American Board of Family Medicine

American Board of Family Medicine
IN-TRAINING EXAMINATION
TIME4 HOURS
Publication or reproduction in whole or in part is strictly prohibited.

Copyright 2014 The American Board of Family Medicine. All rights reserved.
1. A 52-year-old female with morbid obesity is incidentally noted to have mildly elevated AST
(SGOT) levels. She does not consume alcohol and denies using recreational drugs. A workup
for chronic viral hepatitis and hemochromatosis is negative.
Which one of the following is most likely to improve her hepatic condition?
A)
B)
C)
D)
E)
Pentoxifylline
Simvastatin (Zocor)
L-carnitine
Vitamin E
Weight loss
2. A 44-year-old male with papulopustular rosacea sees you for follow-up. You have been treating
his condition with topical azelaic acid (Finacea), and although his condition is improved he is
not satisfied with the results.
You suggest adding which one of the following oral medications?
A)
B)
C)
D)
E)
Clarithromycin (Biaxin)
Clindamycin (Cleocin)
Doxycycline
Erythromycin
Metronidazole (Flagyl)
3. A 52-year-old male has a skin lesion removed from his arm with appropriate sterile precautions.
Which one of the following would be most appropriate to use on this surgical wound?
A)
B)
C)
D)
E)
Petrolatum
Silver sulfadiazine (Silvadene) cream
Mupirocin (Bactroban) ointment
Polymyxin B/bacitracin ointment (Polysporin)
Triple-antibiotic (neomycin/polymyxin B/bacitracin) ointment
4. A 15-year-old male is brought to the office for a well child visit. His parents report that he has
had a nighttime cough and wheezing for the past several months. He is otherwise healthy and
up-to-date on all of his immunizations. You suspect that he has asthma.
Which one of the following would be most appropriate at this point?
A)
B)
C)
D)
E)
Treat empirically with a short-acting $-agonist

Perform spirometry
Order radiologic testing
Start an inhaled corticosteroid
Start a leukotriene inhibitor
5. A 36-year-old female presents with a several-week history of polyuria and intense thirst. She
currently takes no medications. On examination her blood pressure and pulse rate are normal,
and she is clinically euvolemic. Laboratory tests, including serum electrolyte levels, renal
function tests, and plasma glucose, are all normal. A urinalysis is significant only for low
specific gravity. Her 24-hour urine output is >5 L with low urine osmolality.
The most likely cause of this patients condition is a deficiency of
A)
B)
C)
D)
E)
angiotensin II
aldosterone
renin
insulin
arginine vasopressin
6. A 39-year-old female presents with lower abdominal/pelvic pain. On examination, with the
patient in a supine position, you palpate the tender area of her lower abdomen. When you have
her raise both legs off the table while you palpate the abdomen, her pain intensifies.
Which one of the following is the most likely diagnosis?
A)
B)
C)
D)
E)
Appendicitis
A hematoma within the abdominal wall musculature
Diverticulitis
Pelvic inflammatory disease
An ovarian cyst
7. Which one of the following is one of the five basic principles of the patient-centered medical
home?
A)
B)
C)
D)
E)
Utilizing the latest research and advances in treatment and diagnosis

Coordinating a patients care across all elements of the health care system
Acting as a gatekeeper to limit access to specialist care
Serving as the base of a pyramid in support of a complex health care system
Transitioning away from delivering care in an office, and focusing on meeting patients
in their own homes
8. Mild cognitive impairment is characterized by which one of the following?

A)
B)
C)
D)
E)
Localized motor dysfunction

Impairment in at least one activity of daily living
Impairment in at least one instrumental activity of daily living
The presence of the APO E4 allele
Objective evidence of memory decline
9. A healthy 24-year-old male presents with a sore throat of 2 days duration. He reports mild
congestion and a dry cough. On examination his temperature is 37.2C (99.0F). His pharynx
is red without exudates, and there are no anterior cervical nodes. His tympanic membranes are
normal, and his chest is clear.
A)
B)
C)
D)
Analgesics and supportive care only

A rapid strep test
A throat culture and empiric treatment with penicillin
Azithromycin (Zithromax)
10. Routine vaccination against which one of the following organisms has significantly reduced the
risk of bacterial meningitis among young children?
A)
B)
C)
D)
E)
Borrelia burgdorferi
Escherichia coli
Haemophilus influenzae
Listeria monocytogenes
Mycoplasma pneumoniae
11. To prevent joint damage from gout, uric acid levels should be lowered by medication to
A)
B)
C)
D)
<6.0 mg/dL
<8.0 mg/dL
<10.0 mg/dL
a level that keeps the patient symptom-free for 6 months
12. A 30-year-old female sees you because of increasing fatigue. She has no chronic medical
problems and reports no recent acute illnesses. She recalls being told that she was mildly anemic
after the birth of her daughter 3 years ago. The anemia resolved after 3 months of oral iron
supplementation. The patients menstrual periods are regular and last approximately 6 days, with
heavy bleeding for the first 3 days then moderate to mild flow for approximately 3 days. She
denies epistaxis, black stools, or other signs of bleeding.
On examination her temperature is 36.7C (98.1F), pulse rate 93 beats/min, respiratory rate
16/min, and blood pressure 116/58 mm Hg. The remainder of her physical examination is
unremarkable. A CBC is notable for a hemoglobin level of 10.9 g/dL (N 12.016.0) and a mean
corpuscular volume of 70 :m3 (N 78102).
Which one of the following serum levels would be most appropriate for further evaluating her
microcytic anemia at this point?
A)
B)
C)
D)
E)
Ferritin
Folate
Erythropoietin
Hemoglobin A1c
TSH
3
13. An elderly male who has an implanted cardioverter-defibrillator is admitted to long-term care.
He has several chronic comorbidities, including hypertension, a previous stroke, coronary artery
disease, osteoarthritis, advanced chronic systolic heart failure, chronic kidney disease with a
calculated glomerular filtration rate of 20 mL/min/1.73 m2, diabetes mellitus, and
hypercholesterolemia.
The patients quality of life has declined to the point that he wishes to receive only palliative
care. He does not want aggressive treatments, including hospitalization, except for reasons of
comfort. He has decided he does not wish to be resuscitated, including CPR or intubation.
When considering his goals, and after consultation with the patient and his spouse, which one
of the following would be most appropriate for managing his defibrillator?
A)
B)
C)
D)
E)
Adjust the defibrillator to deliver shocks only for ventricular fibrillation

Adjust the defibrillator to deliver shocks only for a heart rate >140 beats/min
Remove the defibrillator generator
Deactivate the defibrillator
Make no change to the defibrillator
14. A 50-year-old male with difficult-to-control hypertension seeks your advice regarding
progressive breast enlargement. Your examination reveals bilateral firm, glandular tissue in a
concentric mass around the nipple-areola complex. You diagnose gynecomastia.
Which one of the following antihypertensive medications is most likely to cause this problem?
A)
B)
C)
D)
E)
Doxazosin (Cardura)
Hydrochlorothiazide
Lisinopril (Prinivil, Zestril)
Losartan (Cozaar)
Spironolactone (Aldactone)
15. A large wooden splinter went deep into the forearm of a 24-year-old male while he was working
in a horse barn, and he has required local anesthesia and a small incision to remove it
completely. After thorough wound cleansing, you inquire about his tetanus status. He is certain
that he received all of his primary childhood vaccines and a tetanus booster at age 20, but does
not know which vaccine he received.
Which one of the following is the best choice for this patient regarding tetanus immunization at
this time?
A)
B)
C)
D)
E)
TT (tetanus toxoid)
Td (tetanus toxoid with reduced diphtheria)
Tdap (tetanus toxoid with reduced diphtheria and acellular pertussis)
TIG (tetanus immune globulin)
No immunization
16. A previously healthy 16-year-old male presents to your office after having a syncopal episode
at the start of track practice. An EKG revealed a QTc of 520 ms. This was confirmed on a
subsequent EKG.
This finding is associated with which one of the following rhythm abnormalities?
A)
B)
C)
D)
E)
Sinus arrest
Third degree atrioventricular block
Paroxysmal supraventricular tachycardia
Polymorphic ventricular tachycardia
Atrial fibrillation with a rapid ventricular response
17. Which one of the following intravenous agents is the best INITIAL management for
hypercalcemic crisis?
A)
B)
C)
D)
Furosemide
Pamidronate
Hydrocortisone
Saline
18. An 84-year-old male is walking across the street and has to hurry to avoid oncoming traffic. He
suddenly develops extreme pain in his knee and falls down, and has to be carried to the
sidewalk.
The following day he comes to the emergency department. He is comfortable when placed in a
knee immobilizer, but is very tender just above the patella. He can bend his knee but when he
tries to straighten his leg it is so weak that he cannot move it at all. Radiographs of the knee are
shown below.
What is the most likely diagnosis?
A)
B)
C)
D)
E)
Patellar tendon rupture

Quadriceps tendon rupture
Tibial plateau fracture
Patellar subluxation
Lumbar radiculopathy
19. A 58-year-old postmenopausal female presents with a recent onset of painless vaginal bleeding.
Her last menses occurred 8 years ago and she has had no bleeding until now. She reports that
her Papanicolaou smears have always been normal, with the last one obtained a year ago. A
pelvic examination today is normal.
Which one of the following management options is the preferred next diagnostic step?
A)
B)
C)
D)
Colposcopy with endocervical curettage

Transvaginal ultrasonography
Saline infusion sonohysterography
Hysteroscopy
5
20. A 67-year-old male is admitted to your inpatient service with a week-long acute exacerbation of
COPD. He also has hypertension and type 2 diabetes mellitus. After 24 hours of intravenous
fluids and intravenous methylprednisolone, he is now tolerating oral intake.
Which one of the following corticosteroid regimens is best for this patient at this time?
A) Continue intravenous methylprednisolone until his COPD is back to baseline, then
switch to oral methylprednisolone for a 14-day total course of treatment
B) Switch to oral prednisone for a 14-day total course of treatment, including the initial
24-hour intravenous treatment
C) Switch to oral prednisone for 4 more days of treatment
D) Use only inhaled corticosteroids by nebulizer
E) Discontinue corticosteroid treatment altogether after 24 hours
21. Which one of the following medications used for anxiety has also been shown to reduce the
symptoms of irritable bowel syndrome?
A)
B)
C)
D)
E)
Buspirone
Clonazepam (Klonopin)
Divalproex sodium (Depakote)
Risperidone (Risperdal)
Citalopram (Celexa)
22. Which one of the following ethnic groups in the United States is at greatest risk for
complications from influenza?
A)
B)
C)
D)
E)
African-American
Asian-American
Mexican-American
Native American
Scandinavian-American
23. The Infectious Diseases Society of America recommends which one of the following as the drug
of choice for group A streptococcal pharyngitis?
A)
B)
C)
D)
E)
Cefadroxil
Cephalexin (Keflex)
Clindamycin (Cleocin)
Penicillin
24. A 7-year-old Hispanic female has a 3-day history of a fever of 104.0F (40.0C), muscle aches,
vomiting, anorexia, and headache. Over the past 12 hours she has developed a painless
maculopapular rash that includes her palms and soles but spares her face, lips, and mouth. She
has recently returned from a week at summer camp in Texas. Her pulse rate is 140 beats/min,
and her blood pressure is 70/40 mm Hg.
A)
B)
C)
D)
E)
Mucocutaneous lymph node syndrome

Leptospirosis
Rocky Mountain spotted fever
Scarlet fever
Toxic shock syndrome
25. A 76-year-old male with metastatic cancer, diabetes mellitus, and stage IV chronic renal disease
develops confusion and myoclonus. His current medications include enalapril (Vasotec), 10
mg/day; glipizide (Glucotrol), 10 mg/day; and morphine sulfate, 30 mg every 4 hours for pain.
The morphine was started 4 weeks ago and the dosage was gradually increased until the pain was
controlled.
Which one of the following is the most likely cause of his symptoms?
A)
B)
C)
D)
A drug-drug interaction
Metastasis to the lumbar spine
Diabetic neuropathy
Toxic metabolites of morphine
26. A 29-year-old female presents with redness of her left eye. She has just returned from a summer
beach vacation with her children and woke up with a red eye. Your examination reveals a watery
discharge, a hyperemic conjunctiva, and a palpable preauricular lymph node. Her cornea is clear
on fluorescein staining.
Which one of the following is most appropriate for this patient?
A)
B)
C)
D)
E)
Reassurance only
Culture-guided antibiotic therapy
Quinolone eyedrops
Corticosteroid/antibiotic eyedrops
Urgent ophthalmologic referral
27. A 75-year-old female is evaluated in the emergency department in the evening for heart failure.
She is acutely symptomatic with dyspnea. Vital signs include a pulse rate of 96 beats/min, a
blood pressure of 140/90 mm Hg, and an oxygen saturation of 94% on room air. A chest
radiograph shows mild pulmonary congestion.
Which one of the following would be most appropriate regarding placement of an indwelling
urinary catheter for accurate measurement of urine output and for patient comfort?
A) Avoiding indwelling urinary catheter placement
B) Placement of an indwelling urinary catheter only until initial diuresis is completed
C) Placement of an indwelling urinary catheter and removal when the patient is transferred
out of the emergency department
D) Placement of an indwelling urinary catheter until 6:00 a.m. tomorrow
E) Placement of an indwelling urinary catheter and removal within 24 hours
28. A 75-year-old male with a history of hypertension sees you after experiencing an episode of
numbness on his right side and loss of strength in his right arm. The numbness and weakness
resolved spontaneously within 20 minutes. Carotid Doppler ultrasonography and cerebral
angiography both reveal significant carotid stenosis.
In addition to starting aspirin, which one of the following would be the most appropriate next
step for this patient?
A)
B)
C)
D)
E)
Aggressive lowering of blood pressure

Clopidogrel (Plavix)
Carotid artery stenting
Evaluation for occult patent ductus arteriosus
High-dose statin therapy
29. A 57-year-old female is hospitalized for hypotension. She has stage IV breast cancer with
extensive visceral and skeletal metastases. For the past 2 weeks she has had fatigue, nausea, and
anorexia. She also reports a 3-lb weight loss during this time. She decided to stop chemotherapy
1 month ago.
The patient appears pale with a pulse rate of 78 beats/min and a blood pressure of 82/54 mm
Hg. Her physical examination is unremarkable except for lower thoracic spine tenderness on
percussion. Laboratory studies reveal a serum sodium level of 132 mEq/L, a potassium level of
5.2 mEq/L, and a hemoglobin level of 10.5 g/L. Chest radiographs reveal scattered pulmonary
metastatic lesions. The patient is started on intravenous fluid resuscitation with normal saline.
On day 2 her blood pressure continues to remain low despite aggressive fluid replacement.
Which one of the following should be administered next to manage her hypotension?
A)
B)
C)
D)
E)
Broad-spectrum antibiotics
Dobutamine
Dopamine
Hydrocortisone
Packed RBCs
8
30. Which one of the following is the most accurate imaging study for assessing early osteomyelitis?
A)
B)
C)
D)
E)
Plain radiography
Ultrasonography
CT
MRI
A bone scan
31. A 43-year-old asymptomatic male is found to have slightly elevated ALT (SGPT) and AST
(SGOT) levels on laboratory work prior to donating blood. He feels well and is otherwise
healthy.
Which one of the following should be ordered to evaluate the patient for hereditary
hemochromatosis?
A)
B)
C)
D)
E)
A serum iron panel, including a serum ferritin level and transferrin saturation
An "-fetoprotein (AFP) level
HFE genetic testing
Hepatic ultrasonography
A liver biopsy
32. Which one of the following findings on pulmonary function testing is most consistent with
restrictive lung disease?
A)
B)
C)
D)
E)
Reduced FEV1 and a decreased FEV1/FVC ratio

