Instructions Radiobiology Spreadsheets

INSTRUCTIONS FOR USE
for
Microsoft () Excel spread sheets
Reporting GYN HDR BT sheet and LQ spread sheet_v2.1
The Microsoft () Excel spread sheet Reporting GYN HDR BT sheet is designed
for reporting gynaecological HDR brachytherapy. It is intended that the data is
entered into the blue fields. On top of the sheet you can enter the dose of external
beam therapy. In the columns F1-F6 the dose of brachytherapy fraction number 1 to
6 (max. possible) can be entered. The 2 columns on the right side give the result in
equivalent (isoeffective) dose in 2 Gy fractions (EQD2) for brachytherapy alone and
brachytherapy plus external beam therapy, respectively. For the volumes the mean
value and the standard deviation is calculated.
The Microsoft () Excel spread sheet LQ spread sheet_v2.1 is designed for
calculating BED (Biologically Effective Dose) and equivalent (isoeffective) dose in 2
Gy fractions (EQD2). It is intended that the data is entered into the blue fields. The
section treatment planning enables to set a total EQD2 isoeffective dose of external
beam therapy plus brachytherapy and the number of remaining brachytherapy
fractions. The physical dose per remaining brachytherapy fraction is than calculated,
in order to come up with the specified isoeffective total dose. This tool can be used to
set a EQD2-dose constraint (CTV-min or OAR-max) for the whole treatment. The
corresponding physical dose constraint per remaining brachytherapy fraction is than
calculated. Recommended tissue parameters are / = 10 Gy for tumour and target
structures of cervical cancer, / = 3 Gy for late effects of the organs at risk bladder,
rectum and sigmoid colon and T1/2 = 1.5 h for tumour and target structures as well as
organs at risk (T1/2 is not relevant for external beam therapy and HDR
brachytherapy).
Both spread sheets work based on the linear-quadratic model for incomplete
monoexponential sublethal cell damage repair (LQ model). If you want to see the
formulas just mark the whole sheet. Please be aware that only repair due to different
fractionation and dose rate schedules is taken into account, the effects of
repopulation, reoxygenation, redistribution and dose and dose rate heterogeneity are
ignored.
We emphasise that these spread sheets are in-house developed research tools and
we ask you to handle the results with care. Neither the authors nor anybody else can
accept any legal responsibility or liability for any errors or omissions that may be
made. In particular (but without limiting the generality of the preceding disclaimer)
effort has been made to check the calculation process; however, it is still possible
that errors have been missed.
For details please refer to the following references:

Ptter
R,
Haie-Meder
C,
Limbergen
EV,
et
al.
Recommendations
from
gynaecological (GYN) GEC ESTRO working group (II): Concepts and terms in 3D
image-based treatment planning in cervix cancer brachytherapy-3D dose volume
parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology.
Radiother Oncol 2006;78:67-77.
Details on radiobiology can be found in the electronic appendix of the online version
of this article.
Steel GG, editor. Basic clinical radiobiology. Arnold, London. 3rd ed 2002.
This is the course book of the ESTRO teaching course on Basic Clinical
Radiobiology.
Further references:
Brenner DJ, Hall EJ. Conditions for the equivalence of continuous to pulsed low dose
rate brachytherapy. Int J Radiat Oncol Biol Phys 1991;20:181-190.
Dale RG. The application of the linear-quadratic dose-effect equation to fractionated
and protracted radiotherapy. Br J Radiol 1985;58:515-528.
Dale RG, Huczkowski J, Trott KR. Possible dose rate dependence of recovery
kinetics as deduced from a preliminary analysis of the effects of fractionated
irradiations at varying dose rates. Br J Radiol 1988;61:153-157.
Dale RG, Coles IP, Deehan C, ODonoghue JA. Calculation of integrated biological
response in brachytherapy. Int J Radiat Oncol Biol Phys 1997;38:633-42.
Dale RG, Coles IP. Allowance for the radiobiological effects of dose gradients in
gynaecological applications. Radiother Oncol 2001;60:S7.
Fowler J, Mount M. Pulsed brachytherapy: the conditions for no significant loss of
therapeutic ratio compared with traditional low dose rate brachytherapy. Int J Radiat
Oncol Biol Phys 1992;23:661-669.
Fowler JF, Van Limbergen EFM. Biological effect of pulsed dose rate brachytherapy
with stepping sources if short half-times of repair are present in tissues. Int J Radiat
Oncol Biol Phys 1997;37:877-883.
Mazeron JJ, Scalliet P, Van Limbergen E, Lartigau E. Radiobiology of brachytherapy
and the dose-rate effect. In: Gerbaulet A, Ptter R, Mazeron JJ, Meertens H, Van
Limbergen E, editors. The GEC-ESTRO handbook of brachytherapy. ESTRO,
Brussels. 2002;95-121.
Nag S, Gupta N. A simple method of obtaining equivalent doses for use in HDR
brachytherapy. Int J Radiat Oncol Biol Phys 2000;46:507-513.
Orton CG, Brenner DJ, Dale RG, Fowler JF. Radiobiology. In: Nag S, editor. High
dose rate brachytherapy: a textbook. Futura Publishing Company, New York.
1994;11-25.
Withers HR, Thames HD Jr, Peters LJ. A new isoeffect curve for change in dose per
fraction. Radiother Oncol 1983;1:187-191.

Instructions Radiobiology Spreadsheets

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INSTRUCTIONS FOR USE

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