Dysmenorrhea in Adolescents

ZEEV HAREL
Division of Adolescent Medicine, Hasbro Childrens Hospital, and
Department of Pediatrics, Brown University Medical School,
Providence, Rhode Island, USA

Dysmenorrhea is the most common gynecologic complaint among adolescent females. Dysmenorrhea in adolescents is usually primary, and is associated with normal ovulatory cycles and
with no pelvic pathology. In approximately 10% of adolescents with severe dysmenorrheic symptoms, pelvic abnormalities such as endometriosis or uterine anomalies may be found. Potent
prostaglandins and leukotrienes play an important role in generating the symptoms of dysmenorrhea. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common pharmacologic
treatment for dysmenorrhea. A loading dose of NSAIDs (typically twice the regular dose) should be
used as initial treatment for dysmenorrhea in adolescents, followed by a regular dose until symptoms abate. Adolescents with symptoms that do not respond to treatment with NSAIDs for three
menstrual periods should be offered hormonal treatment such as combined estrogen/progestin
oral contraceptive pills for three menstrual cycles. Adolescents with dysmenorrhea who do not
respond to this treatment should be evaluated for secondary causes of dysmenorrhea. The adolescent care providers role is to explain the pathophysiology of dysmenorrhea to every adolescent
female, address any concern that the patient has about her menstrual period, and review effective
treatment options for dysmenorrhea with the patient.
Key words: dysmenorrhea; adolescents; secondary dysmenorrhea

The Menstrual Cycle

in the Adolescent Girl
Menarche, the onset of menstrual periods, marks
an important point in life for the female adolescent, as it symbolizes the entrance into womanhood. Mean menarchal age in adolescents in the
United States is 12.2 years in African American girls
and 12.9 years in Caucasian girls.1 In addition to
genetic and racial/ethnic factors, environment and
anthropometrics influence maturational timing in
adolescents.2
In adolescents, the positive stimulatory feedback
mechanism of estrogen on LH does not mature nor
does the LH surge consistently occur until 25 years
after menarche. As a consequence, 5080% of the
cycles are anovulatory and irregular during the first
2 years after menarche, and approximately 10%20%
of cycles remain anovulatory for up to 5 years after
menarche. The length of the interval between the
onset of menses and the establishment of ovulatory
cycles is associated with the age at menarche, with

Address for correspondence: Zeev Harel, M.D., Division of Adolescent

Medicine, Hasbro Childrens Hospital, 593 Eddy Street, Providence, RI
02903. Voice: 401-444-5188; fax: +1-401-444-6218.
[email protected]

early menarche indicating early onset of ovulatory cycles.3 The eventual attainment of ovulatory cycles by
the teenagers leads to normal, repetitive menstrual
bleeding.
While dysmenorrhea (menstrual cramps and other
menstruation-associated symptoms) is less common
during the first 23 years after menarche, when most of
the menstrual cycles are anovulatory, it becomes more
prevalent during mid- and late adolescence, with the
establishment of ovulatory menstrual cycles.4

Prevalence of Dysmenorrhea
in Adolescents
Dysmenorrhea is the most common gynecologic
complaint and the leading cause of recurrent shortterm school or work absenteeism among female adolescents.4 In a study among older adolescent urban
Swedish girls, a majority (72%) reported experiencing
dysmenorrhea, and approximately 15% of adolescents
described the disorder as severe.5 A school absenteeism
rate of 1452% has been reported among U.S. adolescents with dysmenorrhea, with girls experiencing severe cramps more likely to miss school than those with
mild cramps.4,6
Despite the high prevalence of dysmenorrhea in
adolescents, many girls either do not seek medical

C 2008 New York Academy of Sciences.

