Accelerating Science Psychosis

TAKING ISSUE
Accelerating Science-to-Practice for Early Psychosis

Amy B. Goldstein, Ph.D., Robert K. Heinssen, Ph.D., Susan T. Azrin, Ph.D.
It takes approximately 17 years for research ndings to inuence clinical practice, and even longer for a scientic
discovery to have an impact on public health. Seventeen
years also falls within the lower bound of the age of onset for
schizophrenia, a devastating mental disorder characterized
by recurrent psychotic episodes and accumulating disability.
To improve outcomes for young adults with early psychosis,
NIMH launched the Recovery After an Initial Schizophrenia
Episode (RAISE) initiative in 2008. The goals were to develop a comprehensive, person-centered intervention for
rst-episode psychosis (FEP), test it in U.S. community treatment settings, and expedite dissemination, adoption, and implementation of promising ndings.
Rapid uptake of evidence-based interventions can occur
when clinical research purposefully bridges gaps between
service users needs, scientic curiosity, and policy makers
concerns. The RAISE funding announcement took this into
account and required investigators to establish partnerships
with principal stakeholdersthat is, service users, family
members, clinicians, and health care administratorsat
every stage of the research process. RAISE investigators
studied implementation processes alongside outcomes and
developed training and program materials to support the
establishment of coordinated specialty care (CSC) programs
in community clinics. The articles and columns in the special section suggest notable progress after only seven years
a decade earlier than the often cited 17 yearsbecause they
address implementation challenges and answer questions
about feasibility, accountability, acceptability, effectiveness,
and sustainability.
Is it feasible to implement CSC programs in routine settings?
Yes. The articles by Dixon and colleagues and by Mueser and
colleagues each describe team-based multicomponent programs for FEP. Across the two RAISE studies, 19 new CSC
programs were established by training community mental
health providers in stage-specic care for FEP.
Can treatment delity be monitored in a practical way?
Yes. The Best Practices column by Essock and colleagues
describes an approach to CSC delity monitoring that uses
information drawn from readily available data, such as
routine service logs. Practical approaches to delity monitoring may be cost-effective and can provide an ongoing data
source for quality improvement activities.
Psychiatric Services 66:7, July 2015
Will young adults with FEP engage in treatment? Yes. Less

than 10% of RAISE Connection participants dropped out
over two years. Lucksted and colleagues highlight several
features that promoted engagement: the individualized,
exible, and recovery-focused nature of treatment; the emphasis on shared decision making; and the availability of
services such as supported employment and education.
Are CSC programs effective? Yes. After one year of
treatment, Srihari and colleagues found fewer hospitalizations and higher vocational engagement among CSC
patients compared with those in usual care. Likewise, over
two years, Dixon and colleagues noted signicant improvements in symptoms, social functioning, and school and work
activity among Connection Program participants.
Are CSC programs sustainable? Perhaps. In the Research &
Services Partnerships column, Essock and colleagues describe how state mental health authorities in New York and
Maryland supported implementation, evaluation, and expansion of the Connection Program. Involvement in RAISE
inuenced each states decision to commit funds to extend
early intervention services. The novel three-part nancing
model proposed by Frank and colleagues in the Economic
Grand Rounds column offers another strategy for achieving
sustainability: a payment system that rewards delivery of
high-quality FEP care.
These articles and columns convey hope that integrated
and effective care for FEP is possible in the United States. As
CSC programs multiply, we must anticipate new challenges
that might reduce the public health impact of early intervention programs. Addington and colleagues brief report
reminds us that many persons with FEP endure long periods
of untreated psychosis, which augurs poorly for long-term
recovery. Ouellet-Plamondon and colleagues in Canada alert
us to potential disparities in access among minority groups
and the need for different engagement strategies. Close
partnerships between investigators and stakeholders will be
critical for further progress. Through dynamic partnerships
and ongoing collaboration, we should strive to make 17 years
the age at which psychosis is prevented.
Division of Services and Intervention Research, National Institute of Mental
Health, Bethesda, Maryland
Psychiatric Services 2015; 66:665; doi: 10.1176/appi.ps.660708
ps.psychiatryonline.org
665

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TAKING ISSUE

Accelerating Science-to-Practice for Early Psychosis

Psychiatric Services 66:7, July 2015

Will young adults with FEP engage in treatment? Yes. Less

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