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    Dent 355 Rima Huda Lab Keratosis

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    Heba S Radaideh
    This document summarizes various oral mucosal disorders including normal oral mucosa, leukoplakia, lichen planus, and lupus erythematosus. It describes the clinical features, histopathology, and characteristics of these conditions. Key histopathological findings discussed include hyperkeratosis, acanthosis, epithelial dysplasia, sawtooth rete ridges, band-like inflammatory infiltrates, Civatte bodies, and basal cell degeneration. The document provides detailed information on the pathology of these oral diseases.

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    Dent 355 Rima Huda Lab Keratosis

    Uploaded by

    Heba S Radaideh
    70 views57 pages
    This document summarizes various oral mucosal disorders including normal oral mucosa, leukoplakia, lichen planus, and lupus erythematosus. It describes the clinical features, histopathology, and characteristics of these conditions. Key histopathological findings discussed include hyperkeratosis, acanthosis, epithelial dysplasia, sawtooth rete ridges, band-like inflammatory infiltrates, Civatte bodies, and basal cell degeneration. The document provides detailed information on the pathology of these oral diseases.

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    This document summarizes various oral mucosal disorders including normal oral mucosa, leukoplakia, lichen planus, and lupus erythematosus. It describes the clinical features, histopathology, and characteristics of these conditions. Key histopathological findings discussed include hyperkeratosis, acanthosis, epithelial dysplasia, sawtooth rete ridges, band-like inflammatory infiltrates, Civatte bodies, and basal cell degeneration. The document provides detailed information on the pathology of these oral diseases.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    70 views57 pages

    Dent 355 Rima Huda Lab Keratosis

    Uploaded by

    Heba S Radaideh
    This document summarizes various oral mucosal disorders including normal oral mucosa, leukoplakia, lichen planus, and lupus erythematosus. It describes the clinical features, histopathology, and characteristics of these conditions. Key histopathological findings discussed include hyperkeratosis, acanthosis, epithelial dysplasia, sawtooth rete ridges, band-like inflammatory infiltrates, Civatte bodies, and basal cell degeneration. The document provides detailed information on the pathology of these oral diseases.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
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    of 57

    Dent 355 Laboratory Session Keratoses and Related Disorders of Oral Mucosa

    Dr. Rima Safadi Modified from Dr. Huda Hammad

    Normal Oral Mucosa

    Color of normal oral mucosa

    Normal Oral Mucosa

    Color of normal oral mucosa: vascularity, melanin, epithelial thickness, keratinization.

    Normal Oral Mucosa


    Non-keratinized parts

    Normal Oral Mucosa


    Non-keratinized parts

    Normal Oral Mucosa Keratinized Parts

    White Patches

    Debris

    Hyperkeratosis

    Definition of Histopathological Terms

    orthokeratin

    Pyknotic nuclei: parakeratosis

    Granular cell layer

    Definition of Histopathological Terms

    Atrophy
    Acanthosis

    Cellular atypia, Epithelial dysplasia.

    Dysplasia

    Hereditary Conditions (Genodermatoses): Oral Epithelial Nevus (White Sponge Nevus)

    Hereditary Conditions (Genodermatoses): Oral Epithelial Nevus (White Sponge Nevus)

    Hyperkeratosis

    -Intracellular

    edema of prickle and cell layers.

    Hereditary Conditions (Genodermatoses): Leukoedema

    Hereditary Conditions: Leukoedema

    Intracellular edem And glycogen Cells appear vacul

    Thick epithelium with broad rete ridges

    Traumatic Keratoses: Mechanical Trauma-Frictional Keratosis

    Trauma-Frictional Keratosis Habitual cheek biting

    Traumatic Keratoses: Mechanical Trauma-Frictional Keratosis

    Histopathology: Hyperkeratosis +/acanthosis. There is no dysplasia.

    Traumatic Keratoses: Chemical


    Aspirin burn.

    Traumatic Keratoses: Chemical

    Snuff dippers lesion.

