Vitamin A Palmitate Acetate

Technical Information
September 2007
Supersedes issue dated August 2006
Vitamin A Palmitate
Vitamin A Acetate
MEMC 050203e-05/Page 1 of 6
= Registered trademark
of BASF Aktiengesellschaft
Active ingredient for the cosmetics industry.
MEMC 050203e-05 September 2007
Page of 6
Vitamin A Palmitate, Vitamin A Acetate
Structural formula
Product range
Retinyl Palmitate 1.7 Mio IU/g

Retinyl Palmitate 1.7 Mio IU/g stab. with Tocopherol
Retinyl Palmitate 1.7 Mio IU/g stab. with BHT
Retinyl Palmitate 1.0 Mio IU/g stab. with BHT
Retinyl Palmitate 1.0 Mio IU/g stab with Tocopherol
Retinyl Acetate 1.5 Mio IU/g stab. with BHT
Retinyl Palmitate 1.0 Mio IU/g and Retinyl

Acetate 1.5 Mio IU/g are diluted in Sunflower Seed Oil
Synonyms
Retinyl palmitate, all-trans-retinol palmitic acid ester

Retinyl acetate, all-trans-retinol acetate
INCI name
Retinyl Palmitate 1.7 Mio IU/g: Retinyl Palmitate

Retinyl Palmitate 1.0 Mio IU/g: Retinyl Palmitate (and) Helianthus Annuus
(Sunflower) Seed Oil
Retinyl Acetate 1.5 Mio IU/g: Retinyl Acetate (and) Helianthus Annuus
(Sunflower) Seed Oil
10013349
10065085
10068345
10078915
10015772
10013120
Molecular formula
Retinyl Palmitate: C36H60O2

Retinyl Acetate:
C22H32O2
Molar Mass
Retinyl Palmitate
Retinyl Acetate
CAS-No.
79-81-2 (Retinyl Palmitate)

127-47-9 (Retinyl Acetate)
8001-21-6 (Sunflower seed oil)
PRD-No.
Reninyl Palmitate 1.7 Mio

Retinyl Palmitate 1.7 Mio stab. With Tocopherol
Retinyl Palmitate 1.7 Mio stab. With BHT
Retinyl Palmitate 1.0 Mio stab. With Tocoopherol
Retinyl Palmitate 1.0 Mio stab. With BHT
Retinyl Acetate 1.5 Mio stab. With BHT
Description
At room temperature, the product is a viscous, yellow oil that may contain some
crystals. Mild odor. The assay of Vitamin A Palmitate 1.0 Mio IU/g and Vitamin
A Acetate 1.5 Mio IU/g is adjusted by adding pharmaceutical-grade sunflower
seed oil.
Solubility
Miscible with hydrocarbons, ethers, fats and oils. The solvent should contain
no peroxides. Insoluble in water. It is necessary to use a solubilizer in aqueousalcoholic preparations.
524.9 g/mol
328.5 g/mol
30041032
30041031
30041041
30041043
30041040
30041021
Page of 6
Specification
See separate document: Standard Specification (not for regulatory purposes)

available via BASFs WorldAccount:
https://worldaccount.basf.com (registered access).
Monographs
The product complies with the current Ph. Eur., USP and FCC monographs.
Applications
Vitamin A Esters are active ingredients for cosmetic skin-care products. They
release Vitamin A on contact with enzymes in the skin. Vitamin A stimulates
cell growth, increases enzyme activity and normalizes cell division. They are
therefore able to counteract the skin-aging process and improve the appearance
of UV-damaged skin.
1 International unit (IU) can be converted into weight with the following equations
1 IU = 0.3 g Vitamin A alcohol (Retinol)