Reduced FEV1 and a normal FEV1/FVC ratio
Reduced FEV1 and an increased FEV1/FVC ratio
Reduced FVC and an increased FEV1/FVC ratio
Decreased diffusing capacity of the lung for carbon monoxide (DLCO)
33. The parents of a 4-year-old male bring him in for evaluation because of behavioral problems in
his preschool. They report that he is inattentive, hyperactive, and impulsive, has difficulty
remaining seated, always seems to be moving, frequently interrupts others, and talks incessantly.
His teacher also told them that he never plays quietly, has difficulty taking turns, and intrudes
often in other childrens play.
Which one of the following is recommended by the American Academy of Pediatrics for initial
management in this childs case?
A)
B)
C)
D)
E)
Behavioral treatment alone

Methylphenidate (Ritalin) alone
Atomoxetine (Strattera) alone
Methylphenidate combined with behavioral treatment
Methylphenidate combined with atomoxetine
34. A 56-year-old male with diabetes mellitus and hypertension presents with a 6-month history of
generalized pruritus. He reports that he scratches frequently. On examination his skin is dry and
scaly. He has multiple linear excoriations and thickened skin on his forearms, legs, and neck.
Which one of the following is the most likely cause of his pruritus?
A)
B)
C)
D)
Contact dermatitis
Chronic urticaria
Lichen simplex chronicus
Scabies
35. A 50-year-old female with a history of refractory hypertension presents with abdominal pain.
Her laboratory results are significant for a positive Helicobacter pylori antibody. You decide to
initiate treatment for her H. pylori infection with sequential therapy using the following drug
regimen: rabeprazole (Aciphex) plus amoxicillin, followed by clarithromycin (Biaxin) plus
tinidazole (Tindamax). She is currently on multiple medications for her hypertension.
Which one of her antihypertensive agents would be most affected by the treatment regimen
described?
A)
B)
C)
D)
E)
Amlodipine (Norvasc)
Clonidine transdermal (Catapres-TTS)
Hydrochlorothiazide
Metoprolol tartrate (Lopressor)
Ramipril (Altace)
36. A 65-year-old female presents with an 11-mm lesion on her nasolabial fold. You perform a
shave biopsy that confirms basal cell carcinoma.
Which one of the following would be the most appropriate treatment of this lesion?
A)
B)
C)
D)
E)
Excision with wide margins

Electrodesiccation and curettage
Mohs micrographic surgery
Cryotherapy
Imiquimod (Aldara) cream
37. A 39-year-old female presents with a 4-month history of gradually worsening left elbow pain.
She does not recall an injury but frequently lifts and holds her 10-month-old son in her left arm.
She has tenderness over the lateral epicondyle. Her elbow range of motion is normal but she has
pain with supination and pronation. The remainder of the examination is normal.
For long-term pain relief, the best evidence supports which one of the following?
A)
B)
C)
D)
Expectant/conservative management
Physical therapy
Oral anti-inflammatory agents
A corticosteroid injection
10
38. Azithromycin (Zithromax) is prescribed for a 65-year-old male with coronary artery disease.
This drug should be used with caution in this patient due to an increased risk for
A)
B)
C)
D)
an adverse effect on left ventricular function

peripheral edema
elevation of systolic blood pressure
fatal arrhythmias
39. A 62-year-old female with type 2 diabetes mellitus routinely has fasting blood glucose levels in
the 80100 mg/dL range and her hemoglobin A1c level is 7.8%. She has been diligently
monitoring her blood glucose levels and all are acceptable with the exception of elevated bedtime
readings. She currently is on insulin glargine (Lantus), 18 U at night.
Which one of the following changes would be most appropriate for this patient?
A)
B)
C)
D)
E)
Adding rapid-acting insulin at breakfast

Adding rapid-acting insulin at lunch
Adding rapid-acting insulin at dinner
Increasing the nightly insulin glargine dose
Increasing the insulin glargine dosage and giving two-thirds in the morning and one-third
at night
40. A 56-year-old male is brought to the emergency department by his wife because of a 3-day
history of fever up to 102.1F (38.9C). He complains of headache, body aches, and a cough.
His wife notes that he seems to be confused at times, and mentions that he has type 2 diabetes
mellitus.
On examination the patients temperature is 38.7C (101.7F), heart rate 113 beats/min, blood
pressure 96/64 mm Hg, respiratory rate 24/min, and oxygen saturation 93% on room air. You
administer 2 L of oxygen via nasal cannula and his oxygen saturation rises to 98%. A CBC,
blood cultures, and a basic metabolic panel are ordered, as well as a chest radiograph and
urinalysis.
In addition to starting antibiotics, which one of the following would be most appropriate at this
point?
A)
B)
C)
D)
E)
A bolus of normal saline

Bicarbonate therapy
Vasopressin (Pitressin)
Hydrocortisone intravenously
Norepinephrine
11
41. A 4-year-old male is brought to your office by his parents who are concerned that he is
increasingly knock-kneed. His uncle required leg braces as a child, and the parents are
worried about long-term gait abnormalities. On examination, the patients knees touch when he
stands and there is a 15 valgus angle at the knee. He walks with a stable gait.
Which one of the following should you do now?
A)
B)
C)
D)
Refer to orthopedics for therapeutic osteotomy

Refer to physical therapy for customized bracing
Prescribe quadriceps-strengthening exercises
Provide reassurance to the patient and his family
42. A 71-year-old female with a history of hypertension and osteoporosis presents to your office for
preoperative clearance for upcoming eye surgery. She complains of progressively worsening
fatigue over the past 810 months. She says she often feels dizzy but denies a history of
syncope. Her current medications include alendronate and hydrochlorothiazide. You obtain the
EKG shown below as part of her preoperative evaluation.
A)
B)
C)
D)
E)
Clearance for eye surgery with no further evaluation

An exercise treadmill test
A 48-hour Holter monitor
A 7-day event monitor
Referral to a cardiologist for pacemaker placement
43. You are treating an 18-year-old college freshman for allergic rhinitis. It is September, and he
tells you that he has severe symptoms every autumn that impair his academic performance. He
has a strongly positive family history of atopic dermatitis.
Which one of the following intranasal medications is considered optimal treatment for this
condition?
A)
B)
C)
D)
Glucocorticoids
Cromolyn sodium
Decongestants
Antihistamines
12
44. One week after a complete and adequate baseline screening colonoscopy, a 51-year-old female
with no history of previous health problems visits you to review the pathology report on the
biopsy specimen obtained from the solitary 8-mm polyp discovered in her sigmoid colon. The
report confirms that this was a hyperplastic polyp. Her family history is negative for colon
cancer.
Which one of the following is the most appropriate interval for follow-up colonoscopy in this
patient?
A)
B)
C)
D)
1 year
2 years
5 years
10 years
45. A 55-year-old overweight male presents with a complaint of pain in the left big toe. He recently
started jogging 2 miles a day to try to lose weight, but has not changed his diet and says he
drinks 4 cans of beer every night. The pain has developed gradually over the last 2 weeks and
is worse after running.
An examination shows a normal foot with tenderness and swelling of the medial plantar aspect
of the left first metatarsophalangeal joint. Passive dorsiflexion of the toe causes pain in that area.
Plantar flexion produces no discomfort, and no numbness can be appreciated.
A)
B)
C)
D)
Sesamoid fracture
Gout
Mortons neuroma
Cellulitis
46. A 49-year-old white female is concerned because she has painful, cold fingertips that sometimes
turn white when she is hanging out her laundry. Which one of the following medications has
been shown to be useful for this patients condition?
A)
B)
C)
D)
Propranolol
Nifedipine (Procardia)
Ergotamine/caffeine (Cafergot)
Cilostazol (Pletal)
47. A 78-year-old male experiences two episodes of near-syncope within several hours. You order
an EKG, which is shown below.
Which one of the following does this EKG show?
A)
B)
C)
D)
Atrial fibrillation with a slow ventricular response

Sinus bradycardia
Complete heart block
2:1 Mobitz AV block
13
48. A disheveled 89-year-old male with dementia who relies on a caregiver for bathing, dressing,
shopping, and meal preparation is brought in for continued evaluation of weight loss. No medical
cause has been found at this point. On examination a large purplish bruise is noted over his
posterior leg and a more faded greenish-yellow bruise is noted over his abdomen, which his
caregiver explains by saying that he has fallen several times recently. The patient is also noted
to have a large sacral decubitus ulcer.
Which one of the following should you suspect as the cause of bruising in this patient?
A)
B)
C)
D)
E)
Senile purpura
Thrombocytopenia
Leukemia
Elder abuse
Cushing syndrome
49. A 36-year-old male laborer presents to an urgent care center 5 hours after falling off a ladder.
He was 78 feet off the ground, and he fell directly on his anterolateral leg as he landed. Weight
bearing is painful. Foot pulses are normal, as is a sensorineural examination of the foot and leg.
The anterolateral lower leg is quite tender but only slightly swollen, and there is exquisite pain
in that area with passive plantar flexion of the great toe. Radiographs of the lower leg and ankle
are negative.
In addition to ice, elevation, and analgesia, which one of the following would be most
appropriate?
A)
B)
C)
D)
E)
Scheduled oral muscle relaxants

A 6-day oral corticosteroid taper
Physical therapy referral for early mobilization and ultrasound therapy
A short leg splint and nonweight bearing for 57 days
Urgent orthopedic referral for possible fasciotomy
50. A 25-year-old female with hypothyroidism sees you for preconception counseling. Her thyroid
problem has been well managed with levothyroxine (Synthroid), 75 :g daily, but she asks your
advice about changing her treatment to something more natural now that she is planning to
become pregnant.
Which one of the following is the best recommendation for this patient?
A)
B)
C)
D)
Continue the current dosage of levothyroxine

Reduce the current dosage of levothyroxine to 50 :g daily
Change to a comparable dosage of combination levothyroxine/L-triiodothyronine
Change to a comparable dosage of desiccated thyroid
14
51. A 25-year-old female kindergarten teacher comes to your office for evaluation of a cough she
has had for 2 weeks. The preceding week she had symptoms of rhinorrhea, mild malaise,
low-grade fever, and lacrimation. She reports that episodes of coughing are so severe that
vomiting is induced. She was evaluated at a walk-in clinic 1 week ago and was diagnosed with
bronchitis. Treatment with hydrocodone cough syrup and amoxicillin has not helped. On
examination she has mild rhinorrhea and injected conjunctivae, but her lungs are clear. A chest
radiograph is normal and her laboratory results reveal a mild lymphocytosis.
Which one of the following is the most appropriate next step in the management of this patient?
A)
B)
C)
D)
E)
Corticosteroid therapy
A sputum culture
A nasopharyngeal culture and polymerase chain reaction testing
Direct fluorescent antibody testing
Serologic testing
52. Blood pressure classification in children is based on

A)
B)
C)
D)
sex, weight, and height

sex, weight, and age
sex, height, and age
weight, height, and age
53. A 45-year-old male with no known medical problems sees you for a general physical
examination. Which one of the following screening measures is recommended by the U.S.
Preventive Services Task Force for this patient?
A)
B)
C)
D)
E)
A fasting lipid profile

Colorectal cancer screening
Abdominal aortic aneurysm screening
Testicular examination
Prostate-specific antigen (PSA) testing
54. A 35-year-old female with a history of chronic abdominal pain and diarrhea develops tender red
nodules on her shins. These findings are most consistent with which one of the following?
A)
B)
C)
D)
E)
Celiac disease
Crohns disease
Diverticular disease
Irritable bowel syndrome
Clostridium difficile colitis
15
55. A decrease in which one of the following could be expected from long-term use of
postmenopausal estrogen plus progesterone?
A)
B)
C)
D)
E)
Ischemic heart disease

Dementia
All-cause mortality
Breast cancer
Hip fracture
56. In a patient with symptoms of thyrotoxicosis and elevated free T4, the presence of thyroid TSH
receptor site antibodies would indicate which one of the following as the cause of thyroid gland
enlargement?
A)
B)
C)
D)
E)
Toxic multinodular goiter

Toxic adenoma
Hashimotos (lymphadenoid) thyroiditis
Subacute (giant cell) thyroiditis
Graves disease
57. Which one of the following is a risk factor for prolonged recovery from a sports-associated
concussion?
A)
B)
C)
D)
E)
Blurred vision
Headache lasting longer than 60 hours
Amnesia for the injury
Loss of consciousness at the time of injury
Convulsions following the injury
58. A 53-year-old obese female presents with left calf swelling and tenderness. Using the Wells
criteria you determine that she is at intermediate risk for deep vein thrombosis.
Which one of the following is the most appropriate next step in the evaluation and treatment of
this patient?
A)
B)
C)
D)
E)
Anticoagulation
D-dimer assessment
Compression ultrasonography
Impedance plethysmography
Contrast venography
16
59. Which one of the following is recommended with regard to the use of osteoporosis medications
in elderly patients?
A) Substitution of denosumab (Prolia) for bisphosphonates in patients planning extensive
dental work
B) Use of denosumab in patients at increased risk for infection
C) Use of denosumab rather than bisphosphonates in patients with class III or IV renal
dysfunction
D) Continuous use of bisphosphonates for 10 years or more
60. A 4-month-old female is brought to your office by her parents for a 3-day history of fever up
to 101.7F (38.7C). She is fussy and her oral intake is down. She has no rash, no emesis, and
no diarrhea. Her urine output is normal. She is in day care 3 days a week.
On examination she is alert but fussy. Her rectal temperature is 38.4C (101.1F). The
examination is otherwise normal and there are no focal findings of infection. The parents are
reliable and you choose to manage the baby as an outpatient.
Which one of the following tests is most likely to be helpful in this situation?
A)
B)
C)
D)
E)
A CBC with manual differential

A urinalysis and urine culture
A chest radiograph
C-reactive protein
A lumbar puncture
61. A 36-year-old male with a history of complex regional pain syndrome has been on oxycodone
(OxyContin) for the past 5 years. His pain is well controlled.
Which one of the following side effects is most likely to occur with long-term chronic use of
opioids?
A)
B)
C)
D)
E)
Diarrhea
Sedation
Hypoalgesia
Respiratory depression
Hypogonadism
62. An asymptomatic 56-year-old male has an echocardiogram that demonstrates trivial mitral
regurgitation. Which one of the following is the recommended follow-up for this patient if he
remains asymptomatic?
A)
B)
C)
D)
E)
No repeat echocardiography
Repeat echocardiography in 1 year
Repeat echocardiography in 2 years
17
63. A 20-year-old offensive lineman who plays football for the small college in your town presents
to your office at midseason with pain in his right groin. He describes it as a burning, aching
sensation that gets worse when he coughs or strains during a bowel movement, and when he is
required to block opponents or push against the blocking sled in practice.
As part of the physical examination, you have the patient stand, and you insert your finger into
the inguinal canal and follow the spermatic cord to the internal inguinal ring. When you reach
the internal ring the patient reports discomfort. When you ask him to cough and strain the pain
increases and you feel an impulse or bulge at the tip of your finger. The remainder of his
physical examination is normal.
This patients history and examination findings are most consistent with which one of the
following diagnoses?
A)
B)
C)
D)
E)
Athletic pubalgia (sports hernia)

