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    Acesulfame K CAS 55589-62-3

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    Eliana Susilo
    Acesulfame potassium is a sweetener and flavor enhancer with the chemical name of potassium salt of 6-methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide. It is a white crystalline powder that is freely soluble in water and very slightly soluble in ethanol. An acceptable daily intake of 0-15 mg/kg body weight was established. Tests are conducted to check for purity levels including loss on drying, pH, organic impurities, fluoride, and lead content.

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    Acesulfame K CAS 55589-62-3

    Uploaded by

    Eliana Susilo
    42 views2 pages
    Acesulfame potassium is a sweetener and flavor enhancer with the chemical name of potassium salt of 6-methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide. It is a white crystalline powder that is freely soluble in water and very slightly soluble in ethanol. An acceptable daily intake of 0-15 mg/kg body weight was established. Tests are conducted to check for purity levels including loss on drying, pH, organic impurities, fluoride, and lead content.

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    Codex standard for Acesulfame K CAS 55589-62-3

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    Acesulfame potassium is a sweetener and flavor enhancer with the chemical name of potassium salt of 6-methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide. It is a white crystalline powder that is freely soluble in water and very slightly soluble in ethanol. An acceptable daily intake of 0-15 mg/kg body weight was established. Tests are conducted to check for purity levels including loss on drying, pH, organic impurities, fluoride, and lead content.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    42 views2 pages

    Acesulfame K CAS 55589-62-3

    Uploaded by

    Eliana Susilo
    Acesulfame potassium is a sweetener and flavor enhancer with the chemical name of potassium salt of 6-methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide. It is a white crystalline powder that is freely soluble in water and very slightly soluble in ethanol. An acceptable daily intake of 0-15 mg/kg body weight was established. Tests are conducted to check for purity levels including loss on drying, pH, organic impurities, fluoride, and lead content.

    Copyright:

    © All Rights Reserved
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    of 2

    ACESULFAME POTASSIUM

    Prepared at the 57th JECFA (2001) and published in FNP 52 Add 9


    (2001), superseding specifications prepared at the 46th JECFA (1996) and
    published in FNP 52 Add 4 (1996). An ADI of 0-15 mg/kg body weight was
    established at the 37th JECFA (1990).

    SYNONYMS

    Acesulfame K; INS No. 950

    DEFINITION
    Chemical names

    Potassium salt of 6-methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide;


    potassium salt of 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide

    C.A.S. number

    55589-62-3

    Chemical formula

    C4H4KNO4S

    Structural formula

    Formula weight

    201.24

    Assay

    Not less than 99.0% and not more than 101.0% on the dried basis

    DESCRIPTION

    Odourless, white crystalline powder

    FUNCTIONAL USES Sweetener, flavour enhancer


    CHARACTERISTICS
    IDENTIFICATION
    Solubility (Vol. 4)

    Freely soluble in water, very slightly soluble in ethanol

    Spectrophotometry

    Dissolve 10 mg of the sample in 1,000 ml of water. The solution shows an


    absorbance maximum at 2272 nm

    Test for potassium


    (Vol.4)

    Passes test
    Test the residue obtained by igniting 2 g of the sample

    Precipitation test

    Add a few drops of a 10% solution of sodium cobaltinitrite to a solution of


    0.2 g of the sample in 2 ml of acetic acid TS and 2 ml of water. A yellow
    precipitate is produced.

    PURITY

    Loss on drying (Vol. 4)


    pH (Vol. 4)

    Not more than 1.0% (105o, 2 h)


    5.5 - 7.5 (1% soln)

    Organic impurities

    Passes test for 20 mg/kg of UV active components


    See description under TESTS

    Fluoride (Vol. 4)

    Not more than 3 mg/kg


    Method III; using an appropriate sample size and appropriate volumes of
    the standard solution for construction of the calibration curve.

    Lead (Vol. 4)

    Not more than 1 mg/kg


    Determine using an atomic absorption technique appropriate to the
    specified level. The selection of sample size and method of sample
    preparation may be based on the principles of the method described in
    Volume 4, Instrumental Methods.

    TESTS
    PURITY TESTS
    Organic impurities

    Proceed as directed under the method for Chromatography (High


    Performance Liquid Chromatography, FNP 5) using the following
    conditions and using 4-hydroxybenzoic acid ethyl ester as the reference
    substance:
    Column: 25 cm x 4.6 mm stainless steel
    Stationary phase: Reversed phase (C18 silica gel, 3 - 5 m)
    Elution: Isocratic
    Mobile phase: Acetonitrile/0.01 mol/l tetrabutyl ammonium hydrogen
    sulfate (TBAHS) in water; 40/60 v/v
    Flow: About 1 ml/min
    Detector type: UV or Diode array, 227 nm
    Sample size: 20 l of a 10 g/l solution of the sample in deionized water
    The chromatographic system must be capable of separating acesulfame K
    and 4-hydroxybenzoic acid ethyl ester with a resolution of 2.
    If peaks other than that due to acesulfame K appear within three times the
    elution time of acesulfame K, carry out a second run using 20 l of a 0.2
    mg/l solution of the sample.
    The sum of the areas of all peaks eluted in the first run within 3 times the
    elution time of acesulfame K elution time, except for the acesulfame K
    peak, does not exceed the peak area of acesulfame K in the second run.

    METHOD OF
    ASSAY

    Dissolve about 0.15 g of the dried sample (dissolution may be slow),


    accurately weighed, in 50.0 ml glacial acetic acid and titrate
    potentiometrically with 0.1 N perchloric acid, or add two drops of crystal
    violet TS and titrate with 0.1 N perchloric acid, to a blue-green end-point
    which persists for at least 30 sec. Perform a blank determination and make
    any necessary correction. Each ml of 0.1 N perchloric acid is equivalent to
    20.12 mg of C4H4KNO4S.

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