix into the vagina.D/D with inversion ut
b) Investigations
CBC
Blood grouping and Rh
Urine routine and microscopy
Ultrasonography
Pap smear
Endometrial biopsy when diagnosis is in doubt
c) Treatment
Treatment modality should be individualized to each patient after considering patients age,
severity of symptoms, need for fertility preservation, presence of other gynecological diseases
and any other co-morbidity.
Small Leiomyomas discovered incidentally and not associated with any complications
usually do not require any treatment. Performing hysterectomy for an asymptomatic
fibroid for the sole purpose of alleviating the concern that it may be malignant is not
warranted. Such patients should be explained, reassured and called for examination at
periodic intervals.
6
Asymptomatic fibroid may warrant treatment in following situations:
The size of fibroid uterus is more than 12-14 weeks pregnant uterus
Rapidly growing fibroid
Evidence of hydroureter / hydronephrosis resulting because of compression of
ureters by the tumor.
Subserous pedunculated fibroids are liable to undergo torsion of pedicle and
hence may be treated even if asymptomatic.
General measures: Correction of anemia with hematinics (iron & folic acid). Severe
anemics with ongoing blood loss may require packed cell transfusion. Reducing blood
loss during periods.
Medical management:
This should be tailored to suit the needs of the woman. However, the costs & side
effects of different drugs may limit their long term use.
Gonadotropin- releasing hormone agonists may be given pre-operatively in order to
reduce blood loss and operating time prior to hysterectomy, myomectomy or myolysis.
E) High cost
F) Side effects like hot flashes & vaginal dryness
G) Risk of development of osteoporosis if given for more than 6 months.
H) Higher risk of recurrence of fibroids after myomectomy if GnRH analogues have
been given pre-operatively.
Some other drugs that can be employed along with their indications & side effects are
enlisted below:
7
Treatment Indications & Potential unwanted outcomes experienced by some
women (Common: 1 in 100 chance; less common: 1 in 1000 chance; rare: 1
in 10,000 chance; very rare: 1 in 100,000 chance)
Levonorgestrel- Small fibroids not distorting the uterine cavity
releasing intrauterine Common: irregular bleeding that may last for over 6 months; hormone-
system related problems such as breast tenderness, acne or headaches, which, if
present, are generally minor and transient
Less common: amenorrhoea
Rare: uterine perforation at the time of insertion
Tranexamic acid Menorrhagia
Less common: indigestion; diarrhoea; headaches
Non-steroidal anti- Menorrhagia & dysmenorrhea
inflammatory drugs Common: indigestion; diarrhoea
Rare: worsening of asthma in sensitive individuals; peptic ulcers with
possible bleeding and peritonitis
Oral progestogen Size reduction
(norethisterone) Common: weight gain; bloating; breast tenderness; headaches; acne (but
all are usually minor and transient)
Rare: depression
Injected progestogen Size reduction
Common: weight gain; irregular bleeding; amenorrhoea; premenstrual-like
syndrome (including bloating, fluid retention, breast tenderness)
Less common: small loss of bone mineral density, largely recovered when
treatment discontinued
Though many gynaecologists are using danazol & mifepristone to reduce the size of the fibroids
with good results, there is no definite consensus on their use & further trials are necessary to
clearly define their roles.
Surgical treatment
-Hysterectomy is the surgical removal of uterus which may be done abdominally/ vaginally or
laparoscopically based on the size of uterus, mobility and descent of uterus, patients desire and
presence of other gynecological diseases and other co-morbidities. In women who dont wish to
preserve uterus/ fertility, hysterectomy is a definitive treatment. Disadvantages of hysterectomy
are the surgical and anaesthetic risks involved in the same.
8
-Myomectomy is the surgical removal of myomas while uterus is being preserved. This may be
done abdominally/ vaginally/laparoscopically or hysteroscopically, depending on the site and
size of myomas. The merit of myomectomy lies in preservation of fertility but the disadvantage
is risk of recurrence of fibroids, which may require a repeat surgery. Myomectomy is usually
preferred in patients less than 40 years of age, who wish to preserve their menstrual and
reproductive functions. Vaginal myomectomy is suitable for patients with submucous
pedunculated fibroid projecting into vagina.
Patients desirous of fertility & have fibroids that distort the uterine cavity where no
other factors have been identified can be managed by laparoscopic / hysteroscopic
myomectomy & should be referred to a super specialty hospital, in case facilities for the
same are not available in situation1.
Pregnant women may require additional fetal surveillance when the placenta is
implanted over or in close proximity to a fibroid.
b) Investigations
-CBC
-Blood grouping
-Urine routine and microscopy
- Ultrasonography (Transabdominal & transvaginal)
-Sonohysterography /Hysteroscopy
- Pap smear
9
- Endometrial biopsy where indicated.
-Magnetic resonance imaging (if needed)
c) Treatment
Treatment modality should be individualized to each patient after considering patients age,
severity of symptoms, need for fertility preservation, presence of other gynecological diseases
and any other co-morbidity. Management of asymptomatic fibroids, general measures and
medical management as already mentioned in situation1.
Non-surgical treatment:
-Uterine artery embolization is an interventional radiologic procedure to occlude uterine
arteries and hence relieves menorrhagia in more than 90% of patients. In this procedure, a
micro-catheter is introduced into the uterine artery via femoral approach and usually polyvinyl
alcohol foam particles are used to occlude uterine arteries. This results in infarction of myomas.
It has the advantage of being a minimally invasive procedure, avoids surgery and entails a
shorter duration of hospital stay. Its role in preservation of fertility is yet undetermined pending
long term studies. The disadvantage is risk of symptom recurrence in nearly 17% cases.
However, the true place of MRgFUS is yet to be established in comparison with the
other available treatment modalities by way of randomized controlled clinical trials 3.
References
1. Pratap Kumar, Narenda Malhotra. Jeffcoates Principles of gynecology. 7th ed. Jaypee
publishing; 2008
2. Rock, John A.; Jones, Howard W. III. Te Lindes Operative Gynecology. 10th ed.
Lippincott Williams & Wilkins (LWW); 2008
3. Best Practice & Research Clinical Obstetrics and Gynaecology Vol. 22, No. 4, pp. 735
747, 2008
4. SOGC Clinical Practice Guidelines;2003
5. NICE Clinical Guidelines44;2007
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ANTE PARTUM HAEMORRHAGE
Definition:
APH is defined as bleeding from or into the genital tract occurring from 24th week of pregnancy
and prior to the birth of the baby.
Why it occurs?
The causes of APH include placenta previa,abruption placenta,local causes and unexplained
causes. Local causes comprise vasa previa and cervical or vaginal causes.
- Exaggerated show,
- Trauma to cervix or vagina
- Cervical ectropion,
- Carcinoma of cervix or polyps
- Vasa previa
Definition:
The term placenta previa refers to a placenta that overlies or is proximate to the internal
os of the cervix. The placenta normally implants in the upper uterine segment. In placenta
previa, the placenta either totally or partially lies within the lower uterine segment.
Perinatal morbidity and mortality also are primarily related to the complications of
placenta previa, because the hemorrhage is maternal.
Predisposing factors:
12
o Multifetal gestations
o Prior caesarean delivery
o Prior placenta previa
Differential Diagnosis:
a) Clinical Diagnosis:
It is on the basis of history, physical examination and investigations.
History: Nature of bleeding: Painless, recurrent, bright red. Initial bleeding may
not be profuse enough to cause death; but it is a warning sign and requires close
monitoring or refer the patient to higher centre.
On physical examination: Patient might be in shock
Abdominal examination: Height of uterus proportionate to gestational
age, presenting part may be felt high up (not engaged).
Malpresentations, malpositions usually present.
Uterine contraction may or may not be present. Some degree of uterine
irritability is present in about 20% of the cases.
Fetal heart sound may or may not be present, depending upon
theamount of blood loss.
b) Investigations:
13
Ultrasound examination: Rules out types of placenta previa; fetal anomalies,
fetal parameters, presentation and position.
Recent studies have shown that the transvaginal method is safer and more
accurate than the transabdominal method. Transvaginal ultrasonography is
also considered more accurate than transabdominal ultrasonography.
14
Monitor BP
Start IV Line
Restore blood volume by infusing normal saline
Explain the need of blood transfusion
Arrangements made to shift to higher centres.
d) Referral criteria:
Shift to hospitals where blood bank, neonatal and emergency cesarean section
facilities are available.
Situation 2:
(At Super Specialty Facility in Metro location where higher-end technology is
available)
a) Clinical diagnosis:
Diagnosis reached by history, physical examination and sonographic examination
After initial assessment further investigations need to be performed to ascertain cause ,
degree of bleeding, plan the on-going care and to decide mode and time of delivery.
b) Investigations: As above.
15
development of the lower uterine segment.
- MRI: MRI has been suggested as a safe and alternate method and may be
useful in determining the presences of placenta accreta/increta/percreta.
c) Treatment:
NO VAGINAL EXAMINATION
Resuscitate:
Monitor BP
Assess the amount of bleeding.
Start IV line
Restore blood volume by blood products
The definitive treatment depends upon the duration of pregnancy, fetal and maternal
status and extent of hemorrhage:
Type I and Type II anterior - vaginal delivery can be expected. Trial of vaginal
delivery can be given and caesarean is done if patient bleeds
Type II -b, III & IV - Elective/emergency caesarean section has to be done at
the earliest.
16
Fig. Flow chart showing management of Placenta previa
ABRUPTIO PLACENTA
Definition:
Abruptio placenta is the detachment of a normally located placenta from the uterus
before the fetus is delivered. It is an obstetric emergency.
Types:
It can be classified as-
Revealed (separation of placenta with blood visible outside)
Concealed (blood collects behind the separated placenta. Not visible outside)
Mixed, (common type).
17
According to Sher clinical grading for placental separation
Incidence : 1-2%
Perinatal mortality rate associated with placental abruption is high.
Causes: unknown .
But following are risk factors:
o Increased age and parity
o Preeclampsia/ Chronic hypertension
o Preterm ruptured membranes
o Multifetal gestation
o Hydramnios
o Cigarette smoking
o Thrombophilias
o Prior abruption
o Uterine leiomyoma
o External trauma (Sudden jerk or assault over abdomen)
18
o Anaemia
o Short cord.
Complications:
Complications include the following:
o Maternal blood loss leading to shock, disseminated intravascular
coagulation [DIC], mult-iorgan failure.
o Fetal distress or death
o IUGR if chronic and mild.
o In Rh negative mothers, chances of feto-maternal transfusion and Rh
sensitization.
o Prematurity
Situation 1:
At Secondary Hospital/ Non-Metro situation: Optimal Standards of Treatment
in Situations where technology and resources are limited.
a) Clinical Diagnosis:
Placental Abruption is a clinical diagnosis.
