Mucositis is characterized by widespread ulceration of the oral cavity and other mucosal tissues that can occur as an early complication of allogeneic stem cell transplantation. It is a common side effect of both intensive chemotherapy for blood cancers and radiation therapy to the head and neck, which are both parts of the stem cell transplantation process. Mucositis causes severe discomfort and is often the most distressing symptom, while also placing patients at risk for potentially life-threatening infections due to the immunosuppression from the treatment. Clinically, it presents as redness after 4-5 days of chemotherapy or radiation exposure and then develops into frank ulcers 7-10 days later, resulting in significant pain and impaired functioning that
Mucositis is characterized by widespread ulceration of the oral cavity and other mucosal tissues that can occur as an early complication of allogeneic stem cell transplantation. It is a common side effect of both intensive chemotherapy for blood cancers and radiation therapy to the head and neck, which are both parts of the stem cell transplantation process. Mucositis causes severe discomfort and is often the most distressing symptom, while also placing patients at risk for potentially life-threatening infections due to the immunosuppression from the treatment. Clinically, it presents as redness after 4-5 days of chemotherapy or radiation exposure and then develops into frank ulcers 7-10 days later, resulting in significant pain and impaired functioning that
Mucositis is characterized by widespread ulceration of the oral cavity and other mucosal tissues that can occur as an early complication of allogeneic stem cell transplantation. It is a common side effect of both intensive chemotherapy for blood cancers and radiation therapy to the head and neck, which are both parts of the stem cell transplantation process. Mucositis causes severe discomfort and is often the most distressing symptom, while also placing patients at risk for potentially life-threatening infections due to the immunosuppression from the treatment. Clinically, it presents as redness after 4-5 days of chemotherapy or radiation exposure and then develops into frank ulcers 7-10 days later, resulting in significant pain and impaired functioning that
Mucositis is characterized by widespread ulceration of the oral cavity and other mucosal tissues that can occur as an early complication of allogeneic stem cell transplantation. It is a common side effect of both intensive chemotherapy for blood cancers and radiation therapy to the head and neck, which are both parts of the stem cell transplantation process. Mucositis causes severe discomfort and is often the most distressing symptom, while also placing patients at risk for potentially life-threatening infections due to the immunosuppression from the treatment. Clinically, it presents as redness after 4-5 days of chemotherapy or radiation exposure and then develops into frank ulcers 7-10 days later, resulting in significant pain and impaired functioning that
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Mucositis : Early complications of allogeneic transplant
Mucositis, associated with HSCT, is characterised by widespread ulceration of
the moveable, non-keratinised mucosae of the oral cavity most commonly involving the buccal mucosa and the ventrolateral tongue (Scully, Sonis et al. 2006). Oesophageal and gastrointestinal systems are also affected. It is a common acute toxicity associated with both intense chemotherapy reserved for haematological malignancies as well as head and neck radiation, both being integral components of HSCT. Oropharyngeal mucositis may result in severe discomfort and is the most common symptom and distressing complication of HSCT (Bellm, Epstein et al. 2000). Furthermore, concurrent herapy related immunosuppression, specifically neutropoenia, places patients at risk of bacteraemia, septicemia and fungaemia (Ruescher, Sodeifi et al. 1998). Clinically, mucositis first presents as generalized erythema approximately 4-5 days following the initiation of chemotherapy or following a cumulative radiation dose of 10Gy to the head and neck region. At 7-10 days following chemotherapy frank ulceration occurs, associated with significant pain and impaired function. Mucositis commonly extends to involve the esophageal and gastrointestinal mucosa. Opioid analgesics are often essential at this stage and total parenteral nutrition may be required.