Ann. N.Y. Acad. Sci. 1135: 185195 (2008).

doi: 10.1196/annals.1429.007
185

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TABLE 1. Symptoms of dysmenorrhea

Cramps
Nausea
Vomiting
Loss of appetite
Headaches
Backaches
Legaches
Weakness
Dizziness

Diarrhea
Facial blemishes
Abdominal pain
Flushing
Sleeplessness
General aching
Depression
Irritability
Nervousness

advice or are undertreated.7 In one study, a majority

(98%) of adolescents used nonpharmacologic methods such as heat, rest, or distraction to treat dysmenorrhea, with perceived effectiveness of 40% or less.8
In other studies from different populations, 30%-70%
of girls reported at least occasionally self-medicating
with over-the-counter (OTC) pain medications.5,9,10
However, 57% of those who self-medicated with OTC
preparations used subtherapeutic doses.10 Only 54%
of adolescents knew that certain medications could
relieve menstrual cramps,10 and 27% of girls were
unable to recognize any of three nonsteroidal antiinflammatory drugs (NSAIDs) listed as possible treatments for dysmenorrhea.11
In the U.S., some of the OTC medications marketed
for relief of dysmenorrhea do not contain any of the
NSAIDs that have been demonstrated to be effective
in treating the disorder. Furthermore, while dysmenorrhea is a prevalent medical disorder (65%) among
urban adolescent females, only few (2%) reported receiving information regarding menstruation from their
health care provider.12

Dysmenorrhea: Symptoms
and Risk Factors
While lower abdominal cramping is the most common symptom of dysmenorrhea, many adolescents
suffer from other menstruation-associated symptoms
such as headaches, nausea, and vomiting (TABLE 1). In
a recent cross-sectional study among U.S. adolescents
with dysmenorrhea, menstrual cramps were associated with nausea in 55%, and with vomiting in 24%.7
Symptoms typically accompany the start of menstrual
flow or occur within a few hours before or after onset
and last for the first 2448 hours. Severity of symptoms
positively correlates with the onset of ovulatory cycles
and with increased duration and amount of menstrual
flow.5,13 Low fish consumption correlated with severity of dysmenorrhea in two studies.13,14 In addition,

cigarette smoking may increase duration of dysmenorrhea, presumably because of nicotine-induced vasoconstriction.15

Pathophysiology of Primary
Dysmenorrhea
The majority of cases of dysmenorrhea in adolescents are primary (or functional), are associated with
a normal ovulatory cycle and with no pelvic pathology, and have a clear physiologic etiology.4,16 After
ovulation there is a build-up of fatty acids in the phospholipids of the cell membranes. The high intake of
omega-6 fatty acids in the Western diet results in a
predominance of the omega-6 fatty acids in the cell
wall phospholipids.17 After the onset of progesterone
withdrawal before menstruation, these omega-6 fatty
acids, particularly arachidonic acid, are released, and a
cascade of prostaglandins (PGs) and leukotrienes (LTs)
is initiated in the uterus (FIG. 1). The inflammatory
response, which is mediated by these PGs and LTs,
produces both cramps and systemic symptoms such
as nausea, vomiting, bloating, and headaches. In particular, the prostaglandin F2, cyclooxygenase (COX)
metabolite of arachidonic acid, causes potent vasoconstriction and myometrial contractions, leading to
uterine ischemia and pain.18
Chan and Hill measured PGF2 activity in menstrual fluid from tampons and found that PG activity was twice as high in dysmenorrheic than in eumenorrheic women.18 Similar findings were reported
by Rees et al.19 Lundstrom and Green examined endometrial specimens taken from both dysmenorrheic
and eumenorrheic women during the menstrual period and found that women with dysmenorrhea receiving no medication had endometrial PGF2 levels
four times higher than the eumenorrheic women did
on the first day of the menstrual period.20 The intensity
of the menstrual cramps and dysmenorrhea-associated
symptoms are directly proportional to the amount of
PGF2 released.21
While the PG pathway has been extensively investigated in dysmenorrhea, there is a paucity of data regarding the LT pathway. Previous studies have shown
that human uterine tissue has the capacity to synthesize and metabolize LTs,22 and LT receptors have been
detected in uterine tissue.23 Rees et al. found that the
highest LT values were present in uterine tissue obtained (during hysterectomy) from adult women with
a complaint of dysmenorrhea.22 Nigam et al. found a
close correlation between menstrual flow LT-C 4 /D 4
levels and the severity of dysmenorrheic symptoms in