    Similar to chronic friction

    Traumatic Keratoses: Thermal Nicotinic Stomatitis

    Dilated duct of minor salivary gland

    Leukoplakia

    Homogenous Leukoplakia
    Homogeneous - flat, uniform, predominantly white plaques - may show shallow cracks/fissures

    Leukoplakia: Clinical Features

    Speckeled Speckeled

    Erythroplakia

    Leukoplakia: Pathology, Epithelial Dysplasia


    2 features are highly suggestive of smoking as an etiological factor: 1. presence of chevron peaks in keratin.

    2. increased melanin production in basal keratinocytes and leakage of melanin into the underlying connective tissue (melanin incontinence).

    Leukoplakia: Pathology, Epithelial Dysplasia

    Leukoplakia: Pathology, Epithelial Dysplasia

    Leukoplakia: Pathology, Epithelial Dysplasia

    Leukoplakia: Pathology, Epithelial DysplasiaFeatures of Epithelial Dysplasia


    1. Increased and abnormal mitoses.

    Leukoplakia: Pathology, Epithelial DysplasiaFeatures of Epithelial Dysplasia


    2. Basal cell hyperplasia.

    Leukoplakia: Pathology, Epithelial DysplasiaFeatures of Epithelial Dysplasia


    3. Drop-shaped rete ridges.

    Leukoplakia: Pathology, Epithelial DysplasiaFeatures of Epithelial Dysplasia


    4. Disturbed polarity of basal cells or loss of cellular orientation.

    Leukoplakia: Pathology, Epithelial DysplasiaFeatures of Epithelial Dysplasia


    5. Increase in nuclear/ cytoplasmic ratio.

    Leukoplakia: Pathology, Epithelial DysplasiaFeatures of Epithelial Dysplasia


    6. Nuclear hyperchromatism.

    Leukoplakia: Pathology, Epithelial DysplasiaFeatures of Epithelial Dysplasia


    7. Prominent and enlarged nucleoli.

    Leukoplakia: Pathology, Epithelial DysplasiaFeatures of Epithelial Dysplasia


    8. Irregular epithelial stratification or disturbed maturation.

    Leukoplakia: Pathology, Epithelial DysplasiaFeatures of Epithelial Dysplasia


    9. Nuclear and cellular pleomorphism.

    Leukoplakia: Pathology, Epithelial DysplasiaFeatures of Epithelial Dysplasia


    10. Abnormal keratinization (dyskeratosis).

    Leukoplakia: Pathology, Epithelial DysplasiaFeatures of Epithelial Dysplasia


    11. Loss or reduction of intercellular adhesion.

    Regezi

    Lichen Planus: Clinical Features


    Skin lesions:

    Lichen Planus: Clinical Features


    Skin Lesions:

    Lichen Planus: Clinical Features


    Skin and Nail Lesions:

    Lichen Planus: Clinical Features


    Oral Lesions:

    Reticular pattern

    Lichen Planus: Clinical Features


    Oral Lesions:
    Non-erosive types: - reticular or annular, papular, plaque-like.

    Lichen Planus: Clinical Features


    Oral Lesions:

    Erosive/atrophic types

    Lichen Planus: Clinical Features


    Oral Lesions:

    Lichen planus involving the gingiva often presents as a desquamative gingivitis.

    Lichen Planus: Pathology


    Histopathologic Features:

    Ortho- or parakeratosis. Epithelial atrophy or acanthosis (sawtooth pattern of rete ridges). Dense, well-defined band of subepithelial mononuclear infiltrate, mainly T-cells.

    Lichen Planus: Pathology


    Histopathologic Features:

    Lichen Planus: Pathology


    Histopathologic Features:

    Liquefactive degeneration of basal cell layer associated with edema and lymphocytic infiltration. Civatte bodies: hyaline shrunken bodies representing apoptotic cells.

    Lichen Planus: Pathology


    Histopathologic Features:

    Basal cell degeneration may result in subepithelial bullae formation and ulceration.

    Lupus Erythematosus: Clinical Features


    Chronic Discoid Lupus Erythematosus (DLE):

    Lupus Erythematosus: Clinical Features


    Chronic Discoid Lupus Erythematosus (DLE): Oral Lesions

    Lupus erythematosus histopathology

    Deep perivascular Lymphocytic infiltrate

    Lupus Erythematosus: Histopathologic Features

    Subepithelial and deep perivascular lymphocytic infiltrates.

    Liquefactive degenerartion of basal cells.

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