Scribd Logo
Upload

Welcome to Scribd!

  • 215 views

    Isoprenaline

    Uploaded by

    Immanuel Victor George
    Isoprenaline is a non-selective beta 1 and beta 2 adrenergic agonist used to treat conditions like bradycardia, bronchospasm, and heart block. It works by stimulating both beta 1 and beta 2 receptors. Beta 1 stimulation increases heart rate and contractility, while beta 2 stimulation causes bronchodilation and vasodilation. Common side effects include tachycardia, palpitations, headache, and dizziness. Isoprenaline is contraindicated in conditions like tachycardia, arrhythmias, angina, and recent myocardial infarction.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd

    Isoprenaline

    Uploaded by

    Immanuel Victor George
    215 views2 pages
    Isoprenaline is a non-selective beta 1 and beta 2 adrenergic agonist used to treat conditions like bradycardia, bronchospasm, and heart block. It works by stimulating both beta 1 and beta 2 receptors. Beta 1 stimulation increases heart rate and contractility, while beta 2 stimulation causes bronchodilation and vasodilation. Common side effects include tachycardia, palpitations, headache, and dizziness. Isoprenaline is contraindicated in conditions like tachycardia, arrhythmias, angina, and recent myocardial infarction.

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    DOC, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Isoprenaline is a non-selective beta 1 and beta 2 adrenergic agonist used to treat conditions like bradycardia, bronchospasm, and heart block. It works by stimulating both beta 1 and beta 2 receptors. Beta 1 stimulation increases heart rate and contractility, while beta 2 stimulation causes bronchodilation and vasodilation. Common side effects include tachycardia, palpitations, headache, and dizziness. Isoprenaline is contraindicated in conditions like tachycardia, arrhythmias, angina, and recent myocardial infarction.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    215 views2 pages

    Isoprenaline

    Uploaded by

    Immanuel Victor George
    Isoprenaline is a non-selective beta 1 and beta 2 adrenergic agonist used to treat conditions like bradycardia, bronchospasm, and heart block. It works by stimulating both beta 1 and beta 2 receptors. Beta 1 stimulation increases heart rate and contractility, while beta 2 stimulation causes bronchodilation and vasodilation. Common side effects include tachycardia, palpitations, headache, and dizziness. Isoprenaline is contraindicated in conditions like tachycardia, arrhythmias, angina, and recent myocardial infarction.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    of 2

    Isoprenaline

    Generic

    Adrenergic Beta 1 and Beta 2 antagonist, Antiasthmatic, Cardiac stimulant

    Mechanism of action

    Isoprenaline exerts action by non selective beta 2 adrenergic antagonist causing cardiac
    stimulant, bronchodilatation and peripheral vasodilatation. By acting on beta 1 adrenergic
    receptor, it produces positive chronotrophic and inotrophic effects which increase cardiac
    output, in AV block it shortens conduction time and refractory period of the AV block
    and increases the heart rate and strength of the ventricular contractions. By its direct
    action on beta 2 adrenergic receptor it relaxes bronchial smooth muscles and reduces
    residual volume and increases the vital capacity and enhances the removal of secretion.

    Pharmacokinetics

    Absorption – readily absorbed after parental and oral administration


    Distribution – widely all over body
    Metabolism – conjunction by gastrointestinal tract, enzymatic reduction in liver, lungs
    and other tissues
    Excretion – in urine as metabolites and as unchanged drug

    Onset and duration of action

    Few minutes and may last upto 2 to 6 hours

    Indications

    Bradycardia
    Bronchospasm
    Heart block
    Shock

    Dosage

    2 to 4 mcg /body weight/hr or 0.5 to 10 mcg/ minute as infusion titrate according to


    desired action
    Adverse action

    Fluctuations in BP
    Tachycardia
    Palpitations
    Headache
    Dizziness
    Nervousness
    Restlessness
    Tremor
    Anginal pain
    Stokes Adam attack
    Arrhythmias
    Arrest
    Diaphoresis
    Heart burn

    Contra indications

    Hypersensitivity to the drug


    Tachycardia
    Arrhythmias - except responding
    Angina
    VF
    CAD
    Hyperthyroid
    Recent MI
    Pregnancy

    Special precautions

    Hypertension
    Renal impairment
    CAD/IHD
    DM
    AV node disease
    Sensitive to sympathomimetic amines
    Old age
    Breast feeding
    Children

    Storage

    Room temperature

    You might also like