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Harel: Dysmenorrhea in Adolescents

FIGURE 1. Pathophysiology of dysmenorrhea. (From Harel, Z.97 Reprinted by permission.)

adult women with primary dysmenorrhea.24 In a preliminary study, our group found an increase in urinary
LT-E 4 in adolescent girls with dysmenorrhea,25 further indicating a possible involvement of these potent
vasoconstrictors and inflammatory mediators in generating symptoms of dysmenorrhea in adolescents.
Some other mechanisms that are involved in uterine
contractility and relaxation have been suggested in the
pathogenesis of dysmenorrhea. An increased level of
circulatory vasopressin, which is known to induce uterine contractions, has been reported in women with dysmenorrhea during menstruation, but its involvement
in the pathogenesis of primary dysmenorrhea remains
controversial.26 Similarly, more studies are needed to
explore whether low levels of nitric oxide, which are
known to induce myometrial contractions and vasoconstriction, play a role in generating the symptoms of
dysmenorrhea.27

Pathophysiology of Secondary
Dysmenorrhea
Secondary dysmenorrhea refers to painful menstruation associated with pelvic abnormalities, which may
be seen in about 10% of adolescents with dysmenorrhea. Since the incidence of some of the causative
conditions such as endometriosis and fibroids increases
with age, secondary dysmenorrhea is more preva-

lent in adult women than in adolescents. Secondary

dysmenorrhea is more likely to be associated with
chronic pelvic pain, midcycle pain, dyspareunia, and
metrorrhagia.

Endometriosis
Endometriosis is the most common cause of secondary dysmenorrhea in adolescents. It is defined as
the presence and growth of uterine glands and stroma
outside the uterine cavity. The majority of endometriosis implants are located in the pelvis, with the ovaries
being the most common site. Other common sites
of endometriosis include the pelvic peritoneum, anterior and posterior cul-de-sac, uterosacral ligaments,
pelvic lymph nodes, cervix, uterus, vagina, vulva, rectosigmoid colon, and appendix. Rare sites of implantation include the umbilicus, surgical scars, bladder,
kidneys, lungs, and extremities. The incidence of endometriosis in adolescents has been reported to be
between 45% and 70% in a referral population presenting with chronic pelvic pain.28 The youngest reported patient to have biopsy-proven endometriosis
was 10 years of age.29 The 6.9% incidence of endometriosis in first-degree relatives of women with the
disease, compared with the 1%2% incidence in the
general population, implies a possible polygenic multifactorial model of inheritance.30 Although the risk for
endometriosis is about threefold higher among firstdegree relatives, it is far less than the 50% incidence

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one could expect with an autosomal dominant

inheritance.
The most widely accepted theory about the development of endometriosis is Sampsons theory of retrograde menstruation. Deficient cell-mediated immunity with impaired clearing of endometriotic cells from
aberrant locations has also been implicated. Other theories of origin include Meyers theory of multipotential cells undergoing metaplasia, and Halbans theory
of hematogenous and lymphatic dissemination of endometrial cells. Abnormal local hormonal activity and
potent inflammatory mediators are also involved in the
pathophysiology of endometriosis.
Endometriosis is an estrogen-dependent disorder.
Immunohistochemical studies have located estrogen
receptor expression and increased expression of aromatase in epithelial and stromal cells of endometriotic
tissues and peritoneum.31,32 Thus, while aromatase activity is not detectable in normal endometrium, it is
expressed inappropriately in endometriosis, leading to
a rise in local biosynthesis of estrogen. This acquisition of steroidogenic capacity may permit the ectopic
endometrial tissues to survive despite the lack of ovarian steroids during menstruation. In addition, aberrant expression of cytokines such as interleukin-1 and
tumor necrosis factor-alpha may influence the establishment and proliferation of these ectopic endometrial implants.33 Immunohistochemical studies have
shown that the COX-2 expression is upregulated in
endometriotic lesions,34 and this increase in COX-2
is most likely secondary to the increase in estrogen.35
The increased Cox activity results in production of
PGs such as PGE 2 , which, in turn, is a potent inducer
of aromatase expression and activity in endometriotic
stromal cells.36 Another abnormality that contributes
to the rise of estrogen in endometriosis is a deficient
17 -hydroxysteroid dehydrogenase (17 -HSD) type 2
expression which impairs the inactivation of estradiol
to estrone.37 This 17 -HSD type 2 deficiency may
also be viewed as a defective action of progesterone,
which fails to induce this enzyme in endometriotic tissue. Thus, the positive feedback loop in endometriosis
consists of high local levels of estrogen, which induce
transcription of COX-2 and synthesis of PGE 2 , resulting in further expression and activity of aromatase and
further increase in estrogen (FIG. 2). The accumulation
of estrogen and PG results in a potent inflammatory
process and pelvic pain.
The severity of pain from endometriosis involves
several factors. These include the location of the lesion,
depth of invasion, and stretching or scarring of tissue.
In particular, women with deep implants tend to have
more active disease and more severe pain.38 However,

