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    MNMMHJJH

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    Jill Hill
    This document discusses syphilis and gonorrhea. It lists some problems with diagnostic tests for syphilis including false positives. It outlines treatments for syphilis including penicillin and erythromycin which can cause Jarisch-Herxheimer reactions. It also describes Nisseria gonorrhea as a non-motile, gram-negative diplococcus and lists several virulence factors such as a capsule, pili, IgA protease, LPS, and outer membrane proteins. It then outlines the pathogenesis of gonorrhea including how it sticks to and is endocytosed by host cells, causes inflammation and destruction of cells, and resists antibodies by attaching to endothelial cells.

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    MNMMHJJH

    Uploaded by

    Jill Hill
    38 views1 page
    This document discusses syphilis and gonorrhea. It lists some problems with diagnostic tests for syphilis including false positives. It outlines treatments for syphilis including penicillin and erythromycin which can cause Jarisch-Herxheimer reactions. It also describes Nisseria gonorrhea as a non-motile, gram-negative diplococcus and lists several virulence factors such as a capsule, pili, IgA protease, LPS, and outer membrane proteins. It then outlines the pathogenesis of gonorrhea including how it sticks to and is endocytosed by host cells, causes inflammation and destruction of cells, and resists antibodies by attaching to endothelial cells.

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    This document discusses syphilis and gonorrhea. It lists some problems with diagnostic tests for syphilis including false positives. It outlines treatments for syphilis including penicillin and erythromycin which can cause Jarisch-Herxheimer reactions. It also describes Nisseria gonorrhea as a non-motile, gram-negative diplococcus and lists several virulence factors such as a capsule, pili, IgA protease, LPS, and outer membrane proteins. It then outlines the pathogenesis of gonorrhea including how it sticks to and is endocytosed by host cells, causes inflammation and destruction of cells, and resists antibodies by attaching to endothelial cells.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    38 views1 page

    MNMMHJJH

    Uploaded by

    Jill Hill
    This document discusses syphilis and gonorrhea. It lists some problems with diagnostic tests for syphilis including false positives. It outlines treatments for syphilis including penicillin and erythromycin which can cause Jarisch-Herxheimer reactions. It also describes Nisseria gonorrhea as a non-motile, gram-negative diplococcus and lists several virulence factors such as a capsule, pili, IgA protease, LPS, and outer membrane proteins. It then outlines the pathogenesis of gonorrhea including how it sticks to and is endocytosed by host cells, causes inflammation and destruction of cells, and resists antibodies by attaching to endothelial cells.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 1

    Omg come onnnnn

    Problems:
    False-Positive: VDRL after strong immunological stimulus
    FTA-ABS other spirochetes
    Treatment:
    Penicillin
    Alternative erythromycin ()
    Jarisch-Herxheimer reaction

    Nisseria gonorrhea non-motile, gram (-) diplococcus; kidney-bean shaped


    ()
    Virulence Factors:
    1. Capsule anti-phagocytic
    2. Pili adherence; transfer of DNA
    3. IgA protease evade sIgA
    4. LPS release of endotoxin induces inflammations
    5. Outer membrane proteins adhesions

    Pathogenesis
    Nisseria stick to mucous secreting but non ciliated ()
    Endocytosis directed by porins ()
    Massive inflammation
    Destruction of ciliated and non-ciliated host cells
    Organism resist killing Ab
    Attachment to endothelial cells ()

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