0514 Acute Otitis Media
0514 Acute Otitis Media
0514 Acute Otitis Media
A
PAGE 2| Introduction To The
Guidelines: Acute Otitis
Media
May/June 2014
Volume 6, Number 3
Author
Kimberly Kahne, MD
Editor-In-Chief
Sigrid Hahn, MD, MPH
Editorial Board
Luke K. Hermann, MD
Emergency Ultrasound Director, Hutt Valley Hospital, Lower Hutt, New Zealand
Scott M. Silvers, MD
o create this guideline, the AAP and AAFP partnered with the
Agency for Healthcare Research and Quality and the Southern
California Evidence-Based Practice Center. Using an evidence
report created by these agencies, a multidisciplinary writing committee used BRIDGE-Wiz (Building Recommendations in a Developers
Guideline Editor) software to aid in crafting action-oriented recommendations and in determining the strength of the evidence. The relationship between the strength of the evidence and the recommendation is
shown in Table 1.
Age
Otorrhea with
AOM*
Unilateral or
Bilateral AOM*
bilateral AOM* without otorwith severe
rhea
symptoms
6 mo 2y
Antibiotic
therapy
Antibiotic
therapy
2y
Antibiotic
therapy
Antibiotic
therapy
Antibiotic therapy
or additional
observation
*Applies only to children with well-documented AOM with high certainty of diagnosis.
A toxic-appearing child, persistent otalgia more than 48 h, temperature 39C (102.2F) in the
This plan of initial management provides an opportunity for shared decision-making with the
childs family for those categories appropriate for additional observation. If observation is offered,
a mechanism must be in place to ensure follow-up and the initiation of antibiotics if the child worsens or fails to improve within 48 to 72 h of AOM onset.
Abbreviation: AOM, acute otitis media.
Reproduced with permission from Pediatrics, Vol. 131, page e976, Copyright 2013 by the AAP.
These recommendations contrast with the 2004 guideline, which recommended antibiotic therapy for all children aged 6 months to 2 years
with a certain" diagnosis. Evidence has supported the safety of observation or delayed antibiotic usage in young children and is an appropriate management option when there is shared decision-making with the
parent.
There have been no changes to the recommendation for first-line antibiotic choice since the 2004 guideline, despite new data on the effects
of 7-valent pneumococcal conjugate vaccine (PCV7, Prevnar) and
the awareness of an increase in multidrug-resistant strains of pneumococci. High-dose amoxicillin (80-90 mg/kg per day in 2 divided doses)
yields middle ear fluid levels that exceed the minimum inhibitory
concentrations of all intermediate (and many highly resistant) strains of
Streptococcus pneumoniae. The 3 most common bacterial pathogens
in AOM remain S pneumoniae, nontypeable Haemophilus influenzae, and Moraxella catarrhalis. Since the introduction of PCV7, there
has been a shift towards H influenzae and non-PCV7 serotypes of S
pneumoniae. The antibiotic susceptibility pattern for S pneumoniae is
expected to continue to evolve with the use of 7-valent pneumococcal
conjugate vaccine (PCV13, Prevnar 13).
Tables 3 and 4 (page 7) show a number of medications that are clinically effective; however, amoxicillin remains first-line due to its effectiveness in combination with low cost, safety, acceptable taste, and
narrow microbiologic spectrum. Patients who have taken amoxicillin in
the previous 30 days, patients with concurrent conjunctivitis, or patients for whom coverage for beta-lactamase-positive H influenza and
M catarrhalis is desired should be started on amoxicillin-clavulanate
(Augmentin) at a dose of 90 mg/kg/day of amoxicillin with 6.4 mg/kg/
day of clavulanate. Alternative antibiotics vary in their efficacy against
AOM pathogens.
For children aged < 2 years and children with severe symptoms, a
standard 10-day course is recommended. A 7-day course may be recommended for children aged 2 through 5 years with mild or moderate
AOM. For children aged 6 years with mild to moderate symptoms, a
5- to 7-day course is adequate.
Alternative Treatment
(If Penicillin Allergy)
Recommended First-line
Treatment
Amoxicillin-clavulanate* (90
mg/kg/day of amoxicillin with
6.4 mg/kg/day of clavulanate
in 2 divided doses)
or
Ceftriaxone (50 mg IM or IV
for 3 days)
*May be considered in patients who have received amoxicillin in the previous 30 days or who
have the otitis-conjunctivitis syndrome.