Annals of the New York Academy of Sciences

the presence of symptoms does not always predict the

extent of endometriosis.39

Reproductive Tract Anomalies

and Other Causes of Secondary
Dysmenorrhea
In the adolescent age group, the distinct possibility
of a mullerian anomaly must also be considered. The
patient may have a didelphic uterus with unilateral
obstruction, resulting in pelvic pain that may or may
not be cyclic. In particular, girls with an early onset of
severe dysmenorrhea beginning with (or even before)
menarche should be evaluated to rule out an obstructive or partially obstructive anomaly, such as longitudinal or transverse vaginal septum. In addition, an early
age of presentation of endometriosis should raise suspicion of a genital outflow obstructive anomaly. In one
study by Goldstein et al., congenital anomalies of the
reproductive tract were noted in 11% of teenagers with
endometriosis.40
Patients with pregnancy-related complications such
as miscarriage and ectopic pregnancy can present
acutely with severe pain/cramping and bleeding, and
this should be high on the list of differential diagnoses
in a sexually active adolescent. Adhesions, pelvic inflammatory disease (PID), abscess, fibroids (myomas),
adenomyosis, endometrial polyps, ovarian cysts, and,
rarely, ovarian neoplasms are also included in the differential diagnosis of secondary dysmenorrhea.

Treatment of Dysmenorrhea

Nonpharmacologic Approach
Interventions such as herbal preparations,41 transcutaneous nerve stimulation,42 acupuncture,43 and
heat therapy44 have been reported to lessen dysmenorrhea in some studies. Heat therapy can be administered with a heating pad, hot-water bottle, or commercially available adhesive pads which generate heat
by a chemical reaction. Physical activity may also reduce dysmenorrhea45 by improving pelvic blood flow
as well as by stimulating the release of beta-endorphins,
which act as nonspecific analgesics. A low-fat vegetarian diet was associated with a decrease in duration and
intensity of dysmenorrhea in young adult women.46
Dietary supplementation with omega-3 fatty acids had
a beneficial effect on the symptoms of dysmenorrhea
in adolescents in one study.47 Increasing the intake
of dietary omega-3 fatty acids leads to production of
less potent prostaglandins and less potent leukotrienes,
which may have accounted for the reduction in menstrual symptoms observed in adolescent girls in that
study. x

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FIGURE 2. Pathophysiology of endometriosis. (From Harel.97 Reprinted by permission.)