Severity of symptoms and signs depends on degree of separation and blood loss.
Symptoms:
Vaginal Bleeding
Uterine tenderness
frequent uterine contractions
Signs:
19
Vital signs suggestive of cardiovascular compromise
1. Tachycardia
2. Orthostatic changes in blood pressure and pulse
Abdominal examination:
b) Investigations:
c) Treatment:
1.Bed rest for mild symptoms
20
a) Maternal hemodynamic instability
b) Non-reassuring fetal heart rate pattern on
cardiotocography
c) Near-term pregnancy
3. Resuscitation:
1. Start IV Line with normal saline and refer to higher
centre.
2. Blood transfusion: Explain the need of blood
replacement and send the relatives blood
donation.
3. Vaginal delivery may be tried if patient is in
advanced labour and baby is either not
compromised or IUD.
4. Definite management:
Hospitalization
Bed rest if the pregnancy is not near term and if mother and fetus are
stable.
Patient is followed up if:
i. Bleeding does not threaten the life of the mother or fetus.
ii. The fetal heart rate pattern is reassuring.
iii. The pregnancy is not near term.
iv. No Coagulopathy
v. Optimal urinary output
This approach ensures close monitoring of mother and , if needed, rapidly treated.
Corticosteroids should be considered (to accelerate fetal lung maturity) if gestational age is <
34 wk. Injection Betamethasone 12 mg. IM 12hrs.apart total of two injections.
21
If bleeding resolves and maternal and fetal status remains stable, ambulation may be
allowed.
Patient may be discharged from hospital if pregnancy is not term. Patients are followed up in
ante natal clinic.
d) Complications:
Maternal complications
i. Hypovolemic shock
ii. Renal Cortical necrosis
iii. Coagulopathy
iv. Amniotic fluid embolism
v. Maternal Death
vi. Uteroplacental apoplexy (Couvelaire uterus) \
vii. Bleeding into myometrium results in hypotonic wall
viii. Risk of post partum hemorrhage
Fetal complications
e)REFERRAL CRITERIA :
22
Situation 2:
At Super Specialty Facility in Metro location where higher-end technology is available:
a) Clinical Diagnosis: Detailed history, physical examination and
investigations, will be done to confirm the diagnosis.
b) Investigations: Blood count, Blood grouping and typing, cross match,
Coagulogram for DIC screen.
c) Ultrasound: Evaluation of fetal presentation, size, fetal well-being and
placental localization and separation.
d) Treatment:
Admit
History & examinations
Assess blood loss .It is always more than revealed.
Treatment for placental abruption varies depending on gestational
age and the status of the mother and fetus.
Begin continuous external fetal monitoring for both the fetal heart
rate and contractions.
Obtain intravenous access using 2 large-bore intravenous lines.
Institute crystalloid fluid resuscitation for the patient.
Type and cross match blood.
Begin a transfusion if the patient is hemodynamically unstable after
fluid resuscitation.
Correct coagulopathy, if present.
Administer Rh immune globulin if the patient is Rh-negative.
Management of coagulopathy
23
d. Labor
e. Term
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1 Obstetrician CBC Gloves x 10 pairs Stethoscope
Physician RBS Drapes for BP apparatus
Anaesthetist Urine r/e, c/s delivery/Caesarean Pulse oximeter
Paediatrician Blood Gp Rh Suture materials USG machine
Nurses x 2 TSH Foleys catheter ECG monitors
OT technician Serology Urobag Xray
Lab technician VDRL CVP line Lab equipment
House APTT,PT,INR Arterial line Labour room
keeping USG IV canula Labour couch
ECHO Drip sets Delivery/Caesarean
ECG IV Fluids tray
X Ray TED Stockings Vacuum apparatus
Boyles apparatus
OT table
Light source
Oxygen
Suction
Baby warmer
2 Obstetrician CBC Gloves x 15 pairs Stethoscope
Interventional RBS Drapes for BP apparaus
- Cardiologist Urine r/e, c/s delivery/Caesarean Pulse oximeter
Paediatric - Blood Gp Rh Suture materials USG machine
Cardiologist TSH Foleys catheter ECG, Xray
Cardiac - Serology Urobag Lab equipment
Anaesthetist VDRL CVP line Labour room
Neonatologist APTT,PT,INR Arterial line Labour couch
Intensive care USG Venflons Delivery tray
Nurses x 5 ECHO Drip sets Caesarean tray
OT technician ECG IVFluids Vacuum apparatus
25
Lab technician X Ray Epidural Boyles apparatus
Porters Cardiac anaesthesia kit OT table
House catheterization General Light source
keeping ABG studies anaesthesia kit Oxygen
Suction
ICU bed
Syringe pumps
Baby warmer
26
CARDIAC DISEASE IN PREGNANCY
The physiological adaptations of normal pregnancy can induce symptoms and alter
clinical findings that may confound the diagnosis of heart disease.
Heart disease should be suspected or diagnosed at booking for antenatal women.
Heart disease may be suspected when a pregnant lady presents with symptoms of
progressive dyspnea or orthopnea, nocturnal cough, hemoptysis, syncope or chest
pain.
When there are clinical findings like cyanosis, clubbing, distended neck veins,
systolic murmur of grade 3/6 or greater, diastolic murmur, cardiomegaly, persistent
arrhythmias, persistent split second sound, or pulmonary hypertension.
i. Introduction:
The incidence of heart disease in pregnancy is 1% and it is the third leading cause of
death in women of reproductive age group. Risk of maternal mortality ranges from
0 to 50% depending on the cardiac condition.
Rheumatic Heart Disease (RHD) remains an important cause of heart disease especially
in developing countries like India. A large number of women undergoing valve
replacement surgeries on oral anticoagulants warrant specialized care during pregnancy
and childbirth.
With advances in paediatric cardiac surgery more women with congenital heart disease
(CHD) are now surviving and reaching child bearing age. Ischemic heart disease is also
on the rise as a result of increase prevalence of obesity, hypertension and diabetes in
young adults and delayed child bearing.
The effects of maternal anticoagulant therapy with warfarin could lead to abortions,
stillbirths in 7%, warfarin embryopathy in 8%of live born infants. Warfarin exposure in
the 2nd and 3rd trimesters could lead to disharmonic growth of organs due to
hemorrhage in the fetus and deformation from scarring leading to corpus callosum
agenesis, Dandy Walker malformation, cerebellar midline atrophy, optic atrophy and
blindness, microphthalmia, mental retardation and developmental delay.
Fetal growth restriction and preterm birth are more common in pregnancies
complicated by CHD with restricted maternal cardiac output, especially poor in cyanotic
varieties when the fetal wastage rates may be as high as 40%. The etiology of CHD is
multifactorial and incidence is 0.8 %. Incidence of CHD in the offsprings of parents with
CHD ranges from 5 -10%. However, risk may be as high as 50% as in Marfans syndrome.
Women may be aware of their cardiac condition before falling pregnant. An assessment
of the patients clinical status and ventricular function are necessary to best predict the
outcome of pregnancy. In more than 50% of women it is first diagnosed during
pregnancy.
28
Women with conditions like pulmonary hypertension, severe left sided obstructive
lesions, dilated aortopathy(>4cm) and severe systemic ventricular dysfunction should be
counseled for early termination of pregnancy to avoid maternal mortality.
Women with cardiac disease should be counseled regarding the risk of maternal death,
possible reduction in maternal life expectancy, fetal issues, need for timely switch over
of anticoagulant therapy, need for frequent hospital attendance and possible admission,
intense feto-maternal monitoring during labour.
v. DIFFERENTIAL DIAGNOSIS
a. Clinical Diagnosis:
b. Investigations:
29
Basic work up like complete blood counts, urine routine, blood grouping Rh typing,
serology,VDRL, APTT, PT INR, scans for dating, aneuploidy screening qnd foetal
anomalies.
Nonivasive studies like electrocardiography, echocardiography and chest
radiography with abdominal shielding can be conducted during pregnancy to
support the diagnosis.
.
c. Treatment:
Clinical Classification Schemes commonly used are that of NYHA and ACOG
These classification systems are useful to clinicians to evaluate the functional
capacity and to aid in counseling the woman regarding advisability of conception or
continuation of pregnancy.
30
Patent ductus arteriosus
Pulmonic or tricuspid disease
Corrected Tetrology of Fallot
Bioprosthetic Valve
Mitral stenosis (NYHA Classes 1and II)
31
Most women with functional Class 1 and 2 go through pregnancy without morbidity.
However, special attention should be directed toward both prevention and early
recognition of heart failure. Indicators being cough, progressive edema, tachycardia,
haemoptysis and basal rales. Empirical therapy with diuretics and beta-blockers could
be hazardous, so opinion of cardiologist /physician should be taken.
Careful fluid balance should be monitored. Avoid supine position. A semi recumbent
position with lateral tilt preferred.
Monitor vitals - pulse, respiration, BP, Oxygen saturation and intake output.
Cut short 2nd stage of labour with outlet forceps or vacuum extractor to reduce maternal
effort.
Close monitoring of cardiac patient should continue after delivery because early
postpartum period is often a time of acute de-compensation.
d. Referral Criteria:
32
All patients with moderate and major risk of maternal mortality should be referred
to a higher centre for following facilities:-
a) Super specialists in cardiology and anesthesia with in-depth understanding of
each cardiac condition are available.
b) facilities should be available for obstetric care with intensive monitoring of
mother and fetus under the supervision of a high risk pregnancy
specialist(Obstetrician)
c) Neonatologist with a well equipped NICU is available.
d) Referral may be necessary for fetal echocardiography to plan neonatal care in
advance.
a. Clinical diagnosis
A clinical suspicion or recognition of cardiac disease based on history, clinical
symptoms and signs as explained above is made.
b.Investigations
Basic work up as in any pregnancy like complete blood counts, urine routine, blood
grouping Rhtyping, VDRL, serology, APTT, PT, INR, ultrasound for dating, aneuploidy
screening, anomaly scan. Fetal echocardiography when indicated depending upon
the risk of transmission.
33
If indicated, cardiac catheterization can be performed with limited x-ray fluoroscopy
by an interventional cardiologist.
.
c. Treatment
Clinical Classification Schemes commonly used are that of NYHA and ACOG.
These classification systems are useful to clinicians to evaluate the functional
capacity and to aid in counseling the woman regarding advisability of conception or
continuation of pregnancy.
Antenatal period
Severe mitral stenosis is associated with a higher risk of pulmonary edema.
Both beta blockers and balloon mitral valvotomy are safe in pregnancy. Pulmonary
edema should be treated in the usual way with oxygen and diuretics.
Women with prosthetic heart valves on oral anticoagulants will need replacement
with heparin in early pregnancy between 6 to 12 weeks, to prevent embryopathy.
