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    Clog P Dengan Aktivitas (Log 1/IC) : Regression

    Uploaded by

    Nusaibah Romadhoni
    1. The document describes regression analyses conducted to evaluate relationships between various molecular descriptors and biological activity. 2. ClogP, tPSa, and pKa were individually evaluated as predictors of log1/IC50, with pKa showing the strongest correlation. 3. When both ClogP and ClogP2 were included as predictors, the multiple regression model was not statistically significant.

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    Clog P Dengan Aktivitas (Log 1/IC) : Regression

    Uploaded by

    Nusaibah Romadhoni
    31 views6 pages
    1. The document describes regression analyses conducted to evaluate relationships between various molecular descriptors and biological activity. 2. ClogP, tPSa, and pKa were individually evaluated as predictors of log1/IC50, with pKa showing the strongest correlation. 3. When both ClogP and ClogP2 were included as predictors, the multiple regression model was not statistically significant.

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    KJIUGI

    Original Title

    HKSA AKTIVITAS

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    1. The document describes regression analyses conducted to evaluate relationships between various molecular descriptors and biological activity. 2. ClogP, tPSa, and pKa were individually evaluated as predictors of log1/IC50, with pKa showing the strongest correlation. 3. When both ClogP and ClogP2 were included as predictors, the multiple regression model was not statistically significant.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    31 views6 pages

    Clog P Dengan Aktivitas (Log 1/IC) : Regression

    Uploaded by

    Nusaibah Romadhoni
    1. The document describes regression analyses conducted to evaluate relationships between various molecular descriptors and biological activity. 2. ClogP, tPSa, and pKa were individually evaluated as predictors of log1/IC50, with pKa showing the strongest correlation. 3. When both ClogP and ClogP2 were included as predictors, the multiple regression model was not statistically significant.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 6

    Clog P dengan Aktivitas ( Log 1/IC50)

    Regression

    Variables Entered/Removeda

    Variables Variables
    Model Entered Removed Method

    1 ClogPb . Enter

    a. Dependent Variable: log1IC50


    b. All requested variables entered.

    Model Summary

    Adjusted R Std. Error of the


    Model R R Square Square Estimate

    1 ,314a ,098 -,014 ,49515

    a. Predictors: (Constant), ClogP

    ANOVAa

    Model Sum of Squares df Mean Square F Sig.

    1 Regression ,214 1 ,214 ,873 ,377b

    Residual 1,961 8 ,245


    Total 2,175 9

    a. Dependent Variable: log1IC50


    b. Predictors: (Constant), ClogP

    Coefficientsa

    Standardized
    Unstandardized Coefficients Coefficients

    Model B Std. Error Beta t Sig.

    1 (Constant) -1,027 ,269 -3,815 ,005

    ClogP -,071 ,076 -,314 -,935 ,377

    a. Dependent Variable: log1IC50


    tPSa dengan Aktivitas ( Log 1/IC50)

    Regression

    Variables Entered/Removeda

    Variables Variables
    Model Entered Removed Method

    1 tPSab . Enter

    a. Dependent Variable: log1IC50


    b. All requested variables entered.

    Model Summary

    Adjusted R Std. Error of the


    Model R R Square Square Estimate

    1 ,531a ,282 ,192 ,44192

    a. Predictors: (Constant), tPSa

    ANOVAa

    Model Sum of Squares df Mean Square F Sig.

    1 Regression ,613 1 ,613 3,139 ,114b

    Residual 1,562 8 ,195


    Total 2,175 9

    a. Dependent Variable: log1IC50


    b. Predictors: (Constant), tPSa

    Coefficientsa

    Standardized
    Unstandardized Coefficients Coefficients

    Model B Std. Error Beta t Sig.

    1 (Constant) -2,010 ,461 -4,361 ,002

    tPSa ,010 ,006 ,531 1,772 ,114

    a. Dependent Variable: log1IC50


    pKa dengan Aktivitas ( Log 1/IC50)

    Regression

    Variables Entered/Removeda

    Variables Variables
    Model Entered Removed Method

    1 pKab . Enter

    a. Dependent Variable: log1IC50


    b. All requested variables entered.