Nonsteroidal Anti-inflammatory
Drugs
The most common pharmacologic treatments
for dysmenorrhea are nonsteroidal anti-inflammatory
drugs (NSAIDs). Conventional NSAIDs inhibit the activity of both cyclooxygenase-1 and -2 isoforms, leading to a reduction in prostaglandin production. The
resulting lower level of prostaglandin leads to less vigorous contractions of the uterus, and, therefore, to
less discomfort. Chan and Dawood found that PGF2
decreased and pain improved in a small number of
dysmenorrheic women treated with NSAIDs.48 Subsequent larger, randomized, placebo-controlled studies have shown several NSAID preparations, including naproxen sodium, zomepirac sodium, mefenamic
acid, ketoprofen, ibuprofen, and diclofenac, to be effective treatments for primary dysmenorrhea.4954 While
most NSAIDs inhibit only cyclooxygenase, meclofenamate sodium (a fenamate NSAID) has been shown
in vitro to inhibit both cyclooxygenase and lipooxygenase pathways.55 Although Owen found a trend favoring fenamates over ibuprofen, indomethacin, and
naproxen,56 Roy found no significant clinical difference between mefenamic acid and ibuprofen,57 indicating that there is no clear-cut advantage of one
NSAID over another in the treatment of dysmenorrhea. DuRant et al. randomized 45 girls with a mean
age of 15 years to five naproxen sodium dosing regimens for the treatment of dysmenorrhea. By the third
treatment month, a loading dose of 550 mg was associated with greater alleviation of the symptoms of
dysmenorrhea than was the regular dose of 275 mg.58
This suggests that a loading dose of NSAID (typically
twice the regular dose) should be used as initial treatment for dysmenorrhea, followed by a regular dose as
needed.

Specific cyclooxygenase isoform 2 (COX-2) inhibitors may also relieve dysmenorrhea symptoms.59
These specific COX-2 inhibitors spare prostaglandins
produced by COX-1 which are essential for the integrity of the gastric mucosa. Celecoxib (Celebrex
)
is the only available COX-2 inhibitor approved by
the U.S. Food and Drug Administration (FDA) for
treatment of primary dysmenorrhea. Currently, it is
approved for treatment of patients 18 years. The
recommended dosage of celecoxib is 400 mg initially,
followed by 200 mg every 12 hours as needed during
the menstrual period.
Not all adolescents with dysmenorrhea respond to
NSAIDs, and some of those who do respond report
only partial relief.56,60 One possible explanation is
that most NSAIDs inhibit only cyclooxygenase and
do not affect the production of other inflammatory
mediators such as leukotrienes. However, treatment
with the leukotriene receptor antagonist montelukast
(Singulair
), in the FDA-approved dose (for asthma)
and commencing immediately before the menstrual
period, failed to alleviate symptoms of dysmenorrhea
in adolescents.61 Occasionally, adolescents who do not
respond to NSAIDs may have a psychogenic component as part of their dysmenorrhea. In particular, a
history of physical or sexual abuse has been associated
with chronic pelvic pain.62

Hormonal Treatment

Combined Estrogen and Progestin Oral

Contraceptive Pills
Combined oral contraceptive pills (OCPs) are a
widely used treatment for primary dysmenorrhea
in women. OCPs are perhaps an ideal treatment
for adolescent dysmenorrhea; they are safe during

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adolescence, have health benefits important to adolescents, such as alleviation of acne, and would provide
protection against unintended pregnancy.
OCPs prevent or lessen dysmenorrhea directly by
limiting endometrial growth and reducing the amount
of endometrial tissue available for PG and LT production, and indirectly by inhibiting ovulation and subsequent progesterone secretion. The observed decrease
in menstrual fluid PG and LT during OCP use48,63 and
the observed inconclusive serum levels of these inflammatory mediators64,65 are consistent with a change in
local uterine production of PGs and LTs. Ekstrom et al.
found a decrease in intrauterine pressure and alleviation of pain on the first day of menstrual bleeding after
treatment with low-dose OCPs.66,67 Taken together,
these studies suggest that OCPs may decrease pain
by decreasing PG and LT production, as well as by
decreasing intrauterine pressure.
Many studies have reported an association between OCPs use and decreased dysmenorrhea. While
one study suggested that OCPs consisting of the potent progestin levonorgestrel might be more beneficial in treatment of dysmenorrhea,68 other studies
showed OCPs with other progestins to be beneficial as
well.69,70 Overall, the consistency of the effect of OCPs
across populations and with different pill formulations6973 supports the use of OCPs in the treatment of
dysmenorrhea.
Girls on OCPs who continue to experience menstrual symptoms or exacerbation of a medical condition (asthma, arthritis, seizures) during the active
pill-free interval, may be considered for extension of
the duration of active hormones to more than 21 days.
Studies in adult women with menstruation-related
problems showed that an extended cycle regimen (allowing menses every 3 or more months) was easier
to follow, well tolerated, and efficacious in reducing
menstrual symptoms.74,75 The first extended regimen
consisting of active pills (levonorgestrel 0.15 mg and
ethinyl estradiol 0.03 mg daily) for 84 days of continued use followed by 7 days of inactive pills (Seasonale
)
was approved by the FDA in September 2003. A modified version incorporating 7 pills of ethinyl estradiol
0.01 mg in place of the inactive pills (Seasonique
) was
approved by the FDA in May 2006. A study evaluating the effect of Seasonique on dysmenorrhea in
adolescents is ongoing. In May 2007, the FDA approved a low-dose annual regimen (Lybrel
) consisting
of ethinyl estradiol 20 mcg and levonorgestrel 90 mcg
taken daily for 365 days without a placebo phase or
pill-free interval. The main concerns with the extended
cycle regimen are: a potential decrease in endometrial
stability, a possible deleterious effect on lipid profile,

