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Under License of Creative Commons Attribution 3.0 License | This article is available from: http://pediatric-infectious-disease.imedpub.com/ 1
Pediatric Infectious Diseases: Open Access 2017
Vol.2 No.1:38
IAV Infection Stimulates Interferon stimulated-regulatory elements (ISREs) to induce the expression
of many IFN-/ inducible genes [20]. IFNs production, from
Signalling Pathway host cell, is stimulated via several virus infection, some stress
condition and endotoxin exposure resulted in enhancement of
the cell response by activation of Jun N-terminal kinasee (JNK)
and termed stress-activated protein kinasee (SAPK) [21]. Such
events theoretically up-regulates the activity of transcription
factor of AP-1 family.
Working on viral infection in Dr. Khalil Laboratory is financially 16. Ludwig S, Wang XY, Ehrhardt C, Zheng HY, Donelan N, et al. (2002)
The influenza A virus NS1 protein inhibits activation of jun N-
support by Science and Technology Development Fund (STDF),
terminal kinase and AP-1 transcription factors. Journal of Virology
Egypt. Through project ID: 4694. 76: 11166-11171.
17. Lu Y, Qian XY, Krug RM (1994) The Influenza-Virus Ns1 Protein - A
References Novel Inhibitor of Pre-Messenger-Rna Splicing. Genes Dev 8:
1817-1828.
1. Gatherer D (2009) The 2009 H1N1 influenza outbreak in its
historical context. J Clin Virol 45: 174-178. 18. Lin DZ, Lan JF, Zhang ZZ (2007) Structure and function of the NS1
protein of influenza A virus. Acta Biochimica et Biophysica Sinica
2. Neumann G, Brownlee GG, Fodor E, Kawaoka Y (2004)
39: 155-162.
Orthomyxovirus replication, transcription, and polyadenylation.
Biology of Negative Strand Rna Viruses: the Power of Reverse 19. Pichlmair A, Schulz O, Tan CP, Naslund TI, Liljestrom P, et al. (2006)
Genetics. Curr Top Microbiol Immunol 283: 121-143. RIG-I-mediated antiviral responses to single-stranded RNA bearing
5 '-phosphates. Science 314: 997-1001.
3. Ghedin E, Sengamalay NA, Shumway M, Zaborsky J, Feldblyum T,
et al. (2005). Large-scale sequencing of human influenza reveals 20. Sadler AJ, Williams BRG (2008) Interferon-inducible antiviral
the dynamic nature of viral genome evolution. Nature 437: effectors. Nature Reviews Immunology 8: 559-568.
1162-1166.
21. Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, et al.
4. Van Bressem MF, Van Waerebeek K, Raga JA (1999) A review of (2008) TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like
virus infections of cetaceans and the potential impact of Helicase Antiviral Pathway. J Biol Chem 283: 36211-36220.
morbilliviruses, poxviruses and papillomaviruses on host
population dynamics. Dis Aquat Organ 38: 53-65.
22. Prentice E, Jerome WG, Yoshimori T, Mizushima N, Denison MR
(2004) Coronavirus replication complex formation utilizes
5. Hsiang TY, Zhao C, Krug RM (2009) Interferon-Induced ISG15 components of cellular autophagy. J Biol Chem 279: 10136-10141.
Conjugation Inhibits Influenza A Virus Gene Expression and
Replication in Human Cells. J Virol 83: 5971-5977.
23. Fujita M, Sugama S, Nakai M, Takenouchi T, Wei JS, et al. (2007)
alpha-synuclein stimulates differentiation of osteosarcoma cells -
Relevance to down-regulation of proteasome activity. J Biol Chem 32. Nakashima A, Tanaka N, Tamai K, Kyuuma M, IshikawaY, et al.
282: 5736-5748. (2006) Survival of parvovirus B19-infected cells by cellular
autophagy. Virology 349: 254-263.
24. Ozpolat B, Akar U, Mehta K, Lopez-Berestein G (2007) PKC delta
and tissue transglutarninase in pancreatic cancer cells are novel 33. Zhou Z, Jiang XJ, Liu D, Fan Z, Hu XD, et al. (2009) Autophagy is
inhibitors of autophagy. Autophagy 3: 480-483. involved in influenza A virus replication. Autophagy 5: 321-328.
25. Zhirnov OP, Klenk HD (2007) Control of apoptosis in influenza 34. Khalil H (2012) Influenza A virus stimulates autophagy to
virus-infected cells by up-regulation of Akt and p53 signaling. undermine host cell IFN- production. Egyptian Journal of
Apoptosis 12: 1419-1432. Biochemistry & Molecular Biology 30: 283-299.
26. Yen WL, Klionsky DJ (2007) Atg27 is a second transmembrane 35. Takeshita F, Kobiyama K, Miyawaki A, Jounai N, Okuda K (2008)
cycling protein. Autophagy 3: 254-256. The non-canonical role of Atg family members as suppressors of
innate antiviral immune signaling. Autophagy 4: 67-69.
27. Tazi MF, Dakhlallah DA, Caution K, Gerber MM, Chang SW, et al.
(2016) Elevated Mirc1/Mir17-92 cluster expression negatively 36. Tal MC, Iwasaki A (2009) Autophagic control of RLR signaling.
regulates autophagy and CFTR (cystic fibrosis transmembrane Autophagy 5: 749-750.
conductance regulator) function in CF macrophages. Autophagy
12: 2026-2037.
37. Tal MC, Sasai M, Lee HK, Yordy B, Shadel GS, et al. (2009) Absence
of autophagy results in reactive oxygen species-dependent
28. Legakis JE, Yen WL, Klionsky DJ (2007) A cycling protein complex amplification of RLR signaling. Proc Natl Acad Sci USA 106:
required for selective autophagy. Autophagy 3: 422-432. 2770-2775.
29. Birmingham CL, Higgins DE, Brumell JH (2008) Avoiding death by 38. Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, et al. (2002)
autophagy. Autophagy 4: 368-371. Caspase cascades in human immunodeficiency virus-associated
neurodegeneration. J Neurosci 22: 4015-4024.
30. Ogawa M, Yoshimori T, Suzuki T, Sagara H, Mizushima N, et al.
(2005) Escape of intracellular Shigella from autophagy. Science 39. Gunnage M, Munz C (2009) Matrix protein 2 of influenza a virus
307: 727-731. blocks autophagosome fusion with lysosomes. Autophagy 5: 907.
31. Taylor MP, Kirkegaard K (2008) Potential subversion of 40. Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, et al. (2009)
autophagosomal pathway by picornaviruses. Autophagy 4: Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally
286-289. regulate autophagy at different stages. Nat Cell Biol 11: 385-96.