Scribd Logo
Upload

Welcome to Scribd!

  • 19 views

    Psychotherapeutic S

    Uploaded by

    siva
    ,

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Psychotherapeutic S

    Uploaded by

    siva
    19 views17 pages
    ,

    Original Title

    Psychotherapeutic s

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    ,

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    19 views17 pages

    Psychotherapeutic S

    Uploaded by

    siva
    ,

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 17

    Psychotherapeutics

    
    

    
    
    
    
    
    

    Amitriptyline
    Amphetamine &
    dextroamphetamine
    Atomoxetine
    Buproprion
    Desipramine
    Fluoxetine
    Haloperidol
    Lithium

    
    
    
    
    
    
    

    Methylphenidate
    Mirtazapine
    Olanzapine
    Phenelzine
    Risperidone
    Thioridazine
    Venlafaxine

    Amitriptyline
    
    
    
    

    Antidepressant
    Tricyclic
    Blocks neuronal reuptake of
    serotonin > norepinephrine
    Blocks muscarinic & adrenergic receptors
    
    

    Chronic pain
    Depression

    Delayed onset of
    antidepressant effect >4 wks

    AVOID
    MAOI
    SSRI

    Lethargy
    Sedation
    Blurred vision
    Constipation
    Urinary retention
    appetite & wt gain

    OD wide QRS complex VT

    Altered effects by drugs that


    inhibit/induce CYP450

    
    
    
    
    

    Carbamazepine
    Quinidine
    Rifampin

    Amphetamine
    
    

    CNS stimulant
    Sympathomimetic
    amine
    neuronal release of
    norepinephrine
    

    HTN crisis w/ MAOI

    
    
    
    
    
    

    ADHD
    attention span
    motor restlessness

    Tachycardia
    HTN
    Anorexia
    Irritability
    Insomnia
    Tremor
    Growth inhibition
    Drug dependence

    Narcolepsy
    mental alertness
    drowsiness & fatigue

    Atomoxetine
    
    

    ADHD agent
    Selective NE reuptake
    inhibitor

    
    
    

    Inhibits neuronal
    reuptake of NE in CNS
    

    ADHD in children/adults

    levels & effect in slow


    metabolizers CYP2D6

    appetite
    Insomnia
    Levels & effects altered by
    drugs that inhibit/induce
    CYP2D6

    Bupropion
    
    

    Antidepressant
    Neuronal reuptake
    inhibitor

    
    
    
    

    Inhibits neuronal
    reuptake of DA > 5-HT
    & NE
    
    
    

    Depression
    Smoking cessation

    
    

    
    

    Delayed onset for


    antidepressant effects

    Agitation
    HA
    Dry mouth
    N
    Tremor
    Impaired motor &
    cognitive skills
    MAOI adverse effects
    Seizure risks w/
    phenothiazines

    Desipramine
    
    

    Antidepressant
    Tricyclic

    Lethargy
    Sedation
    Blurred vision
    Constipation
    Urinary retention
    appetite & wt gain

    OD wide QRS complex VT

    
    
    

    
    

    Blocks neuronal reuptake NE


    > 5-HT
    Blocks muscarinic & adrenergic receptors
    
    

    Depression
    Chronic pain

    Delayed onset for


    antidepressant effects

    AVOID
    MAOI
    SSRI

    
    

    Fluoxetine
    
    

    Antidepressant
    SSRI

    Anxiety
    Drowsiness
    Insomnia
    Nervousness
    Sexual dysfunction
    Sweating
    Tremor

    levels metabolized by CYP2D6

    
    
    

    Inhibits neuronal reuptake of


    serotonin

    
    
    

    
    
    
    
    
    
    
    
    
    

    Depression
    OCD
    Bulimia nervosa
    Anorexia nervosa
    Fibromyalgia
    Panic attacks
    Phobias
    Prementsrual dysmorphic disorder
    Active metabolite 5-7d half-life
    AVOID MAOI

    Haloperidol
    
    
    

    Typical antipsychotic
    Butyrophenone
    Blocks D2 receptors in
    mesolimbic area,
    chemoreceptor trigger
    zone, solitary tract, &
    basal ganglia
    Blocks muscarinic & adrenergic receptors

    
    
    
    

    
    

    Psychotic disorders

    Schizophrenia

    Tourettes syn

    Neuroleptic malignant
    syn

    Fever
    Respiratory distress
    Tachycardia
    Seizures
    Severe m. stiffness
    Altered BP