Annals of the New York Academy of Sciences

and the question of long-term safety .76 Another concern is that sexually active adolescents may find it difficult to recognize an unexpected pregnancy during the
use of an extended cycle regimen.

Injectable Long-Acting Hormonal

Contraceptives
The injectable contraceptive depot medroxyprogesterone acetate (DMPA) is a progestin-only, long-acting,
effective, and convenient contraceptive method. It
is available in two formulations: the intramuscular
formulation (Depo-Provera
, 150 mg DMPA/1 mL)
approved by the FDA in 1992, and the subcutaneous formulation (Depo-subQ Provera 104
, 104 mg
DMPA/0.65 mL) approved by the FDA in 2004, both
administered every 12 weeks. Since ovulation is inhibited for as many as 7 to 9 months after a single
DMPA intramuscular injection,77 it may be used for
alleviating the symptoms of dysmenorrhea. While the
subcutaneous formulation of DMPA delivers a 30%
lower total dose of DMPA than the intramuscular
formulation, it was found to suppress ovulation for
more than 13 weeks,78 and thus may improve dysmenorrheic symptoms as well. About two-thirds (64%) of
adolescents reported fewer symptoms of dysmenorrhea
while using DMPA as a contraceptive method.79 Since
the use of this progestin-only contraceptive may lead to
relative estrogen deficiency, there is a concern regarding its effect on bone mineral density (BMD), particularly when used during adolescence, a critical period
for BMD accrual. On November 17, 2004, the FDA
issued a black box warning for DMPA, stating that
prolonged use of the method may result in significant
loss of BMD, that the loss is greater the longer the drug
is administered, and that BMD loss may not be completely reversible after discontinuation of DMPA.80 In
a 2006 position paper of the Society for Adolescent
Medicine, Cromer et al. provided a list of clinical guidelines for continuation of DMPA use in the adolescent
age group.81

Other Long-Acting Progestin-Only

Hormonal Contraceptives
The levonorgestrel-releasing intrauterine system
(Mirena
) releases levonorgestrel (20 g/day) into the
uterine cavity for 5 years. Women (aged 2547 years)
who used Mirena considered the absence or reduced
intensity of menstruation and the amelioration of menstrual pain as the main advantages of this method.82
In this study, the proportion of women with menstrual
pain was reduced from 60% before use to 29% after
36 months of use of Mirena.
The etonogestrel subdermal implant (Implanon
),
which was approved by the FDA in 2006, provides

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Harel: Dysmenorrhea in Adolescents

effective contraception for up to 3 years. In a study by

Funk et al., 81% of women (aged 1840 years) with a
history of dysmenorrhea at baseline reported lessening
of symptoms during the use of Implanon.83

Other Long-Acting Combined Estrogen

and Progestin Hormonal Contraceptives
The combined estrogen and progestin transdermal
patch (Ortho Evra
) also has the potential to alleviate
dysmenorrhea. In one study of adolescent girls using
Ortho Evra, 39% of participants reported decrease in
dysmenorrhea symptoms, while 11% reported worsening of symptoms.84 It remains to be determined in
further studies whether Ortho Evra may be less beneficial than OCPs in the management of dysmenorrhea
in adolescemts.
The combined estrogen and progestin vaginal ring
(NuvaRing
) was approved by the FDA in 2001. It is
designed for 3 weeks of use, followed by a 1-week ringfree interval. In one recent study in women (aged 20
39 years), the incidence of dysmenorrhea was reduced
from 25.9% at baseline to 5.7% at the end of the sixth
(NuvaRing) treatment cycle.85