Cefdinir, cefuroxime (Ceftin, Zinacef), cefpodoxime, and ceftriaxone (Rocephin) are highly
Alternative Treatment
Ceftriaxone, 3 days
Clindamycin (Cleocin),
30-40 mg/kg/day in 3 divided
doses, with or without a thirdgeneration cephalosporin
unlikely to be associated with cross-reactivity with penicillin allergy, on the basis of their distinct
chemical structures.
*May be considered in patients who have received amoxicillin in the previous 30 days or who
Reproduced with permission from Pediatrics, Vol. 131, page e983, Copyright 2013 by the AAP.
Cefdinir, cefuroxime, cefpodoxime, and ceftriaxone are highly unlikely to be associated with
cross-reactivity with penicillin allergy on the basis of their distinct chemical structures.
Abbreviations: IM, intramuscular; IV, intravenous
Reproduced with permission from Pediatrics, Vol. 131, page e983, Copyright 2013 by the AAP.
References
1. Grijalva CG, Nuorti JP, Griffin MR. Antibiotic prescription rates for
acute respiratory tract infections in US ambulatory settings. JAMA.
2009;302(7):758-766. (Survey)
10. Schecter NL. Management of pain associated with acute medical illness. In: Schechter NL, Berde CB, Yaster M, eds. Pain in Infants, Children, and Adolescents. Baltimore: Williams & Wilkins; 1993:537-538.
(Textbook chapter)
2. McCaig LF, Besser RE, Hughes JM. Trends in antimicrobial prescribing rates for children and adolescent. JAMA. 2002;287(23):30963102. (Survey)
11. Rovers MM, Glasziou P, Appelman CL, et al. Predictors of pain and/
or fever at 3 to 7 days for children with acute otitis media not treated
initially with antibiotics: a meta-analysis of individual patient data. Pediatrics. 2007;119(3):579-585. (Meta-analysis; 824 patients)
CME Questions
To take the CME test, visit: www.ebmedicine.net/G0514 or scan the QR code below with a smartphone:
1. Which of the following patients meets criteria for the diagnosis of AOM?
a. A 3-year-old girl with otorrhea and evidence of acute otitis externa on examination
b. A 3-year-old girl with mild bulging of the TM and complaints of ear pain for the past 24 hours
c. A 3-year-old girl with moderate erythema of the TM and complaints of ear pain for the past 24 hours
d. A 3-year-old girl with upper respiratory infection symptoms and complaints of right-sided otalgia
2. Which of the following patients meets criteria for the diagnosis of AOM?
a. A 6-month-old boy with mild bulging of the TM and ear-pulling for 2 weeks
b. A 6-month-old boy with mild bulging of the TM
c. A 6-year-old boy with severe bulging of the TM
d. None of the above
3. Which antibiotic should be initiated in a 15-month-old girl diagnosed with uncomplicated bilateral AOM?
a. Amoxicillin 45 mg/kg/day divided into 2 doses
b. Amoxicillin 80-90 mg/kg/day divided into 2 doses
c. Ceftriaxone 50 mg/kg intramuscular injection x 1
d. Clindamycin 30-40 mg/kg/day in divided into 3 doses
4. In which patient is observation an inappropriate form of management?
a. A 3-year-old with unilateral AOM and severe otalgia for 48 hours
b. A 10-month-old with unilateral AOM and fever to 38.5C for 48 hours
c. A 10-month-old with bilateral AOM and fever to 38.5C for 48 hours
d. A and B
e. A and C
EM Practice Guidelines Update 2014
Date of Original Release: May 1, 2014. Date of most recent review: April 15, 2014. Termination date: May
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Accreditation: EB Medicine is accredited by the Accrediting Council for Continuing Medical Education (ACCME)
to provide continuing medical education for physicians. This activity has been planned and implemented in accordance with the Essential Areas and Policies of the ACCME.
Credit Designation: EB Medicine designates this enduring material for a maximum of 2 AMA PRA Category 1
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that can be observed for a period versus prescribing immediate antibiotics; and (3) assess patient history and
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