Scribd Logo
Upload

Welcome to Scribd!

  • 664 views

    Pathophysiology of Diabetic Ketoacidosis

    Uploaded by

    Helcon John Dela Torre
    Diabetic ketoacidosis is a life-threatening complication that can occur in people with diabetes when there is no insulin present to allow cells to use glucose for energy. Without insulin, the body breaks down fat which produces ketones, leading to hyperglycemia, ketosis, and acidosis. It primarily affects those with type 1 diabetes but can also occur in type 2 diabetes during conditions like infection. The absence of insulin causes the body to undergo starvation metabolism even when glucose is available in the bloodstream. This activates pathways that increase ketone and glucose levels in an attempt to produce energy without insulin's help. Ketones are acidic and can lead to metabolic acidosis if not treated.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    Pathophysiology of Diabetic Ketoacidosis

    Uploaded by

    Helcon John Dela Torre
    664 views2 pages
    Diabetic ketoacidosis is a life-threatening complication that can occur in people with diabetes when there is no insulin present to allow cells to use glucose for energy. Without insulin, the body breaks down fat which produces ketones, leading to hyperglycemia, ketosis, and acidosis. It primarily affects those with type 1 diabetes but can also occur in type 2 diabetes during conditions like infection. The absence of insulin causes the body to undergo starvation metabolism even when glucose is available in the bloodstream. This activates pathways that increase ketone and glucose levels in an attempt to produce energy without insulin's help. Ketones are acidic and can lead to metabolic acidosis if not treated.

    Original Description:

    pathophysio of DKA due to low insulin.

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Diabetic ketoacidosis is a life-threatening complication that can occur in people with diabetes when there is no insulin present to allow cells to use glucose for energy. Without insulin, the body breaks down fat which produces ketones, leading to hyperglycemia, ketosis, and acidosis. It primarily affects those with type 1 diabetes but can also occur in type 2 diabetes during conditions like infection. The absence of insulin causes the body to undergo starvation metabolism even when glucose is available in the bloodstream. This activates pathways that increase ketone and glucose levels in an attempt to produce energy without insulin's help. Ketones are acidic and can lead to metabolic acidosis if not treated.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    664 views2 pages

    Pathophysiology of Diabetic Ketoacidosis

    Uploaded by

    Helcon John Dela Torre
    Diabetic ketoacidosis is a life-threatening complication that can occur in people with diabetes when there is no insulin present to allow cells to use glucose for energy. Without insulin, the body breaks down fat which produces ketones, leading to hyperglycemia, ketosis, and acidosis. It primarily affects those with type 1 diabetes but can also occur in type 2 diabetes during conditions like infection. The absence of insulin causes the body to undergo starvation metabolism even when glucose is available in the bloodstream. This activates pathways that increase ketone and glucose levels in an attempt to produce energy without insulin's help. Ketones are acidic and can lead to metabolic acidosis if not treated.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    Pathophysiology of Diabetic Ketoacidosis

    Diabetic Ketoacidosis(DKA) is a complication of diabetes mellitus that is life-


    threatening, if not treated. It is due to the breakdown of fats which turn into ketones
    because there is no insulin present in the body to take glucose into the cell.
    Therefore, you will see hyperglycemia, ketosis, and acidosis.
    DKA primarily occurs in Type I diabetes(DM) due to the absence of insulin.
    However, it will manifest on Type II DM due to conditions such as septicemia. Insulin
    plays a vital role in the regulation of blood glucose and fatty acid metabolism. In
    normal conditions, insulin facilitates the transport of glucose into the cell.
    Conversely, it will also inhibit fatty acid metabolism inside the cell. In DKA, the body
    is experiencing starvation metabolism. Where the cells are starving from glucose to
    form energy due to the absence of insulin. Glucose is present in excessive amount
    in the blood, however the body is not able to utilize it and reacts as if it is starving.
    The body sends signals into the brain to activate emergency pathways to produce
    glucose. Processes such as Proteolysis, Glycogenolysis, Ketogenesis,
    Gluconeogenesis, and Lipolysis are commenced. The end product of this pathways
    will increase both the ketone and glucose in the bloodstream.
    Ketone bodies are considered acids thus predisposing the body to Metabolic
    acidosis. The body tends to compensate on this condition so the kidneys increase in
    ketone excretion and the lungs compensate by getting rid of the excess Carbon
    dioxide. Anion gap acidosis will cause the potassium ions to leave inside the cells
    due the proton-potassium exchange mechanism. Despite the hyperkalemia, the
    body has total depletion of potassium intracellularly.
    G

    You might also like