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    Lymphoma of Bone

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    ahmad shaltout
    1. Lymphoma of bone, also known as primary reticulum cell sarcoma or histiocytic lymphoma, is a rare form of non-Hodgkin's lymphoma that affects the bone. 2. It represents around 5% of primary bone tumors and less than 1% of non-Hodgkin's lymphomas. It most commonly affects the lower femur, upper tibia, and humerus. 3. Symptoms include chronic dull pain and a striking contrast between the size of the bone lesion and the patient's overall well-being. The 5-year survival rate is approximately 54%.

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    Lymphoma of Bone

    Uploaded by

    ahmad shaltout
    31 views1 page
    1. Lymphoma of bone, also known as primary reticulum cell sarcoma or histiocytic lymphoma, is a rare form of non-Hodgkin's lymphoma that affects the bone. 2. It represents around 5% of primary bone tumors and less than 1% of non-Hodgkin's lymphomas. It most commonly affects the lower femur, upper tibia, and humerus. 3. Symptoms include chronic dull pain and a striking contrast between the size of the bone lesion and the patient's overall well-being. The 5-year survival rate is approximately 54%.

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    1. Lymphoma of bone, also known as primary reticulum cell sarcoma or histiocytic lymphoma, is a rare form of non-Hodgkin's lymphoma that affects the bone. 2. It represents around 5% of primary bone tumors and less than 1% of non-Hodgkin's lymphomas. It most commonly affects the lower femur, upper tibia, and humerus. 3. Symptoms include chronic dull pain and a striking contrast between the size of the bone lesion and the patient's overall well-being. The 5-year survival rate is approximately 54%.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    31 views1 page

    Lymphoma of Bone

    Uploaded by

    ahmad shaltout
    1. Lymphoma of bone, also known as primary reticulum cell sarcoma or histiocytic lymphoma, is a rare form of non-Hodgkin's lymphoma that affects the bone. 2. It represents around 5% of primary bone tumors and less than 1% of non-Hodgkin's lymphomas. It most commonly affects the lower femur, upper tibia, and humerus. 3. Symptoms include chronic dull pain and a striking contrast between the size of the bone lesion and the patient's overall well-being. The 5-year survival rate is approximately 54%.

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    Lymphoma of Bone

    • = RETICULUM CELL SARCOMA = HISTIOCYTIC LYMPHOMA


    = PRIMARY LYMPHOMA OF BONE
    • = singular bone lesion
    • the generalized form of reticulum cell sarcoma is lymphoma
    Prevalence 5% of all primary bone tumors; <1% of all NHL; 2–6% of all
    : primary malignant bone tumors in children
    • Incidence of bone marrow involvement:
    o 5–15% in Hodgkin disease;
    o 25–40% in non-Hodgkin lymphoma
    o Bone marrow involvement indicates progression of disease
    o Bone marrow imaging-guidance for biopsy!
    NUC: 40% sensitivity; 88% specificity
    MR: 65% sensitivity; 90% specificity
    Histo mostly large B-cell category; sheets of reticulum cells, larger than those
    : in Ewing sarcoma (DDx: myeloma, inflammation, osteosarcoma,
    eosinophilic granuloma)
    Age: bimodal distribution with peaks in 2nd–3rd and 5th–6th decades;
    50% <40 years; 35% <30 years; M:F = 2:1
    • • chronic dull pain
    • • striking contrast between size of lesion + patient's well-being
    Location lower femur, upper tibia (40% about knee), humerus, pelvis, scapula,
    : ribs, vertebra
    Site: dia- / metaphysis
    • cancellous bone erosion (earliest sign)
    • mottled permeative pattern of separate coalescent areas
    • late cortical destruction
    • lamellated / sunburst periosteal response (rare and less than in Ewing
    sarcoma)
    • lytic / reactive new-bone formation
    • associated soft-tissue mass without calcification (70%)
    • synovitis of knee joint common

    Cx: pathologic fracture (most common among malignant bone tumors)


    Prognosis 54% 5-year survival
    :
    DDx: (1) Osteosarcoma (less medullary extension, younger patients)
    (2) Ewing tumor (systemic symptoms, debility, younger patients)
    (3) Metastatic malignancy (multiple bones involved, more
    destructive)

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