Approach to Adolescents with

Dysmenorrhea
Evaluation of the adolescent with dysmenorrhea
starts with a history that is obtained privately and confidentially. The patient should be asked about age at
menarche, menstrual pattern, onset and character of
menstrual cramps and other menstruation-associated
symptoms, response to analgesic medication, sexual
activity, sexual abuse history, contraception, condom
use, history of sexually transmitted diseases, vaginal
discharge, school performance and school/work absenteeism, and family history of menstrual disorders
(in particular, endometriosis in first-degree relatives).
Psychological aspects of dysmenorrhea as well as psychological sequelae of chronic pelvic pain should be
explored. The Cox Menstrual Symptoms Scale can be
used to assess the frequency and severity of symptoms
of dysmenorrhea.86
Pelvic examination is not necessary if the patient has
never been sexually active, and if the history suggests
primary dysmenorrhea. Because of the risk of pelvic
inflammatory disease, a pelvic examination should be
performed in a sexually active adolescent who develops new-onset or more severe dysmenorrhea. Pelvic
and rectal examinations should be performed in adolescents with a history suggestive of secondary dysmenorrhea. Endometriosis is commonly associated with
adnexal, uterine, or rectovaginal tenderness on pelvic

examination. While palpable nodularity may be found

on rectal examination in adult women with endometriosis, its presence in adolescents is quite uncommon.87
Adolescent care providers should explain the menstrual cycle, menstruation-associated symptoms, and
the physiologic etiology of dysmenorrhea to every
girl who suffers from menstrual cramps and/or other
menstruation-associated symptoms. During counseling, an effort should be made to encourage girls who
smoke to quit smoking, since smoking may be associated with prolonged dysmenorrheic symptoms.15 In
addition, girls should be encouraged to increase consumption of fish such as salmon, tuna, mackerel, and
herring, which are rich in very-long-chain omega-3
polyunsaturated fatty acids. A review of effective treatment options for primary dysmenorrhea should be provided.
Response to treatment is an important component
of the evaluation, because dysmenorrhea resulting
from endometriosis is less likely to respond to NSAIDs
than is primary dysmenorrhea.88 If the pain does not
abate with oral contraceptives, the patient should be
evaluated by a gynecologist for consideration of laparoscopy in order to make a definitive diagnosis of
endometriosis. Since endometriosis in adolescents is
more likely to have an atypical appearance compared
with its appearance in adults, it is important to refer to a
gynecologist who frequently cares for adolescents with
chronic pelvic pain. Pelvic magnetic resonance imaging is indicated if the medical history or/and physical
examination raises suspicion of an obstructive pelvic
anomaly.

Management of Primary
Dysmenorrhea
Treatment with one of the NSAIDs in a therapeutic dose is the preferred initial treatment and should
be tried for at least three menstrual periods. Treatment with NSAIDs is most effective when it starts 1
2 days before the onset of menses. Adolescents who
cannot predict the initiation of their period should be
instructed to start NSAID as soon as menstrual bleeding begins, or as soon as they have any menstruationassociated symptoms. It is important to provide the
adolescent with specific instructions about the dose
and maximum daily frequency of the recommended
NSAID. If one preparation does not provide relief, a
second NSAID preparation should be tried. The adolescent should be instructed to take the NSAID with
food in order to prevent gastric irritation, and to increase fluid intake in order to prevent renal side effects.