Osteitis pubis
Adductor muscle tendinopathy
Ilioinguinal nerve entrapment
Inguinal hernia
64. A 40-year-old runner complains of gradually worsening pain on the lateral aspect of his foot.
He runs on asphalt, and has increased his mileage from 2 miles/day to 5 miles/day over the last
2 weeks. Palpation causes pain over the lateral fifth metatarsal. The pain is also reproduced
when he jumps on the affected leg. When you ask about his shoes he tells you he bought them
several years ago.
A)
B)
C)
D)
Ligamentous sprain of the arch

Stress fracture
Plantar fasciitis
Osteoarthritis of the metatarsal joint
65. A 2-year-old female is brought to the urgent care center with a fever and cough. Her symptoms
started suddenly a few hours ago with a runny nose and fever to 101F. On examination the
child is crying and has a persistent barking cough but has no stridor or significant respiratory
distress. Her lungs are clear to auscultation. Her skin is warm, pink, and well perfused, and her
oxygen saturation is 99% on room air. A chest radiograph is normal.
Which one of the following treatments has been shown to improve outcomes for this problem?
A)
B)
C)
D)
E)
Humidified air
Nebulized albuterol (Proventil, Ventolin)
Oral azithromycin (Zithromax)
Oral dexamethasone
Oxygen therapy
18
66. An 80-year-old male presents with a 10-day history of intermittent colicky abdominal pain. The
pain is low and central and seems to be worse after eating. He has no associated fever or
vomiting but does feel nauseated when the pain is present. He says that prior to this episode he
had hard stools once or twice a week that were difficult to pass. For the past several days he has
had only watery stools, several times a day.
On examination there is fullness in his left lower quadrant with nonspecific tenderness diffusely
and no guarding or rebound. A urine dipstick is normal.
A)
B)
C)
D)
E)
Viral gastroenteritis
Acute colitis
Constipation
Urinary tract infection
Nephrolithiasis
67. Which one of the following therapeutic interventions improves outcomes in adults with acute
respiratory distress syndrome (ARDS)?
A)
B)
C)
D)
E)
Early initiation of antibiotics

Surfactant therapy
Pulmonary artery catheterization
Aggressive intravenous fluid resuscitation
Starting mechanical ventilation with lower tidal volumes
68. According to the Joint Commissions sentinel event program, the most common root cause of
serious medical errors is a deficiency of
A)
B)
C)
D)
E)
competency and credentialing

staffing
communication
leadership
organization culture
69. A 4-year-old male sees you for pre-kindergarten screening. On corneal light reflex testing, the
light reflex in the patients right eye is in the center of the pupil. In the left eye it is located
below the pupil, over the inferior-lateral portion of the iris.
This clinical finding is associated with a congenital palsy of which one of the following cranial
nerves?
A)
B)
C)
D)
E)
Third
Fourth
Fifth
Sixth
Seventh
19
70. A 32-year-old primigravida at 36 weeks gestation complains of headaches. She denies vaginal
bleeding, leakage of fluid, and contractions, and the fetus is moving normally. Her blood
pressure is 155/100 mm Hg and a urinalysis shows 4+ protein. The rest of her examination is
normal and a cervical examination shows 1 cm of dilation, 50% effacement, a soft consistency,
anterior position, and 2 vertex station. Results of a preeclampsia panel are all in the normal
range.
Which one of the following is the most appropriate management for this patient?
A)
B)
C)
D)
Start labetalol (Trandate) and discharge home on bed rest with close follow-up
Start magnesium sulfate and induce labor now
Start magnesium sulfate, administer corticosteroids, and induce labor in 48 hours
Start magnesium sulfate, lower blood pressure to 140/90 mm Hg, and induce labor at
37 weeks gestation
E) Arrange for urgent cesarean section
71. A 75-year-old otherwise healthy white female states that she has passed out three times in the
last month during her daily brisk walk. Which one of the following is the most likely cause of
her syncope?
A)
B)
C)
D)
E)
Vasovagal syncope
Transient ischemic attack
Orthostatic hypotension
Atrial myxoma
Aortic stenosis
72. A 62-year-old male has a 1-month history of intermittent vomiting, early satiety, and a weight
loss of 4 kg (9 lb). Initially he had diarrhea but it has resolved. He does not have abdominal pain
or bloody stools. He says that over-the-counter famotidine (Pepcid) has relieved the symptoms
somewhat.
A)
B)
C)
D)
E)
Abdominal radiographs
Abdominal ultrasonography
Esophagogastroduodenoscopy
Famotidine at a higher dosage
A proton pump inhibitor
20
73. An 18-month-old male is brought to your office by his mother. The patient is tugging at both
ears and has a temperature of 39.0C (102.2F). You diagnose bilateral acute otitis media for
the third time in the last 6 months. The most recent infection was 3 weeks ago and resolution of
the infection was documented after 10 days of treatment with amoxicillin.
Which one of the following antibiotic regimens would be most appropriate at this time?
A) Amoxicillin, 45 mg/kg/day for 10 days
B) Amoxicillin, 90 mg/kg/day for 10 days
C) Amoxicillin, 90 mg/kg/day for 10 days followed by prophylactic treatment with
amoxicillin for 6 months
D) Amoxicillin/clavulanate (Augmentin), 90 mg/kg/day for 10 days
E) Amoxicillin/clavulanate, 90 mg/kg/day for 10 days followed by prophylactic treatment
with amoxicillin for 6 months
74. A 36-year-old white female calls you to report that she removed a small blood-engorged tick
from her upper arm the previous evening, 3 days after returning from a camping trip in the
mountains of New Hampshire.
Which one of the following would you recommend?
A)
B)
C)
D)
E)
A single 200-mg dose of doxycycline

Doxycycline, 100 mg twice daily for 7 days
Azithromycin (Zithromax), 500 mg daily for 7 days
Topical mupirocin ointment (Bactroban), twice daily for 3 days
No treatment unless she develops the typical erythema migrans rash
75. A 45-year-old female had myalgias, a sore throat, and a fever 2 weeks ago. She now has
anterior neck tenderness and swelling, with pain radiating up to her ears. Your examination
reveals a tender goiter.
Which one of the following would support a diagnosis of subacute granulomatous thyroiditis?
A)
B)
C)
D)
Pretibial myxedema
Exophthalmos
Multiple nodules on ultrasonography
Low radioactive iodine uptake (<5%)
21
76. A 48-year-old female sees you for routine follow-up. She was diagnosed with type 2 diabetes
mellitus 2 years ago and has been treated with metformin (Glucophage), 850 mg orally 3 times
daily, and glipizide (Glucotrol XL), 20 mg orally daily, along with diet and exercise. Her other
medical problems include hypertension and obesity. She has no known cardiovascular disease
or microvascular complications. She came in for laboratory testing yesterday, and her
hemoglobin A1c is 8.0% (N <5.7%).
Which one of the following medications would help with both glycemic control and weight loss
for this patient?
A)
B)
C)
D)
Exenatide (Byetta)
Pioglitazone (Actos)
Sitagliptin (Januvia)
Insulin
77. Which one of the following is the best exercise to improve function in older adults living in
nursing homes?
A)
B)
C)
D)
E)
Swimming
Walking
Stretching
Stationary bicycling
Resistance training
78. A 45-year-old female has been admitted to the hospital for an episode of acute diverticulitis.
Which one of the following features would most strongly suggest a need for surgical
intervention?
A)
B)
C)
D)
E)
A previous admission for diverticulitis in the last 12 months

Pain uncontrolled by oral analgesics
A microperforation seen on CT at the site of the diverticulitis
A 4-cm simple abscess at the site of the diverticulitis
The presence of generalized peritonitis
22
79. A 21-year-old female sees you because of a depressed mood since the birth of her son 2 months
ago. She is breastfeeding, and her baby is doing well. She reports no difficulties sleeping, other
than what is to be expected when caring for a newborn. She denies any suicidal or homicidal
ideation and has never had thoughts about hurting the baby. She has a history of depression 2
years ago that was associated with starting college and feeling very isolated in the dormitory.
She began taking sertraline (Zoloft), changed her schedule, and spent more time exercising.
Within 6 months her depression resolved and she stopped the medication. She reports this
current depression feels worse than her previous depression.
Which one of the following would be the most appropriate medication for this patient?
A)
B)
C)
D)
E)
Amitriptyline
Diazepam (Valium)
Phenytoin
Sertraline
Zolpidem (Ambien)
80. An 18-month-old female with atopic dermatitis is brought to your office. She has recently had
a flare-up of her condition that has been slow to resolve, and the mother says the child scratches
constantly despite daily use of emollients.
Which one of the following would be the best treatment?
A)
B)
C)
D)
E)
A topical mild-potency corticosteroid

Topical pimecrolimus (Elidel)
Oral diphenhydramine (Benadryl)
Oral cetirizine (Zyrtec)
Probiotics
81. A 53-year-old white female with chronic hepatitis C is concerned about ulcers in her mouth. She
is not currently receiving therapy. Your examination reveals several ulcers involving the buccal
mucosa. The patient also points out a number of pruritic, reddish-purple plaques on her wrists,
ankles, and back. Laboratory studies are within normal limits except for mildly elevated
transaminases.
A)
B)
C)
D)
E)
Behets syndrome
Lichen planus
Aphthous stomatitis
Herpetic stomatitis
HIV infection
23
82. An 86-year-old female nursing-home resident has type 2 diabetes mellitus, chronic diastolic heart
failure, chronic kidney disease, advanced osteoarthritis, hypertension, Alzheimers disease, and
other comorbidities. She requires assistance with dressing, bathing, and feeding.
For this patient, the American Geriatrics Society recommends a hemoglobin A1c goal of
A)
B)
C)
D)
E)
<7.0%
<8.0%
<8.5%
<9.0%
<9.5%
83. A new serum marker has been developed for the diagnosis of pulmonary embolism. The test has
a likelihood ratio of 1.
Which one of the following conclusions can be made from this information?
A)
B)
C)
D)
The test can confirm pulmonary embolism

The test rules out pulmonary embolism
The test can neither confirm nor rule out pulmonary embolism
The likelihood ratio does not determine how well a test performs
84. A gynecologist requests a preoperative consultation on your patient, a 38-year-old white gravida
2 para 0 abortus 2 whom you referred for total abdominal hysterectomy for adenomatous
endometrial hyperplasia.
The patient has been hospitalized twice for deep-vein thrombophlebitis in the past 2 years and
had spontaneous second-trimester abortions at the ages of 34 and 36. Routine preoperative blood
screening reveals the following:
Platelet count. . . . . . . . . . . . . . . . . . . . . . . . . .
Prothrombin time.. . . . . . . . . . . . . . . . . . . . . .
INR. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Activated partial thromboplastin time.. . . . . .
189,000/mm3 (N 150,000400,000)
12.0 sec (N 10.012.5)
1.1
42 sec (N 2535)
There is no family history of bleeding disorders and the evaluation is otherwise completely
normal.
A repeat activated partial thromboplastin time with a 1:1 mixture of normal plasma does not
correct to normal.
The most likely diagnosis is
A)
B)
C)
D)
E)
protein C deficiency
antiphospholipid antibody syndrome
factor VIII deficiency (hemophilia A)
chronic liver disease
von Willebrand disease
24
85. A 45-year-old female who is a new patient sees you for a well care visit. She requests all
screening tests and procedures that are appropriate for her.
She is unmarried but has been in a monogamous relationship with a male partner for the past 10
years. She reports that she has never had an abnormal Papanicolaou (Pap) test result, but that
when she had a Pap test last year she did not have a test for human papillomavirus (HPV). She
also had normal findings on a mammogram 1 year ago. Her previous physician had been seeing
her every 3 months to monitor her blood pressure, which has consistently been 135140 mm Hg
systolic and 8590 mm Hg diastolic. She takes no antihypertensive medication, but has instituted
dietary and lifestyle changes.
According to the U.S. Preventive Services Task Force, which one of the following screening
tests or procedures is now recommended for this patient?
A)
B)
C)
D)
E)
A bimanual pelvic examination with CA-125 testing to screen for ovarian cancer
A Pap test with co-testing for HPV
Screening for Chlamydia
Screening for diabetes mellitus
Screening for colorectal cancer
86. A 2-week-old female is brought to the office for a well child visit. The physical examination is
completely normal except for a clunking sensation and feeling of movement when adducting the
hip and applying posterior pressure.
Which one of the following would be the most appropriate next step?
A)
B)
C)
D)
Referral for orthopedic consultation

Reassurance only, and follow-up in 2 weeks
Triple diapering and follow-up in 2 weeks
A radiograph of the pelvis
87. A 57-year-old female on dialysis for end-stage renal disease develops chronic, severe
generalized pain. Which one of the following opioids is preferred for management of her pain?
A)
B)
C)
D)
Codeine
Fentanyl
Hydrocodone
Morphine
88. Which one of the following strategies for preventing the spread of Clostridium difficile infection
has been shown to be most effective?
A)
B)
C)
D)
E)
Use of alcohol-based hand sanitizer

Handwashing with soap and water
Screening health care providers for the carrier state
Administration of probiotics to at-risk patients
Use of N95 masks and negative-pressure rooms
25
89. A 55-year-old female has severe sepsis due to pyelonephritis. Her systolic blood pressure
remains at 70 mm Hg despite antibiotics and adequate fluid resuscitation.
Which one of the following should be considered the vasopressor of first choice for this patient?
A)
B)
C)
D)
E)
Dopamine
Epinephrine
Dobutamine
Norepinephrine (Levophed)
90. A 55-year-old male has a 3-month history of chronic shortness of breath and dyspnea on
exertion. His physical examination is unremarkable except for 1+ ankle edema bilaterally and
a soft systolic murmur. A stress echocardiogram is normal. Pulmonary function tests are normal
except for a low diffusing capacity of the lung for carbon monoxide (DLCO).
Which one of the following conditions should be considered in this patient?
A)
B)
C)
D)
E)
Chronic pulmonary thromboembolism

Emphysema
Interstitial lung disease
Asthma
Hypersensitivity pneumonitis
91. In patients who die from an opioid overdose, a second medication is often present that
contributes to the patients death. Which one of the following additional medications is most
likely to be found in conjunction with a fatal opioid overdose?
A)
B)
C)
D)
E)
Acetaminophen
Antidepressants
Antipsychotics
Benzodiazepines
Muscle relaxants
92. You test a patients muscle strength and find that his maximum performance consists of the
ability to move with gravity neutralized. This qualifies as which grade of muscle strength, on
a scale of 0 to 5?
A)
B)
C)
D)
E)
0
1
2
3
4
26
93. A 21-year-old male comes to your office for a follow-up visit to discuss pharmacologic treatment
for his acne. He has moderate inflammatory acne lesions with comedones and several papules
and pustules, but few nodules. Multiple topical antibiotic therapies, in combination with benzoyl
peroxide, have been minimally effective. He is currently using just topical benzoyl peroxide.
You would like to prescribe an oral agent to add to his regimen.
Which one of the following would be the most effective oral medication to start at this time?
A)
B)
C)
D)
Amoxicillin
Ciprofloxacin (Cipro)
Minocycline (Minocin)
Prednisone
94. Based on U.S. Preventive Services Task Force guidelines, screening for lung cancer with
low-dose CT of the chest is indicated for which one of the following patients with a 30-pack-year
smoking history?
A)
B)
C)
D)
A 50-year-old current smoker

