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    Exercise of Solvent Extraction:: Acidified Aqueous Solution of Mixture Ext. With Et O

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    Derdy Janli
    1. A natural compound was extracted from an aqueous solution using ether in three portions. The residue weight after evaporation was calculated based on the compound's partition coefficient of 3.0 between ether and water. 2. Fifty ml of a 0.01 M aqueous alkaloid solution (partition coefficient 8 between chloroform and water) was extracted with 10 ml chloroform. The weight of the residue after evaporation allows calculating the amount extracted based on the alkaloid's molecular weight of 210. 3. The number of extractions needed to remove 99.9% of an enzyme from an aqueous solution using PEG 1150 as solvent is calculated based on the enzyme's partition coefficient of 1.0

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    Exercise of Solvent Extraction:: Acidified Aqueous Solution of Mixture Ext. With Et O

    Uploaded by

    Derdy Janli
    371 views1 page
    1. A natural compound was extracted from an aqueous solution using ether in three portions. The residue weight after evaporation was calculated based on the compound's partition coefficient of 3.0 between ether and water. 2. Fifty ml of a 0.01 M aqueous alkaloid solution (partition coefficient 8 between chloroform and water) was extracted with 10 ml chloroform. The weight of the residue after evaporation allows calculating the amount extracted based on the alkaloid's molecular weight of 210. 3. The number of extractions needed to remove 99.9% of an enzyme from an aqueous solution using PEG 1150 as solvent is calculated based on the enzyme's partition coefficient of 1.0

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    1. A natural compound was extracted from an aqueous solution using ether in three portions. The residue weight after evaporation was calculated based on the compound's partition coefficient of 3.0 between ether and water. 2. Fifty ml of a 0.01 M aqueous alkaloid solution (partition coefficient 8 between chloroform and water) was extracted with 10 ml chloroform. The weight of the residue after evaporation allows calculating the amount extracted based on the alkaloid's molecular weight of 210. 3. The number of extractions needed to remove 99.9% of an enzyme from an aqueous solution using PEG 1150 as solvent is calculated based on the enzyme's partition coefficient of 1.0

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    © All Rights Reserved
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    371 views1 page

    Exercise of Solvent Extraction:: Acidified Aqueous Solution of Mixture Ext. With Et O

    Uploaded by

    Derdy Janli
    1. A natural compound was extracted from an aqueous solution using ether in three portions. The residue weight after evaporation was calculated based on the compound's partition coefficient of 3.0 between ether and water. 2. Fifty ml of a 0.01 M aqueous alkaloid solution (partition coefficient 8 between chloroform and water) was extracted with 10 ml chloroform. The weight of the residue after evaporation allows calculating the amount extracted based on the alkaloid's molecular weight of 210. 3. The number of extractions needed to remove 99.9% of an enzyme from an aqueous solution using PEG 1150 as solvent is calculated based on the enzyme's partition coefficient of 1.0

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    © All Rights Reserved
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    of 1

    Exercise of Solvent Extraction:

    1. A 25.0 ml aliquot of a 0.4% (w/v) aqueous solution of a natural compound was


    extracted with three 10.0 ml portions of ether. The combined ether extracts were
    evaporated to dryness the residue was weighed. The ether/water partition
    coefficient for the compound is 3.0. What was the weight of the residue?
    2. The partition coefficient of an alkaloid between chloroform and water is 8 (it is
    more soluble in the organic solvent). Fifty milliliters of a 0.01 M aqueous solution
    of the alkaloid is extracted with one 10.0 ml portion of chloroform, and the
    chloroform solution is evaporated to dryness. What is the weight of the residue?
    The MW of the alkaloid is 210.
    3. How many extractions are necessary to remove 99.9% of an enzyme from 50 ml
    of an aqueous solution if it is extracted with 25 ml portions of PEG 1150 as
    solvent and its partition coefficient is 1.0?
    4. 100.0 ml of a 1% penicillin solution was extracted with 2 x 20 ml portions of
    amyl acetate. The combined ether extracts were evaporated and the dry residue
    was found to weight 865.5 mg. Calculate the partition coefficient.
    5. A mixture of Ephedrine (pKa=9.5), Salicylic acid (pKa=3) and Phenobarbital
    (pKa=8) was subjected to the following extraction shown in the picture. Tell in
    which fraction (I, II, III, IV) each of the drugs will be predominantly found.
    Acidified aqueous
    solution of mixture
    Ext. with Et2O
    org

    aq

    Extracted with
    pH 6 buffer

    org

    aq

    II

    Make alkaline, ext.


    with CHCl3
    org

    aq

    III

    IV

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