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Annals of the New York Academy of Sciences

Table 2. NSAIDs used during menstruation in the

treatment of primary dysmenorrhea in adolescents and young adults
Drug

Dosage

Ibuprofen
Naproxen sodium
Mefenamic acid
Celecoxiba ,b

200600 mg every 6 h as needed

440550 mg initially, followed by
220275 mg every 8 h as needed
500 mg initially, followed by 250 mg
every 6 h as needed
400 mg initially, followed by 200 mg
every 12 h as needed

For girls 18 years

Cyclooxygenase-2 specific inhibitor
NSAIDs = nonsteroidal anti-inflammatory drugs; h = hours
Source: From Harel.97 Reprinted by permission.
a
b

Because primary dysmenorrhea typically resolves by

day 2 to 3 of the menstrual period, the short course of
treatment limits the development of the side effects of
NSAIDs. A specific COX-2 inhibitor should be considered in adolescents with a prior history of peptic
ulcer or gastrointestinal bleeding, in adolescents who
require high doses of a conventional NSAID during
the period, in adolescents with a history of conventional NSAID gastrointestinal adverse effects, and in
adolescents with coagulation deficiencies. TABLE 2 delineates the most common conventional NSAIDs and
the available specific COX-2 inhibitor used for treatment of dysmenorrhea in the United States.
If treatment with NSAIDs is not effective, a combination estrogen and progestin pill (OCP) should be
offered for at least three menstrual cycles. Every OCP
containing 20 to 35 mcg of estrogen has the potential
for relieving dysmenorrhea. Dysmenorrhea that does
not respond to NSAIDs administered for at least three
menstrual periods and to combined OCPs administered for at least three ensuing menstrual cycles should
raise suspicion of secondary dysmenorrhea.

Management of Secondary
Dysmenorrhea
If dysmenorrhea is not alleviated within 6 months
of treatment with NSAIDs and OCPs, consideration
should be given to the performance of a laparoscopy
to assess the presence of endometriosis. Because of
wide variation in appearance and morphology of endometriosis, a histologic biopsy of the lesions should
be performed during laparoscopy in order to confirm
the diagnosis. Visible implants may also be obliterated
by laser vaporization or resection during this procedure.89,90

Initial medical treatment for endometriosis consists

of low-dose, monophasic oral contraceptives given in
a noncyclic fashion.91 The goals are to avoid endometrial proliferation, and to prevent endometrial
implants from bleeding. It is the endometrial implants
that cause the pain, scarring, and infertility associated
with endometriosis. Medical management in patients
refractory to noncyclic OCP treatment may proceed
to gonadotropin-releasing hormone (GnRH) agonists,
such as nafarelin or leuprolide, for 6 months. However, the low-estrogen state induced by these medications raises concern about bone metabolism, and
the treatment may be associated with bothersome
side effects such as hot flashes, emotional lability, and
headaches.90 Therefore, add back sex steroid therapy should be considered if long-term treatment with
one of the GnRH agonists is planned.92 Medications
such as danazol and methyltestosterone, used in the
past for treatment of endometriosis, are seldom utilized anymore because of high rate of adverse effects.
Preliminary reports indicate that aromatase inhibitors,
which can effectively block the local estrogen biosynthesis in the endometriotic lesions, significantly reduce
lesion size and alleviate pelvic pain in patients with endometriosis.93,94 To prevent ovarian folliculogenesis in
adolescents and young adults, the aromatase inhibitor
may be combined with a progestin, a combination
oral contraceptive, or a GnRH analogue.95 Another
novel approach is the use of a selective progesterone
receptor modulator, which has been shown to reduce
dysmenorrhea and nonmenstrual pain in patients with
endometriosis.96
The management of congenital malformations of
the genital tract may be complex, and patients should
be referred to a clinician who is experienced in management of these disorders. While it has been suggested that endometriosis in patients with genital
tract anomalies usually resolves after a patent outflow tract is established, the evidence for this is not
strong.
The management of secondary dysmenorrhea that
is associated with ovarian disease is beyond the scope
of this review. Functional cysts may resolve with
time alone. Decisions about surgical management of
other ovarian disorders should be made by a gynecologic surgeon who has experience in dealing with
adolescents.

Acknowledgments

I thank Wendy Wholey and Karen Autieri for skillful

preparation of the manuscript.

Harel: Dysmenorrhea in Adolescents

Conflicts of Interest

The author declares no conflicts of interest.

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