Again warfarin should be discontinued and replaced with heparin at 35-36 weeks to
allow clearance of warfarin from the circulation. Heparin is discontinued 4-6hrs
before delivery and regional anesthesia to minimize risks of obstetric hemorrhage
and spinal hematoma. Intravenous heparin is restarted 6 hrs after vaginal delivery
and 24 hours after a caesarean section. Warfarin is usually started the night after
delivery provided there are no bleeding complications and heparin is continued until
34
an INR of 2 or more is achieved. In an emergency situation VitK or fresh frozen
plasma can be used to reverse warfarin anticoagulation and protamine sulfate for
heparin anticoagulation.
Peripartum Cardiomyopathy
Risk factors include multiparity, multiple pregnancy, hypertension, increased age.
35
Diagnostic criteria
a) Development of cardiac failure in the last month of pregnancy or within 5
months after delivery.
b) Absence of an identifiable cause for the cardiac failure.
c) Absence of recognizable heart disease prior to the last month of pregnancy
d) LV systolic dysfunction shown on echo as ejection fraction <45%, and LV end
diastolic dimension >2.7cm/sqm
Recommended treatment
d.Referral Criteria
Even in a metro situation a multidisciplinary specialist team with skill and facilities
may not always be available under one roof. In such instances referral may be
required to an optimal setup under one roof for best feto-maternal outcome.
36
Williams Obstetrics 23nd edition 2008
37
RESOURCES REQUIRED FOR ONE PATIENT / PROCEDURE (PATIENT WEIGHT 60 KGS)
(Units to be specified for human resources, investigations, drugs, and consumables
and equipment. Quantity to also be specified)
38
Cardiologist Urine r/e, c/s delivery/Caesarean Pulse oximeter
Pediatric - Blood Gp Rh Suture materials USG machine
Cardiologist TSH Foleys catheter ECG,Xray
Cardiac - Serology Urobag Lab equipment
Anaesthetist VDRL CVP line Cath lab
Neonatologist APTT,PT,INR Arterial line Labour room
Intensivist USG Venflons Labour couch
Nurses x 5 ECHO Drip sets Delivery tray
Ot technician ECG IVFluids Caesarean tray
Lab technician X Ray Epidural Vacuum appar
Porters Cardiac anaesthesia kit Boyles appar
House keeping catheterization General OT table
ABG studies anaesthesia kit Light source
Oxygen
Suction
ICU bed
Syringe pumps
Baby warmer
39
DYSFUNCTIONAL UTERINE BLEEDING
INTRODUCTION
DUB affects 22 to 30% of women and accounts for 12% of gynaecological referrals.
DUB is not one condition of one etiology it is a group of disorders characterized by
dysfunction of any part of the reproductive system uterus, ovary, pituitary,
hypothalamus, higher centers.
In clinical practice, the diagnosis of DUB is usually made by exclusion of organic disease
of the genital tract or systemic organic disease.
DEFINITION
It is defined as abnormal uterine bleeding without any clinically detectable organic
pathology.
How to make diagnosis?
History:
1. H/o Abnormal Uterine Bleeding:
a) Excessive menses-duration of menstrual flow > 7 days or
menstrual blood loss > 80 ml
b) Frequent menses-duration of menstrual cycle < 21 days
c) Irregular / acyclical uterine bleeding.
40
d) Symptoms suggestive of hypothyroidism, bleeding disorders,
other systemic illness
e) Ingestion of drugs, like antiplatelet drugs (aspirin, clopedrogel)
Examination:
1. A general examination for signs of anemia, thyroid disease or
bleeding disorders.
2. Abdominal examination for masses.
3. All women with abnormal genital tract bleeding must have a
speculum examination to visualize the cervix, vagina and
exclude any local cause.
4. Per vaginal examination look for uterine enlargement
(fibroids), tenderness/fixity (PID, endometriosis), any adnexal
mass.
INCIDENCE:
1. Pubertal or adolescent DUB usually women less than 20 yrs, incidence 4%
2. Reproductive DUB seen in women from 20 to 40 yrs, incidence 57%
3. Perimenopausal DUB women aged above 40 yrs, incidence 39%
4. Postmenopausal DUB incidence around 10%
DIFFERENTIAL DIAGNOSIS:
1. Pregnancy related bleeding
a) Abortions
b) Ectopic pregnancy
c) Guestational trophoblastic disease
2. Fibroid uterus
3. Endometrial cancer
4. Thyroid abnormalities
41
5. PID, Endometriosis.
6. Endometrial TB
7. PCOS
SITUATION 1:
DIAGNOSIS:
Clinical diagnosis is made by history and examination as explained above. Final diagnosis
is only made after investigations.
INVESTIGATIONS:
a) Urine pregnancy test
b) Complete blood count
c) Platelet count, BT, CT, PT, PTT especially in puberty menorrhagia not responding
to treatment
d) Thyroid profile
e) LFT & RFT only in strongly suspected cases
f) USG TAS/TVS: Ultrasound is the first-line diagnostic tool for identifying
structural abnormalities.
g) Pap smear
h) Sonohysterography
i) Endometrial biopsy by Novac curette, By Pipelle aspirator
42
weighing more than or equal to 90 kg to exclude endometrial cancer or atypical
hyperplasia, treatment failure or ineffective medical treatment
TREATMENT:
General
1. Assurance and sympathetic handling of physiological or emotional problems
2. Normal routine activities
3. Correction of anemia by diet, haematinic and even by blood transfusion
4. Clinically evident systemic/endocrine abnormalities should be investigated and
treated accordingly
Medical Management:
Non hormonal methods:
1. Anti fibrinolytic agents oral/IV tranexemic acid 500 mg-1gm twice or thrice
daily till severe bleeding. Effective in ovulatory DUB, iatrogenic menorrhagia
secondary to insertion of IUCD, Von Wilibrands disease
43
2. Prostaglandin synthetase inhibitors (NSAIDS) Mefenamic acid 250 mg 500
mg twice or thrice daily, effective in ovular DUB
3. Ethamsylate 250 500 mg TDS oral/IV
4. Anti tubercular treatment when disease is confirmed
Hormonal Method:
To stop acute episodes of bleeding and to regulate the cycles
1. Progestins
a. Tab nonethisterone 20 30 mg/day in divided doses. It arrests bleeding
in 24 48 hrs; later dose is tapered and continued in cyclical fashion from
5th day of withdrawal flow in subsequent cycles for 3 to 4 cycles.
b. Similarly Medroxy progesterone acetate (MPA) can also be used.
2. Cyclical therapy:
In ovular bleeding:
1. OCP is given from 5th to 25th day of cycle for 3 consecutive
cycles.
In ovular bleeding where patients wants pregnancy or in case of
irregular shedding or ripening dydrogesterone 10 mg per day from
16th to 25th day.
In anovular bleeding:
a) MPA 10mg 5th to 25th day, NE 5mg 5th day to 25th day for 3 consecutive
cycles
b. DMPA 150 mg I.m every three months useful in maintenance therapy in
woman who have difficulty with or cannot take OCPs.
c. Ormeloxifene (Sevista) 2 tab of 60 mg/week that is on Sunday and
Wednesday for 12 weeks, 1 tab of 60 mg on following Sunday or
Wednesday for 12 weeks
d. Levonorgestrol Releasing IUD(Mirena)
44
Surgical Management
Hysterectomy TAH/vaginal hysterectomy/laparoscopic hysterectomy.
Hysterectomy should not be used as a first-line treatment solely for HMB. Hysterectomy
should be considered only when:
Other treatment options have failed, are contraindicated or are declined by the
woman
There is a wish for amenorrhoea
The woman (who has been fully informed) requests it
The woman no longer wishes to retain her uterus and fertility
REFERRAL CRITERIA
SITUATION 2
DIAGNOSIS: As in situation 1
INVESTIGATIONS:
In addition to investigations as in situation 1, certain specific tests like Specific tests for
bleeding disorders :Testing for coagulation disorders (for example, von Willebrand
disease) should be considered in women who have had HMB since menarche and have
personal or family history suggesting a coagulation disorder. [NICE GUIDELINE 2007]
TREATMENT:
1. Along with the general and medical treatment as mentioned in situation 1.
2. conservative surgeries:
45
like Endometrial destruction or ablation hysteroscopic and non
hysteroscopic methods are available (TCRE, uterine thermal balloon ablation,
radio frequency induced endometrial ablation, etc.)
3. Pre-requisite for undergoing these procedures:
a) To exclude atypical endometrium
b) CIN, Ca cervix, Ca endometrium has to be ruled out
c) Not expecting 100% amenorrhea
d) Uterus size less than 12 weeks
e) No pelvic inflammatory disease
f) Completed family
g) If necessary patient should be ready to undergo hysterectomy
h) Ready for regular follow up
i) Surgically fit
j) Patient should know that its not effective contraception
46
Ectopic Pregnancy
Introduction
When implantation of the embryo occurs outside the uterine cavity is called ectopic
pregnancy. Common site of implantation is in the fallopian tube.
The risk of death from an undiagnosed ectopic pregnancy is greater than that of an
induced abortion or delivery. Therefore slogan is If you think ectopic then only you
can diagnose ectopic. Earlier the diagnosis, better is the prognosis with
conservation of the reproductive capacity. Chances of a subsequent successful
pregnancy are reduced in these women.
47
IV Optimal diagnostic criteria, investigations, treatment and referral criteria
Situation1.
At Secondary Hospital/ Non Metro situation: Optimal Standards of treatment in
Situations where technology and resources are limited.
a) Clinical Diagnosis:
Presentation could be diverse depends on whether rupture has occurred. The
reproductive age group woman may present with amenorrhoea, bleeding pv, pain
abdomen, sometimes with shock due to rupture.
b) Investigations:
1. A urine pregnancy test should be positive
2. Ultrasound abdominal/ vaginal- thickened echogenic endometrium, absent
intrauterine gestational sac, sometimes a pseudosac, fluid in the culde sac,
occasionally haematosalpinx, adnexal mass or a tubal ring representing the
gestational sac.
3. Culdocentesis if ultrasound facility is not available
4. Blood grouping crossmatching and reservation
5. Histopathological examination of the operative specimen to confirm diagnosis.
c) Treatment:
The standard aim of care is to control the bleeding and remove the ectopic
pregnancy.
Start an IV line, arrange for blood transfusion, rush patient to the operating room.
General anaesthesia, IV antibiotic prophylaxis given and catherised.
Abdomen entered through a transverse suprapubic inscision.
The affected tube is brought out and salpingectomy is performed.
Strict haemostatsis secured. Peritoneal cavity cleared of blood and blood products.
Mops and instruments counted and abdomen closed in layers.
