Plasma Derivatives
Plasma Derivatives
Plasma Derivatives
Factor VIIa
Produced by recombinant DNA technology
Used in patients with Hemophilia A who have circulating antibodies or
inhibitors to factor VIII
Used in patients with congenital factor VII deficiency
It is also used in trauma, massive transfusion and liver transplantation
Has been most successful in controlling intracranial hemorrhage
Has seen promising results in uncontrolled nonsurgical hemorrhages after
implanting VADs
Its disadvantage is that it has been associated with increased risk of
spontaneous thrombosis and thromboemboli
Factor IX Concentrate
Available in three forms:
Factor IX Concentrate
Recombinant Factor IX
Used with caution in patient with liver disease due to DIC and
thrombosis
Factor IX Concentrate
Recombinant Factor IX
Crystalloids
colloids
Colloids
Crystalloids
transfusion
The other pathway (nonimmune TRALI) consists of a two-hit event. The risk of
developing nonimmune TRALI depends on the patients predisposition to this
disorder
Iron Overload