An 85-year-old current smoker
A 60-year-old who quit smoking 10 years ago
A 75-year-old who quit smoking 20 years ago
95. A 37-year-old male complains of severe headaches that typically involve his right eye, and often
cause the eye to tear. The headaches occur at about the same time each day and recur for several
days in a row before remitting. He reports that he is currently experiencing a third episode of
these headaches.
Which one of the following therapies will help prevent future recurrences of this patients
headaches?
A)
B)
C)
D)
Oxygen
Sumatriptan (Imitrex)
Lithium
Verapamil (Calan, Verelan)
96. An 85-year-old male admitted to the hospital for shortness of breath is diagnosed with terminal
lung cancer. He decides he would like to receive home hospice care. Over the course of his
hospitalization he becomes increasingly confused and forgets where he is and why he is there.
He appears depressed with a flat affect. He repeatedly tries to get out of bed and pulls at his IV
line and catheter.
Which one of the following medications would be most appropriate for treating these symptoms?
A)
B)
C)
D)
E)
Haloperidol
Nortriptyline (Pamelor)
Pentobarbital (Nembutal)
Lorazepam (Ativan)
Mirtazapine (Remeron)
27
97. An 18-month-old male with a history of prematurity at 36 weeks gestation but no baseline lung
disease is brought to the emergency department with a fever of 38.3C (100.9F), rhinorrhea,
cough, wheezing, mild tachypnea, and an oxygen saturation of 88%. A chest radiograph reveals
perihilar infiltrates, and a nasal swab is positive for respiratory syncytial virus (RSV) antigen.
Which one of the following management options has evidence of benefit for this patient?
A)
B)
C)
D)
Aerosolized ribavirin
Supplemental oxygen
Intravenous corticosteroids
Macrolide antibiotics
98. An 85-year-old male smoker presents with a 6-day history of subacute abdominal pain. He
reports nausea without vomiting, and no change in stool. His past medical history includes
coronary artery disease, peripheral vascular disease, and a cholecystectomy. The physical
examination reveals moderate periumbilical tenderness without guarding or rebound.
Laboratory Findings
WBCs.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Segmented neutrophils. . . . . . . . . . . . . . . . .
Bands. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Chemistry panel.. . . . . . . . . . . . . . . . . . . . . . .
Urinalysis.. . . . . . . . . . . . . . . . . . . . . . . . . . . .
Amylase. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Lipase.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Lactic acid. . . . . . . . . . . . . . . . . . . . . . . . . . . .
20,000/mm3 (N 450010,800)
82%
7%
normal
normal
180 U/L (N <140)
normal
3.8 mmol/L (N 0.52.2)
Abdominal CT reveals air within the wall of dilated loops of small bowel.
A)
B)
C)
D)
E)
Acute cholangitis secondary to a common duct stone

Acute diverticulitis
Acute mesenteric ischemia
Acute pancreatitis
Acute appendicitis
28
99. A 75-year-old male reports that his handwriting seems more cramped, he has started shuffling
more as he walks, and he has been experiencing some difficulty turning over in bed, rising from
a chair, and opening jars. He also reports increasing body stiffness and a resting tremor in his
hand.
Given the stage of his disease, which one of the following options for initial medical
management is supported by the best evidence?
A)
B)
C)
D)
E)
Amantadine
Bromocriptine (Parlodel)
Benztropine
Carbidopa/levodopa (Sinemet)
Entacapone (Comtan)
100. When assessing the nutritional status and growth of a full-term infant, it is useful to know that
birth weight is expected to be regained within
A)
B)
C)
D)
5 days
14 days
21 days
28 days
101. A 70-year-old white female with hypertension and atrial fibrillation has been chronically
anticoagulated. A higher dosage of warfarin (Coumadin) would be required to achieve a
therapeutic INR if the patient were found to have
A)
B)
C)
D)
E)
malnutrition
hypothyroidism
heart failure
acute kidney injury
progressive nonalcoholic cirrhosis
102. Which one of the following is most likely to cause hypoglycemia in elderly patients?
A)
B)
C)
D)
E)
Metformin (Glucophage)
Glipizide (Glucotrol)
Sitagliptin (Januvia)
Glyburide (DiaBeta)
29
103. A 75-year-old male presents to the emergency department with a 2-day history of pain and
swelling in his left calf. He had a total knee replacement 2 weeks ago and was discharged home
with a prescription for warfarin (Coumadin). He experienced symptoms of nausea, headache,
and fatigue, which he attributed to the medication. He stopped taking the warfarin and now
refuses to resume it, and he also does not want to be hospitalized. Ultrasonography confirms
thrombosis in the deep veins distal to the popliteal fossa.
Which one of the following would be most appropriate at this time?
A)
B)
C)
D)
Aspirin
Rivaroxaban (Xarelto)
Intravenous tenecteplase (TNKase)
104. A 34-year-old male who recently immigrated to the United States from Mexico comes to your
clinic to complete a comprehensive health evaluation for a custodial job at a hospital, and he
must be screened for tuberculosis. He recalls getting many vaccines as a child, including one for
tuberculosis.
Which one of the following screening tests for tuberculosis is preferred for this patient?
A)
B)
C)
D)
E)
A stained sputum culture for acid-fast bacilli

Skin testing
Serology
Nucleic acid amplification testing
Interferon-gamma release assays
105. A 53-year-old male complains of fatigue, dyspnea, and orthopnea. Which one of the following
would have the highest specificity for heart failure?
A)
B)
C)
D)
E)
Ankle edema
A third heart sound (S3 gallop)
Crackles
Cardiomegaly on a chest radiograph
Elevated BNP
106. A 7-year-old male is brought to your office after hurting his hand when he fell on a wet kitchen
floor. He is unable to describe the mechanism of injury. On examination the maximal point of
tenderness is at the third metacarpophalangeal joint, which also has some generalized swelling
but no ecchymosis. Range of motion is limited in this joint due to pain. A radiograph of the hand
is shown below.
A)
B)
C)
D)
E)
Boxers fracture
Greenstick fracture
Salter-Harris type II fracture
Spiral fracture
No abnormality
30
107. In a patient presenting with unstable angina, which one of the following findings would denote
the highest risk for death or myocardial infarction?
A)
B)
C)
D)
New-onset angina beginning 2 weeks to 2 months before presentation

Angina with hypotension
Angina provoked at a lower threshold than in the past
Increased anginal frequency
108. A 72-year-old white female presents to your office with a 6-week history of tanned skin. She
initially attributed it to having gone on a cruise 2 months ago, but noticed her skin continued to
darken as time passed. She is slender and has lost 5 kg (11 lb) since her last checkup 6 months
ago. She denies fever, malaise, or abdominal pain. Her only medications are hydrochlorothiazide
and a baby aspirin daily.
On examination your suspicion of jaundice is confirmed by the presence of scleral icterus. You
also note a single enlarged left supraclavicular lymph node which is nontender. The abdomen
is soft and nontender; on deep palpation of the right upper quadrant you feel a smooth,
nontender mass.
A)
B)
C)
D)
E)
Biliary cirrhosis
Ascending cholangitis
Obstructing pancreatic pseudocyst
Carcinoma of the head of the pancreas
Hepatocellular carcinoma
109. Hyperbaric oxygen treatment has been shown to be beneficial for which one of the following
conditions?
A)
B)
C)
D)
E)
Tinnitus
Malignant otitis externa
Crush injury wounds
Nonunion of bone fractures
Vascular dementia
110. A 4-year-old female is treated at a local urgent care center with amoxicillin for acute pharyngitis.
Several days after starting treatment her initial symptoms resolve. When she is 8 days into the
10-day course of her antibiotic treatment she returns to your office because she has developed
a diffuse erythematous maculopapular rash starting on her torso and extending to her proximal
extremities.
Which one of the following is the best course of action at this time?
A)
B)
C)
D)
Continue the amoxicillin and begin prednisone and diphenhydramine (Benadryl)

Continue the amoxicillin and change the diagnosis to scarlet fever
Discontinue the amoxicillin and change the diagnosis to viral exanthem
Discontinue the amoxicillin and note amoxicillin as a potential allergy in her record
31
111. An obese 70-year-old male with chronic pain due to osteoarthritis complains of fatigue,
anhedonia, hypersomnolence, and increased appetite. Which one of the following would be the
best pharmacologic agent for this patient?
A)
B)
C)
D)
E)
Duloxetine (Cymbalta)
Mirtazapine (Remeron)
Citalopram (Celexa)
Paroxetine (Paxil)
Nortriptyline (Pamelor)
112. A 42-year-old female with a past medical history significant for type 2 diabetes mellitus,
hypertension, obesity, and major depressive disorder presents with a chief complaint of
amenorrhea for 9 weeks. A home pregnancy test was positive 2 days ago. Her medications
include metformin (Glucophage), insulin glargine (Lantus), lisinopril (Prinivil, Zestril), atenolol
(Tenormin), fluoxetine (Prozac), and bupropion (Wellbutrin). You confirm her pregnancy with
a urine pregnancy test in your office and you believe she is at 11 weeks gestation based on the
date of her last menstrual period.
In addition to the lisinopril, which one of her current medications should be discontinued?
A)
B)
C)
D)
E)
Atenolol
Bupropion
Fluoxetine
Glargine
Metformin
113. A 55-year-old male with diabetes mellitus is found to have asymptomatic microscopic hematuria.
The rest of his urinalysis is negative. He has no other medical problems and quit smoking 10
years ago. His only medication is metformin (Glucophage). A urine culture is negative and his
renal function is normal. CT urography is also negative.
Which one of the following should be the next step in the evaluation of his microscopic
hematuria?
A)
B)
C)
D)
E)
Urine cytology
Cystoscopy
Nephrology referral
Stopping metformin and performing a repeat urinalysis
Antibiotic therapy
32
114. A 24-year-old male who just moved to town for a new job presents to your office with a 2-week
history of a rash. His previous medical records are not available. The physical examination
reveals pink, scaling papules and plaques on the trunk and proximal aspect of the arms and legs.
You suspect pityriasis rosea.
To complete the diagnostic evaluation you should order
A)
B)
C)
D)
E)
a fungal culture
heterophile antibody testing
a platelet count
a rapid plasma reagin (RPR) test
a TSH level
115. A 22-year-old male college student presents with 12 weeks of worsening tenesmus associated
with frequent stools that are mixed with blood and mucus. He is afebrile and has no other signs
of systemic illness. Initial blood and stool testing is normal.
Which one of the following would be most appropriate at this point to evaluate this patient for
the presence of inflammatory bowel disease?
A)
B)
C)
D)
E)
Serum markers
Ultrasonography
CT of the abdomen and pelvis
Colonoscopy with biopsies
A barium enema
116. A 24-year-old gravida 2 para 1 presents to your office for her first prenatal visit at 7 weeks
gestation. You review her vaccine records and note that she received Tdap 1 year ago.
When should you recommend that she get her next Tdap?
A)
B)
C)
D)
E)
Post partum
At this visit
Anytime after the first trimester
Between 27 and 36 weeks gestation
10 years after the last dose
117. Which one of the following is the most likely cause of acute kidney injury in a patient with
eosinophiluria?
A)
B)
C)
D)
E)
Rhabdomyolysis
Poststreptococcal glomerulonephritis
Acute interstitial nephritis
Ethylene glycol poisoning
Tumor lysis syndrome
33
118. Which one of the following patients with atrial fibrillation should be advised to use aspirin rather
than warfarin (Coumadin) for stroke prevention?
A)
B)
C)
D)
E)
A 56-year-old male with type 2 diabetes mellitus and peripheral neuropathy

A 60-year-old female with heart failure and a 30-pack-year smoking history
A 62-year-old male with obesity and hyperlipidemia
A 66-year-old male with hypertension and depression
A 75-year-old female with hypothyroidism and osteoarthritis
119. A 77-year-old female is admitted to the critical care unit for acute respiratory failure and is on
a ventilator for more than 48 hours. Stress ulcer prophylaxis is ordered.
This prophylaxis should be continued until
A)
B)
C)
D)
E)
venous thromboembolism prophylaxis is stopped

the patient is transferred out of the critical care unit
the patient is discharged from the hospital
the patient is discharged from a skilled care or rehabilitation care facility
30 days after discharge from the hospital
120. A 29-year-old female presents with a 1-week history of a rash on her legs. A full review of
systems is significant only for regular borderline-heavy periods that lasted for 7 days during her
last two menstrual cycles. She has not had any recent illness or hospitalization, and takes no
medications. Her examination shows nonblanching purple macules on her upper legs.
A comprehensive metabolic panel reveals normal renal function and liver enzyme tests, and a
urine pregnancy test is negative. A CBC reveals a platelet count of 27,000/mm3 (N
150,000400,000) but is otherwise normal.
Which one of the following is the most likely cause of the rash?
A)
B)
C)
D)
E)
Acute leukemia
Congenital thrombocytopenia
Immune thrombocytopenic purpura
Thrombotic thrombocytopenic purpura
Henoch-Schnlein purpura
34
121. A 24-year-old male presents with a 1-week history of right eye redness. He says his eye hurts,
especially with light exposure. He reports no history of trauma, but recalls his 2-year-old
daughter having pink eye about a month ago. He has a previous history of ankylosing
spondylitis.
On examination his conjunctiva appears injected and he has a sluggishly reacting pupil. No
discharge is noted. Reduced anterior spine flexion is noted on examination of the back.
Fluoroscein staining of the cornea is negative.
Which one of the following is the most appropriate next step to manage this patients eye
condition?
A)
B)
C)
D)
E)
Artificial tears
Ocular antibiotics
Ocular corticosteroids
Oral acetazolamide
Ophthalmic olopatadine (Patanol)
122. A 36-year-old male is diagnosed with midsubstance Achilles tendinopathy. He has had symptoms
for approximately 8 weeks.
For this patient, which one of the following would be the first-line treatment?
A)
B)
C)
D)
E)
Tendon massage
Eccentric exercise
Iontophoresis
Therapeutic ultrasound
Electrical stimulation therapy
123. A 24-year-old female complains of irritability, anxiety, and feeling restless. These symptoms
began 3 months ago after she was in a car accident in which two people died. She has become
very socially withdrawn and when she tries to sleep she has flashbacks to the accident.
In addition to recommending trauma-focused psychotherapy, which one of the following
medications would be most appropriate?
A)
B)
C)
D)
E)
Buspirone
Clonazepam (Klonopin)
Quetiapine (Seroquel)
Topiramate (Topamax)
Sertraline (Zoloft)
35
124. A 58-year-old female presents with a 6-month history of persistent intermittent unilateral
rhinorrhea. The drainage is clear, and seems to be worse in the early morning when she first
gets up. Her past medical history includes hypertension and controlled migraines. Her surgical
history includes a total hysterectomy 5 years ago and septal deviation surgery 7 months ago. She
has tried oral antihistamines and intranasal corticosteroids without relief.
The patient should undergo further evaluation for
A)
B)
C)
D)
vasomotor rhinitis
allergic rhinitis
cerebrospinal fluid rhinorrhea
an intranasal tumor
125. A 25-year-old female reports the absence of menses for the past 6 months. She is currently not
taking any medications. You confirm that she is not pregnant and order additional laboratory
testing. TSH, LH, and FSH levels are normal but she has an elevated prolactin level.
Which one of the following would be most appropriate at this point to further evaluate her
pituitary gland?
A)
B)
C)
D)
A follow-up serum prolactin level in 4 weeks

A prolactin-stimulating hormone level
MRI of the pituitary
Head CT with intravenous contrast
126. A 36-year-old male who participates in his neighborhood basketball league visits your office with
a 3-week history of heel pain. On examination he has pain over the medial plantar region of the
right heel and the pain is aggravated by passive ankle dorsiflexion.
Which one of the following should you order to confirm the diagnosis?
A)
B)
C)
D)
E)
Plain films of the foot