Blood transfused depending on the amount of loss and post op hemoglobin.
48
Inj Anti D immunoglobulin given if the lady is Rh negative and husband
Rh positive
Patient should be advised to report immediately in future pregnancies
49
d) Referral Criteria:
When an unruptured ectopic pregnancy is diagnosed and facilities are lacking for
timely monitoring of serum beta hcg titres and medical management.
When patient is stable and facilities or skill to offer laparoscopic surgery are not
available
When heterotopic pregnancy is diagnosed and patient is desirous of continuing with
the intrauterine conception.
After a life saving laparotomy, for need of blood transfusion.
Situation2.:
At Superspeciality Facility in Metro location where higher end technology is
available.
50
it is an option for clinically stable asymptomatic women with an ultrasound diagnosis of
ectopic pregnancy and a decreasing serum hCG, initially less than serum 1000 iu/l.(ref
rcog greentop)
Women managed expectantly should be followed twice weekly with serial hCG
measurements and weekly by transvaginal examinations to ensure a rapidly decreasing hCG level
(ideally less than 50% of its initial level within seven days) and a reduction in the size of adnexal
mass by seven days. Thereafter, weekly hCG and transvaginal ultrasound examinations are advised
until serum hCG levels are less than 20 iu/l .
On hcg monitoring if the level increases or plateaues ,active medical management is
resorted to.
The most widely used medical treatment at present is intramuscular methotrexate given as a single
dose calculated from patient body surface area.
Dose:
A single dose of 1mg/kg body weight or 50mg/square metre body surface area of
methotrexate given intramuscularly in addition to leukovorum (folic acid antagonist)
0.1mg/kg IM.
Methotrexate should not exceed 4 doses.
There is 70-95% efficiency in the treated cases.
It takes 4-6 weeks for the complete resolution of ectopic pregnancy with
methotrexate.
Methotrexate is also useful in the management of persistent ectopic which is a
complication of conservative surgical treatment and incomplete removal of
trophoblastic tissue.
Serum hCG levels are checked on days four and seven and a further dose is given if hCG levels have
failed to fall by more than 15% between day four and day seven. Large uncontrolled studies have
reported that about 14% of women will require more than one dose of methotrexate and less than 10%
of women treated with this regimen will require surgical intervention.
Can be considered for women with confirmed or high suspicion for ectopic pregnancy
who are hemodynamically stable with no evidence of rupture.
51
Medical management with Methotrexate-
d. Referral criteria:
1. Patients with comorbidities requiring multidisciplinary input.
2. When skilled manpower and facilities are not available.
3. When it is a heterotopic pregnancy usually a consequence of assisted
reproductive techniques, referral to an ART center for further care is necessary.
52
53
ANEMIA IN PREGNANCY
Anemia is defined as a decrease in the oxygen carrying capacity of the blood due to decrease in
amount of RBCs or haemoglobin or both.
PCV<33%
Introduction:
Anemia is a major problem in women of child bearing age in developing countries with
effects that may be deleterious to mothers and fetuses.
Over one third of the worlds population suffers from anemia, mostly iron deficiency anemia.
India continues to be one of the countries with very high prevalence. National Family Health
Survey (NFHS-3) reveals the prevalence of anemia to be 70-80% in children, 70% in pregnant
women and 24% in adult men. Prevalence of anemia in India is nearly two thirds of the pregnant
women because of low bioavailability diet, defective absorption & chronic blood loss due to
hook worm infestation & malaria and rapidly successive multiple pregnancies. Iron deficiency
anemia is responsible for 95% of the anemias during pregnancy.
54
In India, anemia is directly or indirectly responsible for 40 percent of maternal deaths due to
haemorrhage, cardiac failure ,infection & preeclampsia . India contributes to about 80 per cent
of the maternal deaths due to anemia in South Asia. There is 8 to 10-fold increase in MMR when
the Hb falls below 5 g/dl. Maternal anemia is associated with increased perinatal morbidity &
mortality rates consequent to IUGR, preterm births, low iron stores and cognitive & affective
dysfunction in the infant.
India was the first developing country to take up a National Programme to prevent anemia
among pregnant women and children. The National Anemia Prophylaxis Programme of iron and
folic acid distribution to all pregnant women in India through the primary health care system
was evolved and implemented from 1972. In order to tackle this public health problem, a multi-
pronged 12 x 12 initiative has also been launched in the country. The initiative is targeted at all
adolescents across the country with the aim for achieving hemoglobin level of 12 gm% by the
age of 12 years by 2012.
CDC-Up to 56% of all women in India are anemic (Hb < 11 g/dl)
NNMB, DLHS and ICMR surveys showed that over 70 percent of pregnant women are
anemic
The World Health Organization (WHO) estimates that 42% of all women, and 65-75% of
pregnant women in our country are anemic. In India, the second National Family Health Survey
in 19981999 (NFHS-II) showed that 54% of rural women of childbearing age were anemic
compared with 46% of women in urban areas. Kerala has only a 23% prevalence of anemia
compared with 62% in many northeastern states of India.
III.DIFFERENTIAL DIAGNOSIS
Nutritional
Hemorrhagic
Hemoglobinopathies
Bone marrow disorder
HIV
Drug induced
Tuberculosis
Inherited disorders
55
Anemia caused by inflammation, malignancy, chronic diseases & autoimmune disorders
a) Clinical Diagnosis:
Symptoms:
1. Weakness
2. Easy fatiguability
3. Lassitude
4. Dizziness or vertigo especially when standing
5. Headache
6. Irritability
7. Indigestion, loss of appetite
8. Breathlessness
9. Palpitations
10. Generalized swelling
11. Symptoms due to cause of anemia like yellowing of skin & mucous membranes,
bleeding from rectum etc.
Signs:
1. Pallor
2. Icterus
3. Glossitis, stomatitis
4. Koilonychia
5. Tachycardia, systolic murmurs, bounding pulse
6. Fine crepitations at lung bases
56
7. Splenomegaly
8. Hepatomegaly
9. Edema
b)Investigations:
Hb%
PCV
Peripheral smear for immature cells, type of anemia and MP.
Urine routine and microscopy, Urine C/S if required
Stool for Routine and microscopy
USG abdomen
c) Treatment:
Although there are several different forms of anemia, this health profile will only address the
three most common: iron-deficiency anemia, vitamin B12 anemia and folic acid deficiency.
Non-drug treatment
Awareness/ Education
Improvement of dietary habits-diet rich in Vit C, protein and iron, cooking in iron
utensils, avoiding tea & coffee intake with meals & overcooking
Food Fortification
Social services such as improvement of sanitation & personal hygiene for eradication of
helminthiasis
Annual screening for those with risk factors
Routine screening for anaemia & providing iron supplementation for adolescent girls
from school days
Iron rich foods: Pulses, cereals, jaggery, Beet root, Green leafy vegetables, nuts, meat, liver,
poultry, Egg, fish, legumes, dry beans, and dry fruits viz: dates, figs, apricots etc .
57
To be given for 6 months in countries with prevalence <40% & additional 3 months
postpartum where the prevalence >40%
Ferrous sulphate is least expensive and best absorbed form of iron. It also allows more
elemental iron absorbed per gram administered. If for some reason, this is not tolerated, then
ferrous gluconate & fumarate are the next choice for iron therapy.
Oral iron
Parenteral iron
Blood transfusion
Oral Iron
- First line therapy
- 200mg FeSo4 (60mg elemental iron)2- 3 times daily in conjunction with folic acid.
- If patient is non-compliant to oral therapy or if there is gastritis, then reduce doses &
give it after meals or change over to ascorbic acid/ carbonyl iron or parenteral therapy.
- Diagnostic reevaluation if there is no significant clinical or haematological improvement
within 3 weeks.
Parenteral Therapy:
Indications:
Preparations:
- Iron sucrose
- Iron dextran
58
- Iron sorbitol citrate
Total iron deficit (mg) = Amount of iron deficit + amount of iron to replenish stores
Amount of iron deficit (mg) = (Hb target- Hb initial)gm/dl x Body wt (Kg) 2.2 + Stores
Or
where
Iron Sucrose Complex is considered to show a significant improvement of Hb and iron stores in
pregnant women.
The target Hb may be taken as 11gm% for the Indian population according to WHO guidelines.
Deworming necessary :
Prophylactic - all woman of reproductive age should be given 400mcg of folic acid daily.
59
folic acid daily or intermittently has a similar effect in reducing anaemia at term and
improving haemoglobin concentrations in the mother.
d)Referral criteria:
- Maternal risks during Antenatal period: Poor weight gain, preeclampsia, eclampsia,
placenta previa, accidental haemorrhage, premature rupture of membranes, pre
term labour, cardiac failure etc.
- Maternal risks during Postnatal period: Postnatal sepsis, sub involution, embolism,
PPH (primary, secondary).
B)Investigations:
Reticulocyte count
60
Red cell indices
Coombs Test
Iron studies
- serum iron
- serum iron binding capacity
- serum ferritin
Hb electrophoresis
Bone marrow aspiration/ Biopsy
Inj. Iron Dextran (50 mg / ml elemental iron) 2 cc IM on alternate day after test dose x
10 injections by Z technique.
Blood Transfusion
Packed cells to be transfused.
Indications
- Hb < 7 gm/dl & POG > 36 weeks
- Hb < 6 gm/dl & POG < 36 weeks
- CHF due to anaemia(exchange transfusion)
- Replenish blood loss due to APH/PPH
- Not responding to oral & parenteral therapy
Manage congestive cardiac failure/ PIH / Placenta Previa if associated/ where indicated.
Megaloblastic Anemia
LABOUR MANAGEMENT:
61
Oxygen and other measures to deal with heart failure and PPH to be kept ready.
POSTPARTUM MANAGEMENT:
Iron should be continued till the patient restores her normal clinical &
haematological state & for an additional 3 months for store replenishment.
Dietary advice
Effective method of contraception as per WHO guidelines & should not conceive for
atleast 2 years giving time for iron stores to recover.
62
RESOURCES REQUIRED FOR ONE PATIENT / PROCEDURE (PATIENT WEIGHT 60 KGS)
(Units to be specified for human resources, investigations, drugs, and consumables and
equipment. Quantity to also be specified)
63
2. Obstetrician CBC Gloves x 15 pairs Stethoscope
Pathologist Peripheral blood Drapes for BP apparatus
At Super Anaesthetist smear delivery/Caesarean Pulse oximeter
Neonatologist Reticulocyte Suture materials USG machine
Specialty
Intensivist count Foleys catheter ECG
Facility in Nurses x 5 Urine routine Urobag Lab equipment
Metro OT technician and microscopy CVP line Automated cell counter
Lab technician Stool for Arterial line Biochemistry analyser
location
Porters Routine and Venflons Labour room, CTG
where House keeping Microscopy Drip sets Labour couch
higher-end IVFluids Delivery tray
Iron studies Epidural anaesthesia Caesarean tray
technology is LFT,RFT,LDH kit Vacuum apparatus
available Coombs Test General anaesthesia Boyles apparatus
kit OT table
Hb Drugs to manage Light source
electrophoresis cardiac failure , PPH Oxygen
Suction
Bone marrow ICU bed
aspiration/ Syringe pumps
Biopsy Baby warmer
Guidelines developed by
DeMayer EM, Tegman A. Prevalence of anaemia in the World.World Health Organ Qlty
1998; 38 : 302-16.
