CH3 Lee-Ture 2: Mo..ke
CH3 Lee-Ture 2: Mo..ke
CH3 Lee-Ture 2: Mo..ke
Re vi e
Lei IS mo..ke - - - frnrY'l o..n ci /'-..
t
l-bu.+yne
-=-H
de prrtonCltt>s
CLlkyne
Roo.d mo.. p shows houJ to ma..ke 0..1 kyne -Fro rYl
o.\KCtne
(: r C.f
[12
A
No.-OH
...
hV
H2o
'----v-
E2 rx f1 I No..N HdNI13
--='-H
rtDvV do know Who.t co ((\pou-nd S N e. hClv' e?
CI'l 13 N MIZ- \'-Juc.Jea.r ResonaJ\ce
.. 0 -form of spectmscopy
. ihe in+erochon o.f Ii3 ht l'\f ith {Y1Cl-H-er
1/-1 NMR (SKip /3C NIVlF<)
Rod j 0 WO-V f'S -;-0 do CLf) exc.i to...+/" of) J
nLIe-I ea..r SpI n stCA.tes
lei-'S +h i S
gucuyh zeel ener3Y staH's
+/ is an
two:2 r,v
e neeci U v/ vI
en er:9 YurbJiaQ I r5t11
levels f +
.'1: 1/
4
rod (0 ilUCL Ves ( loIN en e'3 'I)
h( + spin -FlIps
;/=+
o spin
on 0
Whj different ener8i es -fOr the spins?
nlAClei
There Qre Only different ener3,es When
In 0- mDjne-tic.. fj eld
++t-t
4++++
/hQre is LA.. +-i n y
preponderance of
Gtp in OLA-r
lYlaqi12
11L
pi c-hA.res
+
-1
,'n 0 (LQ
r
d I ,-ee.--H0 n
r ++t- +++++
.. spins CLQl311Qd wi 60 In enerBy
nO+a.QiS rlQd W!f36 h1jher In energy
In SLLmmD.ry) pu.+ our 0C9
a
n,c mol eCu.../f>s
in (i mO-jneflc -ReId) a-pply rClC')Iowo..ves +0
+he 8O..mple) and jn SOme rYb-nner we measure
h\c/l rete I()wo..ves exc.i+e -the W-mpJf>.
An NMR pecTYu-m
rodfovvo....ve
freq uency
cernll n ener3' es
absorbed b..:J -the
molecule
I
/0 5 0 "-tilt?
PF rn (pCLrts pe r mil) ,'0 n)
Term G INe CLPply to thI S seQ.. J e :
__---
downf-ie.ld up-A' eId
desh;elded shiQlded
hl8her lower ene':9Y
G,n3'e+ pea-/<
<l,------+J------+-1--------1-/
Ie>
5
o
Egu.ivo.len+ H's
How ma(lY dffF types of" HIS are -there
(n ben ne? I
H l/ OflQ -FreCjue.ncy
I Cl.bsorbed rnoleeula
.." - H h..e re.
H ::--Mth ? J
H- 1'1(2. anD
HouJ MOJl Y dI"tfer eJlt H-'S? 2
/' How f{\Ctr\.lj MR pQo.k
s
/
xo Hhe r lrv I. - -2 ppm
l-I C C tt 3 ""'plr>
equivatn-l: ' ., 2';-35':-- L _
Ro...1l0' i 3
H's
/0
0
ppm or peaks In.dico+es &>rY1efhln3
Qbou+ rf\olecule e,-t-vuc tu..re
CD c. heml(aJ --%,'+,+ (what a.re fhe ppM
Q} l..(\+e3rClI j: I
WhOo+ to 8
et
tClbl eon P3 e 480?
- understand n-enc/s/whl'ch mnc-nonal
-3rDLAPS Show u-p at- D- \Xlrficular
pprYl