    Extrapyramidal rxns
    Tardive dyskinesia
    Blurred vision
    Constipation
    Dry mouth
    Urinary retention
    Hypotension

    Lithium
    
    
    

    Mood stabilizer, antimanic


    Inorganic cation
    noradrenergic
    neurotransmission or effects
    b/c of cAMP
    Inhibition of inositol-1phosphatase
    

    Depletion of inositol & IP3

    Improved Na transport via Na


    pump
    

    Bipolar affective disorder

    Monitor serum levels


    Toxicity > 2.5

    
    
    
    
    
    
    
    
    
    

    Polyuria
    Impaired memory
    Acne
    Tremor
    ECG changes
    GI distress
    Hypothyroidism
    Leukocytosis
    NM toxicity w/ haloperidol
    toxicity

    Diuretics
    NSAIDS
    Fluoxetine

    Methyphenidate
    
    

    CNS stimulant
    Sympathomimetic
    amine

    Tachycardia
    HTN
    Anorexia
    Irritability
    Insomnia
    Tremor
    Growth inhibition
    Dependence

    HTN crisis w/ MAOI

    
    
    
    

    neuronal release NE
    

    ADHD
    attention span
    motor restlessness

    
    
    

    Narcolepsy
    mental alertness
    drowsiness &
    fatigue

    Mirtazapine
    
    
    

    Antidepressant
    Tetracyclic
    Inhibits presynaptic 2
    autoreceptors &
    heteroreceptors
    

    NE & 5-HT release

    
    

    Depression
    Appetite stimulation

    AVOID MAOI
    HTN, seizure, death

    
    
    
    

    appetite & wt gain


    Constipation
    Dry mouth
    Drowsiness

    Olanzapine
    
    

    Atypical antipsychotic
    Thienobenzodiazepine

    
    
    

    
    

    Blocks D2 & 5-HT2 receptors


    in CNS
    Blocks H1, muscarinic, & adrenergic receptors

    
    
    
    
    

    
    
    
    

    Schizophrenia
    Manic episodes of biploar
    Anorexia nervosa
    Oral tablets contain
    aspartame
    Avoid in phenylketonuria

    
    
    

    Agitation
    Dizziness
    Restlessness
    Sedation
    Amblyopia
    Orthostatic hypotension
    Tachycardia
    Constipation
    Dry mouth
    Wt gain
    Tremor

    Phenelzine
    
    

    Antidepressant
    MAOI

    Dizziness
    Insomnia
    Restlessness
    Blurred vision
    Orthostatic hypotension
    Diarrhea

    Potentially fatal

    
    
    

    Inhibits MAO & CNS levels


    of NE & 5-HT
    

    Neurotic & atypical


    depression

    
    

    SSRI
    Tricyclics

    Avoid
    Fluoxetine
    Tyramine

    HTN crisis

    Tyramine
    Amphetamines
    Methyldopa
    Levodopa

    Risperidone
    
    

    Atypical antipsychotic
    Benzisoxazole

    
    
    

    
    

    Blocks 5-HT2 > D2


    receptors in CNS
    Blocks H1 & -adrenergic
    receptors
    
    
    

    Schizophrenia
    Psychotic disorders
    Monitor pt for
    neuroleptic malignant
    syn

    
    
    
    

    Aggressive behavior
    Extrapyramidal rxns
    Sleep disturbances
    Insomnia
    Sedation
    Constipation or diarrhea
    Wt gain

    Thioridazine
    
    

    Typical antipsychotic
    Phenothiazine

    
    
    

    Blocks D2 receptors in
    mesolimbic area,
    chemoreceptor trigger
    zone, solitary tract, &
    basal ganglia
    Blocks muscarinic
    receptors
    
    

    Psychotic disorders
    Schizophrenia

    Extrapyramidal rxns
    Tardive dyskinesia
    Photosensitivity
    Potential for V
    arrhythmias & sudden
    death
    Retinal pigmentation
    w/ high doses
    melanosis

    Venlafaxine
    
    

    Antidepressant
    Phenethylamine

    
    
    

    Inhibits neuronal
    reuptake 5-HT & NE

    Depression
    Generalized anxiety
    disorder

    AVOID MAOI

    
    

    Sexual dysfunction
    GI distress
    Dizziness
    Insomnia
    Nervousness

    You might also like