WHO. 2004. Micronutrient deficiency: Battling iron deficiency anaemia: the challenge.
Available from: http://www.who.int/nut/ida.htm, accessed on April 24, 2008.
64
Ezzati M, Lopus AD, Dogers A, Vander HS, Murray C. Selected major risk factors and
global and regional burden of disease. Lancet 2002; 360 : 1347-60.
DLHS on RCH. Nutritional status of children and prevalence of anaemia among children,
adolescent grils and pregnant women 2002-2004. Available from:
http://www.rchindia.org/nr_india.htm 2006, accessed on September 24, 2008.
Toteja GS, Singh P. Micronutrient profile of Indian population.New Delhi: Indian Council
of Medical Research; 2004.
Breymann C. Iron deficiency and anemia in pregnancy: Modern aspects of diagnosis and
therapy. Blood Cells Mol Dis 2002; 29: 506-16.
Practical guide to High Risk Pregnancy and Delivery; Fernando Arias, 2nd edition; chap-3,
pg245-262.
Williams Obstetrics, Eds Cunningham FG, Gant NF, Leveno KJ et al. 22nd Edn. 2005.
65
DIABETES AND PREGNANCY
Outcomes of diabetic pregnancies have improved for the mother and the
newborn due to understanding of the disease process, improved education, and
new treatment modalities delivered in a team approach. Nausea and vomiting
of pregnancy and associated insulin resistance can make glycaemic control a
challenge. Care of women with preexisting diabetes demands careful
monitoring in the preconception, prenatal, and postpartum periods.
b) Case definition:
For both situations of care (mentioned below)
Pre gestational diabetes: Women who present with keto acidosis or random plasma glucose
levels greater than 200mg/dl plus classical signs and symptoms such as polyphagia, polyuria or
polydipsia are labeled as pregestational diabetes. American Diabetes Association (2004) also
recommends that pregnant women with fasting glucose levels of 126mg/dl or greater be
considered to have overt diabetes.
Gestational diabetes mellitus: Current practice is a 2 step testing, screening and diagnosis.
Universal screening is recommended in India as Asians are a high risk group for diabetes.
OSullivan 50 g glucose, 1 hour screening test cutoff ranges from 130mg/dl to 140 mg/dl.
The next step, diagnostic 3 hour 100gm GTT has atleast 2 different algorithms for
diagnosis of GDM.
66
1hr 190 180
2hr 165 155
3hr 145 140
Recently, a single step 75 gm oral glucose tolerance test is also being used wherein a 2
hr plasma glucose level is measured after random administration of oral glucose.A
plasma value > 140 mg% is diagnostic of GDM.It serves both as a screening &a
diagnostic test. However, further studies are required before it is put to routine use in
India.
1-2%of mothers
Glycosuria of pregnancy
Preconception Counselling
All women of reproductive age with preexisting diabetes should be advised about the
potential benefits of prepregnancy planning. They should be offered education on the
role of diet, appropriate body weight, and exercise. The American Diabetes Association
has defined optimal preconceptional glucose control using insulin to include self-
monitored preprandial glucose levels of 70 to 100 mg/dL and postprandial values _ 140
mg/dL and _ 120 mg/dL at 1 and 2 hours, respectively. A reasonable target for HbA1c in
prepregnancy counseling is to aim for 6%. An improvement in HbA1C levels can also be
achieved by switching to short acting modern analogue and by enrolling the
prepregnant subject into education programs that teach enhanced carbohydrate
counting. Women with diabetes whose HbA1c is above 10% should be strongly advised
to avoid pregnancy. In prepregnancy counseling the current drug regime should also be
reviewed. Some hypoglycemic drugs and the newer long acting insulin analogues have
not been evaluated for safety in pregnancy and they should be replaced.
Antihypertensives particularly ACE inhibitors and angiotensin receptor antagonists
should be discontinued prior to pregnancy. Finally, folate, 400 g/d, is given
periconceptionally and during early pregnancy to decrease the risk of neural-tube
defects. When pregnancy occurs without any prepregnancy counseling , then an urgent
assessment of all the previous factors should be undertaken as soon as possible at the
antenatal clinic. Retinal & renal assessments are mandatory in all cases.
67
Situation1: At Secondary Hospital/Non-Metro situation:Optimal standards of situation where
technology and resources are limited
a) Clinical diagnosis:As described in case definition. Women with risk factors for GDM
should be carefully screened like the obese, prior GDM, prior macrosomic infant, elderly
mothers, multiple pregnancy, south east Asians, Hispanics, African Americans, polycystic
ovarian syndrome, family history of diabetes.
Such women at very high risk may benefit from early screening in the first trimester. If
early screening is normal, screening is repeated at 24 to 26 weeks.
b) Investigations:
Non stress test by 32 to 34 weeks. Lack of USG and NST facilities warrant
referral to higher centers.
c) Treatment:
Diet and exercise are instituted first. For many patients with GDM ,oral hypoglycemic
or insulin therapy may be avoided altogether with no increase in adverse perinatal
outcomes on diet alone. For women of normal weight, the American Diabetes
Association recommends a caloric intake of 30 to 35 kcal/kg, taken as three meals and
three snacks daily. For underweight women, this is increased to 40 kcal/kg/d. For those
more than 120 percent above ideal weight, it is decreased to 24 kcal/kg/d. An ideal
dietary composition is 55 percent carbohydrate, 20 percent protein, and 25 percent fat
with less than 10 percent as saturated fat. Generally a diet containing with CHO
restriction to 45-60% preferably complex high fiber carbohydrates sources of known
low Glycemic Index, lean proteins including oily fish, and a balance of polyunsaturated
and monounsaturated fats is recommended. Women with a high BMI might be advised
to restrict calorie intake with expert dietetic advice and consider suitable enhanced
mild or moderate exercise during the pregnancy. 1 to 2 miles walk at least 3 times a
week is recommended.
68
Pharmacotherapy with insulin is instituted when diet and exercise therapy fail as
evidenced by an abnormality in more than half the self monitored glucose values or an
abnormal value in those women tested weekly.
Of the calculated daily dose, 2/3rds is given before breakfast, divided as 2/3rd NPH
insulin and 1/3rd regular insulin, and the remaining 1/3rd of the daily dose is given as 1/2
regular insulin before dinner and 1/2 NPH insulin at bed time.
Antenatal care- twice weekly visits required. Well controlled diabetics can deliver at 40
weeks
Women with pregestational diabetes with nephropathy, retinopathy may worsen and
warrant earlier delivery. Preeclampsia, and IUGR may set in.
Good glycaemic control during pregnancy can avoid ketosis and sepsis.
Labor and delivery- Women with pregestational diabetes and GDM requiring
pharmacotherapy are best managed with IV fluids(100-150ml/hr),insulin drips and
hourly glucose monitoring protocols to maintain blood glucose values at around
69
100mg% during active labor. Women with very mild GDM may not require insulin
therapy but should have blood glucose assessment during labor.
When estimated fetal weight is above 4.5 kg, elective caesarean is planned to avoid
shoulder dystocia and birth trauma. In those where the EFW ranges between 4 to 4.5 kg,
other obstetric factors should be considered in decision making for caesarean
section.Uncontrolled diabetes & presence of end organ disease are other indications of
caesarean section.
Referral criteria:
For expert opinion regarding anomalies and paediatric surgery and for fetal
echocardiography.
When there is need for intensive neonatal care unit to manage problems in the
newborn.
70
b) Investigations: As described in situation I.Fetal echocardiography & periodic doppler
studiesif growth retardation present.
d) Referral Criteria: Even in a metro situation not all centers will be equipped with the
multiple specialists, skilled hands and facilities. The decision to refer to a better facility
should be taken if it warrants to give the best care to the mother and the newborn.
Visit Measures
Preconceptional/ -Offer information, advice and support in relation to
1st visit establishing glycaemic control& effects of diabetes on
pregnancy.
-Review medications for diabetes and its
complications.
-Folic acid supplementation.
-Take a clinical history to ascertain the extent of
diabetes-related complications.
-Offer retinal and renal assessment if these have not
been undertaken in the previous 12 months.
5-6 weeks -Confirm viability of pregnancy and gestational age.
-Establish glycaemic control
16 weeks Offer retinal assessment at 1620 weeks to women
with pre-existing diabetes who showed signs of
diabetic retinopathy at the first antenatal visit.
22-24 weeks Offer four-chamber view of the fetal heart and outflow
tracts plus scans that would be offered at 1820 weeks
as part of routine antenatal care.
28 weeks -Offer ultrasound monitoring of fetal growth and
amniotic fluid volume.
-Offer retinal assessment to women with pre-existing
diabetes who showed no diabetic retinopathy at their
first antenatal clinic visit.
71
32 weeks Offer ultrasound monitoring of fetal growth and
amniotic fluid volume.
72
CARCINOMA CERVIX
Introduction and Case definition:
Carcinoma cervix is the cancer affecting the cervix, which is the lowermost part of the uterus.
Cancer of cervix is a leading cause of mortality worldwide and especially in developing countries
Worldwide cancer cervix is the second most common cancer among women, next only to breast
cancer. But among Indian women, cancer cervix is the commonest cancer. Invasive cancer of
cervix is considered to be a preventable cancer as it is associated with a long pre-invasive state,
which is detectable and treatable to a large extent. Various risk factors for carcinoma cervix are
young age at first intercourse, multiple sexual partners, cigarette smoking, high parity and low
socio-economic status. Human papillomavirus infection has been postulated to be the
etiological factor for inducing dysplasia in the cervical epithelium. About 85% to 90% of cervical
cancers are squamous cell carcinomas, and the rest 1015% are adenocarcinomas.
Incidence in India:
Based on the data of the population based cancer registries, the estimated number of new
cancers during 2007 in India was 90,708.1 As per the same data, the age adjusted incidence rate
of cervical cancer in India per 100,000 persons varies from 12.3 25.4 in various parts of the
country.2
Prevention:
Detection of pre-malignant lesions by Pap smear testing and HPV-DNA testing followed by
appropriate management of the detected lesions forms the mainstay of prevention of
occurrence of invasive cervical cancer.
