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Material Safety Data Sheet

Dimethyl sulfate MSDS
Section 1: Chemical Product and Company Identification
Product Name: Dimethyl sulfate

Contact Information:
Sciencelab.com, Inc.
14025 Smith Rd.
Houston, Texas 77396

Catalog Codes: SLD3298

CAS#: 77-78-1

US Sales: 1-800-901-7247
International Sales: 1-281-441-4400

RTECS: WS8225000
TSCA: TSCA 8(b) inventory: Dimethyl sulfate

Order Online: ScienceLab.com

CI#: Not available.

Synonym:

CHEMTREC (24HR Emergency Telephone), call:

1-800-424-9300

Chemical Formula: (CH3)2SO4

International CHEMTREC, call: 1-703-527-3887

For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:
Name

CAS #

% by Weight

Dimethyl sulfate

77-78-1

100

Toxicological Data on Ingredients: Dimethyl sulfate: ORAL (LD50): Acute: 205 mg/kg [Rat]. 140 mg/kg [Mouse]. VAPOR
(LC50): Acute: 45 ppm 4 hour(s) [Rat].

Section 3: Hazards Identification

Potential Acute Health Effects:
Extremely hazardous in case of skin contact (corrosive, irritant), of eye contact (irritant), of inhalation. Very hazardous in case
of skin contact (permeator), of ingestion. Liquid or spray mist may produce tissue damage particularly on mucous membranes
of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mist may produce severe
irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Severe over-exposure can result
in death. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by
itching, scaling, reddening, or, occasionally, blistering.
Potential Chronic Health Effects:
Extremely hazardous in case of skin contact (corrosive, irritant), of eye contact (irritant), of inhalation. Very hazardous in
case of skin contact (permeator), of ingestion. CARCINOGENIC EFFECTS: Classified + (PROVEN) by OSHA. Classified A2
(Suspected for human.) by ACGIH, 2A (Probable for human.) by IARC, 2 (Reasonably anticipated.) by NTP. MUTAGENIC
EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The
substance is toxic to blood, kidneys, lungs, the nervous system, liver, mucous membranes. Repeated or prolonged exposure
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to the substance can produce target organs damage. Repeated or prolonged contact with spray mist may produce chronic
eye irritation and severe skin irritation. Repeated or prolonged exposure to spray mist may produce respiratory tract irritation
leading to frequent attacks of bronchial infection. Repeated exposure to an highly toxic material may produce general
deterioration of health by an accumulation in one or many human organs. Repeated or prolonged inhalation of vapors may
lead to chronic respiratory irritation.

Section 4: First Aid Measures

Eye Contact:
Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids
open. Cold water may be used. Do not use an eye ointment. Seek medical attention.
Skin Contact:
If the chemical got onto the clothed portion of the body, remove the contaminated clothes as quickly as possible, protecting
your own hands and body. Place the victim under a deluge shower. If the chemical got on the victim's exposed skin, such
as the hands : Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularly
careful to clean folds, crevices, creases and groin. Cold water may be used. If irritation persists, seek medical attention. Wash
contaminated clothing before reusing.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical
attention.
Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation:
Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If
breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It may
be hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious or
corrosive. Seek immediate medical attention.
Ingestion:
Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that
the toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen tight clothing such as a collar,
tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Combustible.
Auto-Ignition Temperature: 495C (923F)
Flash Points: CLOSED CUP: 83.3C (181.9F). (Setaflash) OPEN CUP: 115.6C (240.1F).
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2), sulfur oxides (SO2, SO3...).
Fire Hazards in Presence of Various Substances: Extremely flammable in presence of open flames and sparks.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available. Highly explosive in presence of open flames
and sparks.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: Not available.

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Section 6: Accidental Release Measures

Small Spill:
Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.
Large Spill:
Combustible material. Corrosive liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk.
Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Do not touch spilled
material. Use water spray curtain to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed.
Eliminate all ignition sources. Call for assistance on disposal. Be careful that the product is not present at a concentration level
above TLV. Check TLV on the MSDS and with local authorities.