Ultrasonography of the foot
CT of the foot
MRI of the foot
No diagnostic imaging
127. According to the U.S. Preventive Services Task Force, low-dose aspirin use in women is most
effective for primary prevention of
A)
B)
C)
D)
E)
stroke, beginning at age 50

stroke, beginning at age 55
myocardial infarction, beginning at age 50
myocardial infarction, beginning at age 55
both myocardial infarction and stroke, beginning at age 50
36
128. A 6-year-old male is diagnosed with acute bacterial sinusitis. He has a previous history of a rash
5 days after beginning penicillin treatment.
Which one of the following medications is most appropriate for this patient?
A)
B)
C)
D)
E)
Amoxicillin/clavulanate (Augmentin)
Trimethoprim/sulfamethoxazole (Bactrim)
Cefuroxime (Ceftin)
Doxycycline
129. An 85-year-old male is brought to your office by his family because they are concerned that he
may be depressed. Which one of the following is most likely in a depressed patient in this age
group?
A)
B)
C)
D)
Suicidal ideation
Somatic symptoms
Depressed mood
Preoccupation with guilt
130. A 72-year-old previously healthy male presents with a 3-week history of mild, intermittent chest
pressure that occurs when he walks up a steep hill. Which one of the following EKG
abnormalities would dictate the use of a pharmacologic stress test as opposed to an exercise
stress test?
A)
B)
C)
D)
E)
First degree atrioventricular block

Left bundle branch block
Poor R-wave progression in leads V1 through V3
Q-waves in the inferior leads
Ventricular trigeminy
131. A 20-year-old college student who has been working in the woods on a forestry project presents
with a 3- to 4-day history of a severely pruritic rash on his arms, hands, and face. There is
erythema with multiple bullae and vesicles, some of which are in a streaked linear distribution
on the arms. There are patches of erythema on his face with some vesicles. The itching is intense
and he sleeps fitfully.
In addition to cool compresses and antihistamines for the itching, which one of the following is
the best treatment option for this patient?
A)
B)
C)
D)
Triamcinolone, 20 mg intramuscularly as a single dose

A 6-day oral methylprednisolone (Medrol) dose pack, starting at 24 mg
A 7- to 10-day course of topical halobetasol propionate (Ultravate), 0.05% ointment
A 7- to 10-day course of topical mupirocin (Bactroban) 2%, after decompression of
vesicles and bullae
E) A 10- to 14-day tapering course of oral prednisone, starting at 60 mg
37
132. While making rounds on the rehabilitation floor of your hospital, you see a 62-year-old female
who was recently transferred from the acute-care section of the hospital where she was admitted
for urosepsis. She is a liver-transplant recipient and her specialist has been tapering her
immunosuppressive drug regimen for the last 2 months. According to the nursing staff the
patient became hypoxic suddenly and had a low-grade fever and cough. You note that she looks
ill and uncomfortable, and has an increased respiratory rate. A chest radiograph reveals diffuse
bilateral interstitial infiltrates.
A)
B)
C)
D)
E)
Pneumococcal pneumonia
Staphylococcal pneumonia
Pneumocystis pneumonia
Pulmonary tuberculosis
Pneumothorax
133. A 45-year-old male is hospitalized for the management of alcohol withdrawal syndrome. His
symptoms include tachycardia, diaphoresis, tremors, and visual hallucinations. His CIWA-Ar
(Clinical Institute Withdrawal Assessment for Alcohol, Revised) score is 18, indicating moderate
alcohol withdrawal.
Which one of the following medications has been shown to reduce the risk of developing
seizures in this situation?
A)
B)
C)
D)
E)
Carbamazepine (Tegretol)
Lorazepam (Ativan)
Gabapentin (Neurontin)
Phenytoin (Dilantin)
Valproic acid (Depakene)
134. A 50-year-old female with significant findings of rheumatoid arthritis presents for a preoperative
evaluation for planned replacement of the metacarpophalangeal joints of her right hand under
general anesthesia. She generally enjoys good health and has had ongoing medical care for her
illness.
Of the following, which one would be most important for preoperative assessment of this
patients surgical risk?
A)
B)
C)
D)
E)
Resting pulse rate

Resting oxygen saturation
Erythrocyte sedimentation rate
Rheumatoid factor titer
Cervical spine imaging
38
135. A 38-year-old female presents to the emergency department with an acute onset of fever, chills,
and rapidly progressive right lower extremity redness. She reports being in her usual state of
health until a few hours ago when she developed shaking chills and noted a fever of 103.0F
(39.4C).
Shortly after she arrives she complains of right lower extremity pain and a bright red skin
discoloration from her ankle to her right knee. She is also noted to have a heart rate of 123
beats/min and a WBC count of 22,000/mm3 (N 430010,800). Her past medical history is
significant for congenital arthritis, a recent bilateral hip replacement, and recurrent lower
extremity cellulitis.
You admit the patient to the hospital. When selecting an empiric treatment for this patient, which
one of the following organisms should you be most concerned about?
A)
B)
C)
D)
E)
Candida albicans
Chlamydia trachomatis
Mycoplasma hominis
Group A Streptococcus
Trichophyton rubrum
136. Which one of the following screening practices is recommended for the adolescent population
by the U.S. Preventive Services Task Force?
A)
B)
C)
D)
E)
Lipid screening
Scoliosis screening
Testicular examination
Papanicolaou tests starting 3 years after first sexual intercourse
Chlamydia screening in sexually active females
137. A 75-year-old female presents with a complaint of paresthesias in her feet. On examination she
has mild erythema of her tongue and decreased vibratory sensation in her feet. A CBC reveals
a hemoglobin level of 11.1 g/dL (N 12.016.0) and a mean corpuscular volume of 105 :m3 (N
78102).
The patient takes the following over-the-counter drugs: aspirin, 81 mg/day; ranitidine (Zantac),
150 mg twice daily; and acetaminophen, 325 mg twice daily. Which one of the following
prescription medications the patient takes is most likely causing her problem?
A)
B)
C)
D)
E)
Hydrochlorothiazide
Simvastatin (Zocor)
Omeprazole (Prilosec)
39
138. A 52-year-old female with a history of well-controlled diabetes mellitus presents with right
shoulder pain for 2 months. She cannot recall any injury. The pain is fairly constant, has a
burning quality, and disturbs her sleep.
On examination the patient has no redness or swelling. Passive and active abduction are limited
to 45. There is some limitation of shoulder flexion and internal rotation, but it is less
pronounced. No focal tenderness is found. Plain films are negative.
Which one of the following is the most likely diagnosis for this patient?
A)
B)
C)
D)
E)
Calcific tendinitis
Diabetic neuropathy
Partial rotator cuff tear
Locked posterior dislocation
Frozen shoulder
139. A 25-year-old male presents to your office after recently being diagnosed with HIV infection at
the health department. You obtain blood work and note that his CD4+ count is 180 cells/mm3.
This patient should receive prophylaxis against which one of the following opportunistic
infections?
A)
B)
C)
D)
E)
Histoplasma capsulatum
Microsporidiosis
Mycobacterium avium-intracellulare complex
Pneumocystis
Toxoplasma gondii
140. A 7-year-old female is brought to your office with a complaint of right hip pain and a limp with
an insidious onset. There is no history of injury or repetitive use. Her vital signs are within
normal limits and she has no history of fever or chills or other systemic symptoms. On
examination you note that she cannot fully abduct her hip and she winces with pain on internal
rotation. A FABER test is normal. Her right leg is 2 cm ( in) shorter than the left. Plain films
reveal flattening and sclerosis of the proximal femur with joint space widening.
What is the most likely diagnosis in this patient?
A)
B)
C)
D)
E)
Iliopsoas bursitis
Labral tear
Legg-Calv-Perthes disease
Septic arthritis
Stress fracture
40
141. A 23-year-old female presents with menstrual irregularity, increased facial hair, and acne. Your
evaluation leads to a diagnosis of polycystic ovary syndrome.
Which one of the following is the first-line management for her constellation of symptoms?
A)
B)
C)
D)
E)
Clomiphene (Clomid)
Hormonal contraceptives
142. A 47-year-old male is hospitalized for severe lower-extremity methicillin-resistant

Staphylococcus aureus (MRSA) cellulitis. He is started on intravenous vancomycin and his home
medications, which include metoprolol and escitalopram (Lexapro), are continued. On day 3,
in preparation for discharge, he is transitioned to oral trimethoprim/sulfamethoxazole (Bactrim).
Two hours after taking his first dose he reports severe swelling of his lips, wheezing,
hoarseness, and hives. His blood pressure, which was previously normal, is now 84/62 mm Hg.
You order emergent therapy with intramuscular epinephrine, 0.3 mg; intravenous
methylprednisolone sodium succinate (Solu-Medrol), 125 mg; and intravenous diphenhydramine
(Benadryl), 50 mg. However, no clinical improvement is noted after 15 minutes.
Which one of the following should you recommend now?
A)
B)
C)
D)
E)
Another dose of intramuscular epinephrine

Another dose of intravenous methylprednisolone
Another dose of intravenous diphenhydramine
Intramuscular glucagon
Intramuscular betamethasone sodium phosphate/betamethasone acetate (Celestone
Soluspan)
143. In a woman whose group B Streptococcus status is unknown, which one of the following is a
risk factor requiring empiric intrapartum antibiotic prophylaxis against early-onset group B
streptococcal infection in her newborn?
A)
B)
C)
D)
E)
Fetal tachycardia
Delivery at less than 35 weeks gestation
Rupture of the membranes 12 hours before delivery
Gestational diabetes during the pregnancy
Use of vacuum extraction during delivery
41
144. A patient with advanced dementia is bed-bound and requires total assistance with all activities
of daily living. She was treated recently for pneumonia, which has raised concerns that she is
aspirating. Her oral intake has decreased and is not adequate for the patients nutritional
requirements. She does not have an advance directive. You schedule a family conference.
Which one of the following is your recommended approach to this problem?
A)
B)
C)
D)
E)
Clear liquids
Intravenous fluids
Hand feeding
Percutaneous endoscopic gastrostomy (PEG) tube feeding
Nasogastric tube feeding
145. The National Weight Control Registry includes individuals who have lost substantial weight
without surgery, and have maintained the weight loss for an average of 5 years. Which one of
the following behaviors is typical of these individuals?
A)
B)
C)
D)
E)
Eating breakfast every day

Taking daily vitamin and mineral supplements
Weighing themselves daily
Being physically active >2 hours a day
Eating a low-protein diet
146. A 30-year-old male presents to the emergency department after spraining his ankle while playing
basketball. He has pain over the lateral malleolus.
Radiographs of the ankle would be indicated if he has which one of the following?
A)
B)
C)
D)
E)
An inversion injury
Swelling over the lateral malleolus
Ecchymosis over the lateral malleolus
The inability to bear weight to walk since the injury
A previous history of ankle injury
147. During a preparticipation examination of a 5-year-old male for summer soccer camp, his mother
states that he frequently awakens during the night with complaints of cramping pain in both legs,
and that he seems to experience this after a day of heavy physical activity. She says that she has
never noticed a definite limp. A physical examination of the hips, knees, ankles, and leg
musculature is entirely normal.
Which one of the following would be the most appropriate next step in the evaluation and
management of this patient?
A)
B)
C)
D)
E)
Reassurance, with no activity restrictions or treatment

Recommending that he not participate in running sports
Plain films of both hips and knees
Serum electrolyte levels
Referral to a pediatric orthopedist
42
148. A 28-year-old previously healthy male nonsmoker has a 3-day history of fever and a productive
cough. He presents to the urgent care clinic for evaluation after developing pain in the right
lower chest when breathing deeply. He has not sought medical care for over 5 years and has
never been immunized for influenza.
On examination you note a temperature of 38.6C (101.4F), a blood pressure of 136/74 mm
Hg, a pulse rate of 90 beats/min, an oxygen saturation of 93% on room air, and a respiratory
rate of 20/min. The patient appears uncomfortable but is not in significant distress. The presence
of crackles over the right lower anterior chest prompts an order for chest radiography, which
reveals an air bronchogram and a patchy alveolar infiltrate involving the medial middle lobe.
Which one of the following treatment options would be most appropriate at this time?
A)
B)
C)
D)
E)
Outpatient treatment with oral azithromycin (Zithromax)

Outpatient treatment with oral ciprofloxacin (Cipro)
Outpatient treatment with oseltamivir (Tamiflu)
Inpatient treatment with intravenous ceftriaxone (Rocephin) and oral azithromycin
Inpatient treatment with intravenous ceftriaxone and ciprofloxacin
149. A 32-year-old male presents with a 1-year history of increasing fatigue, polyuria, and a gradual
30-lb weight loss. Serum chemistries reveal a bicarbonate level of 23 mEq/L (N 2228), a
corrected anion gap of 8 mEq/L (N 311), and a glucose level of 658 mg/dL (N 60110). The
patient is admitted to the hospital and his serum glucose drops to 174 mg/dL after he is given
2 L of intravenous normal saline and 10 units of regular insulin subcutaneously. He is observed
overnight and further laboratory testing is done the next morning.
Which one of the following is more consistent with type 2 diabetes mellitus than with type 1
diabetes mellitus?
A)
B)
C)
D)
The patients history of weight loss

The patients response to the initial dose of insulin
The time course of symptom onset
Morning laboratory studies showing a C-peptide level of <1.1 ng/mL (N 1.14.4)
150. A 66-year-old male with known GOLD stage 3 COPD is admitted to the hospital with
pneumonia. His pneumonia improves and he is discharged with home oxygen because of
hypoxemia. He did not require home oxygen before this.
Which one of the following would be most appropriate regarding his future use of home oxygen?
A)
B)
C)
D)
E)
Reduce oxygen use to nighttime only

Stop oxygen when his course of antibiotics and corticosteroids is completed
Reassess the need for oxygen within 3 months
Stop oxygen within 6 months
Continue oxygen indefinitely
43
151. In the hospital setting, the use of atypical antipsychotics is most appropriate for which one of the
following conditions?
A)
B)
C)
D)
Hospital-associated insomnia
ICU-associated delirium
Resistance to care in a patient with dementia
Aggression in a patient with dementia
152. A 70-year-old female presents with a blotchy red rash on both of her legs and feet. The rash
started 2 days ago and is associated with fatigue. Her past medical history is unremarkable
except for acute cystitis treated with a 3-day course of an antibiotic last week. On examination
her vital signs are normal, as is the remainder of her physical examination, with the exception
of a palpable purpuric rash on her lower extremities, shown below. The patients CBC, INR,
and partial thromboplastin time are all normal.
Which one of the following is now indicated?
A)
B)
C)
D)
E)
Supportive care only

Antihistamines
Broad-spectrum antibiotics
Plasmapheresis
Platelet transfusion
153. A 65-year-old male comes to your office to establish care after hospitalization for an acute
myocardial infarction. While reviewing his hospital record you see that he has normal renal
function and had an echocardiogram showing a left ventricular ejection fraction of 40%. His
current medications include metoprolol succinate (Toprol-XL), lisinopril (Prinivil, Zestril),
atorvastatin (Lipitor), and aspirin. In your office today his blood pressure is 132/84 mm Hg and
he is still feeling somewhat weak. He has 1+ pitting edema in his legs and mild dyspnea with
exertion.
Which one of the following, when added to his current regimen, has evidence to support its use
in preventing all-cause mortality?
A)
B)
C)
D)
E)
Chlorthalidone
Ezetimibe (Zetia)
Losartan (Cozaar)
Fish oil
44
154. A 44-year-old African-American female reports diffuse aching, especially in her upper legs and
shoulders. The aching has increased, and she now has trouble going up and down stairs because
of weakness. She has no visual symptoms, and a neurologic examination is normal except for
proximal muscle weakness. Laboratory tests reveal elevated levels of serum creatine kinase and
aldolase. Her symptoms improve significantly when she is treated with corticosteroids.
A)
B)
C)
D)
E)
Duchennes muscular dystrophy