Differential diagnosis
-Fibroid polyp (especially when infected/ulcerated)
-Tuberculosis of cervix
-Cervical erosion
A .Clinical Diagnosis:
History:
-Asymptomatic in early stages
-Vaginal bleeding (postcoital/irregular/postmenopausal)
-Foul smelling, blood stained vaginal discharge
-Loss of weight/ appetite
-Difficulty in micturition (advanced stages)
Examination:
-Malnourished, emaciated appearance (advanced stages)
-Supraclavicular/groin lymphadenopathy (advanced stages)
-Per speculum examination: Ulcero-proliferative friable growth on cervix with or without vaginal
involvement. Cervix may bleed on touch.
73
Per vaginal examination: Expanded firm/friable irregular cervix
Recto-vaginal examination: Nodularity of parametria (parametrial extension of disease)
B .Investigations:
-CBC
-Blood grouping
-Cervical biopsy on out-patient basis at the time of speculum examination for confirmation of
diagnosis where obvious growth is visualized
-In cases where no obvious lesion is found on the cervix at the time of visual examination, apply
3% acetic acid on cervix and take biopsy from dense white areas, if seen.
-Colposcope guided biopsy to be done in cases where there is abnormality detected on Paps
smear and no obvious lesion on cervix. If facility of colposcopy is not available due to lack of
equipment or expertise, patient should be referred to a centre with these facilities are available.
-Endocervical curettage if there is suspicion of endocervical cancer.
-Cone biopsy may be done if required, but only after colposcopy.
-USG
-Contrast CT scan if required.
C.Treatment:
-Treatment of local infection with Tab. Ciprofloxacin 500mg BD X 5days & Tab. Metronidazole
400 mg TDS X 5days.
-Oral iron and other nutritional supplements for malnourished and anemic patients.
D.Referral criteria: All patients with carcinoma cervix should be referred to multi-specialty
hospital that is adequately resourced and equipped with facilities for oncological surgeries,
radiotherapy, chemotherapy and blood transfusion.
(* If a gynae-onco-surgeon is available along with anesthetist and blood bank facility, surgery for
carcinoma cervix stage Ia & Ib1 may be done in situation1. In such situations, if need for post-
operative radiotherapy arises, patient should be referred to situation 2 along with all records
including surgical records)
B. Investigations:
-CBC
-Blood grouping
-Cervical biopsy on out-patient basis at the time of speculum examination for confirmation of
diagnosis where obvious growth is visualized.
-Colposcopic examination and guided biopsy: in cases with abnormal Pap test results and no
obvious lesion on the cervix.
-Endocervical curettage during colposcopy to rule out endocervical carcinoma
-Cervical conization in indicated cases.
74
-KFT
-LFT
-Urine analysis
-Chest X-Ray
-IVP
-Other investigations: Ultrasonography, MRI or contrast CT scan Abdomen if MRI is not
possibleand pelvis may be useful in select cases for planning therapy.
- Cystoscopy / Barium enema / sigmoidoscopy- ifif imaging doesnt rule out involvementC.
Treatment: Treatment modality depends on the stage of disease, age of the patient, patients
desire, need for preservation of ovarian function, presence of co-morbidities, associated
gynecological conditions requiring surgery and availability of facilities and expertise.
Various modalities available are:
-Surgery: For stages I & II a
-Radiotherapy: For all stages
-Chemo-radiation: For patients with high-risk cervical carcinoma after radical hysterectomy and
in patients with locally advanced cervical carcinoma.
Surgery
Advantages:
-Conservation of ovaries
-Surgical injuries to bladder/ bowel are easier to treat compared to chronic bladder and
bowel problems resulting from radiation induced fibrosis and decreased vascularity.
Disadvantages:
-Not curative in advanced stages of carcinoma cervix
-Requires expertise
Surgical management depends on the stage, depth of invasion and lymph-vascular space
invasion.
Types of hysterectomies for carcinoma cervix:
Type II: Also called as modified radical/ Wertheims hysterectomy. Medial half of cardinal and
uterosacral ligaments are removed.
Type III: Also called as radical/ Meigs hysterectomy. Most of the utersacral and cardinal
ligaments along with upper third of vagina are removed.
Type IV: Extended radical hysterectomy. The periureteral tissue, superior vesical artery and up
to three-fourths of vagina are also removed.
Type V: Portions of distal ureters and bladder are also resected.
These days, type IV & type V hysterectomies are mostly not performed as patients with
advanced malignancy are usually given radiotherapy.
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- Bladder dysfunction
- Lypmhocyst formation (<5%)
Chronic complications:
- Hypotonic bladder
- Ureteral strictures
- Recurrent cancer
- Lymphocyst formation
Radiotherapy:
Advantages:
-Can be given in all the stages
-Cure rates equivalent to surgery in early stages
-Avoids surgical and anesthetic complications
Disadvantages:
-Induces radiation fibrosis of bowel and bladder in 6%-8%
-May result in intestinal and urinary strictures (1.4%-5.3%)
-Induces vaginal fibrosis and stenosis
-Premature menopause due to the affects of radiotherapy on ovaries.
Stage II: Carcinoma extending beyond the cervix but not up to lateral pelvic wall.
The carcinoma involves the vagina, but not the lower one-third.
Stage IIa: No obvious parametrial involvement- Type III hysterectomy with pelvic
lymphadenectomy and para-aortic lymph node evaluation.
Stages IIb to IVb: Concurrent Chemo-radiation (Cisplatin based chemotherapy) is the main stay
of treatment. Palliative treatment may be offered in advanced stage carcinoma cervix.
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Stage III: Carcinoma extending up to the lateral pelvic wall.
Carcinoma involves the lower one-third of vagina.
Hydronephrosis or non-functioning kidney.
Stage IV Carcinoma extended beyond the true pelvis or involved mucosa of the bladder or
rectum.
Stage IVa: Spread of the growth to adjacent organs
Stage IV b: Spread to distal organs
Recurrent Cervical cancer: For patients, who were primarily treated with surgery, should be
considered for radiotherapy and vice-versa.
Fertility sparing surgery;
Women requesting fertility conservation should be offered radical trachelectomy and pelvic
lymph node dissection providing the tumour diameter is less than 2 cm and no lymphatic
vascular space invasion is present.
Women with FIGO stage 1A2 and microscopic 1B1 may also be offered cold knife conisation or
large loop excision of transformation zone combined with pelvic LN dissection.
Laproscopic vaginal radical hysterectomy shd not beoffered to patientswith tumour diameter
greater than 2 cm
D. Referral criteria: In case of carcinoma cervix stage IIb or higher, it may be required to refer
the patient to a cancer centre having facility for radiotherapy, as the same may not be available
in all super-specialty hospitals.
References:
1. National Cancer Registry Programme (NCRP, ICMR). Time trends in cancer incidence rates:
1982-2005. Bangalore: NCRP; 2009.
2. A. Nandakumar, T. Ramnath & Meesha Chaturvedi. The magnitude of cancer cervix in
India.National Cancer Registry Programme (ICMR), Bangalore, India. Indian J Med Res 130,
September 2009, pp 219-221
Suggested Reading:
1. Novaks Gynaecology. Ed Berek JS. Fourteenth edition. 2006
2. Te Lindes Operative Gynaecology. Eds Rock J A, Jones III H W. Ninth edition 2003
77
ADNEXAL MASS
Introduction
The finding of an adnexal mass is a common clinical problem seen in women of all ages and
presents a diagnostic and therapeutic challenge. Some of these are diagnosed incidentally
during pelvic examination/radiographic imaging modalities. Primary goal of management is
differentiation of gynecological from non- gynecological, and benign from malignant masses.
Signs:
- General physical pallor, icterus, acne, hirsutism, lymphadenopathy
- Breast & Systemic examination
- Per abdomen Any visceromegaly, distended veins, ascites should be noted along with
assessment of the abdominal mass: size, shape, surface (irregular, nodular), mobility,
tenderness, and accessibility of lower limit. In case of adnexal mass its lower limit cannot
be defined (except in small cyst with long pedicle).
- Per-vaginum: Uterus felt separately from mass in fornices, which may be unilateral or
bilateral, may displace the uterus, movement of mass not transmitted to cervix; there
may be nodules in the POD in malignancy/ tuberculosis/ endometriosis. Presence of a
tense and tender adnexal mass, in a patient presenting as acute abdomen suggests
adnexal torsion, whereas unilateral tender mass with cervical excitation pain raises the
suspicion of ectopic pregnancy, and bilateral tenderness suggests PID.
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- Per Rectal examination to evaluate the rectal mucosa & uterosacral ligaments which may
show thickening or nodularity in endometriosis & ovarian malignancy.
Differential Diagnosis:
Gynecological
- Functional ovarian cyst: Follicular cyst, Corpus luteum cyst
- Inflammatory mass: Tuboovarian abscess, Hydrosalpinx
- Others: Ectopic pregnancy, endometrioma, parovarian cyst, degenerated/pedunculated
leiomyomata, mullerian anomaly
- Benign ovarian Tumors: Serous cystadenoma, Mucinous cystadenoma Mature teratoma,
- Malignant ovarian: Germ cell tumor, Sex-cord or stromal tumor, Epithelial carcinoma
Nongynecological
- Benign: Diverticular abscess, Appendiceal abscess or mucocele, Ureteral/bladder
diverticulum, Pelvic kidney, Paratubal cysts
- Malignant: Gastrointestinal cancers, Retroperitoneal sarcomas, Metastases
Investigations:
Hb, PCV, CBC & ESR; RFT, LFT
Urine pregnancy test
X-ray Chest, abdomen
USG abdomen & pelvis to study the characteristics of the mass such as volume, wall
thickness, septal structure, echogenicity, papillary excrescences, free fluid in abdomen.
Barium meal, enema, IVP (selected cases)
Upper GI endoscopy, colonoscopy (selected cases)
Tumour markers
CA125 - epithilial ovarian tumour, cutoff 35 U/ml
CEA - GI tract tumour
HCG - Chrio carcinoma
Inhibin - Granulosa cell tumour
LDH Dysgerminoma
CA 19-9- Mucinous ovarian neoplasms
Alpha feto proteins- Endodermal Sinus Tumors
Risk of Malignancy Index (RMI screens for suspected ovarian cancer
RMI = CA-125 X USG Points X Menopausal status. Cut off level: 200
- Menopausal status (Premenopausal score 1, Postmenopausal score 3)
- Ultrasound Points: Score 0=0 point, Score 1=1 point & score 2-5 =3 points.