    Model Summary

    Adjusted R Std. Error of the


    Model R R Square Square Estimate

    1 ,771a ,595 ,544 ,33195

    a. Predictors: (Constant), pKa

    ANOVAa

    Model Sum of Squares df Mean Square F Sig.

    1 Regression 1,294 1 1,294 11,743 ,009b

    Residual ,882 8 ,110


    Total 2,175 9

    a. Dependent Variable: log1IC50


    b. Predictors: (Constant), pKa

    Coefficientsa

    Standardized
    Unstandardized Coefficients Coefficients

    Model B Std. Error Beta t Sig.

    1 (Constant) -10,687 2,761 -3,870 ,005

    pKa ,666 ,194 ,771 3,427 ,009

    a. Dependent Variable: log1IC50


    Etotal dengan Aktivitas ( Log 1/IC50)

    Regression

    Variables Entered/Removeda

    Variables Variables
    Model Entered Removed Method

    1 Etotalb . Enter

    a. Dependent Variable: log1IC50


    b. All requested variables entered.

    Model Summary

    Adjusted R Std. Error of the


    Model R R Square Square Estimate

    1 ,404a ,164 ,059 ,47692

    a. Predictors: (Constant), Etotal

    ANOVAa

    Model Sum of Squares df Mean Square F Sig.

    1 Regression ,356 1 ,356 1,565 ,246b

    Residual 1,820 8 ,227


    Total 2,175 9

    a. Dependent Variable: log1IC50


    b. Predictors: (Constant), Etotal

    Coefficientsa

    Standardized
    Unstandardized Coefficients Coefficients

    Model B Std. Error Beta t Sig.

    1 (Constant) -,838 ,349 -2,399 ,043

    Etotal -,014 ,011 -,404 -1,251 ,246

    a. Dependent Variable: log1IC50


    BM dengan Aktivitas ( Log 1/IC50)

    Regression

    Variables Entered/Removeda

    Variables Variables
    Model Entered Removed Method

    1 BMb . Enter

    a. Dependent Variable: log1IC50


    b. All requested variables entered.

    Model Summary

    Adjusted R Std. Error of the


    Model R R Square Square Estimate

    1 ,061a ,004 -,121 ,52049

    a. Predictors: (Constant), BM

    ANOVAa

    Model Sum of Squares df Mean Square F Sig.

    1 Regression ,008 1 ,008 ,030 ,866b

    Residual 2,167 8 ,271


    Total 2,175 9

    a. Dependent Variable: log1IC50


    b. Predictors: (Constant), BM

    Coefficientsa

    Standardized
    Unstandardized Coefficients Coefficients

    Model B Std. Error Beta t Sig.

    1 (Constant) -1,399 ,974 -1,437 ,189

    BM ,000 ,003 ,061 ,174 ,866

    a. Dependent Variable: log1IC50


    Regression

    Variables Entered/Removeda

    Variables Variables
    Model Entered Removed Method

    1 ClogP2, ClogPb . Enter

    a. Dependent Variable: log1IC50


    b. All requested variables entered.

    Model Summary

    Adjusted R Std. Error of the


    Model R R Square Square Estimate

    1 ,369a ,136 -,111 ,5181437

    a. Predictors: (Constant), ClogP2, ClogP

    ANOVAa

    Model Sum of Squares df Mean Square F Sig.

    1 Regression ,296 2 ,148 ,552 ,599b

    Residual 1,879 7 ,268

    Total 2,175 9

    a. Dependent Variable: log1IC50


    b. Predictors: (Constant), ClogP2, ClogP

    Coefficientsa

    Standardized
    Unstandardized Coefficients Coefficients

    Model B Std. Error Beta t Sig.

    1 (Constant) -,922 ,340 -2,707 ,030

    ClogP -,183 ,216 -,802 -,844 ,427

    ClogP2 ,017 ,031 ,526 ,553 ,598

    a. Dependent Variable: log1IC50

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