Myasthenia gravis
Amyotrophic lateral sclerosis
Aseptic necrosis of the femoral head
Polymyositis
155. A 24-year-old gravida 4 para 2 with mild chronic hypertension and an uncomplicated pregnancy
has just delivered a vigorous male by spontaneous vaginal delivery. She is noted to have heavy
vaginal bleeding and a bimanual examination reveals a soft, poorly contracted uterus. Her
temperature is 37.1C (98.8F), blood pressure 158/92 mm Hg, pulse rate 105 beats/min, and
oxygen saturation 95% on room air.
Which one of the following uterotonic agents is CONTRAINDICATED in the management of
this patients postpartum hemorrhage?
A)
B)
C)
D)
Oxytocin (Pitocin)
Methylergonovine
Carboprost tromethamine (Hemabate)
Misoprostol (Cytotec)
156. A 30-year-old female presents to your office as a new patient and requests a refill of
sulfasalazine (Azulfidine) tablets for maintaining remission of her ulcerative colitis. The initial
presentation of her disease was in her teenage years and involved inflammation of the entire
colon. She was then started on sulfasalazine, which has worked well for controlling her
symptoms. She had one flare when she ran out of medicine 7 years ago. She has not seen a
gastroenterologist for many years.
Which one of the following is an appropriate management plan for this patient?
A)
B)
C)
D)
E)
Refill her sulfasalazine and continue usual care unless symptoms recur
Attempt to gradually discontinue the sulfasalazine
Stop sulfasalazine and start azathioprine (Imuran)
Continue sulfasalazine and arrange for colonoscopy to screen for colon cancer
Refer to a colorectal surgeon to discuss colectomy
45
157. Tramadol (Ultram) should be avoided in patients with a history of which one of the following?
A)
B)
C)
D)
Seizures
Heart failure
Ventricular dysrhythmias
Hypertension
158. You see a 58-year-old female whom you suspect has COPD and you recommend formal testing
in order to confirm this diagnosis. The cutoff most often used for COPD diagnosis on a
spirometry test performed while the patient is stable (not experiencing an acute exacerbation of
symptoms) is a postbronchodilator FEV1/FVC ratio
A)
B)
C)
D)
E)
<50% of predicted
<70% of predicted
<85% of predicted
>70% of predicted
>85% of predicted
159. For patients on lithium monotherapy for bipolar disease, monitoring should include periodic
blood levels of lithium, creatinine, and
A)
B)
C)
D)
E)
calcium
hemoglobin A1c
lipids
testosterone
TSH
160. A 28-year-old healthy female calls your clinic with a 2-day history of dysuria, urgency, and
frequency. She has not had a fever, back pain, nausea, or hematuria, and has not noticed any
vaginal discharge or itching. She was seen for similar symptoms 3 months ago and was treated
with a 3-day course of antibiotics, with full resolution of symptoms.
Treatment for this patient should be based on
A)
B)
C)
D)
E)
her reported symptoms

the presence or absence of suprapubic tenderness on examination
the presence or absence of leukocyte esterase on a urine dipstick
findings from a mid-stream urine culture
findings from urine microscopy
46
161. A 44-year-old female with a history of type 2 diabetes mellitus that is well controlled with
metformin (Glucophage) is noted to have mild anterior neck fullness during an annual physical
examination. A review of systems is unremarkable. Ultrasonography of the neck shows a
normal-sized thyroid gland with a 1.2-cm nodule in the right lobe. Her TSH level is normal.
Which one of the following is the most appropriate next step in the management of this patients
thyroid nodule?
A)
B)
C)
D)
E)
A repeat TSH level in 3 months

A radionuclide uptake thyroid scan
Noncontrast CT of the neck
Fine-needle aspiration of the nodule
No further workup
162. A 17-year-old female with a history of morbid obesity sees you to discuss contraceptive options.
She is heterosexual and is currently sexually active with one male partner. She has heavy
irregular periods and associated anemia and is interested in a contraceptive option that will both
provide reliable birth control and decrease her menstrual blood loss. She recently had negative
tests for HIV, gonorrhea, and Chlamydia at a local health department. Her examination is
unremarkable except for a weight of 136 kg (300 lb) and a BMI of 50 kg/m2.
Which one of the following would be the best option for contraception for this patient?
A)
B)
C)
D)
A diaphragm with spermicide

The norelgestromin/ethinyl estradiol transdermal system (Ortho Evra)
The levonorgestrel-releasing intrauterine system (Mirena IUD)
Medroxyprogesterone acetate (Depo-Provera)
163. A 35-year-old otherwise healthy male who is not on any medications presents to your office
complaining of 34 episodes of watery diarrhea beginning 2 days earlier. The diarrhea is
accompanied by some nausea and abdominal cramping. He denies fever, dehydration, and
bloody stool.
Which one of the following is indicated at this time?
A)
B)
C)
D)
E)
Testing for fecal leukocytes

A stool culture
A stool examination for ova and parasites
A stool test for Clostridium difficile toxin
No testing
47
164. A 60-year-old male is scheduled for coronary revascularization. Which one of the following
would reduce his cardiovascular risk the most when given perioperatively?
A)
B)
C)
D)
E)
$-Blockers
Calcium channel blockers
Statins
Aspirin
Warfarin (Coumadin)
165. A 72-year-old white male requests treatment for moderate osteoarthritis pain of the hips and
knees. He has not been treated for this problem previously and has been reluctant to take
medication. He takes lisinopril (Prinivil, Zestril), 20 mg daily, for hypertension, and his blood
pressure is under good control. He also has a known history of stage 3 kidney disease, with a
serum creatinine level of 2.1 mg/dL (N 0.61.5) and a glomerular filtration rate of 36
mL/min/1.73 m2. The patients renal function has been stable for the last 6 months. His CBC
and chemistry panel are otherwise normal.
Which one of the following is the initial treatment of choice for this patient?
A)
B)
C)
D)
E)
Acetaminophen
Celecoxib (Celebrex)
Oxycodone (OxyContin)
Sulindac (Clinoril)
Tramadol (Ultram)
166. An anxious 30-year-old white female comes to the emergency department with shortness of
breath, circumoral paresthesia, and carpopedal spasms. Which one of the following sets of blood
gas values is most consistent with this clinical picture?
A)
B)
C)
D)
pH 7.25 (N 7.357.45), pCO2 25 mm Hg (N 3545), pO2 100 mm Hg (N 80100)

pH 7.25, pCO2 50 mm Hg, pO2 80 mm Hg
167. A 30-year-old otherwise healthy female has concerns about her menses and fertility. Her last
menstrual period was 8 months ago when she stopped taking oral contraceptive pills (OCPs). In
her teens and early twenties she had irregular, sporadic periods. Four years ago she developed
menometrorrhagia and resultant iron deficiency anemia; this was corrected with the use of
OCPs. She is now interested in becoming pregnant. Her physical examination, including a
gynecologic examination, is normal. A urine pregnancy test is negative and her TSH level is in
the normal range.
Which one of the following is the most appropriate next step?
A)
B)
C)
D)
A CBC and metabolic panel

Serum LH and FSH levels
Karyotype analysis
Pelvic ultrasonography
48
168. In frail elderly patients, starvation can be distinguished from cachexia by which one of the
following?
A)
B)
C)
D)
An inflammatory response seen in starvation

A normal appetite in the early stages of cachexia
A rapid decrease in albumin in the early stages of starvation
A reversal of changes with refeeding in starvation
169. A 2-year-old female is brought in by her father for evaluation of a cough. Her cough started 10
days ago along with a runny nose and a low-grade fever. The runny nose and fever are no longer
present but a dry-sounding cough persists.
On examination the patient appears well and has a normal heart rate and respiratory rate. You
note no retractions and lung sounds are also normal.
Which one of the following would be an appropriate management option?
A)
B)
C)
D)
E)
Buckwheat honey
Albuterol (Proventil, Ventolin)
Dextromethorphan
Diphenhydramine (Benadryl)
170. A mother brings her 6-year-old son to your office for evaluation because she found a lump in
his neck below the jaw on the right side. She first noted it a week ago, about a week after he had
recovered from an upper respiratory infection. She reports that her son feels well and is back
to full, unrestricted activity.
When you examine the child you find an enlarged lymph node in the right anterior cervical chain
of nodes. It measures 2 cm in diameter and is somewhat firm, mobile, and nontender. The
remainder of the examination is normal.
A)
B)
C)
D)
E)
Ultrasound evaluation of the lymph node

A fine-needle biopsy of the node
An excisional biopsy of the node
A 10-day course of antibiotics
Follow-up examination in 1 month
49
171. A 50-year-old female with no medical problems presents with a 2-day history of profuse bloody
diarrhea, severe abdominal cramping, and fever. She has recently returned from a week-long
trip to Thailand. Her stool culture is positive for Campylobacter.
Which one of the following is the treatment of choice?
A)
B)
C)
D)
E)
Amoxicillin
Metronidazole (Flagyl)
Rifaximin (Xifaxan)
172. Which one of the following NSAIDs is safest for patients with a previous history of myocardial
infarction?
A)
B)
C)
D)
E)
Ibuprofen
Celecoxib (Celebrex)
Diclofenac (Zorvolex)
Meloxicam (Mobic)
Naproxen (Naprosyn)
173. A 21-year-old sexually active female comes to your office for a Papanicolaou (Pap) test and STD
screening. Her Pap smear is normal but she tests positive for gonorrhea. Chlamydia testing is
negative.
Which one of the following is the recommended treatment?
A)
B)
C)
D)
E)
Doxycycline
Ceftriaxone (Rocephin) plus azithromycin
Ofloxacin
Cefdinir plus levofloxacin (Levaquin)
174. A 6-month-old male is seen in the clinic for a cough, fever, and decreased feeding for the past
2 days. He has no medical problems and no known drug allergies, and has not had nausea or
vomiting. On examination he is fussy but consolable and his mucous membranes are moist. His
temperature is 38.8C (101.8F), pulse rate 92 beats/min, respirations 56/min, oxygen
saturation 96% on room air, and blood pressure 90/50 mm Hg. He has mild intercostal
retractions and crackles are heard at the right lung base. His heartbeat is regular without
murmurs. Capillary refill is normal.
Which one of the following is the best initial treatment for this child?
A)
B)
C)
D)
E)
High-dose oral amoxicillin

Oral azithromycin (Zithromax)
Ceftriaxone (Rocephin) intravenously or intramuscularly every 24 hours
Trimethoprim/sulfamethoxazole (Bactrim)
Erythromycin
50
175. An 18-month-old white female is brought to your office by her father, who states that 8 days ago
the child developed a temperature of 100.0F with a mild sore throat, a runny nose, and loss of
her voice. She is still symptomatic and the father is concerned about the longevity of this illness
and requests antibiotic therapy.
On examination the patient is afebrile with normal tympanic membranes, moderate mucopurulent
posterior pharyngeal drainage, and a normal cardiopulmonary examination. She appears alert
and active in the office, with no signs of acute distress.
Which one of the following is the most appropriate management at this time?
A)
B)
C)
D)
E)
Reassurance and supportive care

Diphenhydramine (Benadryl)
Amoxicillin
Cefdinir
176. A 61-year-old female presents to your office with a sudden painless loss of vision in her right
eye. Her past medical history includes both hypertension and type 2 diabetes mellitus.
Which one of the following would make you suspect retinal vein occlusion as the cause of her
sudden visual loss?
A)
B)
C)
D)
An afferent pupillary defect in the contralateral eye

Right eye redness
Tortuous retinal veins on funduscopic examination
Macular drusen on funduscopic examination
177. A 20-year-old African-American female asks if you can help eradicate an unsightly hypertrophic
growth of skin that has developed in an area where she had a mole removed. She reports that
this tissue has grown to become at least three times larger than the original lesion and that it is
darkly pigmented, firm, and pruritic. On examination you note a firm, smooth, shiny, raised
14-cm plaque on the patients chest that is darker than the surrounding skin.
Which one of the following is first-line therapy for this lesion?
A)
B)
C)
D)
E)
Silicone gel sheeting

Topical imiquimod (Aldara)
Intralesional corticosteroid injection
Surgical excision
Laser destruction
51
178. A 74-year-old female presents to the emergency department in respiratory distress with a slightly
altered mental status. Her urine drug screen is positive for opioids. The patient and her family
deny opioid use. You know this patient well and also doubt she is taking opioids. She has been
taking dextromethorphan, guaifenesin, azithromycin (Zithromax), and pseudoephedrine.
Which one of these could be causing a false-positive test for opioids on her urine drug screen?
A)
B)
C)
D)
Dextromethorphan
Guaifenesin
Azithromycin
Pseudoephedrine
179. A 12-year-old white male who lives in a household with several cats presents with axillary
lymphadenopathy. Which one of the following is the best initial test for establishing a diagnosis
of cat-scratch disease?
A)
B)
C)
D)
Lymph node biopsy

Blood cultures
IgG testing for Bartonella henselae
IgG testing for nontuberculous Mycobacterium species
180. A 49-year-old unemployed African-American male has multiple chronic conditions, including
type 2 diabetes mellitus, chronic kidney disease, hypertension, obstructive sleep apnea, and
lower extremity edema. He is on several medications, which he reports taking sporadically due
to a lack of health insurance and a limited income. He has several abnormal laboratory values,
including a serum creatinine level of 3.1 mg/dL, an increase from his usual levels, which have
ranged from 1.21.6 mg/dL over the past 5 years. You calculate his glomerular filtration rate
to be 27 mL/min/1.73 m2.
Which one of the following medications that he takes should be stopped at this time?
A)
B)
C)
D)
E)
Aspirin
Insulin
Metoprolol (Lopressor, Toprol-XL)
181. A 69-year-old patient presents with a 2-day history of wrist pain after sustaining a fall at home.
On examination there is diffuse swelling and tenderness across the dorsal aspect of the wrist.
Radiographs are shown below.
Which one of the following would be the most appropriate treatment?
A)
B)
C)
D)
E)
A long arm posterior splint

A radial gutter splint
A sugar-tong splint
A thumb spica splint
An ulnar gutter splint
52
182. Which one of the following has been shown to be LEAST effective in the treatment of irritable
bowel syndrome?
A)
B)
C)
D)
Fiber
Probiotics
Antispasmodics
Antidepressants
183. A 23-year-old female complains of lower abdominal and pelvic pain, increased vaginal
discharge, and postcoital bleeding. Her pain worsens during intercourse, and is accompanied by
occasional nausea and vomiting and a feverish feeling. She is sexually active with several male
partners.
A physical examination is remarkable for an oral temperature of 38.6C (101.5F), cervical
motion tenderness, adnexal tenderness without a mass, and a prominent cervical discharge.
Office laboratory results include an elevated erythrocyte sedimentation rate and an elevated
WBC count. Saline microscopy of vaginal secretions shows abundant numbers of WBCs but is
negative for Trichomonas vaginalis and bacterial vaginosis. You order nucleic-acid amplification
tests for Chlamydia trachomatis and Neisseria gonorrhoeae.
A) Treatment based on clinical findings
B) Treatment when results of testing for Chlamydia trachomatis and Neisseria gonorrhoeae
are available
C) Transvaginal ultrasonography
D) Pelvic CT
E) Laparoscopy
184. Which one of the following is associated with the use of stimulant medications for
attention-deficit disorder in adults?
A)
B)
C)
D)
E)
Lower success rates compared to nonstimulant medications

Weight gain
A low risk of medication abuse
Serious adverse cardiovascular events
Increases in blood pressure
53
185. A 70-year-old male with a past medical history significant for long-standing diabetes mellitus and
hypertension presents with a stroke. CT of the head shows mild atrophy, with no acute bleeding.
In the first 24 hours after his stroke, starting treatment to control his blood pressure is
recommended if it reaches what threshold level?
A)
B)
C)
D)
E)
150/90 mm Hg
160/100 mm Hg
180/100 mm Hg
200/110 mm Hg
220/120 mm Hg
186. The preferred site for an emergency airway is

A)
B)
C)
D)
E)
the thyrohyoid membrane

the cricothyroid membrane
immediately below the cricoid cartilage
through the first and second tracheal rings
at the level of the thyroid isthmus
187. An otherwise healthy 55-year-old female is diagnosed with hypertension, based on multiple
measurements of systolic blood pressures ranging from 142 to 148 mm Hg and diastolic blood
pressures in the range of 9096 mm Hg over the past 4 months. You are now discussing
medication options. The patient exercises regularly and conscientiously adheres to a very healthy
diet, and has a BMI of 20 kg/m2. She is concerned with the potential long-term adverse side
effects of medication in general, and asks if any agents have potential advantages.
Which one of the following medications has been shown to reduce bone loss and may reduce her
risk of future hip fractures?
A)
B)
C)
D)
E)
Hydrochlorothiazide
Losartan (Cozaar)
Metoprolol (Lopressor, Toprol-XL)
188. A 3-year-old male is carried into the office by his mother. Yesterday evening he began
complaining of pain around his right hip. Today he has a temperature of 37.6C (99.7F), cries
when bearing weight on his right leg, and will not allow the leg to be moved in any direction.
A radiograph of the hip is normal.
Which one of the following would be most appropriate at this time?
A)
B)
C)
D)
E)
A CBC and an erythrocyte sedimentation rate

A serum antinuclear antibody level
Ultrasonography of the hip
MRI of the hip
In-office aspiration of the hip
54
189. Plan-Do-Check-Act (PDCA) describes which one of the following?