(1 point each for multilocular nature, solid areas, bilaterality metastasis, ascites,)
Ascitic fluid cytology, FNAC of solid tumor has a questionable role
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Family history of breast or ovarian cancer in a first-degree relative
Nodular or fixed pelvic mass (>50 years/ postmenopausal)
* Situation 2: At Super Specialty Facility in Metro location where higher-end
technology is available
Investigations
Color Doppler if available may be used to study low resistance ovarian arterial flow;
however, it does not significantly improve diagnostic accuracy.
CT, MRI, PET may be done to evaluate the mass
TREATMENT
Treatment depends on the diagnosis made after investigations. Patients with suspected
malignancy should be referred to a higher center where facility for frozen section and
services of a Gynecologic Oncologist and Medical Oncologist are available.
T.O. mass:
Hydrosalphinx - usually asymptomatic. No intervention required.
Abscess pus is drained, antibiotics. Tuberculosis should be ruled out in our country.
Ectopic pregnancy:
Medical or surgical management as indicated (detailed in ectopic pregnancy chapter)
Endometrioma:
Usually do not resolve with observation and require Surgery
Small: Electrocoagulation/ laser vaporization
Big: Removal with removal of cyst wall to prevent recurrence
Parovarian Cyst:
No intervention is necessary, unless large or risk for torsion or uncertain diagnosis
Adnexal Torsion
In premenopausal patients on direct visualization if the ovary appears potentially viable, ovarian
conservation can be done following de-torsion; whereas in patients with a non-viable ovary,
suspected malignancy, or postmenopausal patients one should do salpingo-oophorectomy.
Ovarian cyst
Treatment of an adnexal mass is determined by age of pt & reproductive needs, morphology of
lesion on USG/ CT/ MRI, presence of risk factors (postmenopausal, family history of
ovarian/breast cancer, BRCA-1, 2 carriers, presence of ascites/ lymphadenopathy).
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2/3rd of these regress over 2-3 menstrual cycles. Therefore a Wait and See policy is
recommended for 8-10 wks. OCPs can be given for 3 cycles; however, there is no proven
benefit. Aspiration of simple cyst not useful as it reoccurs in 75% within 1 yr.
When one is almost certain regarding the benign nature of the cyst, a yearly follow up is
required, until resolved, for a simple cyst of 5-7 cm in low risk patients & 2-7 cm in high
risk patients; A cyst of >7cm needs further evaluation with MRI /Surgery
Special Situations:
1. Mass with borderline histology
In post menopausal woman TAH with BSO
If fertility to be preserved cystectomy
2. Young women Germ cell tumours
Do unilateral adnexectomy and staging
Radical surgery after finishing childbirth
3. Adnexal masses in pregnancy: mostly cystic, resolve
There is a risk of torsion and rupture
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16-18wks ideal time for surgery
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Caesarean Section
Caesarean section is a form of childbirth in which a surgical incision is made through a mothers
abdomen and uterus to deliver one or more babies. The commonest uterine incision is the
lower segment incision. It may be done electively or as an emergency procedure.
Clinical Diagnosis:
Common indications recognizable during the antenatal period that may require cesarean section
are malpresentations, antepartum haemorrhage, previous caesarean section or surgery on the
uterus, bad obstetric history, IUGR, induction of labour for pre eclampsia, gestational diabetes,
postdatism, premature rupture of membranes, fetal macrosomia, and cephalopelvic
disproportion.
Pre-operative Investigations:
Hb%, BT, CT, urine routine, blood grouping, cross matching and reservation of blood
Ultrasound for presentation, placental position, biophysical profile.
Pre-operative:
Informed Consent
Prepare abdomen, perineum and back
IV line to be established and bladder catherisation
Parenteral H2 blocker and antiemetic
IV antibiotic to be given before skin incision (Avoid co-amoxyclav)
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Operative details:
Abdominal incision could be transverse suprapubic or vertical.
The uterine incision is usually transverse in the lower segment, midline vertical
(Classical) may be indicated occasionally if lower segment is unapproachable due to
dense adhesions.
Baby is extracted, cord clamped, cut and baby handed over to the paediatrician. Cord
blood should be collected in Rh isoimmuniation cases. Placenta with entire membranes
removed by controlled cord traction. Oxytocics administered to contract the uterus and
prevent post patum haemorrhage. Uterus sutured with absorbable sutures to secure
haemostasis in two layers. No need of suturing the peritoneum. Uterus should not be
exteriorised routinely. Surgical mops and instrument count to be checked. Abdominal
wall closed in layers.
Post operative:
Vitals, urine output, and bleeding are monitored,
IV fluids, antibiotics and pain medication given,
DVT prophylaxis advised if indicated,
Oral feeds encouraged with return of bowel sounds after 8 hours.
Early breast feeding and ambulation encouraged.
Cases warranting immediate delivery to save the life of baby or mother should be dealt with. In
situations where skilled manpower and technology is not available, woman may to be referred
to higher institution.
Referral criteria: Situations warranting neonatal intensive care management facilities, need for
blood and blood component therapy, special anaesthesia services like epidural analgesia; For
the management of post operative complications of caesarean section like sepsis, secondary
haemorhage, wound dehiscence, acute renal failure etc where multidisciplinary input is
warranted need to be tackled at super-specialty level.
84
Resources required for one patient/procedure
85
Hypertension in pregnancy/Preeclampsia
Definition: -when high blood pressure is noted during pregnancy, it may be one of the
following:
Gestational Hypertension: new onset BP elevation of systolic >140mmHg/ diastolic
>90mmHg on 2 occasions 6 hrs apart after 20 wks gestation in a previously
normotensive woman
Preeclampsia - gestational hypertension and persistent proteinuria 1+ on dipstick
urine analysis or >300mg/24 hours occurring >20 weeks pregnancy in a previously
normotensive, non proteinuric woman. Oedema is not a defining sign of PE.
Eclampsia - Generalized convulsions occurring after the 20th week of pregnancy in
a patient with underlying pre-ecclampsia
Incidence: 2-8%
A higher incidence is seen in women with age > 40, nulliparity, family or prior pregnancy
h/o PIH, past h/o diabetes mellitus, chronic hypertension, renal disease,
antiphospholipid syndrome, and present pregnancy with multifetal gestation and
vesicular mole.
Complications
If not recognized and managed appropriately, preeclampsia can result in complications
such as eclampsia, hypertensive encephalopathy, pulmonary edema, liver
haematoma/rupture, renal failure, ARDS, HELLP syndrome, disseminated intravascular
coagulation, cortical blindness.
Prediction
In situation 1
Roll over test at 28 -30 wks: increased blood pressure of 20mmHg when patient rolls
over from lateral to supine position means a positive test. The test has a high negative
predictive value although the positive predictive value is low.
In situation 2
If the facility for colour doppler is available it can be performed at 24-26 weeks:
Persistence of diastolic notching in uterine artery after second trimester can be
predictive of preeclampsia.
Prevention
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Low dose Aspirin (50-100mg/d) may reduce the risk of PE by 15%. It can be started in
high risk at 20 weeks and has to be stopped at 34 weeks gestation.
Examination:
Complete general physical and systemic examination should be carried out
including record of maternal weight, BMI, pulse, B.P in all four limbs, and
testing of limb reflexes (presence of hyper-reflexia indicates impending
eclampsia).
Obstetric Examination:
Assess for presentation, fetal heart rate, estimated fetal weight, IUGR and
accidental hemorrhage in severe cases. Per-vaginal examination may be done if
patient is complaining of pain abdomen, or if termination of pregnancy is
decided.
Investigations:
CBC, hematocrit, platelets, P/S for haemolysis
Serum uric Acid, creatinine, blood urea
S. Bilirubin, SGOT, SGPT, LDH
Urine R/E, M/E, C&S*
Total urinary protein excretion on 24-hr specimen*
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Fundoscopy
Referral Criteria - All cases of severe PE and threatened eclampsia should be referred to
situation 2 following the initial management and stabilization, as the clinical course of
these patients is unpredictable and may necessitate maternal and fetal intensive care
and monitoring.
Maternal Assessment:
Blood pressure measurement: At least 4 times a day, more often in severe cases
Urine quantification (24 hour protein ) on admission, repeat not required
Blood tests: Monitor kidney function, electrolytes, full blood count,
transaminases, bilirubin twice a week in mild preeclapsia and thrice a week in
severe preeclampsia
Fetal Assessment:
The following tests should be carried out at diagnosis:
Cardiotocography
Ultrasound for fetal growth and amniotic fluid volume assessment
Umbilical artery doppler velocimetry.
If the results of all fetal monitoring are normal, cardiotocography need not be repeated
more than weekly unless if there is deterioration in maternal condition, vaginal
88
bleeding, abdominal pain, or reduced fetal movement. Repeat ultrasound for fetal
growth, amniotic fluid volume assessment or umbilical artery doppler velocimetry is also
not required more than every 2 weeks.
Antihypertensive Therapy:
It can be initiated if DBP >100mmHg. Lower threshold may be considered if disease has
arisen before 28 wks. Aim is to keep DBP between 80100 mmHg, and SBP less than
150 mmHg. In mild PE, it reduces the occurrence of severe hypertension, but there is no
benefit in terms of maternal & fetal outcome. In severe hypertension therapy is
mandatory to reduce the risk of CVA.
Tab. Methydopa -250- 500 mg 3-4 times /day.
Tab. Labetalol-100-200 mg 2-3 /day. .
Labetalol: IV regimen: 20 mg stat. If DBP>110 after 20 min, give 40mg; to 80
mg & then 80 mg to a total of 220mg. If no response, discuss with senior
physicians and anaesthetists.
Use of ACE inhibitors is contraindicated in pregnant woman
Nitroglycerine (NTG) drip may be useful in hypertensive crisis: Dose - 50mg in
500ml 5%dextrose, start at 10ml/h, by 5ml every 10-15 till SBP 140mmHg
Anticonvulsants
Consider giving intravenous magnesium sulphate to women with severe pre-eclampsia
who are in a critical care setting if birth is planned within 24 hours.
Termination of Pregnancy:
Mild to moderate PE: Terminate at 34+0 to 36+6 weeks depending on maternal and
fetal condition, risk factors and availability of neonatal intensive care.
Severe PE: Terminate at 34 weeks. Induction before 34 weeks may be indicated if:
severe hypertension develops refractory to treatment
maternal or fetal indications of worsening condition
Corticosteroid for Lung Maturity
Two doses of betamethasone 12 mg IM 24 hours apart are recommended between 24-
36 weeks.
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output in preceding hour plus 30 ml. Diuretics and CVP monitoring may be required if
pulmonary oedema is suspected.
Measure blood pressure, hourly in women with mild or moderate hypertension and
continually in women with severe hypertension. Continue use of antihypertensive
treatment during labour.