Section 7: Handling and Storage

Precautions:
Keep locked up Keep container dry. Keep away from heat. Keep away from sources of ignition. Ground all equipment
containing material. Do not ingest. Do not breathe gas/fumes/ vapour/spray. Never add water to this product In case of
insufficient ventilation, wear suitable respiratory equipment If ingested, seek medical advice immediately and show the
container or the label. Avoid contact with skin and eyes
Storage:
Flammable materials should be stored in a separate safety storage cabinet or room. Keep away from heat. Keep away from
sources of ignition. Keep container tightly closed. Keep in a cool, well-ventilated place. Ground all equipment containing
material. Keep container dry. Keep in a cool place.

Section 8: Exposure Controls/Personal Protection

Engineering Controls:
Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective
threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:
Face shield. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Boots.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
product.
Exposure Limits:
TWA: 0.1 (ppm) from ACGIH (TLV) TWA: 0.5 (mg/m3) from ACGIH Consult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties

Physical state and appearance: Liquid. (Oily liquid.)
Odor: Odorless.
Taste: Not available.
Molecular Weight: 126.13 g/mole
Color: Colorless.
pH (1% soln/water): Not available.
Boiling Point: Decomposes. (188C or 370.4F)
Melting Point: -31.8C (-25.2F)
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Critical Temperature: Not available.

Specific Gravity: 1.3322 (Water = 1)
Vapor Pressure: 0.54 mm of Hg (@ 20C)
Vapor Density: 4.35 (Air = 1)
Volatility: 100% (v/v).
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: The product is equally soluble in oil and water; log(oil/water) = 0
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water.
Solubility: Partially soluble in cold water.

Section 10: Stability and Reactivity Data

Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Not available.
Incompatibility with various substances: Not available.
Corrosivity: Not available.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: No.

Section 11: Toxicological Information

Routes of Entry: Dermal contact. Eye contact. Inhalation. Ingestion.
Toxicity to Animals:
WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral
toxicity (LD50): 140 mg/kg [Mouse]. Acute toxicity of the vapor (LC50): 45 ppm 4 hour(s) [Rat].
Chronic Effects on Humans:
CARCINOGENIC EFFECTS: Classified + (PROVEN) by OSHA. Classified A2 (Suspected for human.) by ACGIH, 2A
(Probable for human.) by IARC, 2 (Reasonably anticipated.) by NTP. The substance is toxic to blood, kidneys, lungs, the
nervous system, liver, mucous membranes.
Other Toxic Effects on Humans:
Extremely hazardous in case of skin contact (corrosive, irritant), of inhalation. Very hazardous in case of skin contact
(permeator), of ingestion.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans: Not available.

Section 12: Ecological Information

Ecotoxicity: Not available.
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BOD5 and COD: Not available.

Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are more toxic.
Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:

Section 14: Transport Information

DOT Classification: CLASS 6.1: Poisonous material.
Identification: : Dimethyl sulfate : UN1595 PG: I
Special Provisions for Transport: Poison inhalation hazard

Section 15: Other Regulatory Information

Federal and State Regulations:
California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer,
birth defects or other reproductive harm, which would require a warning under the statute: Dimethyl sulfate California prop. 65:
This product contains the following ingredients for which the State of California has found to cause cancer which would require
a warning under the statute: Dimethyl sulfate Pennsylvania RTK: Dimethyl sulfate Massachusetts RTK: Dimethyl sulfate TSCA
8(b) inventory: Dimethyl sulfate SARA 302/304/311/312 extremely hazardous substances: Dimethyl sulfate SARA 313 toxic
chemical notification and release reporting: Dimethyl sulfate CERCLA: Hazardous substances.: Dimethyl sulfate
Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
Other Classifications:
WHMIS (Canada):
CLASS B-3: Combustible liquid with a flash point between 37.8C (100F) and 93.3C (200F). CLASS D-1A: Material causing
immediate and serious toxic effects (VERY TOXIC). CLASS D-2A: Material causing other toxic effects (VERY TOXIC). CLASS
E: Corrosive liquid.
DSCL (EEC):
R26- Very toxic by inhalation. R35- Causes severe burns. R45- May cause cancer.
HMIS (U.S.A.):
Health Hazard: 4
Fire Hazard: 2
Reactivity: 0
Personal Protection:
National Fire Protection Association (U.S.A.):
Health: 4
Flammability: 2
Reactivity: 0
Specific hazard:
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Protective Equipment:
Gloves. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator
when ventilation is inadequate. Face shield.

Section 16: Other Information

References: Not available.
Other Special Considerations: Not available.
Created: 10/11/2005 11:51 AM
Last Updated: 06/09/2012 12:00 PM
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