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    Data Pengamatan Gambar Keterangan

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    Laras Murni Rahayu
    1. The document describes procedures for determining the concentration of NaOH using potassium biphthalate, and determining the content of aspirin and mefenamic acid in samples. 2. Calculations were shown to find the concentration of NaOH was 0.10575 N. The content of aspirin in samples was determined to be 42.84% and 42.67% in tablets. 3. The content of mefenamic acid in the tablet sample was determined to be an average of 82.63% based on titrations with 0.10575 N NaOH and chemical equivalence calculations.

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    Data Pengamatan Gambar Keterangan

    Uploaded by

    Laras Murni Rahayu
    13 views5 pages
    1. The document describes procedures for determining the concentration of NaOH using potassium biphthalate, and determining the content of aspirin and mefenamic acid in samples. 2. Calculations were shown to find the concentration of NaOH was 0.10575 N. The content of aspirin in samples was determined to be 42.84% and 42.67% in tablets. 3. The content of mefenamic acid in the tablet sample was determined to be an average of 82.63% based on titrations with 0.10575 N NaOH and chemical equivalence calculations.

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    Original Title

    Asam Mefenemat

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    1. The document describes procedures for determining the concentration of NaOH using potassium biphthalate, and determining the content of aspirin and mefenamic acid in samples. 2. Calculations were shown to find the concentration of NaOH was 0.10575 N. The content of aspirin in samples was determined to be 42.84% and 42.67% in tablets. 3. The content of mefenamic acid in the tablet sample was determined to be an average of 82.63% based on titrations with 0.10575 N NaOH and chemical equivalence calculations.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    13 views5 pages

    Data Pengamatan Gambar Keterangan

    Uploaded by

    Laras Murni Rahayu
    1. The document describes procedures for determining the concentration of NaOH using potassium biphthalate, and determining the content of aspirin and mefenamic acid in samples. 2. Calculations were shown to find the concentration of NaOH was 0.10575 N. The content of aspirin in samples was determined to be 42.84% and 42.67% in tablets. 3. The content of mefenamic acid in the tablet sample was determined to be an average of 82.63% based on titrations with 0.10575 N NaOH and chemical equivalence calculations.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 5

    Data Pengamatan

    Gambar Keterangan



    Pembakuan NaOH dengan titik akhir
    titrasi berwarna merah muda dan
    dilakukan secara duplo



    Sampel Mefenamic Acid yang telah
    dihaluskan dan siap ditimbang



    Sampel dipanaskan yang sebelumnya
    telah ditambahkan aseton

    I. Perhitungan
    1. Pembakuan larutan NaOH terhadap kalium biftalat
    Titrasi ke-
    Berat asam sulfanilat
    (gram)
    Volume NaOHyang
    digunakan (ml)
    1 0,1538 7,08
    2 0,1540 7,11
    Rata-rata 0,1539 7,10

    Pembakuan NaOH 0,1 N
    Konsentrasi kalium biftalat :








    = 0,0100 N
    Konsentrasi NaOH 0,1 N :
    - Pembakuan pertama
    V x N
    NaOH
    = V x N
    kalium biftalat

    7,08 mL x N = 75 mL x 0,01 N
    N
    NaOH
    = 0,1059 N
    - Pembakuan kedua
    V x N
    NaOH
    = V x N
    kalium biftalat

    7,10 mL x N = 75 mL x 0,01 N
    N
    NaOH
    = 0,1056 N
    Rata-rata konsentrasi NaOH = 0,10575 N




    2. Penentuan kadar Aspirin
    Titrasi ke-
    Berat aspirin (gram)
    Volume NaOHyang
    digunakan (ml)
    1 0,5018 22,60
    2 0,5039 22,70
    Rata-rata 0,5029 22,65

    - 1,0 mL natrium hidroksida 0,1 N setara dengan 9,008 mg C
    9
    H
    8
    O
    4

    - 22,65 mL natrium hidroksida 0,1056 N setara dengan berapa mg C
    9
    H
    8
    O
    4
    ?
    - Berat 1 tablet sampel : 0,5995 gram





    ()

    ()



    ()
    ()

    Berat aspirin dalam 1 tablet =


    x berat aspirin dalamsampel
    =

    x 0,21546
    = 0,2558 gram
    Kadar aspirin dalamsampel =


    x 100%
    =

    x 100%
    = 42,84 %
    Kadar aspirin dalam 1 tablet =


    x 100%
    =

    x 100%
    = 42,67 %


    3. Penentuan kadar Mefenamic Acid
    Titrasi ke-
    Berat Mefenamic (gram)
    Volume NaOHyang
    digunakan (ml)
    1 0,5005 16,10
    2 0,5005 16,32
    Rata-rata 0,5005 16,21

    - 1,0 mL natrium hidroksida 0,1 N setara dengan 9,008 mg C
    9
    H
    8
    O
    4

    - Berat 1 tablet sampel : 0,6579 gram
    Kadar Asam Mefenamat
    BE asam mefenamat = 241,29 g/ekivalen
    Ekivalen NaOH = ekivalen asam mefenamat
    V
    NaOH
    x N
    NaOH
    = miliekivalen
    - Percobaan pertama
    mek = V
    NaOH
    x N
    NaOH
    = 16,10 mL x 0,10575 N
    = 1,7026



    Massa = mek x berat ekivalen
    = 1,7026 x 241,29 g/ekivalen
    = 410,8143 mg = 0,4108 g










    - Percobaan kedua
    mek = V
    NaOH
    x N
    NaOH
    = 16,32 mL x 0,10575 N
    = 1,7258



    Massa = mek x berat ekivalen
    = 1,7258 x 241,29 g/ekivalen
    = 416,4279 mg = 0,4164 gr









    Rata-rata kadar asam mefenamat dalam tablet sampel adalah 82,63 %

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