0.344 g Vitamin A Acetate

0.55 g Vitamin A Palmitate
Stability and storage
Vitamin A Palmitate 1.7 Mio IU/G is available stabilized and unstabilized. All
grades are available stabilized with approx. 10 mg of DL-alpha-Tocopherol
per Mio IU or with approx. 10 mg of BHT per Mio IU.
Vitamin A Esters are sensitive to air, light, moisture and heat.
The product has a shelf life of 12 months if stored in the original sealed
containers at max. 25C, and 24 months at 5C.
Opened original containers should be flushed with an inert gas and used
up quickly.
Prior to use, the product must be heated to 40C in the unopened container and
homogenized.
Occasionally difficult to dissolve crystals can be found in the product. In such

cases placing the canister in a water bath at 60C and letting it gently warm up,
with homogenisation, will enable complete dissolution of the crystals.
Typical formulations
Antiaging cream
%
A
No. 62/00035
Ingredients
Supplier INCI name
2.00 Cremophor A 25
(1)
Ceteareth-25
2.00 Cremophor A 6
(1)
Ceteareth-6, Stearyl Alcohol
5.00 Lanette O
(27)
Cetearyl Alcohol
5.00 Sunflower Seed Oil

10.00 Luvitol EHO
Sunflower (Helianthus Anuus)

Seed Oil
(1)
10.00 Paraffin Oil

B
Cetearyl Ethylhexanoate
Mineral Oil
0.05 Edeta BD
(1)
Disodium EDTA
3.00 1,2-Propylene Glycol

Care
(1)
Propylene Glycol
2.00 D-Panthenol 50 P
(1)
Panthenol, Propylene Glycol
q.s. Preservative
60.35 Water dem.
C
Aqua
0.50 Vitamin A Palmitate

1.7 Mio. I.E./g
(1)
Retinyl Palmitate
0.10 DL-alpha-Tocopherol
(1)
Tocopherol
q.s. Perfume
Production:
Heat phases A and B separately to about 80C.

Stir phase B into phase A and homogenize.
Cool to about 40C, add phase C and homogenize
again.
Properties:
Viscosity: 5000 mPas Haake Viscotester VT-02

pH value: 7.0
Page of 6
Vitamin lotion
%
A
No. 62/00042
Ingredients
Supplier INCI name
6.00 Cremophor WO 7
(1)
PEG-7 Hydrogenated Castor Oil
2.00 TeCero Wax 1030 K
(73)
Microcrystalline Wax
0.20 Bisabolol nat.
(1)
Bisabolol
1.00 Bees Wax 3044 PH
(73)
Bees Wax
0.50 Cetiol SB 45
(27)
Butyrospermum Parkii (Shea

Butter)
1.00 Jojoba Oil
Jojoba (Buxus Chinensis) Oil
7.00 Luvitol EHO
(1)
Cetearyl Octanoate
7.00 Paraffin Oil
Mineral Oil
0.10 Ascorbyl Palmitate
Ascorbyl Palmitate
5.00 1,2-Propylene Glycol

Care
(1)
Propylene Glycol
0.10 Edeta BD
(1)
Disodium EDTA
(20)
Magnesium Sulfate
q.s. Preservative
0.70 Magnesium Sulfate7-hydrate
63.20 Water dem.
C
Aqua
1.00 Vitamin E Acetate
(1)
Tocopheryl Acetate
0.50 DL-alpha-Tocopherol
(1)
Tocopherol
0.20 Vitamin A Palmitate

1.0 Mio. I.E./g
(1)
Retinyl Palmitate
1.00 Vitamin F Glyceryl

Ester
(58)
Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Arachidonate
2.50 Kollatherm
(23)
Soluble Collagen, Glycerol
1.00 Alpha-Elastin
(23)
Hydrolyzed Elastin
q.s. Perfume
D
Production:
Heat phases A and B separately to about 85C.

Stir phase B into phase A and homogenize.
Cool to about 40C, add phases C and D and
homogenize again.
Properties:
Viscosity: 6000 mPas Haake Viscotester VT-02
Page of 6
Suppliers
1. BASF Aktiengesellschaft
67056 Ludwigshafen, Germany
Tel.: (0621) 60-0
Fax: (0621) 60-42525
20. Merck KGaA

Frankfurter Strae 250,
64293 Darmstadt, Germany
Tel.: (06151) 727869
Fax: (06151) 728333
23. GFN Herstellung von Naturextrakten GmbH,

Straburg 16, D-69483 Wald-Michelbach, Germany
Tel.: (06207) 7007
Fax: (06207) 1276
27. Cognis Deutschland GmbH Care Chemicals

Henkelstr. 67
40191 Dsseldorf, Germany
Tel.: (0211) 7940-2289
Fax: (0211) 798-2016
58. Chemisches Laboratorium Dr. Kurt Richter GmbH (CLR)

