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    K-02 (Imunologi Dasar)

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    This document discusses key concepts in immunology and is based on the textbook "Cellular and Molecular Immunology" by Abbas and Lichtman. It covers topics such as antigens, antibodies, innate immunity, adaptive immunity, T cells, B cells, cytokines, and antigen processing and presentation. The document uses the reference book as its source throughout and appears to be lecture notes or a summary of content from the textbook.

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    K-02 (Imunologi Dasar)

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    amiksalamah
    108 views40 pages
    This document discusses key concepts in immunology and is based on the textbook "Cellular and Molecular Immunology" by Abbas and Lichtman. It covers topics such as antigens, antibodies, innate immunity, adaptive immunity, T cells, B cells, cytokines, and antigen processing and presentation. The document uses the reference book as its source throughout and appears to be lecture notes or a summary of content from the textbook.

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    This document discusses key concepts in immunology and is based on the textbook "Cellular and Molecular Immunology" by Abbas and Lichtman. It covers topics such as antigens, antibodies, innate immunity, adaptive immunity, T cells, B cells, cytokines, and antigen processing and presentation. The document uses the reference book as its source throughout and appears to be lecture notes or a summary of content from the textbook.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    108 views40 pages

    K-02 (Imunologi Dasar)

    Uploaded by

    amiksalamah
    This document discusses key concepts in immunology and is based on the textbook "Cellular and Molecular Immunology" by Abbas and Lichtman. It covers topics such as antigens, antibodies, innate immunity, adaptive immunity, T cells, B cells, cytokines, and antigen processing and presentation. The document uses the reference book as its source throughout and appears to be lecture notes or a summary of content from the textbook.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 40

    Farida Oesman Department of Clinical Pathology Faculty of Medicine, University of Indonesia

    ANTIGEN

    SUBSTANCE BIOLOGIC MOLECULES (SUGAR, LIPID, HORMON) MACROMOLECULES (PROTEIN, POLYSACCHARIDE, PHOSPHOLIPID) THAT SPECIFICALLY BOUND BY

    ANTIBODY T CELL RECEPTOR

    IMMUNOGEN SUBSTANCE (MACROMOLECULES) THAT STIMULATE B CELLS


    TO PRODUCE

    SPECIFIC ANTIBODY

    SMALL MOLECULES HAPTEN


    BOUND TO

    MACROMOLECULES CARRIER

    IMMUNOGEN

    ANTIBODY

    SPECIFIC GLYCOPROTEIN REFERRED TO AS IMMUNOGLOBULIN (GAMMA GLOBULIN)

    COMBINE WITH ANTIGEN COMPLEMENT

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    IgM Ig POOL MW HALF LIFE H CHAIN SUBCLASS SECRETED FORM FUNCTION 10 % 900.000 5 days

    IgG 70-75% 160.000 23 days

    NONE PENTAMER NAIVE B CELL ANTIGEN RECEPTOR C ACTIVATION

    4 MONOMER OPSONIZATION C ACTIVATION ADCC

    IgA Ig POOL MW HALF LIFE H CHAIN SUBCLASS SECRETED FORM FUNCTION 15-20% 360.000 6 days

    IgE

    IgD 1% 160.000 3 days

    200.000 2 days

    2 MONOMER DIMER MUCOSSAL IMMUNITY

    NONE MONOMER

    NONE NONE

    IMMEDIATE HYPERSENSITIVITY ADCC (EOSINOPHIL) DEFENCE AGAINST HELMINTHIC PARASITE

    NAIVE B CELL ANTIGEN RECEPTOR

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    MHC GENE PRODUCT MHC MOLECULE HUMAN LEUKOCYTE ANTIGEN (HLA) CLASS I CLASS II MEMBRANE GLYCOPROTEIN

    CLASS I POLYPETIDE CHAIN PEPTIDE BINDING SIZE OF PEPTIDE BINDING DISTRIBUTION 1, 2, 3 chain 2 MICROGLOBULIN 1 and 2 8 11 RESIDUE NUCLEATED CELLS

    CLASS II 1, 2 chain 1, 2 chain 1 and 1 10 30 RESIDUE DENDRITIC CELLS B CELLS MACROPHAGE HLA - DR, DQ, DP PRESENTED PROCESSED Ag TO T CYTOTOXIC (CD8)

    NOMENCLATURE FUNCTION

    HLA - A, B, C PRESENTED PROCESSED Ag TO T HELPER (CD4)

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    CELLS
    ANTIGEN MITOGEN

    CYTOKINE LYMPHOKINE MONOKINE INTERLEUKIN


    MEDIATE & REGULATE

    IMMUNE & INFLAMMATORY REACTION

    SOURCE

    REC CELLS

    AUTOCRINE ENDO CRINE


    BIOLOGIC EFFECTS

    ACTION

    CYTOKINE

    PARACRINE
    REC CELLS
    TARGET

    PROPERTIES OF CYTOKINE

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    ANTIGEN IMMUNE SYSTEM PRIMARY LYMPHOID THYMUS BONE MARROW SECONDARY LYMPHOID LYMPH NODES SPLEEN MALT (Mucosa Associated Lymphoid Tissues)

    IMMUNE RESPONSE

    IMMUNE RESPONSE

    INNATE IMMUNITY

    ADAPTIVE IMMUNITY

    HOST DEFENSE TISSUE INJURY & DISEASE

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    INNATE IMMUNITY

    CELLULAR PHAGOCYTES (PMN & MN) NK CELLS

    HUMORAL COMPLEMENT CYTOKINES

    PHAGOCYTOSIS INFLAMMATION

    PHAGOCYTOSIS

    RECRUITMENT OF LEUCOCYTES TO SITES OF INFECTION

    RECOGNITION OF MICROBES BY PHAGOCYTES

    PHAGOCYTOSIS AND INTRACELLULAR KILLING OF MICROBES

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    TOLL LIKE Pattern recognition receptor = PRR RECEPTOR


    PHAGOCYTE

    Pathogen-associated molecular pattern = PAMP

    LPS

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    VIRUS

    MICROBES

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    ADAPTIVE IMMUNITY

    CELLULAR T CELLS B CELLS


    CELL MEDIATED IMMUNITY (CMI)

    HUMORAL ANTIBODIES CYTOKINES

    T CELL
    RECOGNIZE
    PROCESSED Ag

    TCR

    NOT RECOGNIZE
    NATIVE Ag

    MHC MOL

    APC

    PROCESSING PRESENTING

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

    ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

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