A)
B)
C)
D)
E)
The accreditation process to become a patient-centered medical home

One of the National Quality Forums Safe Practices for Better Healthcare
The cycle of continuous quality improvement
Donabedian categories of quality measurement
The Chronic Care Model
190. A 44-year-old female presents with a 2-week history of postprandial right upper abdominal pain.
Since yesterday her pain has worsened in intensity and she has been vomiting. The patient does
not use tobacco or drink alcohol, and takes no medications. Laboratory findings include a serum
lipase level of 105 IU/L (N 1451), a serum amylase level of 155 U/L (N 36128), a serum total
bilirubin level of 1.5 mg/dL (N 0.01.0) and an alkaline phosphatase level of 200 IU/L (N
3396).
The recommended initial imaging in this situation is
A)
B)
C)
D)
E)
no routine imaging unless the clinical course becomes complicated

transabdominal ultrasonography
contrast-enhanced CT
magnetic resonance cholangiopancreatography (MRCP)
MRI
191. Which one of the following does the American College of Obstetricians and Gynecologists
recommend as first-line treatment for nausea and vomiting in pregnancy?
A)
B)
C)
D)
E)
Doxylamine (Unisom) and pyridoxine (vitamin B6)

Ondansetron (Zofran)
Prochlorperazine
Promethazine (Phenergan)
Metoclopramide (Reglan)
192. A 69-year-old female is unable to obtain adequate calcium from dietary sources. She is on
long-term therapy with pantoprazole (Protonix) for peptic ulcer disease.
Which one of the following would be the most appropriate calcium supplement for this patient?
A)
B)
C)
D)
E)
Oyster shell calcium

Calcium carbonate
Calcium lactate
Calcium gluconate
Calcium citrate
55
193. A 55-year-old male is brought to the emergency department because of confusion and seizures.
He has a history of hypertension and obstructive sleep apnea due to obesity. He is unconscious
on arrival and no other history is available. An examination shows no focal neurologic findings,
but a general examination is limited because of his size. Breath sounds are diminished, and heart
sounds are difficult to hear. He has venous insufficiency changes on his lower extremities, with
brawny-type edema. Vital signs include a pulse rate of 90 beats/min, a blood pressure of 140/90
mm Hg, and an oxygen saturation of 96%.
Laboratory testing reveals a glucose level of 120 mg/dL and a sodium level of 110 mEq/L (N
135145), with normal renal function tests and liver enzyme levels. A chest radiograph shows
mild cardiomegaly.
Which one of the following is the treatment of choice for this patient?
A)
B)
C)
D)
E)
Valsartan (Diovan)
Furosemide
Hypertonic saline
Conivaptan (Vaprisol)
194. A 58-year-old female consults you about smoking cessation. She has been intolerant of
varenicline (Chantix) but tells you her sister was able to stop smoking with the use of bupropion
(Wellbutrin).
A history of which one of the following would be a relative contraindication to the use of
bupropion?
A)
B)
C)
D)
E)
Coronary artery disease

Depression
Eczema
Hypothyroidism
Seizures
195. The leading type of injury in adults age 65 and older is

A)
B)
C)
D)
E)
automobile accidents
falls
gunshot wounds
fire-related injuries
hypothermia
56
196. A 69-year-old female with coronary artery disease, diabetes mellitus, and chronic asthma
presents to your office for follow-up. During the visit she expresses concerns about recent
reports of unsafe air quality in your region.
Which one of the following is reasonable counseling regarding the health risks of ambient air
pollution for this patient?
A) Ambient air pollution has not been clearly shown to increase complications of her
chronic diseases
B) She should take her normal vigorous daily walk outside despite air quality alerts because
the health benefits of exercise outweigh the risks
C) She should avoid areas near busy roads, which are major sources of multiple outdoor
air pollutants
D) Use of air conditioning will likely make her indoor air quality worse
E) Ozone pollution usually peaks in the winter months
197. A 45-year-old male who is being treated for chronic alcohol dependence with monthly injections
of naltrexone (Vivitrol) presents with significant pain due to a fractured ankle, and intravenous
pain medication is required. Which one of the following medications would be most useful in
this situation?
A)
B)
C)
D)
E)
Fentanyl
Hydromorphone (Dilaudid)
Ketorolac
Meperidine (Demerol)
Morphine
198. A 56-year-old female with a history of poorly controlled type 2 diabetes mellitus presents with
a complaint of progressive loss of sensation and weakness in both legs over the past 2 days and
low back pain that is nonradiating. She also reports that she is unable to feel bowel movements
or urination. She says she has not had any fever or chills.
On examination she has a low-grade fever with a blood pressure of 142/84 mm Hg. She has no
sensation to pinprick or vibration from the T9 level down, bilaterally. She is unable to move her
legs voluntarily or resist gravity, and no reflexes are elicited in the lower extremities. Her WBC
count is 12,700/mm3 (N 400010,000) and her erythrocyte sedimentation rate is 127 mm/hr (N
125).
A)
B)
C)
D)
Antiplatelet therapy
Intravenous corticosteroids
Thoracic spine films
MRI of the thoracic spine
57
199. A 60-year-old white female is admitted to the hospital with a submassive pulmonary embolism.
Which one of the following is most effective for assessing right ventricular dysfunction in this
situation?
A)
B)
C)
D)
Echocardiography
Physical examination
12-Lead electrocardiography
Contrast-enhanced CT of the chest
200. You are caring for a 42-year-old female with symptoms and physical findings consistent with
chronic fatigue syndrome. Her CBC, metabolic panel, TSH level, C-reactive protein level,
rheumatoid factor test, antinuclear antibody test, and phosphorus level are all normal. You have
assessed her for comorbid diagnoses of chronic pain, depression, and sleep disturbance, which
are all negative.
The best evidence-based initial treatment would be
A)
B)
C)
D)
E)
hydrocortisone
methylphenidate (Ritalin)
melatonin
cognitive-behavioral therapy
white fluorescent light therapy
201. A 38-year-old female presents with an itchy rash she says has been present for the past several
months. She has been using over-the-counter hydrocortisone cream with no improvement. On
examination she has an oval 12-cm erythematous plaque on her buttocks. The plaque is covered
with silvery scales.
Which one of the following would be the best initial treatment for her rash?
A)
B)
C)
D)
E)
Clobetasol 0.05% cream (Temovate) applied twice daily

Clotrimazole 1% cream applied twice daily
Diclofenac 3% gel applied twice daily
Mupirocin 2% ointment (Bactroban) applied twice daily
Salicylic acid 2% gel applied twice daily
202. A 66-year-old male sees you for follow-up after a recent hospitalization for his second episode
of diverticulitis in the past 3 years. He is currently in excellent health and takes no daily
medications except for occasional acetaminophen for arthritis pain. His physical examination is
unremarkable except for a BMI of 19.0 kg/m2. He asks you about preventing further recurrences
of his diverticulitis.
You suggest that he do which one of the following?
A)
B)
C)
D)
E)
Lose weight
Increase his dietary fiber intake
Stop acetaminophen use
Avoid eating nuts, corn, or popcorn
Avoid high-impact aerobic exercise
58
203. A 23-year-old male presents to your office with a 2-day history of dull, achy, right testicular
pain. He reports that the pain began gradually, reaching a peak last night. He does not recall any
trauma and denies any urethral complaints.
Your examination reveals an extremely tender right testis with some tenderness extending to the
epididymis. A preliminary report from a stat ultrasound examination shows an enlarged,
heterogeneous right testis with increased color flow.
Which one of the following is the preferred management?
A)
B)
C)
D)
Watchful waiting
Repeat ultrasonography in 24 hours
Antibiotic treatment
Emergent urology referral
204. A 21-year-old male college student presents to the emergency department with a 2-day history
of fever, severe muscle and joint pain, nausea, and vomiting. He spent his winter break traveling
in South America and returned 4 days ago. On examination he has a temperature of 39.4C
(103.0F), gingival bleeding, lower extremity non-pitting edema, right upper quadrant
tenderness, a diffuse maculopapular rash, muscle tenderness, and petechiae on his extremities.
WBCs.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Neutrophils.. . . . . . . . . . . . . . . . . . . . . . . . .
Lymphocytes. . . . . . . . . . . . . . . . . . . . . . . .
Bands. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Hematocrit. . . . . . . . . . . . . . . . . . . . . . . . . . . .
Platelets. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Thick and thin blood smear.. . . . . . . . . . . . . .
AST (SGOT). . . . . . . . . . . . . . . . . . . . . . . . . .
ALT (SGPT). . . . . . . . . . . . . . . . . . . . . . . . . .
Total bilirubin. . . . . . . . . . . . . . . . . . . . . . . . .
Albumin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Creatine phosphokinase.. . . . . . . . . . . . . . . . .
3100/mm3 (N 430010,800)
40% (N 4575)
50% (N 1646)
1% (N 05)
50.0% (N 37.049.0)
75,000/mm3 (N 150,000350,000)
negative
100 U/L (N 1040)
120 U/L (N 730)
1.0 mg/dL (N 0.01.0)
3.5 g/dL (N 3.14.3)
500 U/L (N 60400)

A)
B)
C)
D)
E)
Hepatitis A
Yellow fever
Dengue fever
Typhoid fever
Influenza
59
205. A 25-year-old female with asthma uses her albuterol (Proventil, Ventolin) inhaler only before
running, but reports waking up short of breath four times per month. She went to the emergency
department recently for increased dyspnea during peak ragweed season and remained overnight
until her symptoms improved.
Which one of the following is the best treatment option now?
A)
B)
C)
D)
E)
Oral prednisone as needed

Inhaled albuterol daily
Inhaled cromolyn sodium daily
Inhaled salmeterol (Serevent Diskus) daily
Inhaled fluticasone (Flovent) daily
206. Stretching has NO demonstrable benefit for which one of the following?
A)
B)
C)
D)
E)
Hamstring strain
Chronic neck pain
Joint contracture
Osteoarthritis
Rehabilitation post knee replacement
207. A 3-week-old male is brought to your office because of a fever and increasing fussiness. He had
a rectal temperature at home earlier today of 101.5F (38.6C). The mother reports that he is
not breastfeeding as often as usual and has had fewer wet diapers. He has no nasal congestion
and no cough. There are no recent sick contacts or known exposures.
On examination you note a fever of 39.2C (102.5F) and a pulse rate of 200 beats/min. The
remainder of his examination is normal. You order a full sepsis workup and admit him to the
hospital.
Which one of the following is the best intravenous antibiotic regimen for empiric coverage at
this point?
A)
B)
C)
D)
E)
Ampicillin and cefotaxime (Claforan)

Ampicillin and clindamycin (Cleocin)
Gentamicin
Vancomycin
208. Which one of the following is most appropriate in the management of frostbite?
A)
B)
C)
D)
E)
Complete surgical debridement of hemorrhagic blisters

Rapid rewarming with dry heat and warm blankets
Withholding analgesics to ensure accurate assessment
Vigorously rubbing affected tissues to restore circulation
Leaving simple, non-tense areas of clear blistering intact
60
209. A 32-year-old female comes to your office because she has had increasing difficulty performing
her daily tasks for the past 6 months. She says she worries excessively about routine events
every day and constantly feels tense, restless, jittery, on edge, irritable, and unable to relax.
She also reports that sometimes her heart pounds and races, her hands feel sweaty and clammy,
and her mouth feels like it is full of cotton. She reports difficulty concentrating and falling
asleep at night. A recent TSH level was normal. During your examination you note frequent
sighing, a fine tremor in her hands, bitten nails, and clammy hands.
Based on her symptoms and examination, which one of the following pharmacologic agents for
managing her condition is supported by the best available evidence?
A)
B)
C)
D)
E)
Alprazolam (Xanax)
Buspirone
Hydroxyzine
Escitalopram (Lexapro)
Quetiapine (Seroquel)
210. A 6-year-old male is brought to your office for a well child check. His vital signs are normal;
he is 117 cm (46 in) tall and weighs 19 kg (42 lb). The patient has grown out of his car seat, and
his mother recently was told by a friend that he can now sit in the front seat of a car. She asks
you if this is true.
According to recommendations from the American Academy of Pediatrics, which one of the
following is true for this patient?
A) He should be using a rear-facing child safety seat in the back seat of the car
B) He should be using a belt-positioning booster seat in the back seat of the car
C) He should be using a belt-positioning booster seat and can ride in the front or back seat
of the car
D) He no longer needs a safety seat but should always ride in the back seat of the car
E) He no longer needs a safety seat and can ride in the front or back seat of the car
211. A 40-year-old male is admitted to the hospital with a generalized rash consistent with
Stevens-Johnson syndrome. His previous medical problems include obesity, gout, hypertension,
type 2 diabetes mellitus, and depression. His medications include lisinopril (Prinivil, Zestril),
allopurinol (Zyloprim), colchicine (Colcrys), metoprolol succinate (Toprol-XL), metformin
(Glucophage), and venlafaxine (Effexor XR).
Which one of these medications is most likely to be the cause of his Stevens-Johnson syndrome?
A)
B)
C)
D)
E)
Allopurinol
Colchicine
Lisinopril
Metformin
Venlafaxine
61
212. A 72-year-old male with dyslipidemia and coronary artery disease sees you for a routine
evaluation. He asks if he should take fish oil supplements.
You advise the patient that good evidence shows that supplementation with omega-3 fatty acids
decreases
A)
B)
C)
D)
triglycerides
LDL-cholesterol
cardiovascular events
total mortality
213. A 76-year-old female presents with a history of bilateral shoulder pain for the past month. She
reports stiffness in the morning for about 1 hour and also reports difficulty getting up when
seated in a chair. Acetaminophen is ineffective for her pain. Her erythrocyte sedimentation rate
is 65 mm/hr (N 125).
Which one of the following is the best initial treatment for this condition?
A)
B)
C)
D)
E)
Oral dexamethasone, 8 mg twice a day