Bennigsenstrae 25, 12159 Berlin, Germany
Tel.: 030/852-7075
Fax: 030/851-1822
73. Tromm GmbH, Wachs- und Ceresin-Fabriken

Feuerstrae 7 - 17
50735 Kln (Weidenpesch)
Tel. 49 221 974552-0
Fax: 49 221 974552-30
Note
While the descriptions, designs, data and information contained herein are
presented in good faith and believed to be accurate, it is provided for your
guidance only. Because many factors may affect processing or application/use,
we recommend that you make tests to determine the suitability of a product
for your particular purpose prior to use.
NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING
WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR
PURPOSE, ARE MADE REGARDING PRODUCTS DESCRIBED OR DESIGNS,
OR THAT DATA OR INFORMATION MAY BE USED WITHOUT INFRINGING
THE INTELLECTUAL PROPERTY RIGHTS OF OTHERS. IN NO CASE SHALL
THE DESCRIPTIONS, INFORMATION, DATA OR DESIGNS PROVIDED BE
CONSIDERED A PART OF OUR TERMS AND CONDITIONS OF SALE.
Further, you expressly understand and agree that the descriptions, design, data
and information furnished by BASF hereunder are given gratis and BASF assumes
no obligation or liability for the description, designs, data and information
given or results obtained, all such being given and accepted at your risk.
September 2006
BASF Corporation
Page of 6
Fine Chemicals Division - Cosmetic Solutions - 07932 Florham Park - USA, Region N.J.- www.cosmetics.basf.com

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Technical Information

Active ingredient for the cosmetics industry.

MEMC 050203e-05 September 2007

Vitamin A Palmitate, Vitamin A Acetate

Retinyl Palmitate 1.7 Mio IU/g

Retinyl Palmitate 1.0 Mio IU/g and Retinyl

Retinyl palmitate, all-trans-retinol palmitic acid ester

Retinyl Palmitate 1.7 Mio IU/g: Retinyl Palmitate

Retinyl Palmitate: C36H60O2

79-81-2 (Retinyl Palmitate)

Reninyl Palmitate 1.7 Mio

MEMC 050203e-05 September 2007

Vitamin A Palmitate, Vitamin A Acetate

See separate document: Standard Specification (not for regulatory purposes)

Stability and storage

Occasionally difficult to dissolve crystals can be found in the product. In such

Supplier INCI name

Ceteareth-6, Stearyl Alcohol

5.00 Sunflower Seed Oil

Sunflower (Helianthus Anuus)

10.00 Paraffin Oil

3.00 1,2-Propylene Glycol

Panthenol, Propylene Glycol

0.50 Vitamin A Palmitate

Heat phases A and B separately to about 80C.

Viscosity: 5000 mPas Haake Viscotester VT-02

MEMC 050203e-05 September 2007

Vitamin A Palmitate, Vitamin A Acetate

Supplier INCI name

PEG-7 Hydrogenated Castor Oil

2.00 TeCero Wax 1030 K

0.20 Bisabolol nat.

1.00 Bees Wax 3044 PH

Butyrospermum Parkii (Shea

1.00 Jojoba Oil

Jojoba (Buxus Chinensis) Oil

7.00 Luvitol EHO

7.00 Paraffin Oil

0.10 Ascorbyl Palmitate

5.00 1,2-Propylene Glycol

1.00 Vitamin E Acetate

0.20 Vitamin A Palmitate

1.00 Vitamin F Glyceryl

Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Arachidonate

Soluble Collagen, Glycerol

Heat phases A and B separately to about 85C.

Viscosity: 6000 mPas Haake Viscotester VT-02

MEMC 050203e-05 September 2007

Vitamin A Palmitate, Vitamin A Acetate

20. Merck KGaA

23. GFN Herstellung von Naturextrakten GmbH,

27. Cognis Deutschland GmbH Care Chemicals

58. Chemisches Laboratorium Dr. Kurt Richter GmbH (CLR)

73. Tromm GmbH, Wachs- und Ceresin-Fabriken

MEMC 050203e-05 September 2007

Vitamin A Palmitate, Vitamin A Acetate

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