Do not routinely limit the duration of the second stage of labour in women with
stable mild or moderate hypertension or if blood pressure is controlled within target
ranges in women with severe hypertension. Operative birth is recommended in the
second stage of labour if severe hypertension has not responded to initial treatment
Use of Methergine is contraindicated for active management of 3 rd stage.
Ceasarean Section is indicated for severe IUGR/ primi remote from term with
unfavorable cervix, for fetal distress or other obstetric indications. Thrombo prophylaxis
to be considered in severe PIH.
Analgesia & Anesthesia Issues:
GA Risks: - Aspiration, laryngeal edema, difficult intubation, pulmonary edema/
arrythmias precipitated by pressor response to intubation, neuro-muscular
blockade effect of mag sulf.
Continuous lumbar epidural preferred method of pain relief as well as for
cesarean section provided there is no coagulopathy and platelet count
is > 50,000/cu mm.
Need adequate pre-hydration of 1000 cc, Level should be advanced slowly to
avoid low BP
Postpartum Care
Women with PE who did not require anti-hypertensives: Measure BP at least four
times a day while the woman is an inpatient, at least once between day 3 and day 5
after birth, and on alternate days thereafter until normal. Ask about severe headache
and epigastric pain each time blood pressure is measured. Start antihypertensive
treatment if blood pressure is 150/100 mmHg.
Women with PE who took antihypertensive treatment: Measure BP at least four times
a day while the woman is an inpatient and every 12 days for up to 2 weeks after
transfer to community care. Continue antenatal antihypertensive treatment, and reduce
it if BP falls below 130/80 mmHg. If a woman has taken methyldopa to treat pre-
eclampsia, stop within 2 days of birth, measure platelet count, transaminases and serum
creatinine 4872 hours after birth.
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All women who have had pre-eclampsia should have a medical review 68 weeks after
birth to detect those women who still need antihypertensive treatment. Women who
continue to have proteinuria (1+) a further review is required after 3 months to assess
kidney function. Specific investigations like aPLa, LAC and thrombophilia screen may be
needed.
Eclampsia
Generalized convulsions occurring after the 20th week of pregnancy with underlying
pre-eclampsia
Incidence
Antepartum 40%, Intrapartum 20%, Postpartum 40%. Although seizures may occur as
long as 3 weeks postpartum, majority of cases (98%) occur on the first day.
All cases of eclampsia are best managed at situation 2 or 3.
If a woman with eclampsia is seen at situation 1, she should be stabilized with Magsulph
and antihypertensives and transferred to higher centre only when stable and with full
life support system, to limit maternal and fetal morbidity.
Immediate care is needed with airway support, adequate oxygenation, anticonvulsant
therapy, and BP control. Delivery of neonate is the only definitive treatment, with
Intensive postpartum care.
General Measures:
Do not leave patient alone
Call for help and inform consultants - obstetrician & anesthetist on call
Prevent maternal injury: Place in semi-prone position, guardrails on the bed,
padded tongue blade b/w teeth.
Airway: Maintain patency, start oxygen inhalation, suction of mouth secretions.
Breathing: Assess, Ventilate as required.
Circulation: Left lateral tilt, If pulse, BP absent, initiate CPR, call ICU
After the seizure has ended, a 16- to 18-gauge IV line should be obtained for
drawing specimens for laboratory studies and administering fluids
Attach ECG, automatic BP monitors, pulse oximeter
Indwelling Urinary catheter - Fluid input / output chart
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MgSO4 (50% solution) + 1ml Lidocaine 2% given IM every 4 hrs into alternate
buttock
Magnesium Toxicity:
If urine output < 100 ml in 4 hours withhold Magsulph and review overall
management with attention to fluid balance and blood loss
Absent patellar reflexes: Stop MgSO4 infusion until reflexes return
Respiratory depression: Stop MgSO4 infusion, Give oxygen via facemask
and place in recovery position and Monitor closely
Respiratory arrest:
Stop MgSO4 infusion, Give Calcium gluconate (10 ml slow IV), Intubate and
ventilate.
Cardiac arrest:
Commence CPR, Stop MgSO4 infusion, Give IV Calcium gluconate*, Intubate and
ventilate; If antenatal, immediate delivery
Treatment of Hypertension :
92
Reduction of severe hypertension is mandatory to reduce the risk of CVA &
further seizures.
Insufficient evidence to recommend one antihypertensive in preference to
another and so the choice of which drug to use should depend on personal
preference and availability.
Labetalol (20mg IV to 40 and 80mg every 20 to max. 220mg)
It may precipitate fetal distress, thereby necessitates continuous fetal heart rate
monitoring.
NTG drip (5g/m iv infusion, to max 100g/m)
Fluid therapy:
Close monitoring of fluid intake and urine output is mandatory. Fluid therapy
should be limited to maintenance crystalloid (85ml/h or urine output in
preceding hour plus 30ml) to avoid tissue overload, pulmonary edema & ARDS.
Colloids remain in vascular tree and unless used carefully can cause circulatory
overload.
Antibiotics:
Inj. Ampiciliin 500 mg x 6hrly IV to prevent infection
Associated Complications:
HELLP syndrome (3%), Disseminated intravascular coagulation (3%), renal failure (4%),
ARDS (3%)
Differential Diagnosis -
Cerebral tumors, Cerebral venous thrombosis, Intracranial hemorrhage
Drug overdoses, Electrolyte imbalance
Epilepsy, head trauma, Stroke (ischemic/ non-ischemic)
Monitoring:
Record BP every 10 minutes. Reduce DBP to 90-100 mm Hg with
antihypertensive medication
Auscultate lungs for aspiration after convulsion ended
Monitor the neurologic status, urine output, respirations, and fetal status
Laboratory workup:
CBC, RFT, LFT, Electrolytes, Glucose, PLT, Coagulation profile
Urinalysis for proteinuria
Blood gases & Invasive PCWP monitoring may be necessary for accurate fluid
management in patients with pulmonary edema or anuria
USG abdomen may be used to rule out abruptio placentae
CT scan/ MRI if focal neurological deficits or prolonged coma
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Delivery :
The definitive treatment of eclampsia is delivery.
Attempts to prolong pregnancy in order to improve fetal maturity are unlikely to
be of value.
However, it is inappropriate to deliver an unstable mother even if there is fetal
distress.
Once seizures are controlled, severe hypertension treated, and hypoxia
corrected, delivery can be expedited.
Vaginal delivery should be considered but caesarean section is likely to be
required in primigravidae remote from term with an unfavourable cervix/
deteriorating maternal or fetal condition
After delivery, high dependency care should be continued for a minimum of 24
hours.
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PELVIC ORGAN PROLAPSE
INTRODUCTION
Genital prolapse is a common gynecological operative problem. It can occur at any age,
but is more common in multipara as a result of injury to pelvic floor muscles and fascia
during childbirth and age related estrogen deficiency in postmenopausal women. In
young age and nulliparous women it may be related to collagen deficiency or congenital
elongation of cervix.
DEFINITION:
Pelvic organ prolapse is the downward displacement of one of the pelvic organs from its
normal location. All forms of prolapse are described in relation to the vagina:
WHEN TO SUSPECT/RECOGNISE:
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- Difficulty in emptying rectum, tenesmus, splinting
- Incomplete evacuation of the faeces
- Fecal Incontinence
Sexual Function/ dyspareunia
Vaginal discharge - leucorrhoea, blood stained discharge
Systemic symptoms of precipitating diseases such as chronic bronchitis, asthma,
constipation, abdominal mass, ascites etc. should be asked for.
Abdominal examination
mass per abdomen/free fluid, organomegaly, hernial sites
Local examination
Patient should be asked to hold urine to demonstrate SUI, and examination can
be made in dorsal lithotomy/standing position depending upon the prolapse
severity
Perineum: scar/s, introital laxity
Prolapsed part: location, ulceration, growth, pigmentation, keratinization,
Rugosities, sulci
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Tone of levator ani and Integrity of perineal body is noted
Occult SUI observed if any
Rectovaginal examination
Help differentiate between enterocele and rectocele
DIFFERENTIAL DIAGNOSIS
DIAGNOSIS
- Diagnosis is clinical, confirmed by P/S, P/V, and rectovaginal examination.
INVESTIGATIONS
Routine Investigations
1. CBC, blood grouping and RH typing
2. FBS, PPBS
3. Blood urea, serum creatinine
4. ECG, chest X-ray
5. Urine- R/M and C/S
Special Investigations
1. USG of abdomen and pelvis to rule out associated pelvic pathology and renal
problems due to pressure effect on ureter
2. Papanicolou smear
3. Endometrial aspiration and ECC (if abnormal uterine bleeding)
4. Cervical or ulcer biopsy is done when malignancy is suspected
5. IVP where kinking of ureter is suspected in long standing cases and residual
volume of urine is more than 100 ml
TREATMENT APPROACH
1. Non-surgical Management
a. Physiotherapy
b. Vaginal Pessaries
2. Surgical
PHYSIOTHERAPY
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PFMT (Pelvic Floor Muscle Training) - Kegels exercise Patient is taught to
voluntarily contract the levator ani muscle and external anal sphincters and hold
for 5 seconds each, 15-20 times per session, three sessions a day.
Vaginal cones of successively increasing weights 20 to 100 gms can be used to
hold inside for 15 minutess.
PESSARY TREATMENT
SURGERY
Indications of Surgery
1. Vaginal tampoons to reduce the prolapse and replace the organ back. It helps to
prevent kinking of ureter and congestion of organs and increase the blood flow.
2. Estrogens (oral/local) if atrophic vagina
3. Correction of anemia if present
4. Treatment of UTI if present
5. Treat diabetes and hypertension if present
6. Treat other systemic infection if present
7. Enema (bowel evacuation night before surgery)
8. Prophylactic antibiotics
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Factors determining the choice of surgery
Surgical Options
REFERRAL CRITERIA
Patients with following high risk factors should be referred to higher centers:
1. Previous history of pelvic surgery
2. Presence of urinary or fecal incontinence
3. Presence of urethral hypermobility
4. Presence of pelvic floor neuropathy
5. Co morbid medical conditions
99
SITUATUON 2 (Metro situations where advance technology is available)
DIAGNOSIS
However, a Pelvic Organ Prolapse Quantification (POPQ) system can be used to quantify
prolapse to have a uniform internationally used terminology. This system quantifies
prolapsed based on the topographic position of six defined vaginal points: 2 anterior, 2
apical & 2 posterior with measurements of Genital Hiatus (GH), Perineal Body (PB), and
Total Vaginal Length (TVL). It is a useful tool to enhance communication among
clinicians/ researchers, to follow objectively changes in an individual patient over time,
and to assess the success and durability of various surgical and non-surgical treatments.
INVESTIGATION
100
single fibre electromyography, if available, for identification of discrete fascial defects to
plan appropriate surgical strategy.
TREATMENT
101