Oral methylprednisolone (Medrol Dosepak), taper 24 mg to 0 mg over 7 days
Oral prednisolone (Orapred), 60 mg daily
Oral prednisone, 15 mg/day
Intravenous methylprednisolone, 120 mg every 6 hours
214. You are caring for a 60-year-old female with Crohns disease that is well controlled by
infliximab (Remicade). As your staff updates her immunization status, which one of the
following should be kept in mind?
A)
B)
C)
D)
E)
Hepatitis A vaccine is contraindicated

Pneumococcal vaccine is contraindicated
Tetanus toxoid is contraindicated
Zoster vaccine is contraindicated
All routine immunizations are considered safe
215. Which one of the following is a common cause of prerenal acute kidney injury?
A)
B)
C)
D)
E)
Acute tubular necrosis

Diuretic overuse
Glomerulonephritis
Neurogenic bladder
Prostate hypertrophy
62
216. A 2-month-old female is brought to your office with tachypnea and a staccato cough. She is
afebrile. A chest radiograph shows hyperinflation and bilateral infiltrates, and a CBC reveals
eosinophilia.
Which one of the following is the most likely etiologic agent?
A)
B)
C)
D)
E)
Chlamydia trachomatis
Listeria pneumoniae
Streptococcus pneumoniae
A gram-negative bacteria
Respiratory syncytial virus
217. A 45-year-old male with Down syndrome is brought to your office because of complaints of
increased aggression toward the staff and peers at his group home. He is usually pleasant and
compliant but he has been acting out for the last 2 weeks. He is not considered to be a danger
to himself or others at this point. He is minimally verbal and unable to give a history for himself.
Staff members report no change in appetite or urination, and no signs of outward illness. His
vital signs in your office are within normal limits.
A)
B)
C)
D)
E)
A complete history, physical examination, and basic laboratory tests

CT of the head
Risperidone (Risperdal)
Sertraline (Zoloft)
Valproic acid (Depakene)
218. Which one of the following tests is recommended for the detection and diagnosis of gestational
diabetes mellitus?
A)
B)
C)
D)
E)
Hemoglobin A1c
Fasting blood glucose
2-hour postprandial glucose
An oral glucose tolerance test
A fasting insulin/glucagon ratio
219. CT imaging for which one of the following conditions is best done without contrast?
A)
B)
C)
D)
Acute appendicitis
Diverticulitis
Pulmonary embolism
Nephrolithiasis
63
220. A 46-year-old perimenopausal female complains of hot flashes, which are very troubling to her.
She would like treatment for these symptoms, but has a history of deep vein thrombosis while
taking oral contraceptives.
Which one of the following treatments has evidence of benefit for her symptoms with the least
potential for causing deep vein thrombosis?
A)
B)
C)
D)
E)
Vaginal estradiol
Oral estradiol combined with progestin
Oral phytoestrogens such as soy protein
Oral venlafaxine (Effexor XR)
Topical bio-identical hormones
221. A 72-year-old white female is admitted to the hospital with her first episode of acute heart
failure. She has a history of hypertension treated with a thiazide diuretic. An echocardiogram
reveals no evidence of valvular disease and no segmental wall motion abnormalities. Left
ventricular hypertrophy is noted, and her ejection fraction is 55%. Her pulse rate is 72
beats/min.
The most likely cause of her heart failure is
A)
B)
C)
D)
systolic dysfunction
diastolic dysfunction
hypertrophic cardiomyopathy
high-output failure
222. A 54-year-old female concert pianist presents to your office with a 9-month history of searing
pain and bilateral paresthesias in the distribution of her median nerve. She says that the pain
frequently radiates as far as her shoulder, and that her fingers feel swollen even though they look
normal. She states that she has worsening paresthesias at night and often finds herself flicking
her wrist in an attempt to alleviate her symptoms.
The patients symptoms are reproducible with wrist flexion and she exhibits mild weakness of
the abductor pollicis brevis on examination. She has been wearing neutral wrist splints at night
for the last 8 weeks and has also been taking oral NSAIDs, resulting in only minimal relief. She
is in the middle of her concert season and is unable to take time off for a surgical procedure.
Which one of the following therapies will provide this patient with the longest symptom relief?
A)
B)
C)
D)
E)
Full rest for 8 weeks

Full-time cock-up splinting for 8 weeks
Physical therapy
Oral corticosteroids
Local corticosteroid injection
64
223. In a patient with chronic, severe, noncancer pain, which one of the following would be most
appropriate for initial opioid therapy?
A)
B)
C)
D)
E)
Buprenorphine (Buprenex)
Transdermal fentanyl (Duragesic)
Hydromorphone (Dilaudid)
Methadone (Dolophine)
Morphine
224. In which one of the following cardiac emergency cases should atropine be used?
A)
B)
C)
D)
E)
Symptomatic Mobitz type II atrioventricular block

Cardiac arrest with pulseless electrical activity
Asystolic cardiac arrest
Acute cardiac ischemia and a heart rate <60 beats/min
Sinus bradycardia with hypotension
225. Staff members in your practice often complain about one of your patients. He exhibits odd
behaviors and beliefs, and is always very anxious about his visit and about when he will be seen,
despite long familiarity with your practice.
Which one of the following personality disorders best fits the description of this patient?
A)
B)
C)
D)
E)
Antisocial
Borderline
Dependent
Narcissistic
Schizotypal
226. A 45-year-old male who has been complaining of dyspnea undergoes pulmonary function testing.
The results show an FEV1/FVC ratio of 85% and an FVC below the lower limits of normal.
Based on these results, which one of the following possible causes of dyspnea is most likely?
A)
B)
C)
D)
E)
Asthma
Bronchiectasis
"1-Antitrypsin deficiency
COPD
Idiopathic pulmonary fibrosis
65
227. A 62-year-old female presents to your office with diarrhea and signs and symptoms of
dehydration. She has a temperature of 38.6C (101.5F) and a WBC count of 17,000/mm3 (N
530010,800). You admit her to the hospital, and a Clostridium difficile toxin assay is positive.
Because of the severity of her infection, you initiate oral vancomycin (Vancocin), 125 mg 4
times daily. She has a poor clinical response and you decide to alter the antibiotic regimen to
include intravenous coverage.
Which one of the following intravenous antibiotics would be most appropriate?
A)
B)
C)
D)
E)
Imipenem/cilastatin (Primaxin)
Meropenem (Merrem)
Metronidazole
Vancomycin
228. Which one of the following is NOT a risk factor for stillbirth?
A)
B)
C)
D)
E)
Smoking
Advanced maternal age
Congenital anomalies
Vigorous exercise
BMI >30 kg/m2
229. A 72-year-old female who remains very active and engaged in the community comes to your
office concerned by urinary symptoms that disrupt her life. She reports that she often has a
strong, abrupt desire to void that frequently causes her to leak urine involuntarily. She also
reports occasional episodes of urinary frequency and nocturia.
Which one of the following is the first-line treatment for her condition?
A)
B)
C)
D)
E)
Anticholinergic drugs such as oxybutynin or solifenacin (Vesicare)

$-Adrenergic agonists such as mirabegron (Myrbetriq)
Duloxetine (Cymbalta)
Bladder training
A pessary
66
230. A 13-year-old male presents with a 3-week history of left lower thigh and knee pain. There is
no history of a specific injury, and his past medical history is negative. He has had no fevers,
night sweats, or weight loss, and the pain does not awaken him at night. He tried out for his
schools basketball team but had to quit because of the pain, which was worse when he tried to
run.
Which one of the following physical examination findings would be pathognomonic for slipped
capital femoral epiphysis?
A)
B)
C)
D)
E)
Excessive forward passive motion of the tibia with the knee flexed
Lateral displacement of the patella with active knee flexion
Limited internal rotation of the flexed hip
Reduced hip abduction with the hip flexed
An inability to extend the hip past the neutral position
231. A 54-year-old male presents with hearing loss associated with tinnitus. Which one of the
following additional characteristics would be an indication for MRI of the brain to assess for an
intracranial tumor?
A)
B)
C)
D)
A rapid onset of symptoms

Unilateral symptoms
Association with pain and otorrhea in the affected ear
Exposure to loud noise shortly before the symptoms began
232. A 65-year-old male comes to your office with symptoms consistent with intermittent claudication
in both lower extremities. These symptoms are making it difficult for him to walk any significant
distance and to manage his daily activities. He has smoked one pack of cigarettes per day for the
past 40 years and has moderate hypertension, an elevated LDL-cholesterol level, and a low
HDL-cholesterol level.
On examination you note that the skin on the patients lower legs is cool and shiny, with sparse
hair. Distal pulses are not palpable and capillary refill is prolonged. His ankle-brachial index is
0.85 (N 1.01.4). His cardiac examination is normal, with no evidence of heart failure.
Which one of the following pharmacologic options for improving this patients claudication
symptoms is supported by the best available evidence?
A)
B)
C)
D)
E)
Aspirin
Warfarin (Coumadin)
Pentoxifylline
Cilostazol (Pletal)
67
233. A 54-year-old male presents to your office with a 10-day history of increasing cough. A physical
examination reveals coarse crackles in the left lower lobe. You make a diagnosis of pneumonia.
The patients only current medication is simvastatin (Zocor).
Which one of the following is CONTRAINDICATED in this patient?
A)
B)
C)
D)
E)
Amoxicillin/clavulanate (Augmentin)
Clarithromycin (Biaxin)
Doxycycline
Levofloxacin (Levaquin)
234. A previously healthy 50-year-old male presents with a heart rate of 156 beats/min and a blood
pressure of 126/84 mm Hg. An EKG shows a regular, narrow-complex tachycardia. Vagal
maneuvers have no effect, and the patient appears anxious.
Administration of which one of the following medications is the best initial treatment?
A)
B)
C)
D)
E)
Verapamil (Calan)
Diltiazem
Adenosine (Adenocard)
Digoxin
235. A 52-year-old male with diabetes mellitus reports that he ran out of insulin a week ago. He is
drowsy but responds to your verbal commands, and the remainder of his examination is
unremarkable.
Laboratory Findings
Blood glucose. . . . . . . . . . . . . . . . . . . . . . . . .
Serum sodium. . . . . . . . . . . . . . . . . . . . . . . . .
Serum potassium. . . . . . . . . . . . . . . . . . . . . . .
Serum bicarbonate. . . . . . . . . . . . . . . . . . . . . .
BUN. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
625 mg/dL
128 mEq/L (N 135145)
5.9 mEq/L (N 3.55.0)
12 mEq/L (N 2226)
52 mg/dL (N 825)
Which one of the laboratory abnormalities is an indication that he has severe diabetic
ketoacidosis?
A)
B)
C)
D)
E)
Glucose
Sodium
Potassium
Bicarbonate
BUN
68
236. A 51-year-old female has resistant hypertension, and you decide to test her for primary
hyperaldosteronism. Which one of the following is the preferred initial test for this condition?
A)
B)
C)
D)
E)
A morning serum cortisol level

A morning serum renin to aldosterone ratio
A morning urinary potassium level
A salt suppression test
Abdominal MRI
237. As part of routine care for a 31-year-old female you obtain a Papanicolaou (Pap) test for cervical
cancer screening. The cytology results are normal, and the sample is positive for the presence
of HPV but negative for serotypes 16 and 18.
Which one of the following is the most appropriate management for this patient?
A)
B)
C)
D)
E)
Immediate colposcopy
Repeat Pap and HPV testing in 3 months
Repeat Pap and HPV testing in 6 months
Repeat Pap and HPV testing in 1 year
Repeat Pap and HPV testing in 3 years
238. A 34-year-old female with a history of type 2 diabetes mellitus requests your advice regarding
influenza vaccine. She is concerned because 6 months ago she developed hives after ingesting
eggs and another physician suggested that she avoid influenza vaccine. She has not experienced
wheezing, vomiting, or swelling in her throat after ingesting eggs.
Which one of the following would be the best strategy for this patient?
A)
B)
C)
D)
Avoid giving influenza vaccine

Administer the live-attenuated influenza vaccine and observe for 30 minutes
Administer trivalent inactivated vaccine and observe for 30 minutes
Have the patient take prednisone, 20 mg for 3 days, then administer the live-attenuated
influenza vaccine and observe for 30 minutes
E) Have the patient take prednisone, 20 mg for 3 days, and then administer the trivalent
inactivated vaccine and observe for 30 minutes
239. A 45-year-old male with diabetes mellitus sees you for the first time. If the patient has not
previously received it, which one of the following vaccines is recommended for him by the
Advisory Committee on Immunization Practices?
A)
B)
C)
D)
Hepatitis A
Hepatitis B
Meningococcal
Varicella zoster
69
240. Which one of the following nutritional management strategies is associated with better outcomes
in patients with mild acute pancreatitis whose pain and nausea have resolved?
A)
B)
C)
D)
E)
Waiting until lipase has normalized before beginning oral intake

Early initiation of a clear liquid diet
Early initiation of a low-fat diet
Early initiation of tube feeding
Early initiation of total parenteral nutrition
70

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Treat empirically with a short-acting $-agonist

Utilizing the latest research and advances in treatment and diagnosis

8. Mild cognitive impairment is characterized by which one of the following?

Localized motor dysfunction

Analgesics and supportive care only

Adjust the defibrillator to deliver shocks only for ventricular fibrillation

Patellar tendon rupture

Colposcopy with endocervical curettage

Mucocutaneous lymph node syndrome

Aggressive lowering of blood pressure

Reduced FEV1 and a decreased FEV1/FVC ratio

Behavioral treatment alone

Excision with wide margins

an adverse effect on left ventricular function

Adding rapid-acting insulin at breakfast

A bolus of normal saline

Refer to orthopedics for therapeutic osteotomy

Clearance for eye surgery with no further evaluation

Atrial fibrillation with a slow ventricular response

Scheduled oral muscle relaxants

Continue the current dosage of levothyroxine

52. Blood pressure classification in children is based on

sex, weight, and height

A fasting lipid profile

Ischemic heart disease

Toxic multinodular goiter

A CBC with manual differential

Athletic pubalgia (sports hernia)

Ligamentous sprain of the arch

Early initiation of antibiotics

competency and credentialing

A single 200-mg dose of doxycycline

A previous admission for diverticulitis in the last 12 months

A topical mild-potency corticosteroid

The test can confirm pulmonary embolism

Referral for orthopedic consultation

Use of alcohol-based hand sanitizer

Chronic pulmonary thromboembolism

A 50-year-old current smoker

Acute cholangitis secondary to a common duct stone

A stained sputum culture for acid-fast bacilli

New-onset angina beginning 2 weeks to 2 months before presentation

Continue the amoxicillin and begin prednisone and diphenhydramine (Benadryl)

A 56-year-old male with type 2 diabetes mellitus and peripheral neuropathy

venous thromboembolism prophylaxis is stopped

A follow-up serum prolactin level in 4 weeks

Plain films of the foot

stroke, beginning at age 50

First degree atrioventricular block

Triamcinolone, 20 mg intramuscularly as a single dose

Resting pulse rate

142. A 47-year-old male is hospitalized for severe lower-extremity methicillin-resistant

Another dose of intramuscular epinephrine

Eating breakfast every day

Reassurance, with no activity restrictions or treatment

Outpatient treatment with oral azithromycin (Zithromax)

The patients history of weight loss

Reduce oxygen use to nighttime only