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    Nephrology Formulas

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    M Patel
    The document provides formulas and calculations for assessing kidney function and diagnosing metabolic acidosis. It includes the Creatinine clearance equation, fractional excretion of sodium calculation, urine and serum osmolarity, and anion gap calculation. The anion gap calculation is used to determine the etiology of metabolic acidosis which can be caused by impaired acid excretion, increased acid production, or acid ingestion.

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    Nephrology Formulas

    Uploaded by

    M Patel
    939 views3 pages
    The document provides formulas and calculations for assessing kidney function and diagnosing metabolic acidosis. It includes the Creatinine clearance equation, fractional excretion of sodium calculation, urine and serum osmolarity, and anion gap calculation. The anion gap calculation is used to determine the etiology of metabolic acidosis which can be caused by impaired acid excretion, increased acid production, or acid ingestion.

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    Nephrology Formulas

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    The document provides formulas and calculations for assessing kidney function and diagnosing metabolic acidosis. It includes the Creatinine clearance equation, fractional excretion of sodium calculation, urine and serum osmolarity, and anion gap calculation. The anion gap calculation is used to determine the etiology of metabolic acidosis which can be caused by impaired acid excretion, increased acid production, or acid ingestion.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    939 views3 pages

    Nephrology Formulas

    Uploaded by

    M Patel
    The document provides formulas and calculations for assessing kidney function and diagnosing metabolic acidosis. It includes the Creatinine clearance equation, fractional excretion of sodium calculation, urine and serum osmolarity, and anion gap calculation. The anion gap calculation is used to determine the etiology of metabolic acidosis which can be caused by impaired acid excretion, increased acid production, or acid ingestion.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 3

    FORMULAS o o o o o Ccr= Creatinine concentration Ucr= Urine creatinine concentration V= urine flow rate Pcr= plasma creatinine concentration

    Creatinine clearance equation adjusted for effects of body weight and age on muscle mass (Cockcroft-Gault) o Ccr=
    ( ) ( ( ) )

    (*.85 if F)

    o Ccr= creatinine clearance o Pcr= plasma creatinine

    1. Fractional excretion of sodium (FENa) calculation (Rennke & Dennker, 2nd edition. p.215-216) FENa, precent= quantity of sodium excreted/sodium filtered x 100 =(
    ( ) )

    UNa = sodium urine concentration PCr = Plasma Creatinine concentration PNa = Plasma sodium concentration UCr = Creatinine urine concentration FENa <1% = Favors prerenal disease & acute renal failure o This meaning that >99% of filtered sodium being reabsorbed FENa >2% = impaired tubular reabsorption due to acute tubular necrosis FENa allows direct look at sodium w/o confounding effect of the rate of water reabsorption

    2. Urine and Serum (Plasma) osmolarity (Rennke & Dennker, 2nd edition. p35-36, CP p.54) ***Please note, I could not find info on osmolarity, so used osmolality instead***** Plasma osmolality (Posm) = ( ) ( ) PNa= sodium plasma concentration Among normal subjects, effective Posm ~ 2 x PNa

    3. Anion Gap (Rhoades and Bell p.458-459, CP 145-149) Main use: determine possible etiology of metabolic acidosis o Uses principle that sum of all cations and anions are equal in any body fluid Metabolic acidosis caused by o Impaired acid excretion Renal failure Tubular disorders impairing bicarbonate reasbsorption o Increased acid production Endogenously (eg.-lactic acid or ketoacids) Diarrhea loss of bicarb net results of [ H+] in plasma o Addition acid ingestion For blood plasma: cations= anions [Na+] + [unmeasured cations] =[Cl-] + [HCO3-] + [unmeasured anions] Causes Anion Gap Metabolic acidosis (MUDPILES) Methanol (wood alcohol) blindness Uremia Diabetic ketoacidosis Paraldehyde (sedative hypnotic) Infection, INH, iron tablets Lactic acid Ethylene glycol (antifreeze) renal failure Salicylate Non-Gap Metabolic Acidosis Renal tubular acidosis (RTA)renal bicarb loss Diarrhea & other bowel loss GI losses Carbonic anhyrdrase inhibitors*

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